@mastersthesis{MTMT:32868435, title = {Investigation of the pathomechanism and potential therapeutic targets in radiation-induced heart disease in a rat model [A radiogén szívkárosodás pathomechanizmusának és lehetséges terápiás célpontjainak kísérletes vizsgálata patkány modellben]}, url = {https://m2.mtmt.hu/api/publication/32868435}, author = {Kovács, Mónika Gabriella}, doi = {10.14232/phd.11174}, publisher = {SZTE}, unique-id = {32868435}, year = {2022}, orcid-numbers = {Kovács, Mónika Gabriella/0000-0002-5756-4662} } @article{MTMT:32689754, title = {Investigation of the Antiremodeling Effects of Losartan, Mirabegron and Their Combination on the Development of Doxorubicin-Induced Chronic Cardiotoxicity in a Rat Model}, url = {https://m2.mtmt.hu/api/publication/32689754}, author = {Freiwan, Marah and Kovács, Mónika Gabriella and Kovács, Zsuzsanna and Szűcs, Gergő and Dinh, Hoa and Losonczi, Réka Hajnalka and Siska, Andrea and Kriston, András and Kovács, Ferenc and Horváth, Péter and Földesi, Imre and Cserni, Gábor and Dux, László and Csont, Tamás Bálint and Sárközy, Márta}, doi = {10.3390/ijms23042201}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {23}, unique-id = {32689754}, issn = {1661-6596}, abstract = {Despite the effectiveness of doxorubicin (DOXO) as a chemotherapeutic agent, dose-dependent development of chronic cardiotoxicity limits its application. The angiotensin-II receptor blocker losartan is commonly used to treat cardiac remodeling of various etiologies. The beta-3 adrenergic receptor agonist mirabegron was reported to improve chronic heart failure. Here we investigated the effects of losartan, mirabegron and their combination on the development of DOXO-induced chronic cardiotoxicity. Male Wistar rats were divided into five groups: (i) control; (ii) DOXO-only; (iii) losartan-treated DOXO; (iv) mirabegron-treated DOXO; (v) losartan plus mirabegron-treated DOXO groups. The treatments started 5 weeks after DOXO administration. At week 8, echocardiography was performed. At week 9, left ventricles were prepared for histology, qRT-PCR, and Western blot measurements. Losartan improved diastolic but not systolic dysfunction and ameliorated SERCA2a repression in our DOXO-induced cardiotoxicity model. The DOXO-induced overexpression of Il1 and Il6 was markedly decreased by losartan and mirabegron. Mirabegron and the combination treatment improved systolic and diastolic dysfunction and significantly decreased overexpression of Smad2 and Smad3 in our DOXO-induced cardiotoxicity model. Only mirabegron reduced DOXO-induced cardiac fibrosis significantly. Mirabegron and its combination with losartan seem to be promising therapeutic tools against DOXO-induced chronic cardiotoxicity.}, keywords = {heart failure; diastolic dysfunction; Cardiac fibrosis; angiotensin II receptor blocker; cardiac inflammation; TGF-beta/SMAD signaling pathway; Onco-cardiology; doxorubicin-induced chronic cardiotoxicity; beta-3 adrenoceptor agonist; sarcoendoplasmic reticulum calcium ATPase 2a}, year = {2022}, eissn = {1422-0067}, orcid-numbers = {Freiwan, Marah/0000-0002-2482-0367; Kovács, Mónika Gabriella/0000-0002-5756-4662; Kovács, Zsuzsanna/0000-0002-4197-4579; Szűcs, Gergő/0000-0003-1874-2718; Losonczi, Réka Hajnalka/0009-0001-7220-2184; Földesi, Imre/0000-0002-3329-8136; Cserni, Gábor/0000-0003-1344-7744; Dux, László/0000-0002-1270-1678; Csont, Tamás Bálint/0000-0001-5792-2768; Sárközy, Márta/0000-0002-5929-2146} } @article{MTMT:32517976, title = {Investigation of the Antihypertrophic and Antifibrotic Effects of Losartan in a Rat Model of Radiation-Induced Heart Disease}, url = {https://m2.mtmt.hu/api/publication/32517976}, author = {Kovács, Mónika Gabriella and Kovács, Zsuzsanna and Varga, Zoltán and Szűcs, Gergő and Freiwan, Marah and Farkas, Katalin and Kővári, Bence and Cserni, Gábor and Kriston, András and Kovács, Ferenc and Horváth, Péter and Földesi, Imre and Csont, Tamás Bálint and Kahán, Zsuzsanna and Sárközy, Márta}, doi = {10.3390/ijms222312963}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {22}, unique-id = {32517976}, issn = {1661-6596}, year = {2021}, eissn = {1422-0067}, orcid-numbers = {Kovács, Mónika Gabriella/0000-0002-5756-4662; Kovács, Zsuzsanna/0000-0002-4197-4579; Varga, Zoltán/0000-0001-8537-6282; Szűcs, Gergő/0000-0003-1874-2718; Freiwan, Marah/0000-0002-2482-0367; Kővári, Bence/0000-0002-4498-8781; Cserni, Gábor/0000-0003-1344-7744; Földesi, Imre/0000-0002-3329-8136; Csont, Tamás Bálint/0000-0001-5792-2768; Kahán, Zsuzsanna/0000-0002-5021-8775; Sárközy, Márta/0000-0002-5929-2146} } @article{MTMT:32172362, title = {Comparison of the antiremodeling effects of losartan and mirabegron in a rat model of uremic cardiomyopathy}, url = {https://m2.mtmt.hu/api/publication/32172362}, author = {Kovács, Zsuzsanna and Szűcs, Gergő and Freiwan, Marah and Kovács, Mónika Gabriella and Márványkövi, Fanni and Dinh, Hoa and Siska, Andrea and Farkas, Katalin and Kovács, Ferenc and Kriston, András and Horváth, Péter and Kővári, Bence and Cserni, Bálint Gábor and Cserni, Gábor and Földesi, Imre and Csont, Tamás Bálint and Sárközy, Márta}, doi = {10.1038/s41598-021-96815-5}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {11}, unique-id = {32172362}, issn = {2045-2322}, year = {2021}, eissn = {2045-2322}, orcid-numbers = {Kovács, Zsuzsanna/0000-0002-4197-4579; Szűcs, Gergő/0000-0003-1874-2718; Kovács, Mónika Gabriella/0000-0002-5756-4662; Márványkövi, Fanni/0000-0002-5114-1319; Kővári, Bence/0000-0002-4498-8781; Cserni, Gábor/0000-0003-1344-7744; Földesi, Imre/0000-0002-3329-8136; Csont, Tamás Bálint/0000-0001-5792-2768; Sárközy, Márta/0000-0002-5929-2146} } @article{MTMT:31877554, title = {Pathomechanisms and therapeutic opportunities in radiation‑induced heart disease: from bench to bedside}, url = {https://m2.mtmt.hu/api/publication/31877554}, author = {Sárközy, Márta and Varga, Zoltán and Molnár-Gáspár, Renáta and Szűcs, Gergő and Kovács, Mónika Gabriella and Kovács, Zsuzsanna and Dux, László and Kahán, Zsuzsanna and Csont, Tamás Bálint}, doi = {10.1007/s00392-021-01809-y}, journal-iso = {CLIN RES CARDIOL}, journal = {CLINICAL RESEARCH IN CARDIOLOGY}, volume = {110}, unique-id = {31877554}, issn = {1861-0684}, year = {2021}, eissn = {1861-0692}, pages = {507-531}, orcid-numbers = {Sárközy, Márta/0000-0002-5929-2146; Varga, Zoltán/0000-0001-8537-6282; Molnár-Gáspár, Renáta/0000-0001-9673-4532; Szűcs, Gergő/0000-0003-1874-2718; Kovács, Mónika Gabriella/0000-0002-5756-4662; Kovács, Zsuzsanna/0000-0002-4197-4579; Dux, László/0000-0002-1270-1678; Kahán, Zsuzsanna/0000-0002-5021-8775; Csont, Tamás Bálint/0000-0001-5792-2768} } @article{MTMT:31290812, title = {The effect of the preimplantation factor on the cardiac expression of miR-21 in radiation-induced heart disease}, url = {https://m2.mtmt.hu/api/publication/31290812}, author = {Kovács, Mónika Gabriella and Kiscsatári, Laura and Varga, Zoltán and Kővári, Bence and Fábián, Gabriella and Cserni, Gábor and Thum, Thomas and Csont, Tamás Bálint and Bátkai, Sándor and Barnea, Eytan and Kahán, Zsuzsanna and Sárközy, Márta}, journal-iso = {ACTA PHYSIOL}, journal = {ACTA PHYSIOLOGICA}, volume = {227}, unique-id = {31290812}, issn = {1748-1708}, year = {2019}, eissn = {1748-1716}, pages = {166-167}, orcid-numbers = {Kovács, Mónika Gabriella/0000-0002-5756-4662; Varga, Zoltán/0000-0001-8537-6282; Kővári, Bence/0000-0002-4498-8781; Fábián, Gabriella/0000-0002-2323-4948; Cserni, Gábor/0000-0003-1344-7744; Csont, Tamás Bálint/0000-0001-5792-2768; Kahán, Zsuzsanna/0000-0002-5021-8775; Sárközy, Márta/0000-0002-5929-2146} } @article{MTMT:31290227, title = {A preimplantációs faktor hatása a miR-21 kardiális expressziójára radiogén szívkárosodásban [The effect of preimplantation factor on the cardiac expression of miR-21 in radiation-induced heart disease]}, url = {https://m2.mtmt.hu/api/publication/31290227}, author = {Kovács, Mónika Gabriella and Kiscsatári, Laura and Varga, Zoltán and Kővári, Bence and Fábián, Gabriella and Cserni, Gábor and Thomas, Thum and Csont, Tamás Bálint and Bátkai, Sándor and Eytan, Barnea and Kahán, Zsuzsanna and Sárközy, Márta}, journal-iso = {CARDIOL HUNG}, journal = {CARDIOLOGIA HUNGARICA}, volume = {49}, unique-id = {31290227}, issn = {0133-5596}, year = {2019}, eissn = {1588-0230}, pages = {B29-B30}, orcid-numbers = {Kovács, Mónika Gabriella/0000-0002-5756-4662; Varga, Zoltán/0000-0001-8537-6282; Kővári, Bence/0000-0002-4498-8781; Fábián, Gabriella/0000-0002-2323-4948; Cserni, Gábor/0000-0003-1344-7744; Csont, Tamás Bálint/0000-0001-5792-2768; Kahán, Zsuzsanna/0000-0002-5021-8775; Sárközy, Márta/0000-0002-5929-2146} } @misc{MTMT:31289430, title = {The anti-hypertrophic effect of the beta-3 adrenergic receptor agonist mirabegron in experimental uremic cardiomyopathy}, url = {https://m2.mtmt.hu/api/publication/31289430}, author = {Kovács, Zsuzsanna and Kovács, Mónika Gabriella and Szűcs, Gergő and Andrea, Siska and Imre, Földesi and Csont, Tamás Bálint and Sárközy, Márta}, unique-id = {31289430}, year = {2019}, orcid-numbers = {Kovács, Zsuzsanna/0000-0002-4197-4579; Kovács, Mónika Gabriella/0000-0002-5756-4662; Szűcs, Gergő/0000-0003-1874-2718; Csont, Tamás Bálint/0000-0001-5792-2768; Sárközy, Márta/0000-0002-5929-2146} } @misc{MTMT:31289423, title = {The potential anti-hypertrophic effect of the preimplantation factor in the development of radiation-induced heart disease in rats}, url = {https://m2.mtmt.hu/api/publication/31289423}, author = {Kovács, Mónika Gabriella and Kovács, Zsuzsanna and Varga, Zoltán and Fábián, Gabriella and Eytan, Barnea and Kahán, Zsuzsanna and Csont, Tamás Bálint and Sárközy, Márta}, unique-id = {31289423}, year = {2019}, orcid-numbers = {Kovács, Mónika Gabriella/0000-0002-5756-4662; Kovács, Zsuzsanna/0000-0002-4197-4579; Varga, Zoltán/0000-0001-8537-6282; Fábián, Gabriella/0000-0002-2323-4948; Kahán, Zsuzsanna/0000-0002-5021-8775; Csont, Tamás Bálint/0000-0001-5792-2768; Sárközy, Márta/0000-0002-5929-2146} } @{MTMT:31289422, title = {Krónikus veseelégtelenségben megemelkedik a prohipertrófiás miR-212 bal kamrai expressziója}, url = {https://m2.mtmt.hu/api/publication/31289422}, author = {Sárközy, Márta and Molnár-Gáspár, Renáta and Zvara, Ágnes and Siska, Andrea and Kővári, Bence and Szűcs, Gergő and Márványkövi, Fanni and Kovács, Mónika Gabriella and Diószegi, Petra and Bodai, László and Zsindely, Nóra and Pipicz, Márton and Gömöri, Kamilla and Kiss, Krisztina and Bencsik, Péter and Cserni, Gábor and Puskás, László and Földesi, Imre and Thum, Thomas and Bátkai, Sándor and Csont, Tamás Bálint}, booktitle = {FAMÉ 2019 Magyar Kísérletes és Klinikai Farmakológiai Társaság; Magyar Anatómus Társaság; Magyar Mikrocirkulációs és Vaszkuláris Biológiai Társaság; Magyar Élettani Társaság}, unique-id = {31289422}, year = {2019}, pages = {107-108}, orcid-numbers = {Sárközy, Márta/0000-0002-5929-2146; Molnár-Gáspár, Renáta/0000-0001-9673-4532; Kővári, Bence/0000-0002-4498-8781; Szűcs, Gergő/0000-0003-1874-2718; Márványkövi, Fanni/0000-0002-5114-1319; Kovács, Mónika Gabriella/0000-0002-5756-4662; Diószegi, Petra/0000-0001-8109-2266; Bodai, László/0000-0001-8411-626X; Zsindely, Nóra/0000-0002-6189-3100; Pipicz, Márton/0000-0002-0944-1684; Bencsik, Péter/0000-0003-1936-6232; Csont, Tamás Bálint/0000-0001-5792-2768} }