TY - CONF AU - Nagy, András Levente AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Kiss, Viktória AU - Toldi, Éva AU - Almási, Nikoletta AU - Török, Szilvia AU - Veszelka, Médea AU - Neuperger, Patricia AU - Szebeni, Gábor AU - Varga, Csaba AU - Szabó, Renáta ED - Pap, Péter László ED - László, Zoltán TI - A BGP-15 hatása imatinib-indukált szívkárosodás kezelésében T2 - 24. Kolozsvári Biológus Napok C1 - Kolozsvár PY - 2024 SP - 48 UR - https://m2.mtmt.hu/api/publication/35054657 ID - 35054657 N1 - Előadás LA - Hungarian DB - MTMT ER - TY - CHAP AU - Nagy, András Levente AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Kiss, Viktória AU - Toldi, Éva AU - Almási, Nikoletta AU - Török, Szilvia AU - Veszelka, Médea AU - Neuperger, Patricia AU - Szebeni, Gábor AU - Varga, Csaba AU - Szabó, Renáta ED - Hajdú, Péter TI - A BGP-15 hatása imatinib-indukált szívkárosodás kezelésében T2 - XXVII. Tavaszi Szél Konferencia 2024 - Absztraktkötet PB - Doktoranduszok Országos Szövetsége (DOSZ) C1 - Budapest SN - 9786156457523 PY - 2024 SP - 651 UR - https://m2.mtmt.hu/api/publication/35054634 ID - 35054634 N1 - Poszter szekció előadással LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szabó, Renáta AU - Nagy, András Levente AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Kiss, Viktória AU - Toldi, Éva AU - Almási, Nikoletta AU - Török, Szilvia AU - Veszelka, Médea AU - Neuperger, Patricia AU - Szebeni, Gábor AU - Varga, Csaba TI - Therapeutic effect of BGP-15 in the treatment of imatinib-induced cardiotoxicity in a rat model JF - CARDIOLOGIA HUNGARICA J2 - CARDIOL HUNG VL - 54. évfolyam (1-2) PY - 2024 SP - 263 SN - 0133-5596 UR - https://m2.mtmt.hu/api/publication/35054510 ID - 35054510 N1 - Poszter szekció előadással LA - English DB - MTMT ER - TY - CONF AU - Nagy, Izabella AU - Veszelka, Médea AU - Almási, Nikoletta AU - Török, Szilvia AU - Bagyánszki, Mária AU - Barta, Bence Pál AU - Papdi, Korinna AU - Balog, Dóra AU - Péli, Krisztián AU - Börzsei, Denise AU - Szabó, Renáta AU - Varga, Csaba TI - Naringin-Induced Protection in an Experimental NAFLD Rat Model T2 - Oral & Poster Abstracts; Conference on Pharmacology, Pharmacokinetics & Innovation PY - 2024 SP - 208 UR - https://m2.mtmt.hu/api/publication/34968228 ID - 34968228 N1 - Poszter AB - Non-alcoholic fatty liver disease (NAFLD) is a chronic liver ailment, which prevalence has increased significantly in recent decades. NAFLD is associated with high lipid accumulation in hepatocytes and has been associated with obesity. Naringin (NAR), a natural bioflavonoid found in citrus fruits, such as oranges and grapefruit, has anti-hyperglycaemic and antioxidant effects and may reduce hepatic lipid accumulation. Thus, NAR may be a potential treatment for NAFLD. The present study aimed to investigate the effect of NAR in a 45% fat diet (HFD)-induced NAFLD rat model. A total of 47 male Wistar-Hannover rats were divided into 5 groups: 1) control (CTRL), 2) high-fat diet (HFD 45%), 3) carboxymethyl-cellulose (CMC), 4) naringin 40 mg/kg (NAR1 + HFD), 5) naringin 80 mg/kg (NAR2 + HFD). NAR was prepared with a CMC vehicle in the form of suspension and was administered orally by gavage needle daily for 4 weeks. Our histopathological results showed that after 12 weeks of HFD, the number of fat droplets increased, liver scaffolds collapsed and wider sinuses were observed. Furthermore, white blood cell count and inflammatory marker levels were also increased in the HFD group compared to the CTRL group, however, 4 weeks of NAR treatment resulted in a decrease at both doses. Our histopathological and biochemical results demonstrated that 4 weeks of NAR treatment had a dose-dependent effect on inflammatory changes. Our results demonstrate that 4 weeks of oral administration of NAR is protective against HFD-induced liver damage and thus may be effective in attenuating the progression of NAFLD. LA - English DB - MTMT ER - TY - CONF AU - Almási, Nikoletta AU - Török, Szilvia AU - Veszelka, Médea AU - Nagy, Izabella AU - Balog, Dóra AU - Péli, Krisztián AU - Börzsei, Denise AU - Szabó, Renáta AU - Varga, Csaba TI - Acute Inflammation-Induced Barrier Dysfunction in TNBS Rat Colitis: a Focus on The Gut-Brain Axis T2 - Oral & Poster Abstracts; Conference on Pharmacology, Pharmacokinetics & Innovation PY - 2024 SP - 200 UR - https://m2.mtmt.hu/api/publication/34967931 ID - 34967931 N1 - Poszter LA - English DB - MTMT ER - TY - CONF AU - Veszelka, Médea AU - Almási, Nikoletta AU - Török, Szilvia AU - Bagyánszki, Mária AU - Barta, Bence Pál AU - Bódi, Nikolett AU - Nagy, Izabella AU - Papdi, Korinna AU - Balog, Dóra AU - Szabó, Renáta AU - Börzsei, Denise AU - Varga, Csaba TI - Investigation of the protecitive effect of a bioactive polyphenol in TNBS rat model T2 - Oral & Poster Abstracts; Conference on Pharmacology, Pharmacokinetics & Innovation PY - 2024 SP - 214 EP - 215 PG - 2 UR - https://m2.mtmt.hu/api/publication/34967922 ID - 34967922 N1 - Poszter AB - Inflammatory bowel diseases (IBD) are a group of chronic, incurable diseases of the digestive tract. Chronic inflammation underlies the aetiology of IBD and is closely associated with oxidative/nitrosative stress and a vast generation of reactive oxygen/nitrogen species. Several substances with antioxidant and anti-inflammatory properties are now intensively researched as possible adjunctive or independent treatment options in IBD. Among them, resveratrol (RES), a natural polyphenol is increasingly studied for its possible protective properties against IBD. In the present study, we aimed to investigate the anti-inflammatory effects of RES in three different doses. For this reason, RES supplementation was carried out for 28 days per os. A total of 65 male Wistar-Hannover rats were randomly divided into 7 groups: CTRL, EtOH, TNBS, RES: 5, 10, 20 mg/kg, SASP. On the 25th day of the experiment, animals were challenged by intracolonic injection of 2,4,6-trinitrobenzene sulfonic acid (TNBS) to model IBD. Animals were sacrificed on the 29th day of the experiment. The potential anti-inflammatory effect was investigated by enzyme-linked immunosorbent assay (ELISA) and western blot. The histological features of the gut wall, especially the tunica mucosa layer showed clearly visible differences in the investigated groups. Based on our histological and planimetric analysis 10 mg/kg dose of RES is considered to be effective and significantly attenuated ulceration of the colon compared to the TNBS group. Furthermore, RES-induced protection at a concentration of 10mg/kg/day was mediated by the modulation of inflammatory parameter, such as myeloperoxidase (MPO). RES supplementation also caused a decrease in inflammation by reducing the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α). In addition, our immunohistochemical findings showed that 10 mg/kg/day of RES attenuated the intensity of TNF-α receptors, TNFR1 and TNFR2 in the colon compared to TNBS. In conclusion, our results indicate the protective effects of RES in acute low-grade inflammation in TNBS rats and suggest that RES may be a promising therapeutic alternative in the treatment of IBD. LA - English DB - MTMT ER - TY - CONF AU - Török, Szilvia AU - Almási, Nikoletta AU - Veszelka, Médea AU - Nagy, Izabella AU - Balog, Dóra AU - Péli, Krisztián AU - Börzsei, Denise AU - Szabó, Renáta AU - Varga, Csaba TI - Antioxidant Effects of a Hydrogen Sulfide Donor in Experimental Colitis T2 - Oral & Poster Abstracts; Conference on Pharmacology, Pharmacokinetics & Innovation PY - 2024 SP - 213 UR - https://m2.mtmt.hu/api/publication/34967921 ID - 34967921 N1 - Poszter LA - English DB - MTMT ER - TY - JOUR AU - Nagy, András Levente AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Török, Szilvia AU - Veszelka, Médea AU - Almási, Nikoletta AU - Varga, Csaba AU - Szabó, Renáta TI - A Comprehensive Overview on Chemotherapy-Induced Cardiotoxicity: Insights into the Underlying Inflammatory and Oxidative Mechanisms JF - CARDIOVASCULAR DRUGS AND THERAPY J2 - CARDIOVASC DRUG THER PY - 2024 PG - 15 SN - 0920-3206 DO - 10.1007/s10557-024-07574-0 UR - https://m2.mtmt.hu/api/publication/34947620 ID - 34947620 LA - English DB - MTMT ER - TY - JOUR AU - Lőrincz, Csanád Endre AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Varga, Csaba AU - Szabó, Renáta TI - Mechanisms and Target Parameters in Relation to Polycystic Ovary Syndrome and Physical Exercise: Focus on the Master Triad of Hormonal Changes, Oxidative Stress, and Inflammation JF - BIOMEDICINES J2 - BIOMEDICINES VL - 12 PY - 2024 IS - 3 SP - 560 PG - 15 SN - 2227-9059 DO - 10.3390/biomedicines12030560 UR - https://m2.mtmt.hu/api/publication/34742326 ID - 34742326 AB - Polycystic ovary syndrome (PCOS) is a common endocrine disorder among females of reproductive age with heterogeneous prevalence. It is well known that female reproductive competence depends on the dynamic regulation of the hypothalamic–pituitary–gonadal (HPG) axis; therefore, disruption of this highly regulated system leads to fertility problems. Among disruptors, both oxidative stress and inflammation contribute to an increased LH-FSH ratio and a consequent hyperandrogenism. Shifts in this bidirectional interplay between the neuroendocrine system and oxidative/inflammatory homeostasis result in the accumulation of reactive oxygen/nitrogen species and inflammatory markers as well as alterations in antioxidant defense mechanisms. Evidence shows that lifestyle changes, including regular physical exercise, are recognized as the most effective first-line management to reduce the severity of PCOS symptoms. The aim of our narrative review is to provide insights into the mechanisms and target factors of PCOS-related hormonal changes, oxidative/antioxidant homeostasis, and inflammation, and to discuss the effects of exercise, which takes into account various factors, in relation to PCOS. A better understanding of the PCOS-associated hormonal changes, oxidative and inflammatory circuits, as well as exercise-induced mechanisms of action on those targets may improve the quality of life of women with PCOS. LA - English DB - MTMT ER - TY - JOUR AU - Börzsei, Denise AU - Viktória, Kiss AU - Nagy, András Levente AU - Nagyné Hoffmann, Alexandra AU - Török, Szilvia AU - Almási, Nikoletta AU - Veszelka, Médea AU - Varga, Csaba AU - Szabó, Renáta TI - Moderate-Intensity Swimming Alleviates Oxidative Injury in Ischemic Heart JF - APPLIED SCIENCES-BASEL J2 - APPL SCI-BASEL VL - 14 PY - 2024 IS - 5 PG - 10 SN - 2076-3417 DO - 10.3390/app14052073 UR - https://m2.mtmt.hu/api/publication/34724100 ID - 34724100 AB - The global burden of cardiovascular diseases is indisputable, as it claims nearly 18 million lives a year. In this current study, we aimed to prove that exercise, a cornerstone in cardiovascular disease management, emerges as a powerful tool in the pathology of myocardial ischemia. Male rats were divided into three groups: pre-swimming training + isoproterenol (ISO) treated, isoproterenol-treated, and control-sedentary. Myocardial infarction was induced by the subcutaneous injection of 1.0 mg/kg ISO. After the subsequent rest period, the animals swam for 3 weeks, every day for 25 min. At the end of the experiment, the serum levels of atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), as well as the cardiac concentrations of reactive oxygen species (ROS), catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) were determined. Our results indicate that both cardiac injury biomarkers (ANP, BNP) and ROS levels were significantly lower in swimming rats compared to the sedentary animals. Moreover, the level of enzymatic components of the intracellular antioxidant system, CAT, SOD, and GPx were increased in swimming animals after ISO-induced myocardial infarction. Our findings support the fact that moderate-intensity swimming training can be efficiently used to prevent myocardial infarction-induced ischemic injury, by inhibiting ROS production and strengthening intracellular antioxidant defense. LA - English DB - MTMT ER -