@CONFERENCE{MTMT:35054657, title = {A BGP-15 hatása imatinib-indukált szívkárosodás kezelésében}, url = {https://m2.mtmt.hu/api/publication/35054657}, author = {Nagy, András Levente and Börzsei, Denise and Nagyné Hoffmann, Alexandra and Kiss, Viktória and Toldi, Éva and Almási, Nikoletta and Török, Szilvia and Veszelka, Médea and Neuperger, Patricia and Szebeni, Gábor and Varga, Csaba and Szabó, Renáta}, booktitle = {24. Kolozsvári Biológus Napok}, unique-id = {35054657}, year = {2024}, pages = {48}, orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Szebeni, Gábor/0000-0002-6998-5632; Varga, Csaba/0000-0002-2678-665X} } @{MTMT:35054634, title = {A BGP-15 hatása imatinib-indukált szívkárosodás kezelésében}, url = {https://m2.mtmt.hu/api/publication/35054634}, author = {Nagy, András Levente and Börzsei, Denise and Nagyné Hoffmann, Alexandra and Kiss, Viktória and Toldi, Éva and Almási, Nikoletta and Török, Szilvia and Veszelka, Médea and Neuperger, Patricia and Szebeni, Gábor and Varga, Csaba and Szabó, Renáta}, booktitle = {XXVII. Tavaszi Szél Konferencia 2024 - Absztraktkötet}, unique-id = {35054634}, year = {2024}, pages = {651}, orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Szebeni, Gábor/0000-0002-6998-5632; Varga, Csaba/0000-0002-2678-665X} } @article{MTMT:35054510, title = {Therapeutic effect of BGP-15 in the treatment of imatinib-induced cardiotoxicity in a rat model}, url = {https://m2.mtmt.hu/api/publication/35054510}, author = {Szabó, Renáta and Nagy, András Levente and Börzsei, Denise and Nagyné Hoffmann, Alexandra and Kiss, Viktória and Toldi, Éva and Almási, Nikoletta and Török, Szilvia and Veszelka, Médea and Neuperger, Patricia and Szebeni, Gábor and Varga, Csaba}, journal-iso = {CARDIOL HUNG}, journal = {CARDIOLOGIA HUNGARICA}, volume = {54. évfolyam (1-2)}, unique-id = {35054510}, issn = {0133-5596}, year = {2024}, eissn = {1588-0230}, pages = {263}, orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Szebeni, Gábor/0000-0002-6998-5632; Varga, Csaba/0000-0002-2678-665X} } @CONFERENCE{MTMT:34968228, title = {Naringin-Induced Protection in an Experimental NAFLD Rat Model}, url = {https://m2.mtmt.hu/api/publication/34968228}, author = {Nagy, Izabella and Veszelka, Médea and Almási, Nikoletta and Török, Szilvia and Bagyánszki, Mária and Barta, Bence Pál and Papdi, Korinna and Balog, Dóra and Péli, Krisztián and Börzsei, Denise and Szabó, Renáta and Varga, Csaba}, booktitle = {Oral & Poster Abstracts; Conference on Pharmacology, Pharmacokinetics & Innovation}, unique-id = {34968228}, abstract = {Non-alcoholic fatty liver disease (NAFLD) is a chronic liver ailment, which prevalence has increased significantly in recent decades. NAFLD is associated with high lipid accumulation in hepatocytes and has been associated with obesity. Naringin (NAR), a natural bioflavonoid found in citrus fruits, such as oranges and grapefruit, has anti-hyperglycaemic and antioxidant effects and may reduce hepatic lipid accumulation. Thus, NAR may be a potential treatment for NAFLD. The present study aimed to investigate the effect of NAR in a 45% fat diet (HFD)-induced NAFLD rat model. A total of 47 male Wistar-Hannover rats were divided into 5 groups: 1) control (CTRL), 2) high-fat diet (HFD 45%), 3) carboxymethyl-cellulose (CMC), 4) naringin 40 mg/kg (NAR1 + HFD), 5) naringin 80 mg/kg (NAR2 + HFD). NAR was prepared with a CMC vehicle in the form of suspension and was administered orally by gavage needle daily for 4 weeks. Our histopathological results showed that after 12 weeks of HFD, the number of fat droplets increased, liver scaffolds collapsed and wider sinuses were observed. Furthermore, white blood cell count and inflammatory marker levels were also increased in the HFD group compared to the CTRL group, however, 4 weeks of NAR treatment resulted in a decrease at both doses. Our histopathological and biochemical results demonstrated that 4 weeks of NAR treatment had a dose-dependent effect on inflammatory changes. Our results demonstrate that 4 weeks of oral administration of NAR is protective against HFD-induced liver damage and thus may be effective in attenuating the progression of NAFLD.}, year = {2024}, pages = {208}, orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Bagyánszki, Mária/0000-0003-3533-9461; Barta, Bence Pál/0000-0002-5309-8633; Varga, Csaba/0000-0002-2678-665X} } @CONFERENCE{MTMT:34967931, title = {Acute Inflammation-Induced Barrier Dysfunction in TNBS Rat Colitis: a Focus on The Gut-Brain Axis}, url = {https://m2.mtmt.hu/api/publication/34967931}, author = {Almási, Nikoletta and Török, Szilvia and Veszelka, Médea and Nagy, Izabella and Balog, Dóra and Péli, Krisztián and Börzsei, Denise and Szabó, Renáta and Varga, Csaba}, booktitle = {Oral & Poster Abstracts; Conference on Pharmacology, Pharmacokinetics & Innovation}, unique-id = {34967931}, year = {2024}, pages = {200}, orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X} } @CONFERENCE{MTMT:34967922, title = {Investigation of the protecitive effect of a bioactive polyphenol in TNBS rat model}, url = {https://m2.mtmt.hu/api/publication/34967922}, author = {Veszelka, Médea and Almási, Nikoletta and Török, Szilvia and Bagyánszki, Mária and Barta, Bence Pál and Bódi, Nikolett and Nagy, Izabella and Papdi, Korinna and Balog, Dóra and Szabó, Renáta and Börzsei, Denise and Varga, Csaba}, booktitle = {Oral & Poster Abstracts; Conference on Pharmacology, Pharmacokinetics & Innovation}, unique-id = {34967922}, abstract = {Inflammatory bowel diseases (IBD) are a group of chronic, incurable diseases of the digestive tract. Chronic inflammation underlies the aetiology of IBD and is closely associated with oxidative/nitrosative stress and a vast generation of reactive oxygen/nitrogen species. Several substances with antioxidant and anti-inflammatory properties are now intensively researched as possible adjunctive or independent treatment options in IBD. Among them, resveratrol (RES), a natural polyphenol is increasingly studied for its possible protective properties against IBD. In the present study, we aimed to investigate the anti-inflammatory effects of RES in three different doses. For this reason, RES supplementation was carried out for 28 days per os. A total of 65 male Wistar-Hannover rats were randomly divided into 7 groups: CTRL, EtOH, TNBS, RES: 5, 10, 20 mg/kg, SASP. On the 25th day of the experiment, animals were challenged by intracolonic injection of 2,4,6-trinitrobenzene sulfonic acid (TNBS) to model IBD. Animals were sacrificed on the 29th day of the experiment. The potential anti-inflammatory effect was investigated by enzyme-linked immunosorbent assay (ELISA) and western blot. The histological features of the gut wall, especially the tunica mucosa layer showed clearly visible differences in the investigated groups. Based on our histological and planimetric analysis 10 mg/kg dose of RES is considered to be effective and significantly attenuated ulceration of the colon compared to the TNBS group. Furthermore, RES-induced protection at a concentration of 10mg/kg/day was mediated by the modulation of inflammatory parameter, such as myeloperoxidase (MPO). RES supplementation also caused a decrease in inflammation by reducing the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α). In addition, our immunohistochemical findings showed that 10 mg/kg/day of RES attenuated the intensity of TNF-α receptors, TNFR1 and TNFR2 in the colon compared to TNBS. In conclusion, our results indicate the protective effects of RES in acute low-grade inflammation in TNBS rats and suggest that RES may be a promising therapeutic alternative in the treatment of IBD.}, year = {2024}, pages = {214-215}, orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Bagyánszki, Mária/0000-0003-3533-9461; Barta, Bence Pál/0000-0002-5309-8633; Bódi, Nikolett/0000-0002-9774-1387; Varga, Csaba/0000-0002-2678-665X} } @CONFERENCE{MTMT:34967921, title = {Antioxidant Effects of a Hydrogen Sulfide Donor in Experimental Colitis}, url = {https://m2.mtmt.hu/api/publication/34967921}, author = {Török, Szilvia and Almási, Nikoletta and Veszelka, Médea and Nagy, Izabella and Balog, Dóra and Péli, Krisztián and Börzsei, Denise and Szabó, Renáta and Varga, Csaba}, booktitle = {Oral & Poster Abstracts; Conference on Pharmacology, Pharmacokinetics & Innovation}, unique-id = {34967921}, year = {2024}, pages = {213}, orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X} } @article{MTMT:34947620, title = {A Comprehensive Overview on Chemotherapy-Induced Cardiotoxicity: Insights into the Underlying Inflammatory and Oxidative Mechanisms}, url = {https://m2.mtmt.hu/api/publication/34947620}, author = {Nagy, András Levente and Börzsei, Denise and Nagyné Hoffmann, Alexandra and Török, Szilvia and Veszelka, Médea and Almási, Nikoletta and Varga, Csaba and Szabó, Renáta}, doi = {10.1007/s10557-024-07574-0}, journal-iso = {CARDIOVASC DRUG THER}, journal = {CARDIOVASCULAR DRUGS AND THERAPY}, unique-id = {34947620}, issn = {0920-3206}, keywords = {Inflammation; CHEMOTHERAPY; cardiotoxicity; Oxidative stress}, year = {2024}, eissn = {1573-7241}, orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X} } @article{MTMT:34742326, title = {Mechanisms and Target Parameters in Relation to Polycystic Ovary Syndrome and Physical Exercise: Focus on the Master Triad of Hormonal Changes, Oxidative Stress, and Inflammation}, url = {https://m2.mtmt.hu/api/publication/34742326}, author = {Lőrincz, Csanád Endre and Börzsei, Denise and Nagyné Hoffmann, Alexandra and Varga, Csaba and Szabó, Renáta}, doi = {10.3390/biomedicines12030560}, journal-iso = {BIOMEDICINES}, journal = {BIOMEDICINES}, volume = {12}, unique-id = {34742326}, abstract = {Polycystic ovary syndrome (PCOS) is a common endocrine disorder among females of reproductive age with heterogeneous prevalence. It is well known that female reproductive competence depends on the dynamic regulation of the hypothalamic–pituitary–gonadal (HPG) axis; therefore, disruption of this highly regulated system leads to fertility problems. Among disruptors, both oxidative stress and inflammation contribute to an increased LH-FSH ratio and a consequent hyperandrogenism. Shifts in this bidirectional interplay between the neuroendocrine system and oxidative/inflammatory homeostasis result in the accumulation of reactive oxygen/nitrogen species and inflammatory markers as well as alterations in antioxidant defense mechanisms. Evidence shows that lifestyle changes, including regular physical exercise, are recognized as the most effective first-line management to reduce the severity of PCOS symptoms. The aim of our narrative review is to provide insights into the mechanisms and target factors of PCOS-related hormonal changes, oxidative/antioxidant homeostasis, and inflammation, and to discuss the effects of exercise, which takes into account various factors, in relation to PCOS. A better understanding of the PCOS-associated hormonal changes, oxidative and inflammatory circuits, as well as exercise-induced mechanisms of action on those targets may improve the quality of life of women with PCOS.}, year = {2024}, eissn = {2227-9059}, pages = {560-575}, orcid-numbers = {Varga, Csaba/0000-0002-2678-665X} } @article{MTMT:34724100, title = {Moderate-Intensity Swimming Alleviates Oxidative Injury in Ischemic Heart}, url = {https://m2.mtmt.hu/api/publication/34724100}, author = {Börzsei, Denise and Viktória, Kiss and Nagy, András Levente and Nagyné Hoffmann, Alexandra and Török, Szilvia and Almási, Nikoletta and Veszelka, Médea and Varga, Csaba and Szabó, Renáta}, doi = {10.3390/app14052073}, journal-iso = {APPL SCI-BASEL}, journal = {APPLIED SCIENCES-BASEL}, volume = {14}, unique-id = {34724100}, abstract = {The global burden of cardiovascular diseases is indisputable, as it claims nearly 18 million lives a year. In this current study, we aimed to prove that exercise, a cornerstone in cardiovascular disease management, emerges as a powerful tool in the pathology of myocardial ischemia. Male rats were divided into three groups: pre-swimming training + isoproterenol (ISO) treated, isoproterenol-treated, and control-sedentary. Myocardial infarction was induced by the subcutaneous injection of 1.0 mg/kg ISO. After the subsequent rest period, the animals swam for 3 weeks, every day for 25 min. At the end of the experiment, the serum levels of atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), as well as the cardiac concentrations of reactive oxygen species (ROS), catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) were determined. Our results indicate that both cardiac injury biomarkers (ANP, BNP) and ROS levels were significantly lower in swimming rats compared to the sedentary animals. Moreover, the level of enzymatic components of the intracellular antioxidant system, CAT, SOD, and GPx were increased in swimming animals after ISO-induced myocardial infarction. Our findings support the fact that moderate-intensity swimming training can be efficiently used to prevent myocardial infarction-induced ischemic injury, by inhibiting ROS production and strengthening intracellular antioxidant defense.}, year = {2024}, eissn = {2076-3417}, orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X} }