@article{MTMT:33734067,
	title = {Cluster headache and kynurenines},
	url = {https://m2.mtmt.hu/api/publication/33734067},
	author = {Tuka, Bernadett and Körtési, Tamás and Nánási, Nikolett and Tömösi, Ferenc and Janáky, Tamás and Veréb, Dániel and Szok, Délia and Tajti, János and Vécsei, László},
	doi = {10.1186/s10194-023-01570-9},
	journal-iso = {J HEADACHE PAIN},
	journal = {JOURNAL OF HEADACHE AND PAIN},
	volume = {24},
	unique-id = {33734067},
	issn = {1129-2369},
	abstract = {The glutamatergic neurotransmission has important role in the pathomechanism of primary headache disorders. The kynurenine metabolites derived from catabolism of tryptophan (Trp) have significant involvement not only in glutamatergic processes, but also in the neuroinflammation, the oxidative stress and the mitochondrial dysfunctions. Previously we identified a depressed peripheral Trp metabolism in interictal period of episodic migraineurs, which prompted us to examine this pathway in patients with episodic cluster headache (CH) as well. Our aims were to compare the concentrations of compounds both in headache-free and attack periods, and to find correlations between Trp metabolism and the clinical features of CH. Levels of 11 molecules were determined in peripheral blood plasma of healthy controls (n = 22) and interbout/ictal periods of CH patients (n = 24) by neurochemical measurements.Significantly decreased L-kynurenine (KYN, p < 0.01), while increased quinolinic acid (QUINA, p < 0.005) plasma concentrations were detected in the interbout period of CH patients compared to healthy subjects. The levels of KYN are further reduced during the ictal period compared to the controls (p < 0.006). There was a moderate, negative correlation between disease duration and interbout QUINA levels (p < 0.048, R =  - 0.459); and between the total number of CH attacks experienced during the lifetime of patients and the interbout KYN concentrations (p < 0.024, R =  - 0.516). Linear regression models revealed negative associations between age and levels of Trp, kynurenic acid, 3-hdyroxyanthranilic acid and QUINA in healthy control subjects, as well as between age and ictal level of anthranilic acid.Our results refer to a specifically altered Trp metabolism in CH patients. The onset of metabolic imbalance can be attributed to the interbout period, where the decreased KYN level is unable to perform its protective functions, while the concentration of QUINA, as a toxic compound, increases. These processes can trigger CH attacks, which may be associated with glutamate excess induced neurotoxicity, neuroinflammation and oxidative stress. Further studies are needed to elucidate the exact functions of these molecular alterations that can contribute to identify new, potential biomarkers in the therapy of CH.},
	keywords = {clinical features; Episodic cluster headache; Interbout and ictal periods; Plasma kynurenine metabolites},
	year = {2023},
	eissn = {1129-2377},
	orcid-numbers = {Tuka, Bernadett/0000-0002-1410-4666; Körtési, Tamás/0000-0002-8535-5067; Tömösi, Ferenc/0000-0002-6657-5777; Janáky, Tamás/0000-0002-6466-8283; Veréb, Dániel/0000-0003-2077-5252; Tajti, János/0000-0003-0857-5266; Vécsei, László/0000-0001-8037-3672}
}

@article{MTMT:33611558,
	title = {Plasma metabolite fingerprint could discriminate inflammatory bowel disease patients from healthy subjects},
	url = {https://m2.mtmt.hu/api/publication/33611558},
	author = {Farkas, Klaudia and Endre, G and Bacsur, Péter and Resál, Tamás and Kocsmárszky-Koósz, V and Tömösi, Ferenc and Tóth, E and Rutka, Mariann and Bálint, Anita and Fábián, Anna and Bor, Renáta and Szepes, Zoltán and Goretity, Á and Thibodeau, I and Molnár, Tamás},
	doi = {10.1093/ecco-jcc/jjac190.0053},
	journal-iso = {J CROHNS COLITIS},
	journal = {JOURNAL OF CROHNS & COLITIS},
	volume = {17},
	unique-id = {33611558},
	issn = {1873-9946},
	year = {2023},
	eissn = {1876-4479},
	pages = {i73-i76},
	orcid-numbers = {Farkas, Klaudia/0000-0003-0599-182X; Bacsur, Péter/0000-0002-8534-0068; Resál, Tamás/0000-0002-3842-9094; Tömösi, Ferenc/0000-0002-6657-5777; Rutka, Mariann/0000-0003-2360-7836; Bálint, Anita/0000-0002-3624-896X; Fábián, Anna/0000-0002-0824-7476; Bor, Renáta/0000-0001-9393-5240; Szepes, Zoltán/0000-0002-9466-8719; Molnár, Tamás/0000-0002-4913-7599}
}

@mastersthesis{MTMT:34113116,
	title = {Targeted metabolomics of tryptophan and its metabolites in neurological diseases [A triptofán és metabolitjainak célzott metabolomikai vizsgálata neurológiai kórképekben]},
	url = {https://m2.mtmt.hu/api/publication/34113116},
	author = {Tömösi, Ferenc},
	doi = {10.14232/phd.11474},
	publisher = {Universití of Szeged},
	unique-id = {34113116},
	year = {2022},
	orcid-numbers = {Tömösi, Ferenc/0000-0002-6657-5777}
}

@article{MTMT:33265905,
	title = {Effects of sub-chronic, in vivo administration of sigma-1 receptor ligands on platelet and aortic arachidonate cascade in streptozotocin-induced diabetic rats},
	url = {https://m2.mtmt.hu/api/publication/33265905},
	author = {Váczi, Sándor and Barna, Lilla and Laczi, Krisztián and Tömösi, Ferenc and Rákhely, Gábor and Penke, Botond and Fülöp, Lívia and Bogár, Ferenc and Janáky, Tamás and Deli, Mária Anna and Mezei, Zsófia},
	doi = {10.1371/journal.pone.0265854},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {17},
	unique-id = {33265905},
	issn = {1932-6203},
	year = {2022},
	eissn = {1932-6203},
	orcid-numbers = {Váczi, Sándor/0000-0002-9642-7126; Laczi, Krisztián/0000-0002-9399-7406; Tömösi, Ferenc/0000-0002-6657-5777; Rákhely, Gábor/0000-0003-2557-3641; Penke, Botond/0000-0003-0938-0567; Fülöp, Lívia/0000-0002-8010-0129; Bogár, Ferenc/0000-0002-0611-1452; Janáky, Tamás/0000-0002-6466-8283; Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:32801748,
	title = {Effects of sub-chronic, in vivo administration of sigma non-opioid intracellular receptor 1 ligands on platelet and aortic arachidonate cascade in rats},
	url = {https://m2.mtmt.hu/api/publication/32801748},
	author = {Váczi, Sándor and Barna, Lilla and Laczi, Krisztián and Tömösi, Ferenc and Rákhely, Gábor and Penke, Botond and Fülöp, Lívia and Bogár, Ferenc and Janáky, Tamás and Deli, Mária Anna and Mezei, Zsófia},
	doi = {10.1016/j.ejphar.2022.174983},
	journal-iso = {EUR J PHARMACOL},
	journal = {EUROPEAN JOURNAL OF PHARMACOLOGY},
	volume = {925},
	unique-id = {32801748},
	issn = {0014-2999},
	year = {2022},
	eissn = {1879-0712},
	orcid-numbers = {Váczi, Sándor/0000-0002-9642-7126; Laczi, Krisztián/0000-0002-9399-7406; Tömösi, Ferenc/0000-0002-6657-5777; Rákhely, Gábor/0000-0003-2557-3641; Penke, Botond/0000-0003-0938-0567; Fülöp, Lívia/0000-0002-8010-0129; Bogár, Ferenc/0000-0002-0611-1452; Janáky, Tamás/0000-0002-6466-8283; Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:32489937,
	title = {Indoleamine 2,3-Dioxygenase Cannot Inhibit Chlamydia trachomatis Growth in HL-60 Human Neutrophil Granulocytes},
	url = {https://m2.mtmt.hu/api/publication/32489937},
	author = {Virók, Dezső and Tömösi, Ferenc and Keller-Pintér, Anikó and Szabó, Kitti and Bogdanov, Anita and Póliska, Szilárd and Rázga, Zsolt and Bruszel, Bella and Cseh, Zsuzsanna and Kókai, Dávid and Paróczai, Dóra and Endrész, Valéria and Janáky, Tamás and Burián, Katalin},
	doi = {10.3389/fimmu.2021.717311},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {12},
	unique-id = {32489937},
	issn = {1664-3224},
	year = {2021},
	eissn = {1664-3224},
	orcid-numbers = {Tömösi, Ferenc/0000-0002-6657-5777; Keller-Pintér, Anikó/0000-0002-4105-8458; Szabó, Kitti/0000-0002-1177-2036; Bogdanov, Anita/0000-0003-3067-8835; Rázga, Zsolt/0000-0003-4717-8482; Endrész, Valéria/0000-0002-9402-3857; Janáky, Tamás/0000-0002-6466-8283; Burián, Katalin/0000-0003-1300-2374}
}

@CONFERENCE{MTMT:32475125,
	title = {Quality by Design based formulation of intranasal meloxicam containing human serum albumin nanoparticles},
	url = {https://m2.mtmt.hu/api/publication/32475125},
	author = {Katona, Gábor and Balogh, György Tibor and Dargó, Gergő and Gáspár, Róbert and Márki, Árpád and Ducza, Eszter and Sztojkov-Ivanov, Anita and Tömösi, Ferenc and Kecskeméti, Gábor and Janáky, Tamás and Kiss, Tamás and Ambrus, Rita and Pallagi, Edina and Révész, Piroska and Pannonhalminé Csóka, Ildikó},
	booktitle = {13th Central European Symposium on Pharmaceutical Technology},
	unique-id = {32475125},
	year = {2021},
	pages = {71-71},
	orcid-numbers = {Katona, Gábor/0000-0003-1564-4813; Balogh, György Tibor/0000-0003-3347-1880; Dargó, Gergő/0000-0002-1141-8379; Gáspár, Róbert/0000-0002-1571-7579; Márki, Árpád/0000-0002-6056-8891; Tömösi, Ferenc/0000-0002-6657-5777; Kecskeméti, Gábor/0000-0002-5584-6869; Janáky, Tamás/0000-0002-6466-8283; Kiss, Tamás/0000-0003-0011-0501; Révész, Piroska/0000-0002-5336-6052; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@article{MTMT:32382697,
	title = {Kynurenic acid and kynurenine aminotransferase are potential biomarkers of early neurological improvement after thrombolytic therapy : a pilot study},
	url = {https://m2.mtmt.hu/api/publication/32382697},
	author = {Annus, Ádám and Tömösi, Ferenc and Rárosi, Ferenc and Huszár Lászlóné Fehér, Evelin and Janáky, Tamás and Kecskeméti, Gábor and Toldi, József and Klivényi, Péter and Sztriha, László Krisztián and Vécsei, László},
	doi = {10.17219/acem/141646},
	journal-iso = {ADV CLIN EXP MED},
	journal = {ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE},
	volume = {30},
	unique-id = {32382697},
	issn = {1899-5276},
	abstract = {Biomarkers for predicting treatment response to thrombolysis in acute ischemic stroke are currently lacking. Both, animal models and clinical studies have provided evidence that the kynurenine (KYN) pathway is activated in ischemic stroke.In our pilot study, we aimed to investigate whether KYN pathway enzymes and metabolites could serve as potential biomarkers for treatment response in the hyperacute phase of ischemic stroke.We included 48 acute ischemic stroke patients who received thrombolysis. Blood samples were taken both before and 12 h after treatment. Concentrations of 11 KYN metabolites were determined using ultra-high-performance liquid chromatography-mass spectrometry. To assess the treatment response, we used early neurological improvement (ENI), calculated as the difference between the admission and discharge National Institutes of Health Stroke Scale (NIHSS) scores. We performed receiver operating characteristic (ROC) analysis for KYN pathway metabolites and enzymes that showed a correlation with ENI.In the samples taken before thrombolysis, significantly lower concentrations of kynurenic acid (KYNA) and kynurenine aminotransferase (KAT) activity were found in patients who had ENI (p = 0.01 and p = 0.002, respectively). According to the ROC analysis, the optimal cut-off value to predict ENI for KYNA was 37.80 nM (sensitivity (SN) 69.2%, specificity (SP) 68.4%) and 0.0127 for KAT activity (SN 92.3%, SP 73.7%).Our research is the first clinical pilot study to analyze changes in the KYN pathway in ischemic stroke patients who received thrombolytic treatment. Based on our results, baseline KYNA concentration and KAT activity could serve as potential biomarkers to predict early treatment response to thrombolysis.},
	keywords = {thrombolysis; KYNURENINE; ischemic stroke; ACUTE STROKE; biomarker},
	year = {2021},
	eissn = {2451-2680},
	pages = {1225-1232},
	orcid-numbers = {Annus, Ádám/0000-0003-0498-6578; Tömösi, Ferenc/0000-0002-6657-5777; Rárosi, Ferenc/0000-0002-1014-9242; Huszár Lászlóné Fehér, Evelin/0000-0003-2564-3937; Janáky, Tamás/0000-0002-6466-8283; Kecskeméti, Gábor/0000-0002-5584-6869; Toldi, József/0000-0001-7355-0503; Klivényi, Péter/0000-0002-5389-3266; Vécsei, László/0000-0001-8037-3672}
}

@article{MTMT:32082174,
	title = {Clinical relevance of depressed kynurenine pathway in episodic migraine patients: potential prognostic markers in the peripheral plasma during the interictal period},
	url = {https://m2.mtmt.hu/api/publication/32082174},
	author = {Tuka, Bernadett and Nyári, Aliz and Cseh, Edina Katalin and Körtési, Tamás and Veréb, Dániel and Tömösi, Ferenc and Kecskeméti, Gábor and Janáky, Tamás and Tajti, János and Vécsei, László},
	doi = {10.1186/s10194-021-01239-1},
	journal-iso = {J HEADACHE PAIN},
	journal = {JOURNAL OF HEADACHE AND PAIN},
	volume = {22},
	unique-id = {32082174},
	issn = {1129-2369},
	year = {2021},
	eissn = {1129-2377},
	orcid-numbers = {Tuka, Bernadett/0000-0002-1410-4666; Körtési, Tamás/0000-0002-8535-5067; Veréb, Dániel/0000-0003-2077-5252; Tömösi, Ferenc/0000-0002-6657-5777; Kecskeméti, Gábor/0000-0002-5584-6869; Janáky, Tamás/0000-0002-6466-8283; Tajti, János/0000-0003-0857-5266; Vécsei, László/0000-0001-8037-3672}
}

@article{MTMT:31916683,
	title = {Transition metal-catalyzed A-ring C–H activations and C(sp2)–C(sp2) couplings in the 13α-estrone series and in vitro evaluation of antiproliferative properties},
	url = {https://m2.mtmt.hu/api/publication/31916683},
	author = {Traj, Péter and Ali, Hazhmat and Motzwickler-Németh, Anett and Dajcs, Sámuel Trisztán and Tömösi, Ferenc and Tea, Lanisnik-Rizner and Zupkó, István and Mernyák, Erzsébet},
	doi = {10.1080/14756366.2021.1900165},
	journal-iso = {J ENZYM INHIB MED CH},
	journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY},
	volume = {36},
	unique-id = {31916683},
	issn = {1475-6366},
	year = {2021},
	eissn = {1475-6374},
	pages = {895-902},
	orcid-numbers = {Tömösi, Ferenc/0000-0002-6657-5777; Zupkó, István/0000-0003-3243-5300; Mernyák, Erzsébet/0000-0003-4494-1817}
}