TY - THES AU - Nekkaa, Imane TI - The pharmaceutical chemical tendency towards continuous-flow processing PB - Szegedi Tudományegyetem (SZTE) PY - 2019 SP - 55 DO - 10.14232/phd.10033 UR - https://m2.mtmt.hu/api/publication/30800853 ID - 30800853 LA - English DB - MTMT ER - TY - JOUR AU - Nekkaa, Imane AU - Bogdán, Dóra AU - Gáti, Tamás AU - Béni, Szabolcs AU - Juhász, Tünde AU - Palkó, Márta AU - Paragi, Gábor AU - Tóth, Gábor AU - Fülöp, Ferenc AU - Mándity, István TI - Flow-chemistry enabled efficient synthesis of β-peptides: backbone topology vs. helix formation JF - CHEMICAL COMMUNICATIONS J2 - CHEM COMMUN VL - 55 PY - 2019 IS - 21 SP - 3061 EP - 3064 PG - 4 SN - 1359-7345 DO - 10.1039/c8cc10147g UR - https://m2.mtmt.hu/api/publication/30535263 ID - 30535263 N1 - Funding Agency and Grant Number: Hungarian Research Foundation (OTKA) [K 115731]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences; Bolyai + New National Excellence Program of the Ministry of Human Capacities [UNKP-18-4-SE-121]; [GINOP-2.3.2-15-2016-00014]; [GINOP-2.3.2-15-2016-00034] Funding text: We are grateful to the Hungarian Research Foundation (OTKA No. K 115731). The financial support of the GINOP-2.3.2-15-2016-00014 and GINOP-2.3.2-15-2016-00034 projects are acknowledged. This work was partially supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences and by the Bolyai + New National Excellence Program (grant number: UNKP-18-4-SE-121) of the Ministry of Human Capacities (S. Beni). Funding Agency and Grant Number: Hungarian Research Foundation (OTKA)Orszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [K 115731]; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences; Bolyai + New National Excellence Program of the Ministry of Human Capacities [UNKP-18-4-SE-121]; [GINOP-2.3.2-15-2016-00014]; [GINOP-2.3.2-15-2016-00034] Funding text: We are grateful to the Hungarian Research Foundation (OTKA No. K 115731). The financial support of the GINOP-2.3.2-15-2016-00014 and GINOP-2.3.2-15-2016-00034 projects are acknowledged. This work was partially supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences and by the Bolyai + New National Excellence Program (grant number: UNKP-18-4-SE-121) of the Ministry of Human Capacities (S. Beni). Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 7., Szeged, H-6720, Hungary Department of Organic Chemistry, Faculty of Pharmacy, Semmelweis University Hgyes, Endre u. 7., Budapest, H-1092, Hungary Servier Research Institute of Medicinal Chemistry (SRIMC), Záhony utca 7., Budapest, H-1031, Hungary Department of Pharmacognosy, Faculty of Pharmacy, Semmelweis University, Ülli út 26., Budapest, H-1085, Hungary Institute of Materials and Environmental Chemistry, Research Center for Natural Sciences, Hungarian Academy of Sciences Magyar, Tudósok krt. 2., Budapest, H-1117, Hungary Department of Medical Chemistry, University of Szeged, Dóm t. 8., Szeged, H-6720, Hungary MTA SZTE Biomimetic Systems Research Group, Dóm t. 8., Szeged, H-6720, Hungary MTA TTK Lendület Artificial Transporter Research Group, Institute of Materials and Environmental Chemistry, Research Center for Natural Sciences, Hungarian Academy of Sciences Magyar, Tudósok krt. 2., Budapest, H-1117, Hungary Cited By :4 Export Date: 25 July 2020 CODEN: CHCOF Correspondence Address: Fülöp, F.; Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 7., Hungary; email: fulop@pharm.u-szeged.hu CAplus AN 2019:196581; MEDLINE PMID: 30720807 (Journal; Article); Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 7., Szeged, H-6720, Hungary Department of Organic Chemistry, Faculty of Pharmacy, Semmelweis University Hgyes, Endre u. 7., Budapest, H-1092, Hungary Servier Research Institute of Medicinal Chemistry (SRIMC), Záhony utca 7., Budapest, H-1031, Hungary Department of Pharmacognosy, Faculty of Pharmacy, Semmelweis University, Ülli út 26., Budapest, H-1085, Hungary Institute of Materials and Environmental Chemistry, Research Center for Natural Sciences, Hungarian Academy of Sciences Magyar, Tudósok krt. 2., Budapest, H-1117, Hungary Department of Medical Chemistry, University of Szeged, Dóm t. 8., Szeged, H-6720, Hungary MTA SZTE Biomimetic Systems Research Group, Dóm t. 8., Szeged, H-6720, Hungary MTA TTK Lendület Artificial Transporter Research Group, Institute of Materials and Environmental Chemistry, Research Center for Natural Sciences, Hungarian Academy of Sciences Magyar, Tudósok krt. 2., Budapest, H-1117, Hungary Cited By :7 Export Date: 11 July 2021 CODEN: CHCOF Correspondence Address: Fülöp, F.; Institute of Pharmaceutical Chemistry, Eötvös u. 7., Hungary; email: fulop@pharm.u-szeged.hu AB - Enantiodiscriminative helix formation was observed for beta-peptide H14 helices. This observation is caused by the synperiplanar orientation of H-O atoms which is more unfavorable than those for H-H interaction. The 1,2 H-O interaction leads to the destruction of the helical structure. The introduction of a double C-C bond in the backbone rules out helix formation. LA - English DB - MTMT ER - TY - JOUR AU - Nekkaa, Imane AU - Palkó, Márta AU - Mándity, István AU - Miklós, Ferenc AU - Fülöp, Ferenc TI - Continuous-Flow retro-Diels–Alder Reaction: A Process Window for Designing Heterocyclic Scaffolds JF - EUROPEAN JOURNAL OF ORGANIC CHEMISTRY J2 - EUR J ORG CHEM VL - 2018 PY - 2018 IS - 32 SP - 4456 EP - 4464 PG - 9 SN - 1434-193X DO - 10.1002/ejoc.201800682 UR - https://m2.mtmt.hu/api/publication/27671648 ID - 27671648 N1 - Funding Agency and Grant Number: Hungarian Research Foundation (OTKA) [K 115731]; [GINOP-2.3.2-15-2016-00014] Funding text: We are grateful to the Hungarian Research Foundation (OTKA No. K 115731). The financial support from the GINOP-2.3.2-15-2016-00014 project is acknowledged. Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary Institute of Organic Chemistry, Semmelweis University, Hogyes Endre u. 7, Budapest, 1092, Hungary MTA TTK Lendület Artificial Transporter Research Group, Institute of Materials and Environmental Chemistry, Hungarian Academy of Sciences, Magyar Tudosok krt. 2, Budapest, 1117, Hungary MTA-SZTE Stereochemistry Research Group, Hungarian Academy of Sciences, Eötvös u. 6, Szeged, 6720, Hungary Cited By :4 Export Date: 25 July 2020 CODEN: EJOCF Correspondence Address: Fülöp, F.; Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, Hungary; email: fulop@pharm.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Nekkaa, Imane AU - Palkó, Márta AU - Mándity, István AU - Fülöp, Ferenc TI - Continuous-flow retro-Diels-Alder reaction: an efficient method for the preparation of pyrimidinone derivatives JF - BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY J2 - BEILSTEIN J ORG CHEM VL - 14 PY - 2018 SP - 318 EP - 324 PG - 7 SN - 1860-5397 DO - 10.3762/bjoc.14.20 UR - https://m2.mtmt.hu/api/publication/3374074 ID - 3374074 N1 - Funding Agency and Grant Number: Hungarian Research Foundation (OTKA) [K 115731]; [GINOP-2.3.2-15-2016-00014] Funding text: We are grateful to the Hungarian Research Foundation (OTKA No. K 115731). The financial support of the GINOP-2.3.2-15-2016-00014 project is acknowledged. AB - The syntheses of various pyrimidinones as potentially bioactive products by means of the highly controlled continuous-flow retro-Diels-Alder reaction of condensed pyrimidinone derivatives are presented. Noteworthy, the use of this approach allowed us to rapidly screen a selection of conditions and quickly confirm the viability of preparing the desired pyrimidinones in short reaction times. Yields typically higher than those published earlier using conventional batch or microwave processes were achieved. LA - English DB - MTMT ER - TY - GEN AU - Nekkaa, Imane AU - Mándity, István AU - Fülöp, Ferenc TI - Homochirality in the Unnatural Peptide World: A Significant Biomimetic Property ET - 0 PY - 2017 UR - https://m2.mtmt.hu/api/publication/3288024 ID - 3288024 N1 - Konferencia 2017-09-05 Balatonfüred LA - English DB - MTMT ER - TY - GEN AU - Nekkaa, Imane TI - Homochirality in the Unnatural Peptide World: A Significant Biomimetic Property ET - 0 PY - 2017 UR - https://m2.mtmt.hu/api/publication/3288021 ID - 3288021 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Mándity, István AU - Nekkaa, Imane AU - Paragi, Gábor AU - Fülöp, Ferenc TI - Homochirality of beta-Peptides: A Significant Biomimetic Property of Unnatural Systems JF - CHEMISTRYOPEN J2 - CHEMISTRYOPEN VL - 6 PY - 2017 IS - 4 SP - 492 EP - 496 PG - 5 SN - 2191-1363 DO - 10.1002/open.201700078 UR - https://m2.mtmt.hu/api/publication/3266869 ID - 3266869 AB - Homochirality, an interesting phenomenon of life, is mainly an unresolved problem and was thought to be a property of living matter. Herein, we show that artificial beta-peptides have the tendency toward homochiral diastereoselective chain elongation. Chain-length-dependent stereochemical discrimination was investigated in the synthesis of foldamers with various side chains and secondary structures. It was found that there is a strong tendency toward the synthesis of homochiral oligomers. The size of the side chain drastically influenced the selectivity of the stereodiscriminative chain-elongation reaction. It is noteworthy that water as the co-solvent increases the selectivity. Such behavior is a novel fundamental biomimetic property of foldamers with a potential of future industrial application. LA - English DB - MTMT ER - TY - CHAP AU - Nekkaa, Imane AU - Mándity, István AU - Fülöp, Ferenc ED - Bohner, Bíborka ED - Mesterházy, Edit TI - Stereochemical discrimination in the synthesis of beta-peptide oligomers: Origin of homochirality T2 - XXXVIII. Kémiai Előadói Napok PB - Magyar Kémikusok Egyesülete (MKE) CY - Szeged SN - 9789639970649 PY - 2015 SP - 28 EP - 28 PG - 1 UR - https://m2.mtmt.hu/api/publication/3288013 ID - 3288013 LA - English DB - MTMT ER -