@mastersthesis{MTMT:30800853, title = {The pharmaceutical chemical tendency towards continuous-flow processing}, url = {https://m2.mtmt.hu/api/publication/30800853}, author = {Nekkaa, Imane}, doi = {10.14232/phd.10033}, publisher = {SZTE}, unique-id = {30800853}, year = {2019} } @article{MTMT:30535263, title = {Flow-chemistry enabled efficient synthesis of β-peptides: backbone topology vs. helix formation}, url = {https://m2.mtmt.hu/api/publication/30535263}, author = {Nekkaa, Imane and Bogdán, Dóra and Gáti, Tamás and Béni, Szabolcs and Juhász, Tünde and Palkó, Márta and Paragi, Gábor and Tóth, Gábor and Fülöp, Ferenc and Mándity, István}, doi = {10.1039/c8cc10147g}, journal-iso = {CHEM COMMUN}, journal = {CHEMICAL COMMUNICATIONS}, volume = {55}, unique-id = {30535263}, issn = {1359-7345}, abstract = {Enantiodiscriminative helix formation was observed for beta-peptide H14 helices. This observation is caused by the synperiplanar orientation of H-O atoms which is more unfavorable than those for H-H interaction. The 1,2 H-O interaction leads to the destruction of the helical structure. The introduction of a double C-C bond in the backbone rules out helix formation.}, keywords = {SELECTIVITY; DESIGN; SECONDARY STRUCTURE; STABILITY; OLIGOMERS; AMINO-ACID; FOLDAMER HELICES}, year = {2019}, eissn = {1364-548X}, pages = {3061-3064}, orcid-numbers = {Bogdán, Dóra/0000-0003-4455-8914; Béni, Szabolcs/0000-0001-7056-6825; Palkó, Márta/0000-0002-8265-7377; Paragi, Gábor/0000-0001-5408-1748; Tóth, Gábor/0000-0002-3604-4385; Fülöp, Ferenc/0000-0003-1066-5287; Mándity, István/0000-0003-2865-6143} } @article{MTMT:27671648, title = {Continuous-Flow retro-Diels–Alder Reaction: A Process Window for Designing Heterocyclic Scaffolds}, url = {https://m2.mtmt.hu/api/publication/27671648}, author = {Nekkaa, Imane and Palkó, Márta and Mándity, István and Miklós, Ferenc and Fülöp, Ferenc}, doi = {10.1002/ejoc.201800682}, journal-iso = {EUR J ORG CHEM}, journal = {EUROPEAN JOURNAL OF ORGANIC CHEMISTRY}, volume = {2018}, unique-id = {27671648}, issn = {1434-193X}, year = {2018}, eissn = {1099-0690}, pages = {4456-4464}, orcid-numbers = {Palkó, Márta/0000-0002-8265-7377; Mándity, István/0000-0003-2865-6143; Fülöp, Ferenc/0000-0003-1066-5287} } @article{MTMT:3374074, title = {Continuous-flow retro-Diels-Alder reaction: an efficient method for the preparation of pyrimidinone derivatives}, url = {https://m2.mtmt.hu/api/publication/3374074}, author = {Nekkaa, Imane and Palkó, Márta and Mándity, István and Fülöp, Ferenc}, doi = {10.3762/bjoc.14.20}, journal-iso = {BEILSTEIN J ORG CHEM}, journal = {BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY}, volume = {14}, unique-id = {3374074}, issn = {1860-5397}, abstract = {The syntheses of various pyrimidinones as potentially bioactive products by means of the highly controlled continuous-flow retro-Diels-Alder reaction of condensed pyrimidinone derivatives are presented. Noteworthy, the use of this approach allowed us to rapidly screen a selection of conditions and quickly confirm the viability of preparing the desired pyrimidinones in short reaction times. Yields typically higher than those published earlier using conventional batch or microwave processes were achieved.}, keywords = {ACID; TOOL; SATURATED HETEROCYCLES; Chemistry; TECHNOLOGY; DECOMPOSITION; Continuous-flow; Pyrimidinones; thermolysis; REACTORS; Process windows; retro-Diels-Alder reaction; norbornene-fused heterocycles; desulfurisation}, year = {2018}, eissn = {1860-5397}, pages = {318-324}, orcid-numbers = {Palkó, Márta/0000-0002-8265-7377; Mándity, István/0000-0003-2865-6143; Fülöp, Ferenc/0000-0003-1066-5287} } @misc{MTMT:3288024, title = {Homochirality in the Unnatural Peptide World: A Significant Biomimetic Property}, url = {https://m2.mtmt.hu/api/publication/3288024}, author = {Nekkaa, Imane and Mándity, István and Fülöp, Ferenc}, unique-id = {3288024}, year = {2017}, orcid-numbers = {Mándity, István/0000-0003-2865-6143} } @misc{MTMT:3288021, title = {Homochirality in the Unnatural Peptide World: A Significant Biomimetic Property}, url = {https://m2.mtmt.hu/api/publication/3288021}, author = {Nekkaa, Imane}, unique-id = {3288021}, year = {2017} } @article{MTMT:3266869, title = {Homochirality of beta-Peptides: A Significant Biomimetic Property of Unnatural Systems}, url = {https://m2.mtmt.hu/api/publication/3266869}, author = {Mándity, István and Nekkaa, Imane and Paragi, Gábor and Fülöp, Ferenc}, doi = {10.1002/open.201700078}, journal-iso = {CHEMISTRYOPEN}, journal = {CHEMISTRYOPEN}, volume = {6}, unique-id = {3266869}, issn = {2191-1363}, abstract = {Homochirality, an interesting phenomenon of life, is mainly an unresolved problem and was thought to be a property of living matter. Herein, we show that artificial beta-peptides have the tendency toward homochiral diastereoselective chain elongation. Chain-length-dependent stereochemical discrimination was investigated in the synthesis of foldamers with various side chains and secondary structures. It was found that there is a strong tendency toward the synthesis of homochiral oligomers. The size of the side chain drastically influenced the selectivity of the stereodiscriminative chain-elongation reaction. It is noteworthy that water as the co-solvent increases the selectivity. Such behavior is a novel fundamental biomimetic property of foldamers with a potential of future industrial application.}, keywords = {AMINO-ACIDS; ORIGIN; DESIGN; SECONDARY STRUCTURE; FOLDAMERS; CONFIGURATION; Chemistry; CHIRALITY; diastereoselectivity; asymmetric autocatalysis; CORRELATION-ENERGY; BETA-PEPTIDE; foldamer; CHIRAL MOLECULE; homochiralty}, year = {2017}, eissn = {2191-1363}, pages = {492-496}, orcid-numbers = {Mándity, István/0000-0003-2865-6143; Paragi, Gábor/0000-0001-5408-1748; Fülöp, Ferenc/0000-0003-1066-5287} } @{MTMT:3288013, title = {Stereochemical discrimination in the synthesis of beta-peptide oligomers: Origin of homochirality}, url = {https://m2.mtmt.hu/api/publication/3288013}, author = {Nekkaa, Imane and Mándity, István and Fülöp, Ferenc}, booktitle = {XXXVIII. Kémiai Előadói Napok}, unique-id = {3288013}, year = {2015}, pages = {28-28}, orcid-numbers = {Mándity, István/0000-0003-2865-6143} }