@mastersthesis{MTMT:34109013,
	title = {BRCA1/2 patogén és ismeretlen klinikai szignifikanciájú variánsok azonosítása és vizsgálati lehetőségei},
	url = {https://m2.mtmt.hu/api/publication/34109013},
	author = {Gráf, Alexandra},
	doi = {10.14232/phd.11427},
	publisher = {Universití of Szeged},
	unique-id = {34109013},
	year = {2022}
}

@article{MTMT:33029933,
	title = {A Comprehensive Evaluation of the Performance of Prediction Algorithms on Clinically Relevant Missense Variants},
	url = {https://m2.mtmt.hu/api/publication/33029933},
	author = {Qorri, Erda and Takács, Bertalan Vilmos and Gráf, Alexandra and Enyedi, Márton Zsolt and Pintér, Lajos and Kiss, Ernő and Haracska, Lajos},
	doi = {10.3390/ijms23147946},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {33029933},
	issn = {1661-6596},
	year = {2022},
	eissn = {1422-0067},
	orcid-numbers = {Kiss, Ernő/0000-0002-7344-1750}
}

@article{MTMT:32606165,
	title = {The Rad5 Helicase and RING Domains Contribute to Genome Stability through their Independent Catalytic Activities},
	url = {https://m2.mtmt.hu/api/publication/32606165},
	author = {Tóth, Róbert and Balogh, Dávid and Pintér, Lajos and Jaksa, G. and Szeplaki, B. and Gráf, Alexandra and Győrfy, Zsuzsanna and Enyedi, Márton Zsolt and Kiss, Ernő and Haracska, Lajos and Unk, Ildikó},
	doi = {10.1016/j.jmb.2021.167437},
	journal-iso = {J MOL BIOL},
	journal = {JOURNAL OF MOLECULAR BIOLOGY},
	volume = {434},
	unique-id = {32606165},
	issn = {0022-2836},
	abstract = {Genomic stability is compromised by DNA damage that obstructs replication. Rad5 plays a prominent role in DNA damage bypass processes that evolved to ensure the continuation of stalled replication. Like its human orthologs, the HLTF and SHPRH tumor suppressors, yeast Rad5 has a RING domain that supports ubiquitin ligase activity promoting PCNA polyubiquitylation and a helicase domain that in the case of HLTF and Rad5 was shown to exhibit an ATPase-linked replication fork reversal activity. The RING domain is embedded in the helicase domain, confusing their separate investigation and the understanding of the exact role of Rad5 in DNA damage bypass. Particularly, it is still debated whether the helicase domain plays a catalytic or a non-enzymatic role during error-free damage bypass and whether it facilitates a function separately from the RING domain. In this study, through in vivo and in vitro characterization of domain-specific mutants, we delineate the contributions of the two domains to Rad5 function. Yeast genetic experiments and whole-genome sequencing complemented with biochemical assays demonstrate that the ubiquitin ligase and the ATPase-linked activities of Rad5 exhibit independent catalytic activities in facilitating separate pathways during error-free lesion bypass. Our results also provide important insights into the mutagenic role of Rad5 and indicate its tripartite contribution to DNA damage tolerance. © 2021 The Author(s)},
	keywords = {MUTAGENESIS; enzyme assay; DNA damage tolerance; Rad5; yeast genetics},
	year = {2022},
	eissn = {1089-8638},
	orcid-numbers = {Kiss, Ernő/0000-0002-7344-1750}
}

@misc{MTMT:32936853,
	title = {Egysejt szekvenálással a BRCA2 mozaicizmus és a tumorigenezis molekuláris hátterének nyomában},
	url = {https://m2.mtmt.hu/api/publication/32936853},
	author = {Gráf, Alexandra and Enyedi, Márton Zsolt and Szabó-Kriston, Éva and Jaksa, Gábor and Pintér, Lajos and Sükösd, Farkas and Ezer, Éva and Bálind, Árpád and Horváth, Péter and Kiss, Ernő and Haracska, Lajos},
	unique-id = {32936853},
	year = {2021}
}

@article{MTMT:32058695,
	title = {The Combination of Single-Cell and Next-Generation Sequencing Can Reveal Mosaicism for BRCA2 Mutations and the Fine Molecular Details of Tumorigenesis},
	url = {https://m2.mtmt.hu/api/publication/32058695},
	author = {Gráf, Alexandra and Enyedi, Márton Zsolt and Pinter, Lajos and Kriston-Pal, Eva and Jaksa, Gabor and Bálind, Árpád and Ezer, Eva and Horváth, Péter and Sükösd, Farkas and Kiss, Ernő and Haracska, Lajos},
	doi = {10.3390/cancers13102354},
	journal-iso = {CANCERS},
	journal = {CANCERS},
	volume = {13},
	unique-id = {32058695},
	year = {2021},
	eissn = {2072-6694},
	orcid-numbers = {Kiss, Ernő/0000-0002-7344-1750}
}

@misc{MTMT:32936930,
	title = {Single yeast colony mutagenesis screen and mutagenic signature analysis based on next-generation sequencing},
	url = {https://m2.mtmt.hu/api/publication/32936930},
	author = {Gráf, Alexandra and Róbert, Tóth and Márton, Enyedi and Bence, Széplaki and Gábor, Jaksa and Lajos, Pintér and Ernő, Kiss and Lajos, Haracska},
	unique-id = {32936930},
	year = {2019}
}

@misc{MTMT:32937011,
	title = {Tumorevolució vizsgálata egysejt-analízissel},
	url = {https://m2.mtmt.hu/api/publication/32937011},
	author = {Gráf, Alexandra and Kovács, Mária and Bálind, Árpád and Gyuris, Zoltán and Pintér, Lajos and Kiss, Ernő and Horváth, Péter and Haracska, Lajos:},
	unique-id = {32937011},
	year = {2018}
}

@CONFERENCE{MTMT:32936949,
	title = {Single yeast colony mutagenesis screen based on next-generation sequencing},
	url = {https://m2.mtmt.hu/api/publication/32936949},
	author = {Gráf, Alexandra and Róbert, Tóth and Márton, Enyedi and Bence, Széplaki and Gábor, Jaksa and Zoltán, Gyuris and Lajos, Pintér and Ernő, Kiss and Lajos, Haracska},
	booktitle = {Straub-Napok},
	unique-id = {32936949},
	year = {2018},
	pages = {15}
}

@misc{MTMT:32936866,
	title = {Egy sejt, egy kolónia-miért jó, ha kevés a kiindulási anyag?},
	url = {https://m2.mtmt.hu/api/publication/32936866},
	author = {Gráf, Alexandra and Enyedi, Márton Zsolt and Tóth, Róbert and Pintér, Lajos and Jaksa, Gábor and Kovács, Mária and Bálind, Árpád and Horváth, Péter and Kiss, Ernő and Haracska, Lajos},
	unique-id = {32936866},
	year = {2018}
}

@article{MTMT:3343343,
	title = {The dosage-dependent effect exerted by the NM23-H1/H2 homolog NDK-1 on distal tip cell migration in C. elegans},
	url = {https://m2.mtmt.hu/api/publication/3343343},
	author = {Farkas, Zsolt and Fancsalszky, Luca and Saskői, Éva and Gráf, Alexandra and Tárnok, Krisztián and Mehta, A and Vellainé Takács, Krisztina},
	doi = {10.1038/labinvest.2017.99},
	journal-iso = {LAB INVEST},
	journal = {LABORATORY INVESTIGATION},
	volume = {98},
	unique-id = {3343343},
	issn = {0023-6837},
	abstract = {Abnormal regulation of cell migration and altered rearrangement of the cytoskeleton are fundamental properties of metastatic cells. The first identified metastasis suppressor NM23-H1, which displays nucleoside-diphosphate kinase (NDPK) activity is involved in these processes. NM23-H1 inhibits the migratory and invasive potential of some cancer cells. Correspondingly, numerous invasive cancer cell lines (eg, breast, colon, oral, hepatocellular carcinoma, and melanoma) display low endogenous NM23 levels. In this review, we summarize mechanisms, which are linked to the anti-metastatic activity of NM23. In human cancer cell lines NM23-H1 was shown to regulate cytoskeleton dynamics through inactivation of Rho/Rac-type GTPases. The Drosophila melanogaster NM23 homolog abnormal wing disc (AWD) controls tracheal and border cell migration. The molecular function of AWD is well characterized in both processes as a GTP supplier of Shi/Dynamin whereby AWD regulates the level of chemotactic receptors on the surface of migrating cells through receptor internalization, by its endocytic function. Our group studied the role of the sole group I NDPK, NDK-1 in distal tip cell (DTC) migration in Caenorhabditis elegans. In the absence of NDK-1 the migration of DTCs is incomplete. A half dosage of NDPK as present in ndk-1 (+/-) heterozygotes results in extra turns and overshoots of migrating gonad arms. Conversely, an elevated NDPK level also leads to incomplete gonadal migration owing to a premature stop of DTCs in the third phase of migration, where NDK-1 acts. We propose that NDK-1 exerts a dosage-dependent effect on the migration of DTCs. Our data derived from DTC migration in C. elegans is consistent with data on AWD's function in Drosophila. The combined data suggest that NDPK enzymes control the availability of surface receptors to regulate cell-sensing cues during cell migration. The dosage of NDPKs may be a coupling factor in cell migration by modulating the efficiency of receptor recycling. © 2018 USCAP, Inc All rights reserved.},
	keywords = {EXPRESSION; DROSOPHILA; MELANOMA-CELLS; TUMOR-METASTASIS; Adenocarcinoma cells; border cells; ALPHA-ISOFORM; METASTASIS SUPPRESSOR; SUPPRESSOR GENE NM23; NUCLEOSIDE-DIPHOSPHATE-KINASE},
	year = {2018},
	eissn = {1530-0307},
	pages = {182-189},
	orcid-numbers = {Farkas, Zsolt/0000-0001-8531-8912; Saskői, Éva/0000-0001-6691-8576; Tárnok, Krisztián/0000-0003-3491-4014; Vellainé Takács, Krisztina/0000-0002-4472-0363}
}