@article{MTMT:34538603, title = {P421 The faecal biomarker LDN-051 is a novel tool for monitoring disease activity and therapeutic response in Inflammatory Bowel Diseases}, url = {https://m2.mtmt.hu/api/publication/34538603}, author = {Jójárt, Boldizsár and Resál, Tamás and Kata, Diána and Molnár, Tünde and Bacsur, Péter and Szabó, Viktória and Varga, Árpád and Szántó, Kata Judit and Pallagi, Petra and Földesi, Imre and Molnár, Tamás and Maléth, József and Farkas, Klaudia}, doi = {10.1093/ecco-jcc/jjad212.0551}, journal-iso = {J CROHNS COLITIS}, journal = {JOURNAL OF CROHNS & COLITIS}, volume = {18}, unique-id = {34538603}, issn = {1873-9946}, year = {2024}, eissn = {1876-4479}, pages = {i869-i869}, orcid-numbers = {Jójárt, Boldizsár/0000-0002-2764-3925; Resál, Tamás/0000-0002-3842-9094; Kata, Diána/0000-0002-4432-9380; Molnár, Tünde/0000-0002-6842-6521; Bacsur, Péter/0000-0002-8534-0068; Szabó, Viktória/0000-0001-6547-9102; Varga, Árpád/0000-0002-2379-139X; Szántó, Kata Judit/0000-0003-0749-5061; Pallagi, Petra/0000-0001-8906-0840; Földesi, Imre/0000-0002-3329-8136; Molnár, Tamás/0000-0002-4913-7599; Maléth, József/0000-0001-5768-3090; Farkas, Klaudia/0000-0003-0599-182X} } @article{MTMT:34167015, title = {Plasminogen activator inhibitor 1 is a novel faecal biomarker for monitoring disease activity and therapeutic response in inflammatory bowel diseases}, url = {https://m2.mtmt.hu/api/publication/34167015}, author = {Jójárt, Boldizsár and Resál, Tamás and Kata, Diána and Molnár, Tünde and Bacsur, Péter and Szabó, Viktória and Varga, Árpád and Szántó, Kata Judit and Pallagi, Petra and Földesi, Imre and Molnár, Tamás and Maléth, József and Farkas, Klaudia}, doi = {10.1093/ecco-jcc/jjad160}, journal-iso = {J CROHNS COLITIS}, journal = {JOURNAL OF CROHNS & COLITIS}, volume = {18}, unique-id = {34167015}, issn = {1873-9946}, abstract = {Crohn's disease and ulcerative colitis require lifelong treatment and patient monitoring. Current biomarkers have several limitations, therefore, there is an unmet need to identify novel biomarkers in inflammatory bowel disease (IBD). Previously, the role of plasminogen activator inhibitor 1 (PAI-1) was established in the pathogenesis of IBD and suggested as a potential biomarker. Therefore, we aimed to comprehensively analyze the selectivity of PAI-1 in IBD, its correlation with the disease activity, and its potential to predict therapeutic response.Blood, colon biopsy, organoid cultures (OC), and faecal samples were used from active and inactive IBD patients and control subjects. Serpin E1 gene expressions and PAI-1 protein levels and localization in serum, biopsy, and fecal samples were evaluated by qRT-PCR, ELISA, and immunostaining, respectively.The study population comprised 132 IBD patients (56 CD and 76 UC) and 40 non-IBD patients. We demonstrated that the serum, mucosal, and faecal PAI-1 concentration is elevated in IBD patients, showing clinical and endoscopic activity. In responders (decrease of eMayo≥3 in UC; or SES-CD>50% in CD), the initial PAI-1 level decreased significantly upon successful therapy. OCs derived from active IBD patients produced higher concentrations of PAI-1 than the controls, suggesting that epithelial cells could be a source of PAI-1. Moreover, faecal PAI-1 selectively increases in active IBD but not other organic gastrointestinal diseases.The serum, mucosal, and faecal PAI-1 concentration correlates with the disease activity and therapeutic response in IBD, suggesting that PAI-1 could be utilized as a novel non-invasive, disease-specific faecal biomarker in the patient follow-up.}, keywords = {Inflammatory bowel disease; PAI-1; faecal marker}, year = {2024}, eissn = {1876-4479}, pages = {392-405}, orcid-numbers = {Jójárt, Boldizsár/0000-0002-2764-3925; Resál, Tamás/0000-0002-3842-9094; Kata, Diána/0000-0002-4432-9380; Molnár, Tünde/0000-0002-6842-6521; Bacsur, Péter/0000-0002-8534-0068; Szabó, Viktória/0000-0001-6547-9102; Varga, Árpád/0000-0002-2379-139X; Szántó, Kata Judit/0000-0003-0749-5061; Pallagi, Petra/0000-0001-8906-0840; Földesi, Imre/0000-0002-3329-8136; Molnár, Tamás/0000-0002-4913-7599; Maléth, József/0000-0001-5768-3090; Farkas, Klaudia/0000-0003-0599-182X} } @misc{MTMT:34687647, title = {Orai1 calcium channel inhibition prevents progression of chronic pancreatitis}, url = {https://m2.mtmt.hu/api/publication/34687647}, author = {Szabó, Viktória and Csákány-Papp, Noémi and Görög, Marietta and Madácsy, Tamara and Varga, Árpád and Kiss, Aletta Kata and Tél, Bálint and Jójárt, Boldizsár and Crul, Tim and Dudás, Krisztina Márta and Bagyánszki, Mária and Bódi, Nikolett and Ayaydin, Ferhan and Jee, Shyam and Tiszlavicz, László and Stauderman, Kenneth and Hebbar, Sudarshan and Pallagi, Petra and Maléth, József}, unique-id = {34687647}, year = {2023}, orcid-numbers = {Szabó, Viktória/0000-0001-6547-9102; Csákány-Papp, Noémi/0000-0002-3614-2698; Görög, Marietta/0000-0003-3615-3140; Madácsy, Tamara/0000-0001-5598-9723; Varga, Árpád/0000-0002-2379-139X; Kiss, Aletta Kata/0000-0001-6404-1555; Tél, Bálint/0000-0003-2066-6494; Jójárt, Boldizsár/0000-0002-2764-3925; Crul, Tim/0000-0002-6053-7016; Dudás, Krisztina Márta/0000-0003-2383-7412; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090} } @article{MTMT:34687430, title = {ORAI1 CALCIUM CHANNEL INHIBITION PREVENTS PROGRESSION OF RECURRENT ACUTE AND CHRONIC PANCREATITIS}, url = {https://m2.mtmt.hu/api/publication/34687430}, author = {Szabó, Viktória and Csákány-Papp, Noémi and Görög, Marietta and Madácsy, Tamara and Varga, Árpád and Kiss, AK and Tél, Bálint and Jójárt, Boldizsár and Crul, Tim and Dudás, Krisztina Márta and Bagyánszki, M and Bódi, N and Ayaydin, F and Jee, S and Tiszlavicz, L and Stauderman, K and Hebbar, S and Pallagi, Petra and Maléth, József}, journal-iso = {UEG JOURNAL}, journal = {UNITED EUROPEAN GASTROENTEROLOGY JOURNAL}, volume = {11}, unique-id = {34687430}, issn = {2050-6406}, year = {2023}, eissn = {2050-6414}, pages = {66-66}, orcid-numbers = {Szabó, Viktória/0000-0001-6547-9102; Csákány-Papp, Noémi/0000-0002-3614-2698; Görög, Marietta/0000-0003-3615-3140; Madácsy, Tamara/0000-0001-5598-9723; Varga, Árpád/0000-0002-2379-139X; Tél, Bálint/0000-0003-2066-6494; Jójárt, Boldizsár/0000-0002-2764-3925; Crul, Tim/0000-0002-6053-7016; Dudás, Krisztina Márta/0000-0003-2383-7412; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090} } @misc{MTMT:34672053, title = {The inhibition of Orai1 calcium channel reduces the progression of chronic pancreatitis}, url = {https://m2.mtmt.hu/api/publication/34672053}, author = {Szabó, Viktória and Csákány-Papp, Noémi and Görög, Marietta and Madácsy, Tamara and Varga, Árpád and Kiss, Aletta Kata and Tél, Bálint and Jójárt, Boldizsár and Crul, Tim and Dudás, Krisztina Márta and Bagyánszki, Mária and Bódi, Nikolett and Ayaydin, Ferhan and Shyam, Jee and Tiszlavicz, László and Stauderman, Kenneth and Hebbar, Sudarshan and Pallagi, Petra and Maléth, József}, unique-id = {34672053}, year = {2023}, pages = {1}, orcid-numbers = {Szabó, Viktória/0000-0001-6547-9102; Csákány-Papp, Noémi/0000-0002-3614-2698; Görög, Marietta/0000-0003-3615-3140; Madácsy, Tamara/0000-0001-5598-9723; Varga, Árpád/0000-0002-2379-139X; Kiss, Aletta Kata/0000-0001-6404-1555; Tél, Bálint/0000-0003-2066-6494; Jójárt, Boldizsár/0000-0002-2764-3925; Crul, Tim/0000-0002-6053-7016; Dudás, Krisztina Márta/0000-0003-2383-7412; Bagyánszki, Mária/0000-0003-3533-9461; Bódi, Nikolett/0000-0002-9774-1387; Tiszlavicz, László/0000-0003-1134-6587; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090} } @article{MTMT:34593890, title = {LDN-051 a novel fecal biomarker for monitoring disease activity and therapeutic response in inflammatory bowel diseases – results of a phase 2 clinical trial}, url = {https://m2.mtmt.hu/api/publication/34593890}, author = {Jójárt, Boldizsár and Resál, Tamás and Kata, Diána and Molnár, Tünde and Bacsur, Péter and Szabó, Viktória and Varga, Árpád and Szántó, Kata Judit and Földesi, Imre and Molnár, Tamás and Maléth, József and Farkas, Klaudia}, journal-iso = {UEG JOURNAL}, journal = {UNITED EUROPEAN GASTROENTEROLOGY JOURNAL}, volume = {11}, unique-id = {34593890}, issn = {2050-6406}, year = {2023}, eissn = {2050-6414}, pages = {291-292}, orcid-numbers = {Jójárt, Boldizsár/0000-0002-2764-3925; Resál, Tamás/0000-0002-3842-9094; Kata, Diána/0000-0002-4432-9380; Molnár, Tünde/0000-0002-6842-6521; Bacsur, Péter/0000-0002-8534-0068; Szabó, Viktória/0000-0001-6547-9102; Varga, Árpád/0000-0002-2379-139X; Szántó, Kata Judit/0000-0003-0749-5061; Földesi, Imre/0000-0002-3329-8136; Molnár, Tamás/0000-0002-4913-7599; Maléth, József/0000-0001-5768-3090; Farkas, Klaudia/0000-0003-0599-182X} } @article{MTMT:34024396, title = {Human pancreatic ductal organoids with controlled polarity provide a novel ex vivo tool to study epithelial cell physiology}, url = {https://m2.mtmt.hu/api/publication/34024396}, author = {Varga, Árpád and Madácsy, Tamara and Görög, Marietta and Kiss, Aletta Kata and Susánszki, Petra and Szabó, Viktória and Jójárt, Boldizsár and Dudás, Krisztina Márta and Farkas, Gyula Jr. and Szederkényi, Edit and Lázár, György ifj and Attila, Farkas and Ferhan, Ayaydin and Pallagi, Petra and Maléth, József}, doi = {10.1007/s00018-023-04836-2}, journal-iso = {CELL MOL LIFE SCI}, journal = {CELLULAR AND MOLECULAR LIFE SCIENCES}, volume = {80}, unique-id = {34024396}, issn = {1420-682X}, year = {2023}, eissn = {1420-9071}, orcid-numbers = {Varga, Árpád/0000-0002-2379-139X; Madácsy, Tamara/0000-0001-5598-9723; Görög, Marietta/0000-0003-3615-3140; Kiss, Aletta Kata/0000-0001-6404-1555; Susánszki, Petra/0000-0002-2114-7306; Szabó, Viktória/0000-0001-6547-9102; Jójárt, Boldizsár/0000-0002-2764-3925; Dudás, Krisztina Márta/0000-0003-2383-7412; Farkas, Gyula Jr./0000-0003-4054-0864; Szederkényi, Edit/0000-0002-3583-6874; Lázár, György ifj/0000-0001-7155-2978; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090} } @article{MTMT:34012222, title = {The inhibition of ORAI1 CA2+ channel prevents the progression of recurrent acute pancreatitis to chronic pancreatitis in mice}, url = {https://m2.mtmt.hu/api/publication/34012222}, author = {Szabó, Viktória and Csákány-Papp, Noémi and Görög, Marietta and Madácsy, Tamara and Varga, Árpád and Kiss, Aletta Kata and Tél, Bálint and Jójárt, Boldizsár and Dudás, Krisztina Márta and Bagyánszki, Mária and Bódi, Nikolett and Ayaydin, F. and Shyam, J. and Tiszlavicz, László and Stauderman, K. and Hebbar, S. and Pallagi, Petra and Maléth, József}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {9}, unique-id = {34012222}, year = {2023}, eissn = {2415-9107}, pages = {101-102}, orcid-numbers = {Szabó, Viktória/0000-0001-6547-9102; Csákány-Papp, Noémi/0000-0002-3614-2698; Görög, Marietta/0000-0003-3615-3140; Madácsy, Tamara/0000-0001-5598-9723; Varga, Árpád/0000-0002-2379-139X; Kiss, Aletta Kata/0000-0001-6404-1555; Tél, Bálint/0000-0003-2066-6494; Jójárt, Boldizsár/0000-0002-2764-3925; Dudás, Krisztina Márta/0000-0003-2383-7412; Bagyánszki, Mária/0000-0003-3533-9461; Bódi, Nikolett/0000-0002-9774-1387; Tiszlavicz, László/0000-0003-1134-6587; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090} } @article{MTMT:34012221, title = {CFTR regulatory machinery as a potential novel therapeutic target in pancreatic ductal adenocarcinomas}, url = {https://m2.mtmt.hu/api/publication/34012221}, author = {Susánszki, Petra and Varga, Árpád and Görög, Marietta and Szabó, Viktória and Madácsy, Tamara and Dudás, Krisztina Márta and Kiss, Aletta Kata and Pallagi, Petra and Maléth, József}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {9}, unique-id = {34012221}, year = {2023}, eissn = {2415-9107}, pages = {101-101}, orcid-numbers = {Susánszki, Petra/0000-0002-2114-7306; Varga, Árpád/0000-0002-2379-139X; Görög, Marietta/0000-0003-3615-3140; Szabó, Viktória/0000-0001-6547-9102; Madácsy, Tamara/0000-0001-5598-9723; Dudás, Krisztina Márta/0000-0003-2383-7412; Kiss, Aletta Kata/0000-0001-6404-1555; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090} } @article{MTMT:34012214, title = {Pressure-induced inflammatory processes are mediated by PIEZO1 in human pancreatic organoids}, url = {https://m2.mtmt.hu/api/publication/34012214}, author = {Kiss, Aletta Kata and Varga, Árpád and Susánszki, Petra and Lázár, György ifj and Groma, Gergely and Pallagi, Petra and Maléth, József}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {9}, unique-id = {34012214}, year = {2023}, eissn = {2415-9107}, pages = {86-87}, orcid-numbers = {Kiss, Aletta Kata/0000-0001-6404-1555; Varga, Árpád/0000-0002-2379-139X; Susánszki, Petra/0000-0002-2114-7306; Lázár, György ifj/0000-0001-7155-2978; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090} }