TY - CONF AU - Bali, Zsolt Kristóf AU - Bruszt, Nóra AU - Nagy, Lili Veronika AU - Tadepalli, Sai Ambika AU - Hernádi, István TI - The rat psychomotor vigilance task and its validation as a translational tool for testing potential drug candidates for age-related cognitive deficits T2 - International Neuroscience Conference, Pécs 2024 PY - 2024 UR - https://m2.mtmt.hu/api/publication/34547368 ID - 34547368 LA - English DB - MTMT ER - TY - CONF AU - Bruszt, Nóra AU - Bali, Zsolt Kristóf AU - Nagy, Lili Veronika AU - Khalil, Szuhád Leila AU - Kolozsvári, Áron Olivér AU - Hernádi, István TI - Long-term effects of memantine and two alpha7 nicotinic acetylcholine receptor compounds on novel object recognition memory of aged rats T2 - International Neuroscience Conference, Pécs 2024 PY - 2024 UR - https://m2.mtmt.hu/api/publication/34547293 ID - 34547293 LA - English DB - MTMT ER - TY - JOUR AU - Bali, Zsolt Kristóf AU - Nagy, Lili Veronika AU - Bruszt, Nóra AU - Bodó, Kornélia AU - Engelmann, Péter AU - Hernádi, Zsófia AU - Göntér, Kitti AU - Tadepalli, Sai Ambika AU - Hernádi, István TI - Increased brain cytokine level associated impairment of vigilance and memory in aged rats can be alleviated by alpha7 nicotinic acetylcholine receptor agonist treatment JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 46 PY - 2024 IS - 1 SP - 645 EP - 664 PG - 20 SN - 2509-2715 DO - 10.1007/s11357-023-01019-6 UR - https://m2.mtmt.hu/api/publication/34397962 ID - 34397962 AB - Age-related neurocognitive disorders are common problems in developed societies. Aging not only affects memory processes, but may also disturb attention, vigilance, and other executive functions. In the present study, we aimed to investigate age-related cognitive deficits in rats and associated molecular alterations in the brain. We also aimed to test the effects of the alpha7 nicotinic acetylcholine receptor (nAChR) agonist PHA-543613 on memory as well as on the sustained attention and vigilance of aged rats. Short- and long-term spatial memories of the rats were tested using the Morris water maze (MWM) task. To measure attention and vigilance, we designed a rat version of the psychomotor vigilance task (PVT) that is frequently used in human clinical examinations. At the end of the behavioral experiments, mRNA and protein expression of alpha7 nAChRs, cytokines, and brain-derived neurotrophic factor (BDNF) were quantitatively measured in the hippocampus, frontal cortex, striatum, and cerebellum. Aged rats showed marked cognitive deficits in both the MWM and the PVT. The deficit was accompanied by increased IL-1beta and TNFalpha mRNA expression and decreased BDNF protein expression in the hippocampus. PHA-543613 significantly improved the reaction time of aged rats in the PVT, especially for unexpectedly appearing stimuli, while only slightly (non-significantly) alleviating spatial memory deficits in the MWM. These results indicate that targeting alpha7 nAChRs may be an effective strategy for the amelioration of attention and vigilance deficits in age-related neurocognitive disorders. LA - English DB - MTMT ER - TY - CONF AU - Bodó, Angelika AU - Bali, Zsolt Kristóf AU - Nagy, Lili Veronika AU - Kovács, Péter AU - Kitka, Tamás AU - Hernádi, István TI - Application of multiple AAV serotypes and experimental setups for inhibition of food intake by silencing LHA using DREADD technology T2 - Joint Neuroscience Meeting of the Hungarian Neuroscience Society (MITT) & the Austrian Neuroscience Association (ANA) PY - 2023 PG - 1 UR - https://m2.mtmt.hu/api/publication/34111147 ID - 34111147 LA - English DB - MTMT ER - TY - CONF AU - Bali, Zsolt Kristóf AU - Bruszt, Nóra AU - Nagy, Lili Veronika AU - Bodó, Kornélia AU - Engelmann, Péter AU - Göntér, Kitti AU - Ambika Tadepalli, Sai AU - Hernádi, István TI - Alpha7 nicotinic acetylcholine receptor agonist PHA-543613 effectively reverses cognitive deficits of aged rats in the psychomotor vigilance task T2 - Joint Neuroscience Meeting of the Hungarian Neuroscience Society (MITT) & the Austrian Neuroscience Association (ANA) PY - 2023 UR - https://m2.mtmt.hu/api/publication/34104778 ID - 34104778 LA - English DB - MTMT ER - TY - CONF AU - Bruszt, Nóra AU - Bali, Zsolt Kristóf AU - Nagy, Lili Veronika AU - Kolozsvári, Áron AU - Engelmann, Péter AU - Bodó, Kornélia AU - Hernádi, István TI - Combinations of memantine and alpha7 nicotinic acetylcholine receptor ligands exert superior efficacy over monotreatments in the improvement of cognitive performance of aged rats T2 - Joint Neuroscience Meeting of the Hungarian Neuroscience Society (MITT) & the Austrian Neuroscience Association (ANA) PY - 2023 SP - 92 UR - https://m2.mtmt.hu/api/publication/33704642 ID - 33704642 LA - English DB - MTMT ER - TY - CONF AU - Kolozsvári, Áron AU - Bali, Zsolt Kristóf AU - Bruszt, Nóra AU - Nagy, Lili Veronika AU - Fazekas, Bálint AU - Amrein, Krisztina AU - Czeiter, Endre AU - Büki, András AU - Hernádi, István TI - Alleviation of longterm cognitive impairment with memantine combined with alfa7 nicotic receptor ligand after repetitive mild traumatic brain injury in rats T2 - Joint Neuroscience Meeting of the Hungarian Neuroscience Society (MITT) & the Austrian Neuroscience Association (ANA) PY - 2023 SP - 136 UR - https://m2.mtmt.hu/api/publication/33704639 ID - 33704639 LA - English DB - MTMT ER - TY - CONF AU - Kolozsvári, Áron AU - Bali, Zsolt Kristóf AU - Bruszt, Nóra AU - Nagy, Lili Veronika AU - Fazekas, Bálint AU - Amrein, Krisztina AU - Czeiter, Endre AU - Büki, András AU - Hernádi, István TI - Kognitív teljesítményfokozó farmakonok hosszútávú hatásai ismétlődő enyhe koponyatraumával kiváltott kognitív zavarban T2 - Gyógyszerkutatás, Innováció és Farmakokinetika Konferencia - Annual Congress of Pharmacology Research and Innovation PY - 2022 SP - 27 UR - https://m2.mtmt.hu/api/publication/33704627 ID - 33704627 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bali, Zsolt Kristóf AU - Bruszt, Nóra AU - Kőszegi, Zsombor AU - Nagy, Lili Veronika AU - Atlasz, Tamás AU - Kovács, Péter AU - Csupor, Dezső AU - Csupor-Löffler, Boglárka AU - Hernádi, István TI - Aconitum Alkaloid Songorine Exerts Potent Gamma-Aminobutyric Acid-A Receptor Agonist Action In Vivo and Effectively Decreases Anxiety without Adverse Sedative or Psychomotor Effects in the Rat JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 14 PY - 2022 IS - 10 PG - 15 SN - 1999-4923 DO - 10.3390/pharmaceutics14102067 UR - https://m2.mtmt.hu/api/publication/33117614 ID - 33117614 AB - Songorine (SON) is a diterpenoid alkaloid from Aconitum plants. Preparations of Aconitum roots have been employed in traditional oriental herbal medicine, however, their mechanisms of action are still unclear. Since GABA-receptors are possible brain targets of SON, we investigated which subtypes of GABA-receptors contribute to the effects of SON, and how SON affects anxiety-like trait behavior and psychomotor cognitive performance of rats. First, we investigated the effects of microiontophoretically applied SON alone and combined with GABA-receptor agents picrotoxin and saclofen on neuronal firing activity in various brain areas. Next, putative anxiolytic effects of SON (1.0–3.0 mg/kg) were tested against the GABA-receptor positive allosteric modulator reference compound diazepam (1.0–5.0 mg/kg) in the elevated zero maze (EOM). Furthermore, basic cognitive effects were assessed in a rodent version of the psychomotor vigilance task (PVT). Local application of SON predominantly inhibited the firing activity of neurons. This inhibitory effect of SON was successfully blocked by GABA(A)-receptor antagonist picrotoxin but not by GABA(B)-receptor antagonist saclofen. Similar to GABA(A)-receptor positive allosteric modulator diazepam, SON increased the time spent by animals in the open quadrants of the EOM without any signs of adverse psychomotor and cognitive effects observed in the PVT. We showed that, under in vivo conditions, SON acts as a potent GABA(A)-receptor agonist and effectively decreases anxiety without observable side effects. The present findings facilitate the deeper understanding of the mechanism of action and the widespread pharmacological use of diterpene alkaloids in various CNS indications. LA - English DB - MTMT ER - TY - CONF AU - Nagy, Lili Veronika AU - Bali, Zsolt Kristóf AU - Hernádi, István TI - Modulation of firing activity of CA1 hippocampal pyramidal neurons by systemically applied alpha7 nicotinic acetylcholine receptor selective compounds and memantine in the anesthetized rat, in vivo T2 - International Neuroscience Meeting, Budapest 2022 PY - 2022 SP - 130 UR - https://m2.mtmt.hu/api/publication/32859793 ID - 32859793 N1 - Poszter LA - English DB - MTMT ER -