@CONFERENCE{MTMT:34547368,
	title = {The rat psychomotor vigilance task and its validation as a translational tool for testing potential drug candidates for age-related cognitive deficits},
	url = {https://m2.mtmt.hu/api/publication/34547368},
	author = {Bali, Zsolt Kristóf and Bruszt, Nóra and Nagy, Lili Veronika and Tadepalli, Sai Ambika and Hernádi, István},
	booktitle = {International Neuroscience Conference, Pécs 2024},
	unique-id = {34547368},
	year = {2024},
	orcid-numbers = {Bali, Zsolt Kristóf/0000-0003-0712-0788; Hernádi, István/0000-0001-7882-4817}
}

@CONFERENCE{MTMT:34547293,
	title = {Long-term effects of memantine and two alpha7 nicotinic acetylcholine receptor compounds on novel object recognition memory of aged rats},
	url = {https://m2.mtmt.hu/api/publication/34547293},
	author = {Bruszt, Nóra and Bali, Zsolt Kristóf and Nagy, Lili Veronika and Khalil, Szuhád Leila and Kolozsvári, Áron Olivér and Hernádi, István},
	booktitle = {International Neuroscience Conference, Pécs 2024},
	unique-id = {34547293},
	year = {2024},
	orcid-numbers = {Bali, Zsolt Kristóf/0000-0003-0712-0788; Hernádi, István/0000-0001-7882-4817}
}

@article{MTMT:34397962,
	title = {Increased brain cytokine level associated impairment of vigilance and memory in aged rats can be alleviated by alpha7 nicotinic acetylcholine receptor agonist treatment},
	url = {https://m2.mtmt.hu/api/publication/34397962},
	author = {Bali, Zsolt Kristóf and Nagy, Lili Veronika and Bruszt, Nóra and Bodó, Kornélia and Engelmann, Péter and Hernádi, Zsófia and Göntér, Kitti and Tadepalli, Sai Ambika and Hernádi, István},
	doi = {10.1007/s11357-023-01019-6},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {46},
	unique-id = {34397962},
	issn = {2509-2715},
	abstract = {Age-related neurocognitive disorders are common problems in developed societies. Aging not only affects memory processes, but may also disturb attention, vigilance, and other executive functions. In the present study, we aimed to investigate age-related cognitive deficits in rats and associated molecular alterations in the brain. We also aimed to test the effects of the alpha7 nicotinic acetylcholine receptor (nAChR) agonist PHA-543613 on memory as well as on the sustained attention and vigilance of aged rats. Short- and long-term spatial memories of the rats were tested using the Morris water maze (MWM) task. To measure attention and vigilance, we designed a rat version of the psychomotor vigilance task (PVT) that is frequently used in human clinical examinations. At the end of the behavioral experiments, mRNA and protein expression of alpha7 nAChRs, cytokines, and brain-derived neurotrophic factor (BDNF) were quantitatively measured in the hippocampus, frontal cortex, striatum, and cerebellum. Aged rats showed marked cognitive deficits in both the MWM and the PVT. The deficit was accompanied by increased IL-1beta and TNFalpha mRNA expression and decreased BDNF protein expression in the hippocampus. PHA-543613 significantly improved the reaction time of aged rats in the PVT, especially for unexpectedly appearing stimuli, while only slightly (non-significantly) alleviating spatial memory deficits in the MWM. These results indicate that targeting alpha7 nAChRs may be an effective strategy for the amelioration of attention and vigilance deficits in age-related neurocognitive disorders.},
	year = {2024},
	eissn = {2509-2723},
	pages = {645-664},
	orcid-numbers = {Bali, Zsolt Kristóf/0000-0003-0712-0788; Hernádi, István/0000-0001-7882-4817}
}

@CONFERENCE{MTMT:34111147,
	title = {Application of multiple AAV serotypes and experimental setups for inhibition of food intake by silencing LHA using DREADD technology},
	url = {https://m2.mtmt.hu/api/publication/34111147},
	author = {Bodó, Angelika and Bali, Zsolt Kristóf and Nagy, Lili Veronika and Kovács, Péter and Kitka, Tamás and Hernádi, István},
	booktitle = {Joint Neuroscience Meeting of the Hungarian Neuroscience Society (MITT) & the Austrian Neuroscience Association (ANA)},
	unique-id = {34111147},
	year = {2023},
	orcid-numbers = {Bali, Zsolt Kristóf/0000-0003-0712-0788; Kovács, Péter/0000-0001-5732-7432; Hernádi, István/0000-0001-7882-4817}
}

@CONFERENCE{MTMT:34104778,
	title = {Alpha7 nicotinic acetylcholine receptor agonist PHA-543613 effectively reverses cognitive deficits of aged rats in the psychomotor vigilance task},
	url = {https://m2.mtmt.hu/api/publication/34104778},
	author = {Bali, Zsolt Kristóf and Bruszt, Nóra and Nagy, Lili Veronika and Bodó, Kornélia and Engelmann, Péter and Göntér, Kitti and Ambika Tadepalli, Sai and Hernádi, István},
	booktitle = {Joint Neuroscience Meeting of the Hungarian Neuroscience Society (MITT) & the Austrian Neuroscience Association (ANA)},
	unique-id = {34104778},
	year = {2023},
	orcid-numbers = {Bali, Zsolt Kristóf/0000-0003-0712-0788; Hernádi, István/0000-0001-7882-4817}
}

@CONFERENCE{MTMT:33704642,
	title = {Combinations of memantine and alpha7 nicotinic acetylcholine receptor ligands exert superior efficacy over monotreatments in the improvement of cognitive performance of aged rats},
	url = {https://m2.mtmt.hu/api/publication/33704642},
	author = {Bruszt, Nóra and Bali, Zsolt Kristóf and Nagy, Lili Veronika and Kolozsvári, Áron and Engelmann, Péter and Bodó, Kornélia and Hernádi, István},
	booktitle = {Joint Neuroscience Meeting of the Hungarian Neuroscience Society (MITT) & the Austrian Neuroscience Association (ANA)},
	unique-id = {33704642},
	year = {2023},
	pages = {92},
	orcid-numbers = {Bali, Zsolt Kristóf/0000-0003-0712-0788; Hernádi, István/0000-0001-7882-4817}
}

@CONFERENCE{MTMT:33704639,
	title = {Alleviation of longterm cognitive impairment with memantine combined with alfa7 nicotic receptor ligand after repetitive mild traumatic brain injury in rats},
	url = {https://m2.mtmt.hu/api/publication/33704639},
	author = {Kolozsvári, Áron and Bali, Zsolt Kristóf and Bruszt, Nóra and Nagy, Lili Veronika and Fazekas, Bálint and Amrein, Krisztina and Czeiter, Endre and Büki, András and Hernádi, István},
	booktitle = {Joint Neuroscience Meeting of the Hungarian Neuroscience Society (MITT) & the Austrian Neuroscience Association (ANA)},
	unique-id = {33704639},
	year = {2023},
	pages = {136},
	orcid-numbers = {Bali, Zsolt Kristóf/0000-0003-0712-0788; Fazekas, Bálint/0000-0002-8445-4100; Czeiter, Endre/0000-0002-9578-6944; Hernádi, István/0000-0001-7882-4817}
}

@CONFERENCE{MTMT:33704627,
	title = {Kognitív teljesítményfokozó farmakonok hosszútávú hatásai ismétlődő enyhe koponyatraumával kiváltott kognitív zavarban},
	url = {https://m2.mtmt.hu/api/publication/33704627},
	author = {Kolozsvári, Áron and Bali, Zsolt Kristóf and Bruszt, Nóra and Nagy, Lili Veronika and Fazekas, Bálint and Amrein, Krisztina and Czeiter, Endre and Büki, András and Hernádi, István},
	booktitle = {Gyógyszerkutatás, Innováció és Farmakokinetika Konferencia - Annual Congress of Pharmacology Research and Innovation},
	unique-id = {33704627},
	year = {2022},
	pages = {27},
	orcid-numbers = {Bali, Zsolt Kristóf/0000-0003-0712-0788}
}

@article{MTMT:33117614,
	title = {Aconitum Alkaloid Songorine Exerts Potent Gamma-Aminobutyric Acid-A Receptor Agonist Action In Vivo and Effectively Decreases Anxiety without Adverse Sedative or Psychomotor Effects in the Rat},
	url = {https://m2.mtmt.hu/api/publication/33117614},
	author = {Bali, Zsolt Kristóf and Bruszt, Nóra and Kőszegi, Zsombor and Nagy, Lili Veronika and Atlasz, Tamás and Kovács, Péter and Csupor, Dezső and Csupor-Löffler, Boglárka and Hernádi, István},
	doi = {10.3390/pharmaceutics14102067},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {14},
	unique-id = {33117614},
	issn = {1999-4923},
	abstract = {Songorine (SON) is a diterpenoid alkaloid from Aconitum plants. Preparations of Aconitum roots have been employed in traditional oriental herbal medicine, however, their mechanisms of action are still unclear. Since GABA-receptors are possible brain targets of SON, we investigated which subtypes of GABA-receptors contribute to the effects of SON, and how SON affects anxiety-like trait behavior and psychomotor cognitive performance of rats. First, we investigated the effects of microiontophoretically applied SON alone and combined with GABA-receptor agents picrotoxin and saclofen on neuronal firing activity in various brain areas. Next, putative anxiolytic effects of SON (1.0–3.0 mg/kg) were tested against the GABA-receptor positive allosteric modulator reference compound diazepam (1.0–5.0 mg/kg) in the elevated zero maze (EOM). Furthermore, basic cognitive effects were assessed in a rodent version of the psychomotor vigilance task (PVT). Local application of SON predominantly inhibited the firing activity of neurons. This inhibitory effect of SON was successfully blocked by GABA(A)-receptor antagonist picrotoxin but not by GABA(B)-receptor antagonist saclofen. Similar to GABA(A)-receptor positive allosteric modulator diazepam, SON increased the time spent by animals in the open quadrants of the EOM without any signs of adverse psychomotor and cognitive effects observed in the PVT. We showed that, under in vivo conditions, SON acts as a potent GABA(A)-receptor agonist and effectively decreases anxiety without observable side effects. The present findings facilitate the deeper understanding of the mechanism of action and the widespread pharmacological use of diterpene alkaloids in various CNS indications.},
	year = {2022},
	eissn = {1999-4923},
	orcid-numbers = {Bali, Zsolt Kristóf/0000-0003-0712-0788; Kőszegi, Zsombor/0000-0003-2192-0159; Atlasz, Tamás/0000-0002-8112-8633; Kovács, Péter/0000-0001-5732-7432; Csupor, Dezső/0000-0002-4088-3333; Hernádi, István/0000-0001-7882-4817}
}

@CONFERENCE{MTMT:32859793,
	title = {Modulation of firing activity of CA1 hippocampal pyramidal neurons by systemically applied alpha7 nicotinic acetylcholine receptor selective compounds and memantine in the anesthetized rat, in vivo},
	url = {https://m2.mtmt.hu/api/publication/32859793},
	author = {Nagy, Lili Veronika and Bali, Zsolt Kristóf and Hernádi, István},
	booktitle = {International Neuroscience Meeting, Budapest 2022},
	unique-id = {32859793},
	year = {2022},
	pages = {130},
	orcid-numbers = {Bali, Zsolt Kristóf/0000-0003-0712-0788; Hernádi, István/0000-0001-7882-4817}
}