TY - JOUR AU - Rónavári, Andrea AU - Ochirkhuyag, Altantuya AU - Igaz, Nóra AU - Szerencsés, Bettina AU - Ballai, Gergő AU - Huliák, Ildikó AU - Bocz, Csenge AU - Kovács, Ákos AU - Pfeiffer, Ilona AU - Csontné Kiricsi, Mónika AU - Kónya, Zoltán TI - Preparation, characterization and in vitro evaluation of the antimicrobial and antitumor activity of MnOx nanoparticles JF - COLLOIDS AND SURFACES A : PHYSICOCHEMICAL AND ENGINEERING ASPECTS J2 - COLLOID SURFACE A VL - 688 PY - 2024 SN - 0927-7757 DO - 10.1016/j.colsurfa.2024.133528 UR - https://m2.mtmt.hu/api/publication/34687262 ID - 34687262 LA - English DB - MTMT ER - TY - JOUR AU - Szerencsés, Bettina AU - Vörös, Mónika AU - Bagi, Kristóf AU - Háznagy, Márton Benedek AU - Hunyadi, Attila AU - Vágvölgyi, Csaba AU - Pfeiffer, Ilona AU - Vágvölgyi, Máté TI - Semi-Synthetic Ecdysteroid 6-Oxime Derivatives of 20-Hydroxyecdysone Possess Anti-Cryptococcal Activity JF - MICROBIOLOGY RESEARCH J2 - MICROBIOL RES-ITALY VL - 13 PY - 2022 IS - 4 SP - 985 EP - 994 PG - 10 SN - 2036-7473 DO - 10.3390/microbiolres13040071 UR - https://m2.mtmt.hu/api/publication/33538161 ID - 33538161 N1 - Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, 6726, Hungary Institute of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Szeged, 6720, Hungary Export Date: 28 March 2023 Correspondence Address: Vágvölgyi, C.; Department of Microbiology, Hungary; email: csaba@bio.u-szeged.hu Correspondence Address: Pfeiffer, I.; Department of Microbiology, Hungary; email: pfeiffer@bio.u-szeged.hu Chemicals/CAS: ecdysterone, 5289-74-7; indometacin, 53-86-1, 74252-25-8, 7681-54-1; quinidine, 56-54-2; verapamil, 152-11-4, 52-53-9 AB - Cryptococcosis, a life-threatening fungal infection, frequently occurs in patients suffering from AIDS. The treatment of the disease is hampered by the limited number of the effective drugs and the increasing resistance; therefore, to find new active substances is needed. As meningitis is the most serious infection affecting the AIDS patients, effective drugs have to be capable of entering to the central nervous system. Ecdysteroids are natural bioactive molecules with considerable anabolic activity and without toxic side effects on humans. The aim of this work was to study the anti-cryptococcal activity of a natural ecdysteroid, 20E, and its three semi-synthetic derivatives obtained by structural modification of the original molecule. We established the minimum inhibitory concentration of the compounds with microdilution method and demonstrated their fungicidal activity by flow cytometry and cultivation of the drug-treated cells. The interaction of the compounds with each other and efflux transporter inhibitors was assessed by checkerboard titration method. Two derivatives, 20E-EOx and 20E-ZOx, inhibited the growth of Cryptococcus neoformans with minimum inhibitory concentration 2 mg/mL and 1 mg/mL, respectively; both compounds possess fungicidal effect. A combination of the ecdysteroids with each other and verapamil resulted in additive interaction. This study confirmed that structural modification of an originally non-antimicrobial molecule can enhance its effectiveness. LA - English DB - MTMT ER - TY - JOUR AU - Rónavári, Andrea AU - Bélteky, Péter AU - Boka, Eszter AU - Zakupszky, Dalma AU - Igaz, Nóra AU - Szerencsés, Bettina AU - Pfeiffer, Ilona AU - Kónya, Zoltán AU - Csontné Kiricsi, Mónika TI - Polyvinyl-Pyrrolidone-Coated Silver Nanoparticles—The Colloidal, Chemical, and Biological Consequences of Steric Stabilization under Biorelevant Conditions JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 16 PG - 21 SN - 1661-6596 DO - 10.3390/ijms22168673 UR - https://m2.mtmt.hu/api/publication/32131688 ID - 32131688 N1 - Department of Applied and Environmental Chemistry, Faculty of Science and Informatics, University of Szeged, Szeged, H-6720, Hungary Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, Szeged, H-6726, Hungary Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, H-6726, Hungary MTA-SZTE Reaction Kinetics and Surface Chemistry Research Group, Szeged, H-6720, Hungary Cited By :2 Export Date: 11 March 2022 Correspondence Address: Kónya, Z.; Department of Applied and Environmental Chemistry, Hungary; email: konya@chem.u-szeged.hu Chemicals/CAS: povidone, 9003-39-8; silver, 7440-22-4; Anti-Infective Agents; Antineoplastic Agents; Povidone; Silver LA - English DB - MTMT ER - TY - JOUR AU - Bélteky, Péter AU - Rónavári, Andrea AU - Zakupszky, Dalma AU - Boka, Eszter AU - Igaz, Nóra AU - Szerencsés, Bettina AU - Pfeiffer, Ilona AU - Vágvölgyi, Csaba AU - Csontné Kiricsi, Mónika AU - Kónya, Zoltán TI - Are Smaller Nanoparticles Always Better? Understanding the Biological Effect of Size-Dependent Silver Nanoparticle Aggregation Under Biorelevant Conditions JF - INTERNATIONAL JOURNAL OF NANOMEDICINE J2 - INT J NANOMED VL - 16 PY - 2021 SP - 3021 EP - 3040 PG - 20 SN - 1176-9114 DO - 10.2147/IJN.S304138 UR - https://m2.mtmt.hu/api/publication/31982606 ID - 31982606 N1 - Department of Applied and Environmental Chemistry, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary MTA-SZTE Reaction Kinetics and Surface Chemistry Research Group, Szeged, Hungary Export Date: 31 May 2021 Correspondence Address: Kónya, Z.; Department of Applied and Environmental Chemistry, Rerrich Square 1, Hungary; email: konya@chem.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Szerencsés, Bettina AU - Gácser, Attila AU - Endre, Gabriella AU - Racskóné Domonkos, Ildikó AU - Tiricz, Hilda AU - Vágvölgyi, Csaba AU - Szolomájer, János AU - Howan, Dian Herlinda Octorina AU - Tóth, Gábor AU - Pfeiffer, Ilona AU - Kondorosi, Éva TI - Symbiotic NCR Peptide Fragments Affect the Viability, Morphology and Biofilm Formation of Candida Species JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 7 PG - 20 SN - 1661-6596 DO - 10.3390/ijms22073666 UR - https://m2.mtmt.hu/api/publication/31953278 ID - 31953278 N1 - Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, H-6726, Hungary Biological Research Centre, Institute of Plant Biology, Szeged, H-6726, Hungary Department of Medical Chemistry, University of Szeged, Szeged, H-6720, Hungary MTA-SZTE Biomimetic Systems Research Group, University of Szeged, Szeged, H-6720, Hungary Export Date: 26 April 2021 Correspondence Address: Kondorosi, E.; Biological Research Centre, Hungary; email: eva.kondorosi@gmail.com Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, H-6726, Hungary Biological Research Centre, Institute of Plant Biology, Szeged, H-6726, Hungary Department of Medical Chemistry, University of Szeged, Szeged, H-6720, Hungary MTA-SZTE Biomimetic Systems Research Group, University of Szeged, Szeged, H-6720, Hungary Export Date: 1 May 2021 Correspondence Address: Kondorosi, E.; Biological Research Centre, Hungary; email: eva.kondorosi@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Rónavári, Andrea AU - Igaz, Nóra AU - Adamecz, Dóra Izabella AU - Szerencsés, Bettina AU - Molnár, Csaba AU - Kónya, Zoltán AU - Pfeiffer, Ilona AU - Csontné Kiricsi, Mónika TI - Green Silver and Gold Nanoparticles: Biological Synthesis Approaches and Potentials for Biomedical Applications JF - MOLECULES J2 - MOLECULES VL - 26 PY - 2021 IS - 4 PG - 39 SN - 1420-3049 DO - 10.3390/molecules26040844 UR - https://m2.mtmt.hu/api/publication/31852610 ID - 31852610 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office-NKFIHNational Research, Development & Innovation Office (NRDIO) - Hungary [GINOP-2.3.2-15-2016-00038, GINOP-2.3.2-15-2016-00035, EFOP-3.6.1-16-201600008]; "Palyazat_kodja_elneve zese""Sorsz" grant of the New National Excellence Program of the Ministry for Innovation and Technology; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences [BO/00878/19/8] Funding text: Financial support by the National Research, Development and Innovation Office-NKFIH through projects GINOP-2.3.2-15-2016-00038, GINOP-2.3.2-15-2016-00035 and EFOP-3.6.1-16-201600008 is gratefully acknowledged. Furthermore, this work was supported by a "Palyazat_kodja_elneve zese""Sorsz" (M.K.) grant of the New National Excellence Program of the Ministry for Innovation and Technology and by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00878/19/8 for M.K.). LA - English DB - MTMT ER - TY - CHAP AU - Bélteky, Péter AU - Rónavári, Andrea AU - Eszter, Boka AU - Dalma, Zakupszky AU - Igaz, Nóra AU - Szerencsés, Bettina AU - Tóth, Ildikó AU - Pfeiffer, Ilona AU - Csontné Kiricsi, Mónika AU - Zoltán, Kónya ED - Csiszár, Beáta ED - Hankó, Csilla ED - Kajos, Luca Fanni ED - Kovács, Olivér Béla ED - Mező, Emerencia ED - Szabó, Rebeka ED - Guth, Kitti TI - The effect of biological conditions on silver nanoparticle toxicity: just how important nanoparticle aggregation really is? T2 - IX. INTERDISZCIPLINÁRIS DOKTORANDUSZ KONFERENCIA 2020 ABSZTRAKTKÖTET PB - Pécsi Tudományegyetem Doktorandusz Önkormányzat CY - Pécs SN - 9789634295822 PY - 2020 SP - 311 EP - 311 PG - 1 UR - https://m2.mtmt.hu/api/publication/31821390 ID - 31821390 LA - English DB - MTMT ER - TY - JOUR AU - Szerencsés, Bettina AU - Igaz, Nóra AU - Tóbiás, Ákos AU - Prucsi, Zsombor AU - Rónavári, Andrea AU - Bélteky, Péter AU - Madarász, Dániel AU - Papp, Csaba Gergő AU - Makra, Ildikó AU - Vágvölgyi, Csaba AU - Kónya, Zoltán AU - Pfeiffer, Ilona AU - Csontné Kiricsi, Mónika TI - Size-dependent activity of silver nanoparticles on the morphological switch and biofilm formation of opportunistic pathogenic yeasts JF - BMC MICROBIOLOGY J2 - BMC MICROBIOL VL - 20 PY - 2020 IS - 1 PG - 13 SN - 1471-2180 DO - 10.1186/s12866-020-01858-9 UR - https://m2.mtmt.hu/api/publication/31353819 ID - 31353819 N1 - Department of Microbiology, University of Szeged, Szeged, Hungary Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary Department of Applied and Environmental Chemistry, University of Szeged, Szeged, Hungary HAS-USZ Reaction Kinetics and Surface Chemistry Research Group, Szeged, Hungary Cited By :2 Export Date: 31 May 2021 Correspondence Address: Kiricsi, M.; Department of Biochemistry and Molecular Biology, Közép fasor 52, Hungary; email: kiricsim@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Szerencsés, Bettina AU - Mülbacher, Anna AU - Vágvölgyi, Csaba AU - Pfeiffer, Ilona TI - In vitro interactions of amphotericin B and non-antifungal compounds against opportunistic human pathogen Cryptococcus neoformans JF - ACTA BIOLOGICA SZEGEDIENSIS J2 - ACTA BIOL SZEGED VL - 63 PY - 2019 IS - 2 SP - 181 EP - 184 PG - 4 SN - 1588-385X DO - 10.14232/abs.2019.2.181-184 UR - https://m2.mtmt.hu/api/publication/31364282 ID - 31364282 N1 - Cited By :1 Export Date: 23 August 2021 CODEN: ABSCC Correspondence Address: Pfeiffer, I.; Department of Microbiology, Hungary; email: pfeiffer@bio.u-szeged.hu Cited By :1 Export Date: 24 August 2021 CODEN: ABSCC Correspondence Address: Pfeiffer, I.; Department of Microbiology, Hungary; email: pfeiffer@bio.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Bélteky, Péter AU - Rónavári, Andrea AU - Igaz, Nóra AU - Szerencsés, Bettina AU - Tóth, Ildikó AU - Pfeiffer, Ilona AU - Csontné Kiricsi, Mónika AU - Kónya, Zoltán TI - Silver nanoparticles: aggregation behavior in biorelevant conditions and its impact on biological activity JF - INTERNATIONAL JOURNAL OF NANOMEDICINE J2 - INT J NANOMED VL - 14 PY - 2019 SP - 667 EP - 687 PG - 21 SN - 1176-9114 DO - 10.2147/IJN.S185965 UR - https://m2.mtmt.hu/api/publication/30398793 ID - 30398793 N1 - Department of Applied and Environmental Chemistry, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary MTA-SZTE Reaction Kinetics and Surface Chemistry Research Group, Szeged, Hungary Cited By :25 Export Date: 31 May 2021 Correspondence Address: Kónya, Z.; Department of Applied and Environmental Chemistry, Rerrich Square 1, Hungary; email: konya@chem.u-szeged.hu AB - Purpose: The biomedical applications of silver nanoparticles (AgNPs) are heavily investigated due to their cytotoxic and antimicrobial properties. However, the scientific literature is lacking in data on the aggregation behavior of nanoparticles, especially regarding its impact on biological activity. Therefore, to assess the potential of AgNPs in therapeutic applications, two different AgNP samples were compared under biorelevant conditions. LA - English DB - MTMT ER -