TY - JOUR AU - Howe, Emilie Isager AU - Zeldovich, Marina AU - Andelic, Nada AU - von Steinbuechel, Nicole AU - Fure, Silje C R AU - Borgen, Ida M H AU - Forslund, Marit V AU - Hellstrøm, Torgeir AU - Søberg, Helene L AU - Sveen, Unni AU - Rasmussen, Mari AU - Kleffelgaard, Ingerid AU - Tverdal, Cathrine AU - Helseth, Eirik AU - Løvstad, Marianne AU - Lu, Juan AU - Arango-Lasprilla, Juan Carlos AU - Tenovuo, Olli AU - Azouvi, Philippe AU - Dawes, Helen AU - Roe, Cecilie ED - Åkerlund, Cecilia / Collaborator ED - Amrein, Krisztina / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Antoni, Anna / Collaborator ED - Audibert, Gérard / Collaborator ED - Azzolini, Maria Luisa / Collaborator ED - Bartels, Ronald / Collaborator ED - Barzó, Pál / Collaborator ED - Beauvais, Romuald / Collaborator ED - Beer, Ronny / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Benali, Habib / Collaborator ED - Berardino, Maurizio / Collaborator ED - Beretta, Luigi / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Brinck, Vibeke / Collaborator ED - Brooker, Joanne / Collaborator ED - Brorsson, Camilla / Collaborator ED - Buki, Andras / Collaborator ED - Bullinger, Monika / Collaborator ED - Cabeleira, Manuel / Collaborator ED - Caccioppola, Alessio / Collaborator ED - Calappi, Emiliana / Collaborator ED - Calvi, Maria Rosa / Collaborator ED - Cameron, Peter / Collaborator ED - Carbayo Lozano, Guillermo / Collaborator ED - Carbonara, Marco / Collaborator ED - Cavallo, Simona / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Clusmann, Hans / Collaborator ED - Coburn, Mark / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, Jamie D / Collaborator ED - Correia, Marta / Collaborator ED - Čović, Amra / Collaborator ED - Curry, Nicola / Collaborator ED - Czeiter, Endre / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Dark, Paul / Collaborator ED - De Keyser, Véronique / Collaborator ED - Degos, Vincent / Collaborator ED - Della Corte, Francesco / Collaborator ED - den Boogert, Hugo / Collaborator ED - Depreitere, Bart / Collaborator ED - Đilvesi, Đula / Collaborator ED - Dixit, Abhishek / Collaborator ED - Donoghue, Emma / Collaborator ED - Dreier, Jens / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Ercole, Ari / Collaborator ED - Esser, Patrick / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Fabricius, Martin / Collaborator ED - Feigin, Valery L / Collaborator ED - Foks, Kelly / Collaborator ED - Frisvold, Shirin / Collaborator ED - Furmanov, Alex / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Galanaud, Damien / Collaborator ED - Gantner, Dashiell / Collaborator ED - Gao, Guoyi / Collaborator ED - George, Pradeep / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giga, Lelde / Collaborator ED - Glocker, Ben / Collaborator ED - Golubovic, Jagoš / Collaborator ED - Gomez, Pedro A / Collaborator ED - Gratz, Johannes / Collaborator ED - Gravesteijn, Benjamin / Collaborator ED - Grossi, Francesca / Collaborator ED - Gruen, Russell L / Collaborator ED - Gupta, Deepak / Collaborator ED - Haagsma, Juanita A / Collaborator ED - Haitsma, Iain / Collaborator ED - Helbok, Raimund / Collaborator ED - Horton, Lindsay / Collaborator ED - Huijben, Jilske / Collaborator ED - Hutchinson, Peter J / Collaborator ED - Jacobs, Bram / Collaborator ED - Jankowski, Stefan / Collaborator ED - Jarrett, Mike / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Johnson, Faye / Collaborator ED - Jones, Kelly / Collaborator ED - Karan, Mladen / Collaborator ED - Kolias, Angelos G / Collaborator ED - Kompanje, Erwin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Kornaropoulos, Evgenios / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Kovács, Noémi / Collaborator ED - Kowark, Ana / Collaborator ED - Lagares, Alfonso / Collaborator ED - Lanyon, Linda / Collaborator ED - Laureys, Steven / Collaborator ED - Lecky, Fiona / Collaborator ED - Ledoux, Didier / Collaborator ED - Lefering, Rolf / Collaborator ED - Legrand, Valerie / Collaborator ED - Lejeune, Aurelie / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Lingsma, Hester / Collaborator ED - Maas, Andrew I R / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Maegele, Marc / Collaborator ED - Majdan, Marek / Collaborator ED - Manara, Alex / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martino, Costanza / Collaborator ED - Maréchal, Hugues / Collaborator ED - Mattern, Julia / Collaborator ED - McMahon, Catherine / Collaborator ED - Melegh, Béla / Collaborator ED - Menon, David / Collaborator ED - Menovsky, Tomas / Collaborator ED - Mikolic, Ana / Collaborator ED - Misset, Benoit / Collaborator ED - Muraleedharan, Visakh / Collaborator ED - Murray, Lynnette / Collaborator ED - Negru, Ancuta / Collaborator ED - Nelson, David / Collaborator ED - Newcombe, Virginia / Collaborator ED - Nieboer, Daan / Collaborator ED - Nyirádi, József / Collaborator ED - Olubukola, Otesile / Collaborator ED - Oresic, Matej / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Payen, Jean-François / Collaborator ED - Perera, Natascha / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Persona, Paolo / Collaborator ED - Peul, Wilco / Collaborator ED - Piippo-Karjalainen, Anna / Collaborator ED - Pirinen, Matti / Collaborator ED - Pisica, Dana / Collaborator ED - Ples, Horia / Collaborator ED - Polinder, Suzanne / Collaborator ED - Pomposo, Inigo / Collaborator ED - Posti, Jussi P / Collaborator ED - Puybasset, Louis / Collaborator ED - Radoi, Andreea / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Helmrich, Isabel Retel / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Richter, Sophie / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Roise, Olav / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey V / Collaborator ED - Rosenlund, Christina / Collaborator ED - Rosenthal, Guy / Collaborator ED - Rossaint, Rolf / Collaborator ED - Rossi, Sandra / Collaborator ED - Rueckert, Daniel / Collaborator ED - Rusnák, Martin / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sanchez-Porras, Renan / Collaborator AU - Sándor, János ED - Schäfer, Nadine / Collaborator ED - Schmidt, Silke / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Sewalt, Charlie / Collaborator ED - Singh, Ranjit D / Collaborator ED - Skandsen, Toril / Collaborator ED - Smielewski, Peter / Collaborator ED - Sorinola, Abayomi / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Stanworth, Simon / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Steyerberg, Ewout W / Collaborator ED - Stocchetti, Nino / Collaborator ED - Sundström, Nina / Collaborator ED - Takala, Riikka / Collaborator AU - Tamás, Viktória ED - Tamosuitis, Tomas / Collaborator ED - Taylor, Mark Steven / Collaborator ED - Ao, Braden Te / Collaborator ED - Theadom, Alice / Collaborator ED - Thomas, Matt / Collaborator ED - Tibboel, Dick / Collaborator ED - Timmers, Marjolein / Collaborator ED - Tolias, Christos / Collaborator ED - Trapani, Tony / Collaborator ED - Tudora, Cristina Maria / Collaborator ED - Unterberg, Andreas / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Vallance, Shirley / Collaborator ED - Valeinis, Egils / Collaborator ED - Vámos, Zoltán / Collaborator ED - van der Jagt, Mathieu / Collaborator ED - Van der Steen, Gregory / Collaborator ED - van der Naalt, Joukje / Collaborator ED - van Dijck, Jeroen T J M / Collaborator ED - van Erp, Inge A M / Collaborator ED - van Essen, Thomas A / Collaborator ED - Van Hecke, Wim / Collaborator ED - van Heugten, Caroline / Collaborator ED - Van Praag, Dominique / Collaborator ED - van Veen, Ernest / Collaborator ED - Vyvere, Thijs Vande / Collaborator ED - van Wijk, Roel P J / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Vega, Emmanuel / Collaborator ED - Velt, Kimberley / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Volovici, Victor / Collaborator ED - von Steinbüchel, Nicole / Collaborator ED - Voormolen, Daphne / Collaborator ED - Vulekovic, Petar / Collaborator ED - Wang, Kevin K W / Collaborator ED - Whitehouse, Daniel / Collaborator ED - Wiegers, Eveline / Collaborator ED - Williams, Guy / Collaborator ED - Wilson, Lindsay / Collaborator ED - Winzeck, Stefan / Collaborator ED - Wolf, Stefan / Collaborator ED - Yang, Zhihui / Collaborator ED - Ylén, Peter / Collaborator ED - Younsi, Alexander / Collaborator ED - Zeiler, Frederick A / Collaborator ED - Zelinkova, Veronika / Collaborator ED - Ziverte, Agate / Collaborator ED - Zoerle, Tommaso / Collaborator TI - Rehabilitation and outcomes after complicated vs uncomplicated mild TBI. results from the CENTER-TBI study. TS - results from the CENTER-TBI study. JF - BMC HEALTH SERVICES RESEARCH J2 - BMC HEALTH SERV RES VL - 22 PY - 2022 IS - 1 SN - 1472-6963 DO - 10.1186/s12913-022-08908-0 UR - https://m2.mtmt.hu/api/publication/34724962 ID - 34724962 AB - Despite existing guidelines for managing mild traumatic brain injury (mTBI), evidence-based treatments are still scarce and large-scale studies on the provision and impact of specific rehabilitation services are needed. This study aimed to describe the provision of rehabilitation to patients after complicated and uncomplicated mTBI and investigate factors associated with functional outcome, symptom burden, and TBI-specific health-related quality of life (HRQOL) up to six months after injury.Patients (n = 1379) with mTBI from the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study who reported whether they received rehabilitation services during the first six months post-injury and who participated in outcome assessments were included. Functional outcome was measured with the Glasgow Outcome Scale - Extended (GOSE), symptom burden with the Rivermead Post Concussion Symptoms Questionnaire (RPQ), and HRQOL with the Quality of Life after Brain Injury - Overall Scale (QOLIBRI-OS). We examined whether transition of care (TOC) pathways, receiving rehabilitation services, sociodemographic (incl. geographic), premorbid, and injury-related factors were associated with outcomes using regression models. For easy comparison, we estimated ordinal regression models for all outcomes where the scores were classified based on quantiles.Overall, 43% of patients with complicated and 20% with uncomplicated mTBI reported receiving rehabilitation services, primarily in physical and cognitive domains. Patients with complicated mTBI had lower functional level, higher symptom burden, and lower HRQOL compared to uncomplicated mTBI. Rehabilitation services at three or six months and a higher number of TOC were associated with unfavorable outcomes in all models, in addition to pre-morbid psychiatric problems. Being male and having more than 13 years of education was associated with more favorable outcomes. Sustaining major trauma was associated with unfavorable GOSE outcome, whereas living in Southern and Eastern European regions was associated with lower HRQOL.Patients with complicated mTBI reported more unfavorable outcomes and received rehabilitation services more frequently. Receiving rehabilitation services and higher number of care transitions were indicators of injury severity and associated with unfavorable outcomes. The findings should be interpreted carefully and validated in future studies as we applied a novel analytic approach.ClinicalTrials.gov NCT02210221. LA - English DB - MTMT ER - TY - JOUR AU - Pinczker, Veronika AU - Makai, Alexandra AU - Molics, Bálint AU - Boncz, Imre AU - Tamás, Viktória AU - Járomi, Melinda TI - EFFECTS OF NAVIGATED RTMS FOR THE HEMIPARETIC UPPER EXTREMITY MOTOR FUNCTION IN STROKE PATIENTS - PILOT STUDY JF - VALUE IN HEALTH J2 - VALUE HEALTH VL - 25 PY - 2022 IS - 12 SP - S487 EP - S487 PG - 1 SN - 1098-3015 UR - https://m2.mtmt.hu/api/publication/33710664 ID - 33710664 LA - English DB - MTMT ER - TY - JOUR AU - Riemann, Lennart AU - Alhalabi, Obada T. AU - Unterberg, Andreas W. W. AU - Younsi, Alexander ED - Barzó, Pál / Collaborator ED - Cecilia, Åkerlund / Collaborator ED - Krisztina, Amrein / Collaborator ED - Nada, Andelic / Collaborator ED - Lasse, Andreassen / Collaborator ED - Audny, Anke / Collaborator ED - Anna, Antoni / Collaborator ED - Gérard, Audibert / Collaborator ED - Philippe, Azouvi / Collaborator ED - Maria, Luisa Azzolini / Collaborator ED - Ronald, Bartels / Collaborator ED - Romuald, Beauvais / Collaborator ED - Ronny, Beer / Collaborator ED - Bo-Michael, Bellander / Collaborator ED - Antonio, Belli / Collaborator ED - Habib, Benali / Collaborator ED - Maurizio, Berardino / Collaborator ED - Luigi, Beretta / Collaborator ED - Morten, Blaabjerg / Collaborator ED - Peter, Bragge / Collaborator ED - Alexandra, Brazinova / Collaborator ED - Vibeke, Brinck / Collaborator ED - Joanne, Brooker / Collaborator ED - Camilla, Brorsson / Collaborator ED - Andras, Buki / Collaborator ED - Monika, Bullinger / Collaborator ED - Manuel, Cabeleira / Collaborator ED - Alessio, Caccioppola / Collaborator ED - Emiliana, Calappi / Collaborator ED - Maria, Rosa Calvi / Collaborator ED - Peter, Cameron / Collaborator ED - Guillermo, Carbayo Lozano / Collaborator ED - Marco, Carbonara / Collaborator ED - Simona, Cavallo / Collaborator ED - Giorgio, Chevallard / Collaborator ED - Arturo, Chieregato / Collaborator ED - Giuseppe, Citerio / Collaborator ED - Hans, Clusmann / Collaborator ED - Mark, Coburn / Collaborator ED - Jonathan, Coles / Collaborator ED - Jamie, D Cooper / Collaborator ED - Marta, Correia / Collaborator ED - Amra, Cović / Collaborator ED - Nicola, Curry / Collaborator ED - Endre, Czeiter / Collaborator ED - Marek, Czosnyka / Collaborator ED - Claire, Dahyot-Fizelier / Collaborator ED - Paul, Dark / Collaborator ED - Helen, Dawes / Collaborator ED - Véronique, De Keyser / Collaborator ED - Vincent, Degos / Collaborator ED - Francesco, Della Corte / Collaborator ED - Hugo, den Boogert / Collaborator ED - Bart, Depreitere / Collaborator ED - Ðula, Ðilvesi / Collaborator ED - Abhishek, Dixit / Collaborator ED - Emma, Donoghue / Collaborator ED - Jens, Dreier / Collaborator ED - Guy-Loup, Dulière / Collaborator ED - Ari, Ercole / Collaborator ED - Patrick, Esser / Collaborator ED - Erzsébet, Ezer / Collaborator ED - Martin, Fabricius / Collaborator ED - Valery, L Feigin / Collaborator ED - Kelly, Foks / Collaborator ED - Shirin, Frisvold / Collaborator ED - Alex, Furmanov / Collaborator ED - Pablo, Gagliardo / Collaborator ED - Damien, Galanaud / Collaborator ED - Dashiell, Gantner / Collaborator ED - Guoyi, Gao / Collaborator ED - Pradeep, George / Collaborator ED - Alexandre, Ghuysen / Collaborator ED - Lelde, Giga / Collaborator ED - Ben, Glocker / Collaborator ED - Jagoš, Golubovic / Collaborator ED - Pedro, A Gomez / Collaborator ED - Johannes, Gratz / Collaborator ED - Benjamin, Gravesteijn / Collaborator ED - Francesca, Grossi / Collaborator ED - Russell, L Gruen / Collaborator ED - Deepak, Gupta / Collaborator ED - Juanita, A Haagsma / Collaborator ED - Iain, Haitsma / Collaborator ED - Raimund, Helbok / Collaborator ED - Eirik, Helseth / Collaborator ED - Lindsay, Horton / Collaborator ED - Jilske, Huijben / Collaborator ED - Peter, J Hutchinson / Collaborator ED - Bram, Jacobs / Collaborator ED - Stefan, Jankowski / Collaborator ED - Mike, Jarrett / Collaborator ED - Ji-Yao, Jiang / Collaborator ED - Faye, Johnson / Collaborator ED - Kelly, Jones / Collaborator ED - Mladen, Karan / Collaborator ED - Angelos, G Kolias / Collaborator ED - Erwin, Kompanje / Collaborator ED - Daniel, Kondziella / Collaborator ED - Evgenios, Kornaropoulos / Collaborator ED - Lars-Owe, Koskinen / Collaborator ED - Noémi, Kovács / Collaborator ED - Ana, Kowark / Collaborator ED - Alfonso, Lagares / Collaborator ED - Linda, Lanyon / Collaborator ED - Steven, Laureys / Collaborator ED - Fiona, Lecky / Collaborator ED - Didier, Ledoux / Collaborator ED - Rolf, Lefering / Collaborator ED - Valerie, Legrand / Collaborator ED - Aurelie, Lejeune / Collaborator ED - Leon, Levi / Collaborator ED - Roger, Lightfoot / Collaborator ED - Hester, Lingsma / Collaborator ED - Andrew, Ir Maas / Collaborator ED - Ana, M Castaño-León / Collaborator ED - Marc, Maegele / Collaborator ED - Marek, Majdan / Collaborator ED - Alex, Manara / Collaborator ED - Geoffrey, Manley / Collaborator ED - Costanza, Martino / Collaborator ED - Hugues, Maréchal / Collaborator ED - Julia, Mattern / Collaborator ED - Catherine, McMahon / Collaborator ED - Béla, Melegh / Collaborator ED - David, Menon / Collaborator ED - Tomas, Menovsky / Collaborator ED - Ana, Mikolic / Collaborator ED - Benoit, Misset / Collaborator ED - Visakh, Muraleedharan / Collaborator ED - Lynnette, Murray / Collaborator ED - Ancuta, Negru / Collaborator ED - David, Nelson / Collaborator ED - Virginia, Newcombe / Collaborator ED - Daan, Nieboer / Collaborator ED - József, Nyirádi / Collaborator ED - Otesile, Olubukola / Collaborator ED - Matej, Oresic / Collaborator ED - Fabrizio, Ortolano / Collaborator ED - Aarno, Palotie / Collaborator ED - Paul, M Parizel / Collaborator ED - Jean-François, Payen / Collaborator ED - Natascha, Perera / Collaborator ED - Vincent, Perlbarg / Collaborator ED - Paolo, Persona / Collaborator ED - Wilco, Peul / Collaborator ED - Anna, Piippo-Karjalainen / Collaborator ED - Matti, Pirinen / Collaborator ED - Dana, Pisica / Collaborator ED - Horia, Ples / Collaborator ED - Suzanne, Polinder / Collaborator ED - Inigo, Pomposo / Collaborator ED - Jussi, P Posti / Collaborator ED - Louis, Puybasset / Collaborator ED - Andreea, Radoi / Collaborator ED - Arminas, Ragauskas / Collaborator ED - Rahul, Raj / Collaborator ED - Malinka, Rambadagalla / Collaborator ED - Isabel, Retel Helmrich / Collaborator ED - Jonathan, Rhodes / Collaborator ED - Sylvia, Richardson / Collaborator ED - Sophie, Richter / Collaborator ED - Samuli, Ripatti / Collaborator ED - Saulius, Rocka / Collaborator ED - Cecilie, Roe / Collaborator ED - Olav, Roise / Collaborator ED - Jonathan, Rosand / Collaborator ED - Jeffrey, V Rosenfeld / Collaborator ED - Christina, Rosenlund / Collaborator ED - Guy, Rosenthal / Collaborator ED - Rolf, Rossaint / Collaborator ED - Sandra, Rossi / Collaborator ED - Daniel, Rueckert / Collaborator ED - Martin, Rusnák / Collaborator ED - Juan, Sahuquillo / Collaborator ED - Oliver, Sakowitz / Collaborator ED - Renan, Sanchez-Porras / Collaborator ED - Janos, Sandor / Collaborator ED - Nadine, Schäfer / Collaborator ED - Silke, Schmidt / Collaborator ED - Herbert, Schoechl / Collaborator ED - Guus, Schoonman / Collaborator ED - Rico, Frederik Schou / Collaborator ED - Elisabeth, Schwendenwein / Collaborator ED - Charlie, Sewalt / Collaborator ED - Ranjit, D Singh / Collaborator ED - Toril, Skandsen / Collaborator ED - Peter, Smielewski / Collaborator ED - Abayomi, Sorinola / Collaborator ED - Emmanuel, Stamatakis / Collaborator ED - Simon, Stanworth / Collaborator ED - Robert, Stevens / Collaborator ED - William, Stewart / Collaborator ED - Ewout, W Steyerberg / Collaborator ED - Nino, Stocchetti / Collaborator ED - Nina, Sundström / Collaborator ED - Riikka, Takala / Collaborator ED - Tamás, Viktória / Collaborator ED - Tomas, Tamosuitis / Collaborator ED - Mark, Steven Taylor / Collaborator ED - Braden, Te Ao / Collaborator ED - Olli, Tenovuo / Collaborator ED - Alice, Theadom / Collaborator ED - Matt, Thomas / Collaborator ED - Dick, Tibboel / Collaborator ED - Marjolein, Timmers / Collaborator ED - Christos, Tolias / Collaborator ED - Tony, Trapani / Collaborator ED - Cristina, Maria Tudora / Collaborator ED - Andreas, Unterberg / Collaborator ED - Peter, Vajkoczy / Collaborator ED - Shirley, Vallance / Collaborator ED - Egils, Valeinis / Collaborator ED - Zoltán, Vámos / Collaborator ED - Mathieu, van der Jagt / Collaborator ED - Gregory, Van der Steen / Collaborator ED - Joukje, van der Naalt / Collaborator ED - Jeroen, Tjm van Dijck / Collaborator ED - Inge, A van Erp / Collaborator ED - Thomas, A van Essen / Collaborator ED - Wim, Van Hecke / Collaborator ED - Caroline, van Heugten / Collaborator ED - Dominique, Van Praag / Collaborator ED - Ernest, van Veen / Collaborator ED - Thijs, Vande Vyvere / Collaborator ED - Roel, P J van Wijk / Collaborator ED - Alessia, Vargiolu / Collaborator ED - Emmanuel, Vega / Collaborator ED - Kimberley, Velt / Collaborator ED - Jan, Verheyden / Collaborator ED - Paul, M Vespa / Collaborator ED - Anne, Vik / Collaborator ED - Rimantas, Vilcinis / Collaborator ED - Victor, Volovici / Collaborator ED - Nicole, von Steinbüchel / Collaborator ED - Daphne, Voormolen / Collaborator ED - Petar, Vulekovic / Collaborator ED - Kevin, Kw Wang / Collaborator ED - Daniel, Whitehouse / Collaborator ED - Eveline, Wiegers / Collaborator ED - Guy, Williams / Collaborator ED - Lindsay, Wilson / Collaborator ED - Stefan, Winzeck / Collaborator ED - Stefan, Wolf / Collaborator ED - Zhihui, Yang / Collaborator ED - Peter, Ylén / Collaborator ED - Alexander, Younsi / Collaborator ED - Frederick, A Zeiler / Collaborator ED - Veronika, Zelinkova / Collaborator ED - Agate, Ziverte / Collaborator ED - Tommaso, Zoerle / Collaborator TI - Concomitant spine trauma in patients with traumatic brain injury: Patient characteristics and outcomes JF - FRONTIERS IN NEUROLOGY J2 - FRONT NEUR VL - 13 PY - 2022 PG - 11 SN - 1664-2295 DO - 10.3389/fneur.2022.861688 UR - https://m2.mtmt.hu/api/publication/33236529 ID - 33236529 N1 - Export Date: 21 January 2023 AB - ObjectiveSpine injury is highly prevalent in patients with poly-trauma, but data on the co-occurrence of spine trauma in patients with traumatic brain injury (TBI) are scarce. In this study, we used the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) database to assess the prevalence, characteristics, and outcomes of patients with TBI and a concurrent traumatic spinal injury (TSI). MethodsData from the European multi-center CENTER-TBI study were analyzed. Adult patients with TBI (>= 18 years) presenting with a concomitant, isolated TSI of at least serious severity (Abbreviated Injury Scale; AIS >= 3) were included. For outcome analysis, comparison groups of TBI patients with TSI and systemic injuries (non-isolated TSI) and without TSI were created using propensity score matching. Rates of mortality, unfavorable outcomes (Glasgow Outcome Scale Extended; GOSe < 5), and full recovery (GOSe 7-8) of all patients and separately for patients with only mild TBI (mTBI) were compared between groups at 6-month follow-up. ResultsA total of 164 (4%) of the 4,254 CENTER-TBI core study patients suffered from a concomitant isolated TSI. The median age was 53 [interquartile range (IQR): 37-66] years and 71% of patients were men. mTBI was documented in 62% of cases, followed by severe TBI (26%), and spine injuries were mostly cervical (63%) or thoracic (31%). Surgical spine stabilization was performed in 19% of cases and 57% of patients were admitted to the ICU. Mortality at 6 months was 11% and only 36% of patients regained full recovery. There were no significant differences in the 6-month rates of mortality, unfavorable outcomes, or full recovery between TBI patients with and without concomitant isolated TSI. However, concomitant non-isolated TSI was associated with an unfavorable outcome and a higher mortality. In patients with mTBI, a negative association with full recovery could be observed for both concomitant isolated and non-isolated TSI. ConclusionRates of mortality, unfavorable outcomes, and full recovery in TBI patients with and without concomitant, isolated TSIs were comparable after 6 months. However, in patients with mTBI, concomitant TSI was a negative predictor for a full recovery. These findings might indicate that patients with moderate to severe TBI do not necessarily exhibit worse outcomes when having a concomitant TSI, whereas patients with mTBI might be more affected. LA - English DB - MTMT ER - TY - JOUR AU - Bockhop, Fabian AU - Zeldovich, Marina AU - Cunitz, Katrin AU - Van Praag, Dominique AU - van der Vlegel, Marjolein AU - Beissbarth, Tim AU - Hagmayer, York AU - von Steinbuechel, Nicole ED - Åkerlund, Cecilia / Collaborator ED - Amrein, Krisztina / Collaborator ED - Andelic, Nada / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Antoni, Anna / Collaborator ED - Audibert, Gérard / Collaborator ED - Azouvi, Philippe / Collaborator ED - Azzolini, Maria Luisa / Collaborator ED - Bartels, Ronald / Collaborator ED - Barzó, Pál / Collaborator ED - Beauvais, Romuald / Collaborator ED - Beer, Ronny / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Benali, Habib / Collaborator ED - Berardino, Maurizio / Collaborator ED - Beretta, Luigi / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Brinck, Vibeke / Collaborator ED - Brooker, Joanne / Collaborator ED - Brorsson, Camilla / Collaborator ED - Büki, András / Collaborator ED - Bullinger, Monika / Collaborator ED - Cabeleira, Manuel / Collaborator ED - Caccioppola, Alessio / Collaborator ED - Calappi, Emiliana / Collaborator ED - Calvi, Maria Rosa / Collaborator ED - Cameron, Peter / Collaborator ED - Carbayo Lozano, Guillermo / Collaborator ED - Carbonara, Marco / Collaborator ED - Cavallo, Simona / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Clusmann, Hans / Collaborator ED - Coburn, Mark / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, Jamie D / Collaborator ED - Correia, Marta / Collaborator ED - Čović, Amra / Collaborator ED - Curry, Nicola / Collaborator ED - Czeiter, Endre / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Dark, Paul / Collaborator ED - Dawes, Helen / Collaborator ED - De Keyser, Véronique / Collaborator ED - Degos, Vincent / Collaborator ED - Della Corte, Francesco / Collaborator ED - den Boogert, Hugo / Collaborator ED - Depreitere, Bart / Collaborator ED - Đilvesi, Đula / Collaborator ED - Dixit, Abhishek / Collaborator ED - Donoghue, Emma / Collaborator ED - Dreier, Jens / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Ercole, Ari / Collaborator ED - Esser, Patrick / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Fabricius, Martin / Collaborator ED - Feigin, Valery L / Collaborator ED - Foks, Kelly / Collaborator ED - Frisvold, Shirin / Collaborator ED - Furmanov, Alex / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Galanaud, Damien / Collaborator ED - Gantner, Dashiell / Collaborator ED - Guoyi, Gao / Collaborator ED - George, Pradeep / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giga, Lelde / Collaborator ED - Glocker, Ben / Collaborator ED - Golubovic, Jagoš / Collaborator ED - A Gomez, Pedro / Collaborator ED - Gratz, Johannes / Collaborator ED - Gravesteijn, Benjamin / Collaborator ED - Grossi, Francesca / Collaborator ED - L Gruen, Russell / Collaborator ED - Gupta, Deepak / Collaborator ED - A Haagsma, Juanita / Collaborator ED - Haitsma, Iain / Collaborator ED - Helbok, Raimund / Collaborator ED - Helseth, Eirik / Collaborator ED - Horton, Lindsay / Collaborator ED - Huijben, Jilske / Collaborator ED - J Hutchinson, Peter / Collaborator ED - Jacobs, Bram / Collaborator ED - Jankowski, Stefan / Collaborator ED - Jarrett, Mike / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Johnson, Faye / Collaborator ED - Jones, Kelly / Collaborator ED - Karan, Mladen / Collaborator ED - G Kolias, Angelos / Collaborator ED - Kompanje, Erwin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Kornaropoulos, Evgenios / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Kovács, Noémi / Collaborator ED - Kowark, Ana / Collaborator ED - Lagares, Alfonso / Collaborator ED - Lanyon, Linda / Collaborator ED - Laureys, Steven / Collaborator ED - Lecky, Fiona / Collaborator ED - Ledoux, Didier / Collaborator ED - Lefering, Rolf / Collaborator ED - Legrand, Valerie / Collaborator ED - Lejeune, Aurelie / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Lingsma, Hester / Collaborator ED - I R Maas, Andrew / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Maegele, Marc / Collaborator ED - Majdan, Marek / Collaborator ED - Manara, Alex / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martino, Costanza / Collaborator ED - Maréchal, Hugues / Collaborator ED - Mattern, Julia / Collaborator ED - McMahon, Catherine / Collaborator ED - Melegh, Béla / Collaborator ED - Menon, David / Collaborator ED - Menovsky, Tomas / Collaborator ED - Mikolic, Ana / Collaborator ED - Misset, Benoit / Collaborator ED - Muraleedharan, Visakh / Collaborator ED - Murray, Lynnette / Collaborator ED - Negru, Ancuta / Collaborator ED - Nelson, David / Collaborator ED - Newcombe, Virginia / Collaborator ED - Nieboer, Daan / Collaborator ED - Nyirádi, József / Collaborator ED - Olubukola, Otesile / Collaborator ED - Oresic, Matej / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Payen, Jean-François / Collaborator ED - Perera, Natascha / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Persona, Paolo / Collaborator ED - Peul, Wilco / Collaborator ED - Piippo-Karjalainen, Anna / Collaborator ED - Pirinen, Matti / Collaborator ED - Pisica, Dana / Collaborator ED - Ples, Horia / Collaborator ED - Polinder, Suzanne / Collaborator ED - Pomposo, Inigo / Collaborator ED - Posti, Jussi P / Collaborator ED - Puybasset, Louis / Collaborator ED - Radoi, Andreea / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Helmrich, Isabel Retel / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Richter, Sophie / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Roe, Cecilie / Collaborator ED - Roise, Olav / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey V / Collaborator ED - Rosenlund, Christina / Collaborator ED - Rosenthal, Guy / Collaborator ED - Rossaint, Rolf / Collaborator ED - Rossi, Sandra / Collaborator ED - RueckertMartin Rusnák, Daniel / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sanchez-Porras, Renan / Collaborator ED - Sándor, János / Collaborator ED - Schäfer, Nadine / Collaborator ED - Schmidt, Silke / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Sewalt, Charlie / Collaborator ED - Singh, Ranjit D / Collaborator ED - Skandsen, Toril / Collaborator ED - Smielewski, Peter / Collaborator ED - Sorinola, Abayomi Akinrinsola / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Stanworth, Simon / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Steyerberg, Ewout W / Collaborator ED - Stocchetti, Nino / Collaborator ED - Sundström, Nina / Collaborator ED - Takala, Riikka / Collaborator ED - Tamás, Viktória / Collaborator ED - Tamosuitis, Tomas / Collaborator ED - Steven Taylor, Mark / Collaborator ED - Te Ao, Braden / Collaborator ED - Tenovuo, Olli / Collaborator ED - Theadom, Alice / Collaborator ED - Thomas, Matt / Collaborator ED - Tibboel, Dick / Collaborator ED - Timmers, Marjolein / Collaborator ED - Tolias, Christos / Collaborator ED - Trapani, Tony / Collaborator ED - Maria Tudora, Cristina / Collaborator ED - Unterberg, Andreas / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Vallance, Shirley / Collaborator ED - Valeinis, Egils / Collaborator ED - Vámos, Zoltán / Collaborator ED - van der Jagt, Mathieu / Collaborator ED - Van der Steen, Gregory / Collaborator ED - Naalt, Joukje van der / Collaborator ED - T J M van Dijck, Jeroen / Collaborator ED - van Erp, Inge A M / Collaborator ED - van Essen, Thomas A / Collaborator ED - Hecke, Wim Van / Collaborator ED - van Heugten, Caroline / Collaborator ED - Van Praag, Dominique / Collaborator ED - van Veen, Ernest / Collaborator ED - Vande Vyvere, Thijs / Collaborator ED - van Wijk, Roel P J / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Vega, Emmanuel / Collaborator ED - Velt, Kimberley / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Volovici, Victor / Collaborator ED - von Steinbüchel, Nicole / Collaborator ED - Voormolen, Daphne / Collaborator ED - Vulekovic, Petar / Collaborator ED - K W Wang, Kevin / Collaborator ED - Whitehouse, Daniel / Collaborator ED - Wiegers, Eveline / Collaborator ED - Williams, Guy / Collaborator ED - Wilson, Lindsay / Collaborator ED - Winzeck, Stefan / Collaborator ED - Wolf, Stefan / Collaborator ED - Yang, Zhihui / Collaborator ED - Ylén, Peter / Collaborator ED - Younsi, Alexander / Collaborator ED - Zeiler, Frederick A / Collaborator ED - Zelinkova, Veronika / Collaborator ED - Ziverte, Agate / Collaborator ED - Zoerle, Tommaso / Collaborator TI - Measurement invariance of six language versions of the post-traumatic stress disorder checklist for DSM-5 in civilians after traumatic brain injury JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 12 PY - 2022 IS - 1 PG - 15 SN - 2045-2322 DO - 10.1038/s41598-022-20170-2 UR - https://m2.mtmt.hu/api/publication/33195955 ID - 33195955 N1 - Funding Agency and Grant Number: European Union [602150]; Hannelore Kohl Stiftung (Germany); OneMind (USA); Integra LifeSciences Corporation (USA); Projekt DEAL Funding text: Open Access funding enabled and organized by Projekt DEAL. CENTER-TBI was supported by the European Union 7th Framework programme (EC Grant 602150). Additional funding was obtained from the Hannelore Kohl Stiftung (Germany), from OneMind (USA), and from Integra LifeSciences Corporation (USA). The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. AB - Traumatic brain injury (TBI) is frequently associated with neuropsychiatric impairments such as symptoms of post-traumatic stress disorder (PTSD), which can be screened using self-report instruments such as the Post-Traumatic Stress Disorder Checklist for DSM-5 (PCL-5). The current study aims to inspect the factorial validity and cross-linguistic equivalence of the PCL-5 in individuals after TBI with differential severity. Data for six language groups (n ≥ 200; Dutch, English, Finnish, Italian, Norwegian, Spanish) were extracted from the CENTER-TBI study database. Factorial validity of PTSD was evaluated using confirmatory factor analyses (CFA), and compared between four concurrent structural models. A multi-group CFA approach was utilized to investigate the measurement invariance (MI) of the PCL-5 across languages. All structural models showed satisfactory goodness-of-fit with small between-model variation. The original DSM-5 model for PTSD provided solid evidence of MI across the language groups. The current study underlines the validity of the clinical DSM-5 conceptualization of PTSD and demonstrates the comparability of PCL-5 symptom scores between language versions in individuals after TBI. Future studies should apply MI methods to other sociodemographic (e.g., age, gender) and injury-related (e.g., TBI severity) characteristics to improve the monitoring and clinical care of individuals suffering from PTSD symptoms after TBI. LA - English DB - MTMT ER - TY - JOUR AU - Van Praag, Dominique L G AU - Wouters, Kristien AU - Van Den Eede, Filip AU - Wilson, Lindsay AU - Maas, Andrew I R ED - Åkerlund, Cecilia / Collaborator ED - Amrein, Krisztina / Collaborator ED - Andelic, Nada / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Antoni, Anna / Collaborator ED - Audibert, Gérard / Collaborator ED - Azouvi, Philippe / Collaborator ED - Azzolini, Maria Luisa / Collaborator ED - Bartels, Ronald / Collaborator ED - Barzó, Pál / Collaborator ED - Beauvais, Romuald / Collaborator ED - Beer, Ronny / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Benali, Habib / Collaborator ED - Berardino, Maurizio / Collaborator ED - Beretta, Luigi / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Brinck, Vibeke / Collaborator ED - Brooker, Joanne / Collaborator ED - Brorsson, Camilla / Collaborator ED - Büki, András / Collaborator ED - Bullinger, Monika / Collaborator ED - Cabeleira, Manuel / Collaborator ED - Caccioppola, Alessio / Collaborator ED - Calappi, Emiliana / Collaborator ED - Calvi, Maria Rosa / Collaborator ED - Cameron, Peter / Collaborator ED - Lozano, Guillermo Carbayo / Collaborator ED - Carbonara, Marco / Collaborator ED - Cavallo, Simona / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Ceyisakar, Iris / Collaborator ED - Clusmann, Hans / Collaborator ED - Coburn, Mark / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, Jamie D / Collaborator ED - Correia, Marta / Collaborator ED - Čović, Amra / Collaborator ED - Curry, Nicola / Collaborator ED - Czeiter, Endre / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Dark, Paul / Collaborator ED - Dawes, Helen / Collaborator ED - De Keyser, Véronique / Collaborator ED - Degos, Vincent / Collaborator ED - Della Corte, Francesco / Collaborator ED - Boogert, Hugo den / Collaborator ED - Depreitere, Bart / Collaborator ED - Đilvesi, Đula / Collaborator ED - Dixit, Abhishek / Collaborator ED - Donoghue, Emma / Collaborator ED - Dreier, Jens / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Ercole, Ari / Collaborator ED - Esser, Patrick / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Fabricius, Martin / Collaborator ED - Feigin, Valery L / Collaborator ED - Foks, Kelly / Collaborator ED - Frisvold, Shirin / Collaborator ED - Furmanov, Alex / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Galanaud, Damien / Collaborator ED - Gantner, Dashiell / Collaborator ED - Gao, Guoyi / Collaborator ED - George, Pradeep / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giga, Lelde / Collaborator ED - Glocker, Ben / Collaborator ED - Golubovic, Jagoš / Collaborator ED - Gomez, Pedro A / Collaborator ED - Gratz, Johannes / Collaborator ED - Gravesteijn, Benjamin / Collaborator ED - Grossi, Francesca / Collaborator ED - Gruen, Russell L / Collaborator ED - Gupta, Deepak / Collaborator ED - Haagsma, Juanita A / Collaborator ED - Haitsma, Iain / Collaborator ED - Helbok, Raimund / Collaborator ED - Helseth, Eirik / Collaborator ED - Horton, Lindsay / Collaborator ED - Huijben, Jilske / Collaborator ED - Hutchinson, Peter J / Collaborator ED - Jacobs, Bram / Collaborator ED - Jankowski, Stefan / Collaborator ED - Jarrett, Mike / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Johnson, Faye / Collaborator ED - Jones, Kelly / Collaborator ED - Karan, Mladen / Collaborator ED - Kolias, Angelos G / Collaborator ED - Kompanje, Erwin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Koraropoulos, Evgenios / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Kovács, Noémi / Collaborator ED - Kowark, Ana / Collaborator ED - Lagares, Alfonso / Collaborator ED - Lanyon, Linda / Collaborator ED - Laureys, Steven / Collaborator ED - Lecky, Fiona / Collaborator ED - Ledoux, Didier / Collaborator ED - Lefering, Rolf / Collaborator ED - Legrand, Valerie / Collaborator ED - Lejeune, Aurelie / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Lingsma, Hester / Collaborator ED - Maas, Andrew Ir / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Maegele, Marc / Collaborator ED - Majdan, Marek / Collaborator ED - Manara, Alex / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martino, Costanza / Collaborator ED - Maréchal, Hugues / Collaborator ED - Mattern, Julia / Collaborator ED - McMahon, Catherine / Collaborator ED - Melegh, Béla / Collaborator ED - Menon, David / Collaborator ED - Menovsky, Tomas / Collaborator ED - Mikolic, Ana / Collaborator ED - Misset, Benoit / Collaborator ED - Muraleedharan, Visakh / Collaborator ED - Murray, Lynnette / Collaborator ED - Negru, Ancuta / Collaborator ED - Nelson, David / Collaborator ED - Newcombe, Virginia / Collaborator ED - Nieboer, Daan / Collaborator ED - Nyirádi, József / Collaborator ED - Olubukola, Otesile / Collaborator ED - Oresic, Matej / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Payen, Jean-François / Collaborator ED - Perera, Natascha / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Persona, Paolo / Collaborator ED - Peul, Wilco / Collaborator ED - Piippo-Karjalainen, Anna / Collaborator ED - Pirinen, Matti / Collaborator ED - Ples, Horia / Collaborator ED - Polinder, Suzanne / Collaborator ED - Pomposo, Inigo / Collaborator ED - Posti, Jussi P / Collaborator ED - Puybasset, Louis / Collaborator ED - Radoi, Andreea / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Richter, Sophie / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Roe, Cecilie / Collaborator ED - Roise, Olav / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey V / Collaborator ED - Rosenlund, Christina / Collaborator ED - Rosenthal, Guy / Collaborator ED - Rossaint, Rolf / Collaborator ED - Rossi, Sandra / Collaborator ED - Rueckert, Daniel / Collaborator ED - Rusnák, Martin / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sanchez-Porras, Renan / Collaborator ED - Sandor, Janos / Collaborator ED - Schäfer, Nadine / Collaborator ED - Schmidt, Silke / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Sewalt, Charlie / Collaborator ED - Skandsen, Toril / Collaborator ED - Smielewski, Peter / Collaborator ED - Sorinola, Abayomi Akinrinsola / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Stanworth, Simon / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Steyerberg, Ewout W / Collaborator ED - Stocchetti, Nino / Collaborator ED - Sundström, Nina / Collaborator ED - Synnot, Anneliese / Collaborator ED - Takala, Riikka / Collaborator ED - Tamás, Viktória / Collaborator ED - Tamosuitis, Tomas / Collaborator ED - Taylor, Mark Steven / Collaborator ED - Ao, Braden Te / Collaborator ED - Tenovuo, Olli / Collaborator ED - Theadom, Alice / Collaborator ED - Thomas, Matt / Collaborator ED - Tibboel, Dick / Collaborator ED - Timmers, Marjolein / Collaborator ED - Tolias, Christos / Collaborator ED - Trapani, Tony / Collaborator ED - Tudora, Cristina Maria / Collaborator ED - Unterberg, Andreas / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Vallance, Shirley / Collaborator ED - Valeinis, Egils / Collaborator ED - Vámos, Zoltán / Collaborator ED - van der Jagt, Mathieu / Collaborator ED - Van der Steen, Gregory / Collaborator ED - van der Naalt, Joukje / Collaborator ED - van Dijck, Jeroen Tjm / Collaborator ED - van Essen, Thomas A / Collaborator ED - Van Hecke, Wim / Collaborator ED - van Heugten, Caroline / Collaborator ED - Van Praag, Dominique / Collaborator ED - Vyvere, Thijs Vande / Collaborator ED - van Wijk, Roel Pj / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Vega, Emmanuel / Collaborator ED - Velt, Kimberley / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Volovici, Victor / Collaborator ED - von Steinbüchel, Nicole / Collaborator ED - Voormolen, Daphne / Collaborator ED - Vulekovic, Petar / Collaborator ED - Wang, Kevin Kw / Collaborator ED - Wiegers, Eveline / Collaborator ED - Williams, Guy / Collaborator ED - Wilson, Lindsay / Collaborator ED - Winzeck, Stefan / Collaborator ED - Wolf, Stefan / Collaborator ED - Yang, Zhihui / Collaborator ED - Ylén, Peter / Collaborator ED - Younsi, Alexander / Collaborator ED - Zeiler, Frederick A / Collaborator ED - Zelinkova, Veronika / Collaborator ED - Ziverte, Agate / Collaborator ED - Zoerle, Tommaso / Collaborator TI - Neurocognitive correlates of probable posttraumatic stress disorder following traumatic brain injury JF - BRAIN AND SPINE J2 - BRAIN SPINE VL - 2 PY - 2022 PG - 11 SN - 2772-5294 DO - 10.1016/j.bas.2021.100854 UR - https://m2.mtmt.hu/api/publication/33163294 ID - 33163294 N1 - Funding Agency and Grant Number: European Union [602150]; Hannelore Kohl Stiftung (Germany); OneMind (USA); Integra LifeSciences Corporation (USA) Funding text: The data used in preparation of this manuscript was obtained in the context of CENTER-TBI, a large collaborative research project funded by the European Union 7th Framework program (EC grant 602150) . Additional funding was obtained from the Hannelore Kohl Stiftung (Germany) , from OneMind (USA) and from Integra LifeSciences Corporation (USA) . AB - Neurocognitive problems associated with posttraumatic stress disorder (PTSD) can interact with impairment resulting from traumatic brain injury (TBI).We aimed to identify neurocognitive problems associated with probable PTSD following TBI in a civilian sample.The study is part of the CENTER-TBI project (Collaborative European Neurotrauma Effectiveness Research) that aims to better characterize TBI. For this cross-sectional study, we included patients of all severities aged over 15, and a Glasgow Outcome Score Extended (GOSE) above 3. Participants were assessed at six months post-injury on the PTSD Checklist-5 (PCL-5), the Trail Making Test (TMT), the Rey Auditory Verbal Learning Test (RAVLT) and the Cambridge Neuropsychological Test Automated Battery (CANTAB). Primary analysis was a complete case analysis. Regression analyses were performed to investigate the association between the PCL-5 and cognition.Of the 1134 participants included in the complete case analysis, 13.5% screened positive for PTSD. Probable PTSD was significantly associated with higher TMT-(B-A) (OR ​= ​1.35, 95% CI: 1.14-1.60, p ​< ​.001) and lower RAVLT-delayed recall scores (OR ​= ​0.74, 95% CI: 0.61-0.91, p ​= ​.004) after controlling for age, sex, psychiatric history, baseline Glasgow Coma Scale and education.Poorer performance on cognitive tests assessing task switching and, to a lesser extent, delayed verbal recall is associated with probable PTSD in civilians who have suffered TBI. LA - English DB - MTMT ER - TY - JOUR AU - Sebestyén, Gabriella AU - Lendvai-Emmert, Dominika AU - Tamás, Viktória AU - Csendes, Márk Lajos AU - Magyar-Sümegi, Zsófia Dina AU - Tóth, Péter József AU - Büki, András TI - Neuronavigated theta burst stimulation for achieve safer tumor resection near motor speech area – case study JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 141 PY - 2022 SP - S145 EP - S146 PG - 1 SN - 1388-2457 DO - 10.1016/j.clinph.2022.07.384 UR - https://m2.mtmt.hu/api/publication/33121609 ID - 33121609 LA - English DB - MTMT ER - TY - JOUR AU - Retel Helmrich, Isabel Rosalie Arianne AU - van Klaveren, David AU - Andelic, Nada AU - Lingsma, Hester AU - Maas, Andrew AU - Menon, David AU - Polinder, Suzanne AU - Roe, Cecilie AU - Steyerberg, Ewout W. AU - Van Veen, Ernest AU - Wilson, Lindsay ED - Barzó, Pál / Collaborator ED - Cecilia, Åkerlund / Collaborator ED - Krisztina, Amrein / Collaborator ED - Nada, Andelic / Collaborator ED - Lasse, Andreassen / Collaborator ED - Audny, Anke / Collaborator ED - Anna, Antoni / Collaborator ED - Gérard, Audibert / Collaborator ED - Philippe, Azouvi / Collaborator ED - Maria, Luisa Azzolini / Collaborator ED - Ronald, Bartels / Collaborator ED - Romuald, Beauvais / Collaborator ED - Ronny, Beer / Collaborator ED - Bo-Michael, Bellander / Collaborator ED - Antonio, Belli / Collaborator ED - Habib, Benali / Collaborator ED - Maurizio, Berardino / Collaborator ED - Luigi, Beretta / Collaborator ED - Morten, Blaabjerg / Collaborator ED - Peter, Bragge / Collaborator ED - Alexandra, Brazinova / Collaborator ED - Vibeke, Brinck / Collaborator ED - Joanne, Brooker / Collaborator ED - Camilla, Brorsson / Collaborator ED - Andras, Buki / Collaborator ED - Monika, Bullinger / Collaborator ED - Manuel, Cabeleira / Collaborator ED - Alessio, Caccioppola / Collaborator ED - Emiliana, Calappi / Collaborator ED - Maria, Rosa Calvi / Collaborator ED - Peter, Cameron / Collaborator ED - Guillermo, Carbayo Lozano / Collaborator ED - Marco, Carbonara / Collaborator ED - Simona, Cavallo / Collaborator ED - Giorgio, Chevallard / Collaborator ED - Arturo, Chieregato / Collaborator ED - Giuseppe, Citerio / Collaborator ED - Hans, Clusmann / Collaborator ED - Mark, Coburn / Collaborator ED - Jonathan, Coles / Collaborator ED - Jamie, D Cooper / Collaborator ED - Marta, Correia / Collaborator ED - Amra, Čović / Collaborator ED - Nicola, Curry / Collaborator ED - Endre, Czeiter / Collaborator ED - Marek, Czosnyka / Collaborator ED - Claire, Dahyot-Fizelier / Collaborator ED - Paul, Dark / Collaborator ED - Helen, Dawes / Collaborator ED - Véronique, De Keyser / Collaborator ED - Vincent, Degos / Collaborator ED - Francesco, Della Corte / Collaborator ED - Hugo, den Boogert / Collaborator ED - Bart, Depreitere / Collaborator ED - Đula, Đilvesi / Collaborator ED - Abhishek, Dixit / Collaborator ED - Emma, Donoghue / Collaborator ED - Jens, Dreier / Collaborator ED - Guy-Loup, Dulière / Collaborator ED - Ari, Ercole / Collaborator ED - Patrick, Esser / Collaborator ED - Erzsébet, Ezer / Collaborator ED - Martin, Fabricius / Collaborator ED - Valery, L Feigin / Collaborator ED - Kelly, Foks / Collaborator ED - Shirin, Frisvold / Collaborator ED - Alex, Furmanov / Collaborator ED - Pablo, Gagliardo / Collaborator ED - Damien, Galanaud / Collaborator ED - Dashiell, Gantner / Collaborator ED - Guoyi, Gao / Collaborator ED - Pradeep, George / Collaborator ED - Alexandre, Ghuysen / Collaborator ED - Lelde, Giga / Collaborator ED - Ben, Glocker / Collaborator ED - Jagos, Golubovic / Collaborator ED - Pedro, Gomez / Collaborator ED - Johannes, Gratz / Collaborator ED - Benjamin, Gravesteijn / Collaborator ED - Francesca, Grossi / Collaborator ED - Russell, L Gruen / Collaborator ED - Deepak, Gupta / Collaborator ED - Juanita, A Haagsma / Collaborator ED - Iain, Haitsma / Collaborator ED - Raimund, Helbok / Collaborator ED - Eirik, Helseth / Collaborator ED - Lindsay, Horton / Collaborator ED - Jilske, Huijben / Collaborator ED - Peter, J Hutchinson / Collaborator ED - Bram, Jacobs / Collaborator ED - Stefan, Jankowski / Collaborator ED - Mike, Jarrett / Collaborator ED - Ji-Yao, Jiang / Collaborator ED - Faye, Johnson / Collaborator ED - Kelly, Jones / Collaborator ED - Mladen, Karan / Collaborator ED - Angelos, G Kolias / Collaborator ED - Erwin, Kompanje / Collaborator ED - Daniel, Kondziella / Collaborator ED - Evgenios, Kornaropoulos / Collaborator ED - Lars-Owe, Koskinen / Collaborator ED - Noémi, Kovács / Collaborator ED - Ana, Kowark / Collaborator ED - Alfonso, Lagares / Collaborator ED - Linda, Lanyon / Collaborator ED - Steven, Laureys / Collaborator ED - Fiona, Lecky / Collaborator ED - Didier, Ledoux / Collaborator ED - Rolf, Lefering / Collaborator ED - Valerie, Legrand / Collaborator ED - Aurelie, Lejeune / Collaborator ED - Leon, Levi / Collaborator ED - Roger, Lightfoot / Collaborator ED - Hester, Lingsma / Collaborator ED - Andrew, Ir Maas / Collaborator ED - Ana, M Castaño-León / Collaborator ED - Marc, Maegele / Collaborator ED - Marek, Majdan / Collaborator ED - Alex, Manara / Collaborator ED - Geoffrey, Manley / Collaborator ED - Costanza, Martino / Collaborator ED - Hugues, Maréchal / Collaborator ED - Julia, Mattern / Collaborator ED - Catherine, McMahon / Collaborator ED - Béla, Melegh / Collaborator ED - David, Menon / Collaborator ED - Tomas, Menovsky / Collaborator ED - Ana, Mikolic / Collaborator ED - Benoit, Misset / Collaborator ED - Visakh, Muraleedharan / Collaborator ED - Lynnette, Murray / Collaborator ED - Ancuta, Negru / Collaborator ED - David, Nelson / Collaborator ED - Virginia, Newcombe / Collaborator ED - Daan, Nieboer / Collaborator ED - József, Nyirádi / Collaborator ED - Otesile, Olubukola / Collaborator ED - Matej, Oresic / Collaborator ED - Fabrizio, Ortolano / Collaborator ED - Aarno, Palotie / Collaborator ED - Paul, M Parizel / Collaborator ED - Jean-François, Payen / Collaborator ED - Natascha, Perera / Collaborator ED - Vincent, Perlbarg / Collaborator ED - Paolo, Persona / Collaborator ED - Wilco, Peul / Collaborator ED - Anna, Piippo-Karjalainen / Collaborator ED - Matti, Pirinen / Collaborator ED - Horia, Ples / Collaborator ED - Suzanne, Polinder / Collaborator ED - Inigo, Pomposo / Collaborator ED - Jussi, P Posti / Collaborator ED - Louis, Puybasset / Collaborator ED - Andreea, Radoi / Collaborator ED - Arminas, Ragauskas / Collaborator ED - Rahul, Raj / Collaborator ED - Malinka, Rambadagalla / Collaborator ED - Jonathan, Rhodes / Collaborator ED - Sylvia, Richardson / Collaborator ED - Sophie, Richter / Collaborator ED - Samuli, Ripatti / Collaborator ED - Saulius, Rocka / Collaborator ED - Cecilie, Roe / Collaborator ED - Olav, Roise / Collaborator ED - Jonathan, Rosand / Collaborator ED - Jeffrey, V Rosenfeld / Collaborator ED - Christina, Rosenlund / Collaborator ED - Guy, Rosenthal / Collaborator ED - Rolf, Rossaint / Collaborator ED - Sandra, Rossi / Collaborator ED - Daniel, Rueckert / Collaborator ED - Martin, Rusnák / Collaborator ED - Juan, Sahuquillo / Collaborator ED - Oliver, Sakowitz / Collaborator ED - Renan, Sanchez-Porras / Collaborator ED - Janos, Sandor / Collaborator ED - Nadine, Schäfer / Collaborator ED - Silke, Schmidt / Collaborator ED - Herbert, Schoechl / Collaborator ED - Guus, Schoonman / Collaborator ED - Rico, Frederik Schou / Collaborator ED - Elisabeth, Schwendenwein / Collaborator ED - Charlie, Sewalt / Collaborator ED - Toril, Skandsen / Collaborator ED - Peter, Smielewski / Collaborator ED - Abayomi, Sorinola / Collaborator ED - Emmanuel, Stamatakis / Collaborator ED - Simon, Stanworth / Collaborator ED - Robert, Stevens / Collaborator ED - William, Stewart / Collaborator ED - Ewout, W Steyerberg / Collaborator ED - Nino, Stocchetti / Collaborator ED - Nina, Sundström / Collaborator ED - Riikka, Takala / Collaborator ED - Tamás, Viktória / Collaborator ED - Tomas, Tamosuitis / Collaborator ED - Mark, Steven Taylor / Collaborator ED - Braden, Te Ao / Collaborator ED - Olli, Tenovuo / Collaborator ED - Alice, Theadom / Collaborator ED - Matt, Thomas / Collaborator ED - Dick, Tibboel / Collaborator ED - Marjolein, Timmers / Collaborator ED - Christos, Tolias / Collaborator ED - Tony, Trapani / Collaborator ED - Cristina, Maria Tudora / Collaborator ED - Andreas, Unterberg / Collaborator ED - Peter, Vajkoczy / Collaborator ED - Shirley, Vallance / Collaborator ED - Egils, Valeinis / Collaborator ED - Zoltán, Vámos / Collaborator ED - Mathieu, van der Jagt / Collaborator ED - Gregory, Van der Steen / Collaborator ED - Joukje, van der Naalt / Collaborator ED - Jeroen, van Dijck / Collaborator ED - Thomas, A van Essen / Collaborator ED - Wim, Van Hecke / Collaborator ED - Caroline, van Heugten / Collaborator ED - Dominique, Van Praag / Collaborator ED - Thijs, Vande Vyvere / Collaborator ED - Roel, P J van Wijk / Collaborator ED - Alessia, Vargiolu / Collaborator ED - Emmanuel, Vega / Collaborator ED - Kimberley, Velt / Collaborator ED - Jan, Verheyden / Collaborator ED - Paul, M Vespa / Collaborator ED - Anne, Vik / Collaborator ED - Rimantas, Vilcinis / Collaborator ED - Victor, Volovici / Collaborator ED - Nicole, von Steinbüchel / Collaborator ED - Daphne, Voormolen / Collaborator ED - Petar, Vulekovic / Collaborator ED - Kevin, Kw Wang / Collaborator ED - Eveline, Wiegers / Collaborator ED - Guy, Williams / Collaborator ED - Lindsay, Wilson / Collaborator ED - Stefan, Winzeck / Collaborator ED - Stefan, Wolf / Collaborator ED - Zhihui, Yang / Collaborator ED - Peter, Ylén / Collaborator ED - Alexander, Younsi / Collaborator ED - Frederick, A Zeiler / Collaborator ED - Veronika, Zelinkova / Collaborator ED - Agate, Ziverte / Collaborator ED - Tommaso, Zoerle / Collaborator TI - Discrepancy between disability and reported well-being after traumatic brain injury JF - JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY J2 - J NEUROL NEUROSUR PS VL - 93 PY - 2022 IS - 7 SP - 785 EP - 796 PG - 12 SN - 0022-3050 DO - 10.1136/jnnp-2021-326615 UR - https://m2.mtmt.hu/api/publication/33016765 ID - 33016765 N1 - Funding Agency and Grant Number: European Union [602 150]; Integra LifeSciences Corporation (USA); Hannelore Kohl Stiftung (Germany); OneMind (USA) Funding text: The research leading to these results was supported by the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 602 150 (CENTER-TBI). Additional funding was obtained from the Hannelore Kohl Stiftung (Germany), from OneMind (USA) and from Integra LifeSciences Corporation (USA). AB - Background Following traumatic brain injury (TBI), the clinical focus is often on disability. However, patients' perceptions of well-being can be discordant with their disability level, referred to as the 'disability paradox'. We aimed to examine the relationship between disability and health-related quality of life (HRQoL) following TBI, while taking variation in personal, injury-related and environment factors into account. Methods We used data from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury study. Disability was assessed 6 months post-injury by the Glasgow Outcome Scale-Extended (GOSE). HRQoL was assessed by the SF-12v2 physical and mental component summary scores and the Quality of Life after Traumatic Brain Injury overall scale. We examined mean total and domain HRQoL scores by GOSE. We quantified variance in HRQoL explained by GOSE, personal, injury-related and environment factors with multivariable regression. Results Six-month outcome assessments were completed in 2075 patients, of whom 78% had mild TBI (Glasgow Coma Scale 13-15). Patients with severe disability had higher HRQoL than expected on the basis of GOSE alone, particularly after mild TBI. Up to 50% of patients with severe disability reported HRQoL scores within the normative range. GOSE, personal, injury-related and environment factors explained a limited amount of variance in HRQoL (up to 29%). Conclusion Contrary to the idea that discrepancies are unusual, many patients with poor functional outcomes reported well-being that was at or above the boundary considered satisfactory for the normative sample. These findings challenge the idea that satisfactory HRQoL in patients with disability should be described as 'paradoxical' and question common views of what constitutes 'unfavourable' outcome. LA - English DB - MTMT ER - TY - JOUR AU - Wilson, Lindsay AU - Horton, Lindsay AU - Polinder, Suzanne AU - Newcombe, Virginia F. J. AU - von Steinbuechel, Nicole AU - Maas, Andrew I. R. AU - Menon, David K. ED - Barzó, Pál / Collaborator ED - Cecilia, Åkerlund / Collaborator ED - Krisztina, Amrein / Collaborator ED - Nada, Andelic / Collaborator ED - Lasse, Andreassen / Collaborator ED - Audny, Anke / Collaborator ED - Anna, Antoni / Collaborator ED - Gérard, Audibert / Collaborator ED - Philippe, Azouvi / Collaborator ED - Maria, Luisa Azzolini / Collaborator ED - Ronald, Bartels / Collaborator ED - Romuald, Beauvais / Collaborator ED - Ronny, Beer / Collaborator ED - Bo-Michael, Bellander / Collaborator ED - Antonio, Belli / Collaborator ED - Habib, Benali / Collaborator ED - Maurizio, Berardino / Collaborator ED - Luigi, Beretta / Collaborator ED - Morten, Blaabjerg / Collaborator ED - Peter, Bragge / Collaborator ED - Alexandra, Brazinova / Collaborator ED - Vibeke, Brinck / Collaborator ED - Joanne, Brooker / Collaborator ED - Camilla, Brorsson / Collaborator ED - Andras, Buki / Collaborator ED - Monika, Bullinger / Collaborator ED - Manuel, Cabeleira / Collaborator ED - Alessio, Caccioppola / Collaborator ED - Emiliana, Calappi / Collaborator ED - Maria, Rosa Calvi / Collaborator ED - Peter, Cameron / Collaborator ED - Guillermo, Carbayo Lozano / Collaborator ED - Marco, Carbonara / Collaborator ED - Simona, Cavallo / Collaborator ED - Giorgio, Chevallard / Collaborator ED - Arturo, Chieregato / Collaborator ED - Giuseppe, Citerio / Collaborator ED - Hans, Clusmann / Collaborator ED - Mark, Coburn / Collaborator ED - Jonathan, Coles / Collaborator ED - Jamie, D. Cooper / Collaborator ED - Marta, Correia / Collaborator ED - Amra, Čović / Collaborator ED - Nicola, Curry / Collaborator ED - Endre, Czeiter / Collaborator ED - Marek, Czosnyka / Collaborator ED - Claire, Dahyot-Fizelier / Collaborator ED - Paul, Dark / Collaborator ED - Helen, Dawes / Collaborator ED - Véronique, De Keyser / Collaborator ED - Vincent, Degos / Collaborator ED - Francesco, Della Corte / Collaborator ED - Hugo, den Boogert / Collaborator ED - Bart, Depreitere / Collaborator ED - Đula, Đilvesi / Collaborator ED - Abhishek, Dixit / Collaborator ED - Emma, Donoghue / Collaborator ED - Jens, Dreier / Collaborator ED - Guy-Loup, Dulière / Collaborator ED - Ari, Ercole / Collaborator ED - Patrick, Esser / Collaborator ED - Erzsébet, Ezer / Collaborator ED - Martin, Fabricius / Collaborator ED - Valery, L. Feigin / Collaborator ED - Kelly, Foks / Collaborator ED - Shirin, Frisvold / Collaborator ED - Alex, Furmanov / Collaborator ED - Pablo, Gagliardo / Collaborator ED - Damien, Galanaud / Collaborator ED - Dashiell, Gantner / Collaborator ED - Guoyi, Gao / Collaborator ED - Pradeep, George / Collaborator ED - Alexandre, Ghuysen / Collaborator ED - Lelde, Giga / Collaborator ED - Ben, Glocker / Collaborator ED - Jagoš, Golubovic / Collaborator ED - Pedro, A. Gomez / Collaborator ED - Johannes, Gratz / Collaborator ED - Benjamin, Gravesteijn / Collaborator ED - Francesca, Grossi / Collaborator ED - Russell, L. Gruen / Collaborator ED - Deepak, Gupta / Collaborator ED - Juanita, A. Haagsma / Collaborator ED - Iain, Haitsma / Collaborator ED - Raimund, Helbok / Collaborator ED - Eirik, Helseth / Collaborator ED - Jilske, Huijben / Collaborator ED - Peter, J. Hutchinson / Collaborator ED - Bram, Jacobs / Collaborator ED - Stefan, Jankowski / Collaborator ED - Mike, Jarrett / Collaborator ED - Ji-yao, Jiang / Collaborator ED - Faye, Johnson / Collaborator ED - Kelly, Jones / Collaborator ED - Mladen, Karan / Collaborator ED - Angelos, G. Kolias / Collaborator ED - Erwin, Kompanje / Collaborator ED - Daniel, Kondziella / Collaborator ED - Evgenios, Kornaropoulos / Collaborator ED - Lars-Owe, Koskinen / Collaborator ED - Noémi, Kovács / Collaborator ED - Ana, Kowark / Collaborator ED - Alfonso, Lagares / Collaborator ED - Linda, Lanyon / Collaborator ED - Steven, Laureys / Collaborator ED - Fiona, Lecky / Collaborator ED - Didier, Ledoux / Collaborator ED - Rolf, Lefering / Collaborator ED - Valerie, Legrand / Collaborator ED - Aurelie, Lejeune / Collaborator ED - Leon, Levi / Collaborator ED - Roger, Lightfoot / Collaborator ED - Hester, Lingsma / Collaborator ED - Ana, M. Castaño-León / Collaborator ED - Marc, Maegele / Collaborator ED - Marek, Majdan / Collaborator ED - Alex, Manara / Collaborator ED - Geoffrey, Manley / Collaborator ED - Costanza, Martino / Collaborator ED - Hugues, Maréchal / Collaborator ED - Julia, Mattern / Collaborator ED - Catherine, McMahon / Collaborator ED - Béla, Melegh / Collaborator ED - Tomas, Menovsky / Collaborator ED - Ana, Mikolic / Collaborator ED - Benoit, Misset / Collaborator ED - Visakh, Muraleedharan / Collaborator ED - Lynnette, Murray / Collaborator ED - Ancuta, Negru / Collaborator ED - David, Nelson / Collaborator ED - Daan, Nieboer / Collaborator ED - József, Nyirádi / Collaborator ED - Otesile, Olubukola / Collaborator ED - Matej, Oresic / Collaborator ED - Fabrizio, Ortolano / Collaborator ED - Aarno, Palotie / Collaborator ED - Paul, M. Parizel / Collaborator ED - Jean-François, Payen / Collaborator ED - Natascha, Perera / Collaborator ED - Vincent, Perlbarg / Collaborator ED - Paolo, Persona / Collaborator ED - Wilco, Peul / Collaborator ED - Anna, Piippo-Karjalainen / Collaborator ED - Matti, Pirinen / Collaborator ED - Dana, Pisica / Collaborator ED - Horia, Ples / Collaborator ED - Inigo, Pomposo / Collaborator ED - Jussi, P. Posti / Collaborator ED - Louis, Puybasset / Collaborator ED - Andreea, Radoi / Collaborator ED - Arminas, Ragauskas / Collaborator ED - Rahul, Raj / Collaborator ED - Malinka, Rambadagalla / Collaborator ED - Isabel, Retel Helmrich / Collaborator ED - Jonathan, Rhodes / Collaborator ED - Sylvia, Richardson / Collaborator ED - Sophie, Richter / Collaborator ED - Samuli, Ripatti / Collaborator ED - Saulius, Rocka / Collaborator ED - Cecilie, Roe / Collaborator ED - Olav, Roise / Collaborator ED - Jonathan, Rosand / Collaborator ED - Jeffrey, V. Rosenfeld / Collaborator ED - Christina, Rosenlund / Collaborator ED - Guy, Rosenthal / Collaborator ED - Rolf, Rossaint / Collaborator ED - Sandra, Rossi / Collaborator ED - Daniel, Rueckert / Collaborator ED - Martin, Rusnák / Collaborator ED - Juan, Sahuquillo / Collaborator ED - Oliver, Sakowitz / Collaborator ED - Renan, Sanchez-Porras / Collaborator ED - Janos, Sandor / Collaborator ED - Nadine, Schäfer / Collaborator ED - Silke, Schmidt / Collaborator ED - Herbert, Schoechl / Collaborator ED - Guus, Schoonman / Collaborator ED - Rico, Frederik Schou / Collaborator ED - Elisabeth, Schwendenwein / Collaborator ED - Charlie, Sewalt / Collaborator ED - Ranjit, D. Singh / Collaborator ED - Toril, Skandsen / Collaborator ED - Peter, Smielewski / Collaborator ED - Abayomi, Sorinola / Collaborator ED - Emmanuel, Stamatakis / Collaborator ED - Simon, Stanworth / Collaborator ED - Robert, Stevens / Collaborator ED - William, Stewart / Collaborator ED - Ewout, W. Steyerberg / Collaborator ED - Nino, Stocchetti / Collaborator ED - Riikka, Takala / Collaborator ED - Tamás, Viktória / Collaborator ED - Tomas, Tamosuitis / Collaborator ED - Mark, Steven Taylor / Collaborator ED - Braden, Te Ao / Collaborator ED - Olli, Tenovuo / Collaborator ED - Alice, Theadom / Collaborator ED - Matt, Thomas / Collaborator ED - Dick, Tibboel / Collaborator ED - Marjolein, Timmers / Collaborator ED - Christos, Tolias / Collaborator ED - Tony, Trapani / Collaborator ED - Cristina, Maria Tudora / Collaborator ED - Andreas, Unterberg / Collaborator ED - Peter, Vajkoczy / Collaborator ED - Shirley, Vallance / Collaborator ED - Egils, Valeinis / Collaborator ED - Zoltán, Vámos / Collaborator ED - Mathieu, van der Jagt / Collaborator ED - Gregory, Van der Steen / Collaborator ED - Joukje, van der Naalt / Collaborator ED - Jeroen, T.J.M. van Dijck / Collaborator ED - Inge, A. van Erp / Collaborator ED - Thomas, A. van Essen / Collaborator ED - Wim, Van Hecke / Collaborator ED - Caroline, van Heugten / Collaborator ED - Dominique, Van Praag / Collaborator ED - Ernest, van Veen / Collaborator ED - Thijs, Vande Vyvere / Collaborator ED - Roel, P. J. van Wijk / Collaborator ED - Alessia, Vargiolu / Collaborator ED - Emmanuel, Vega / Collaborator ED - Kimberley, Velt / Collaborator ED - Jan, Verheyden / Collaborator ED - Paul, M. Vespa / Collaborator ED - Anne, Vik / Collaborator ED - Rimantas, Vilcinis / Collaborator ED - Victor, Volovici / Collaborator ED - Daphne, Voormolen / Collaborator ED - Petar, Vulekovic / Collaborator ED - Kevin, K.W. Wang / Collaborator ED - Daniel, Whitehouse / Collaborator ED - Eveline, Wiegers / Collaborator ED - Guy, Williams / Collaborator ED - Stefan, Winzeck / Collaborator ED - Stefan, Wolf / Collaborator ED - Zhihui, Yang / Collaborator ED - Peter, Ylén / Collaborator ED - Alexander, Younsi / Collaborator ED - Frederick, A. Zeiler / Collaborator ED - Veronika, Zelinkova / Collaborator ED - Agate, Ziverte / Collaborator ED - Tommaso, Zoerle / Collaborator TI - Tailoring Multi-Dimensional Outcomes to Level of Functional Recovery after Traumatic Brain Injury JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM VL - 39 PY - 2022 IS - 19-20 SP - 1363 EP - 1381 PG - 19 SN - 0897-7151 DO - 10.1089/neu.2022.0013 UR - https://m2.mtmt.hu/api/publication/33016757 ID - 33016757 N1 - Export Date: 21 January 2023 CODEN: JNEUE AB - There is increasing emphasis on assessing multi-dimensional outcomes in traumatic brain injury (TBI), but achieving this aim is hampered by a plethora of overlapping assessment tools. There is a clear need for advice on the choice of outcomes and we examined level of functional recovery as a framework to guide selection of assessments. In this cohort study we analysed cross-sectional data from 2604 patients enrolled in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) project. Patients were followed up 6 months after injury and assessed on the Glasgow Outcome Scale-Extended (GOSE), cognitive tests, and patient-reported outcomes. We describe assessment completeness and prevalence of impairment. Relationships between outcomes were visualized using UpSet plots and hierarchical cluster analysis. GOSE categories varied markedly for both completion rates, 34-91% for patient-reported outcomes and 9-81% for cognitive tests, and prevalence of impairment, 3-82% for patient-reported outcomes and 9-59% for cognitive tests. In complete case samples, the GOSE identified impairment in 59-61%, whereas the most impaired patient-reported outcome was the Short Form-12 version 2 (SF-12v2) Physical Component Summary (28% overall), and the most impaired cognitive test was Trail Making Test (TMT) Part A (19% overall). The findings show that degree of disability is a key context of use for cognitive tests and patient-reported outcomes. Level of functional recovery provides a guide to the feasibility of different types of assessment and the likelihood of impairment, and can help tailor suitable assessment approaches in clinical practice and research studies. LA - English DB - MTMT ER - TY - JOUR AU - van der Vlegel, Marjolein AU - Mikolić, Ana AU - Lee, Hee Quentin AU - Kaplan, Z L Rana AU - Retel, Helmrich Isabel R A AU - van Veen, Ernest AU - Andelic, Nada AU - Steinbuechel, Nicole V AU - Plass, Anne Marie AU - Zeldovich, Marina AU - Wilson, Lindsay AU - Maas, Andrew I R AU - Haagsma, Juanita A AU - Polinder, Suzanne ED - Åkerlund, Cecilia / Collaborator ED - George, Pradeep / Collaborator ED - Lanyon, Linda / Collaborator ED - Muraleedharan, Visakh / Collaborator ED - Nelson, David / Collaborator ED - Amrein, Krisztina / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Kovács, Noémi / Collaborator ED - Melegh, Béla / Collaborator ED - Nyirádi, József / Collaborator ED - Tamás, Viktória / Collaborator ED - Vámos, Zoltán / Collaborator ED - Sorinola, Abayomi Akinrinsola / Collaborator ED - Andelic, Nada / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Frisvold, Shirin / Collaborator ED - Antoni, Anna / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Audibert, Gérard / Collaborator ED - Azouvi, Philippe / Collaborator ED - Azzolini, Maria Luisa / Collaborator ED - Beretta, Luigi / Collaborator ED - Calvi, Maria Rosa / Collaborator ED - Bartels, Ronald / Collaborator ED - Boogert, Hugo den / Collaborator ED - Barzó, Pál / Collaborator ED - Beauvais, Romuald / Collaborator ED - Perera, Natascha / Collaborator ED - Beer, Ronny / Collaborator ED - Helbok, Raimund / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Benali, Habib / Collaborator ED - Degos, Vincent / Collaborator ED - Galanaud, Damien / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Berardino, Maurizio / Collaborator ED - Cavallo, Simona / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Rosenlund, Christina / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Majdan, Marek / Collaborator ED - Taylor, Mark Steven / Collaborator ED - Zelinkova, Veronika / Collaborator ED - Brinck, Vibeke / Collaborator ED - Jarrett, Mike / Collaborator ED - Brooker, Joanne / Collaborator ED - Donoghue, Emma / Collaborator ED - Synnot, Anneliese / Collaborator ED - Brorsson, Camilla / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Sundström, Nina / Collaborator ED - Büki, András / Collaborator ED - Czeiter, Endre / Collaborator ED - Bullinger, Monika / Collaborator ED - Cabeleira, Manuel / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dixit, Abhishek / Collaborator ED - Ercole, Ari / Collaborator ED - Koraropoulos, Evgenios / Collaborator ED - Menon, David / Collaborator ED - Newcombe, Virginia / Collaborator ED - Richter, Sophie / Collaborator ED - Smielewski, Peter / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Williams, Guy / Collaborator ED - Winzeck, Stefan / Collaborator ED - Zeiler, Frederick A / Collaborator ED - Caccioppola, Alessio / Collaborator ED - Calappi, Emiliana / Collaborator ED - Carbonara, Marco / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Zoerle, Tommaso / Collaborator ED - Stocchetti, Nino / Collaborator ED - Cameron, Peter / Collaborator ED - Gantner, Dashiell / Collaborator ED - Murray, Lynnette / Collaborator ED - Trapani, Tony / Collaborator ED - Vallance, Shirley / Collaborator ED - Lozano, Guillermo Carbayo / Collaborator ED - Pomposo, Inigo / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Gomez, Pedro A / Collaborator ED - Lagares, Alfonso / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Ceyisakar, Iris / Collaborator ED - Gravesteijn, Benjamin / Collaborator ED - Haagsma, Juanita A / Collaborator ED - Huijben, Jilske / Collaborator ED - Lingsma, Hester / Collaborator ED - Nieboer, Daan / Collaborator ED - Mikolic, Ana / Collaborator ED - Polinder, Suzanne / Collaborator ED - Sewalt, Charlie / Collaborator ED - Steyerberg, Ewout W / Collaborator ED - Velt, Kimberley / Collaborator ED - Voormolen, Daphne / Collaborator ED - Wiegers, Eveline / Collaborator ED - Peul, Wilco / Collaborator ED - van Dijck, Jeroen T J M / Collaborator ED - van Essen, Thomas A / Collaborator ED - van Wijk, Roel P J / Collaborator ED - Clusmann, Hans / Collaborator ED - Coburn, Mark / Collaborator ED - Kowark, Ana / Collaborator ED - Rossaint, Rolf / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, Jamie D / Collaborator ED - Correia, Marta / Collaborator ED - Čovid, Amra / Collaborator ED - von Steinbüchel, Nicole / Collaborator ED - Curry, Nicola / Collaborator ED - Stanworth, Simon / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Dark, Paul / Collaborator ED - Johnson, Faye / Collaborator ED - Dawes, Helen / Collaborator ED - Esser, Patrick / Collaborator ED - van Heugten, Caroline / Collaborator ED - De Keyser, Véronique / Collaborator ED - Maas, Andrew I R / Collaborator ED - Menovsky, Tomas / Collaborator ED - Van, der Steen Gregory / Collaborator ED - Corte, Francesco Della / Collaborator ED - Grossi, Francesca / Collaborator ED - Depreitere, Bart / Collaborator ED - Đilvesi, Đula / Collaborator ED - Golubovic, Jagoš / Collaborator ED - Karan, Mladen / Collaborator ED - Vulekovic, Petar / Collaborator ED - Dreier, Jens / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Wolf, Stefan / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Maréchal, Hugues / Collaborator ED - Fabricius, Martin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Feigin, Valery L / Collaborator ED - Jones, Kelly / Collaborator ED - Ao, Braden Te / Collaborator ED - Theadom, Alice / Collaborator ED - Foks, Kelly / Collaborator ED - Haitsma, Iain / Collaborator ED - Volovici, Victor / Collaborator ED - Furmanov, Alex / Collaborator ED - Rosenthal, Guy / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Gao, Guoyi / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giga, Lelde / Collaborator ED - Valeinis, Egils / Collaborator ED - Ziverte, Agate / Collaborator ED - Glocker, Ben / Collaborator ED - Rueckert, Daniel / Collaborator ED - Gratz, Johannes / Collaborator ED - Gruen, Russell L / Collaborator ED - Gupta, Deepak / Collaborator ED - Roe, Cecilie / Collaborator ED - Helseth, Eirik / Collaborator ED - Roise, Olav / Collaborator ED - Horton, Lindsay / Collaborator ED - Wilson, Lindsay / Collaborator ED - Hutchinson, Peter J / Collaborator ED - Kolias, Angelos G / Collaborator ED - Jacobs, Bram / Collaborator ED - van der Naalt, Joukje / Collaborator ED - Jankowski, Stefan / Collaborator ED - Kompanje, Erwin / Collaborator ED - Timmers, Marjolein / Collaborator ED - Laureys, Steven / Collaborator ED - Ledoux, Didier / Collaborator ED - Misset, Benoit / Collaborator ED - Lecky, Fiona / Collaborator ED - Olubukola, Otesile / Collaborator ED - Lefering, Rolf / Collaborator ED - Schäfer, Nadine / Collaborator ED - Legrand, Valerie / Collaborator ED - Lejeune, Aurelie / Collaborator ED - Vega, Emmanuel / Collaborator ED - Mattern, Julia / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Maegele, Marc / Collaborator ED - Manara, Alex / Collaborator ED - Thomas, Matt / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martino, Costanza / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sanchez-Porras, Renan / Collaborator ED - Younsi, Alexander / Collaborator ED - McMahon, Catherine / Collaborator ED - Negru, Ancuta / Collaborator ED - Oresic, Matej / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Payen, Jean-François / Collaborator ED - Persona, Paolo / Collaborator ED - Piippo-Karjalainen, Anna / Collaborator ED - Pirinen, Matti / Collaborator ED - Ples, Horia / Collaborator ED - Posti, Jussi P / Collaborator ED - Puybasset, Louis / Collaborator ED - Radoi, Andreea / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey V / Collaborator ED - Rossi, Sandra / Collaborator ED - Rusnák, Martin / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sándor, János / Collaborator ED - Schmidt, Silke / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Skandsen, Toril / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Takala, Riikka / Collaborator ED - Tamosuitis, Tomas / Collaborator ED - Tenovuo, Olli / Collaborator ED - Tibboel, Dick / Collaborator ED - Tolias, Christos / Collaborator ED - Tudora, Cristina Maria / Collaborator ED - van der Jagt, Mathieu / Collaborator ED - Van, Hecke Wim / Collaborator ED - Van, Praag Dominique / Collaborator ED - Vyvere, Thijs Vande / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Wang, Kevin K W / Collaborator ED - Yang, Zhihui / Collaborator ED - Ylén, Peter / Collaborator TI - Health care utilization and outcomes in older adults after Traumatic Brain Injury : A CENTER-TBI study JF - INJURY: INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED J2 - INJURY VL - 53 PY - 2022 IS - 8 SP - 2774 EP - 2782 PG - 9 SN - 0020-1383 DO - 10.1016/j.injury.2022.05.009 UR - https://m2.mtmt.hu/api/publication/32899084 ID - 32899084 N1 - Funding Agency and Grant Number: CENTER-TBI study Funding text: We are grateful to all patients and investigators who partici-pated in the CENTER-TBI study. AB - The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in older adults who sustained a TBI.We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care utilization and outcomes were described for patients aged ≥65 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury.Of 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six-month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with functional impairment, lower generic and disease-specific HRQoL and mental health symptoms.The rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive. LA - English DB - MTMT ER - TY - JOUR AU - Thomas, Ilias AU - Dickens, Alex M AU - Posti, Jussi P AU - Czeiter, Endre AU - Duberg, Daniel AU - Sinioja, Tim AU - Kråkström, Matilda AU - Retel Helmrich, Isabel R A AU - Wang, Kevin K W AU - Maas, Andrew I R AU - Steyerberg, Ewout W AU - Menon, David K AU - Tenovuo, Olli AU - Hyötyläinen, Tuulia AU - Büki, András AU - Orešič, Matej ED - Åkerlund, Cecilia / Collaborator ED - Amrein, Krisztina / Collaborator ED - Andelic, Nada / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Antoni, Anna / Collaborator ED - Audibert, Gérard / Collaborator ED - Azouvi, Philippe / Collaborator ED - Azzolini, Maria Luisa / Collaborator ED - Bartels, Ronald / Collaborator ED - Barzó, Pál / Collaborator ED - Beauvais, Romuald / Collaborator ED - Beer, Ronny / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Benali, Habib / Collaborator ED - Berardino, Maurizio / Collaborator ED - Beretta, Luigi / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Brinck, Vibeke / Collaborator ED - Brooker, Joanne / Collaborator ED - Brorsson, Camilla / Collaborator ED - Bullinger, Monika / Collaborator ED - Cabeleira, Manuel / Collaborator ED - Caccioppola, Alessio / Collaborator ED - Calappi, Emiliana / Collaborator ED - Calvi, Maria Rosa / Collaborator ED - Cameron, Peter / Collaborator ED - Lozano, Guillermo Carbayo / Collaborator ED - Carbonara, Marco / Collaborator ED - Cavallo, Simona / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Clusmann, Hans / Collaborator ED - Coburn, Mark / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, Jamie D / Collaborator ED - Correia, Marta / Collaborator ED - Čović, Amra / Collaborator ED - Curry, Nicola / Collaborator ED - Czeiter, Endre / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Dark, Paul / Collaborator ED - Dawes, Helen / Collaborator ED - De Keyser, Véronique / Collaborator ED - Degos, Vincent / Collaborator ED - Corte, Francesco Della / Collaborator ED - den Boogert, Hugo / Collaborator ED - Depreitere, Bart / Collaborator ED - Đilvesi, Đula / Collaborator ED - Dixit, Abhishek / Collaborator ED - Donoghue, Emma / Collaborator ED - Dreier, Jens / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Ercole, Ari / Collaborator ED - Esser, Patrick / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Fabricius, Martin / Collaborator ED - Feigin, Valery L / Collaborator ED - Foks, Kelly / Collaborator ED - Frisvold, Shirin / Collaborator ED - Furmanov, Alex / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Galanaud, Damien / Collaborator ED - Gantner, Dashiell / Collaborator ED - Gao, Guoyi / Collaborator ED - George, Pradeep / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giga, Lelde / Collaborator ED - Glocker, Ben / Collaborator ED - Golubovic, Jagoš / Collaborator ED - Gomez, Pedro A / Collaborator ED - Gratz, Johannes / Collaborator ED - Gravesteijn, Benjamin / Collaborator ED - Grossi, Francesca / Collaborator ED - Gruen, Russell L / Collaborator ED - Gupta, Deepak / Collaborator ED - Haagsma, Juanita A / Collaborator ED - Haitsma, Iain / Collaborator ED - Helbok, Raimund / Collaborator ED - Helseth, Eirik / Collaborator ED - Horton, Lindsay / Collaborator ED - Huijben, Jilske / Collaborator ED - Hutchinson, Peter J / Collaborator ED - Jacobs, Bram / Collaborator ED - Jankowski, Stefan / Collaborator ED - Jarrett, Mike / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Johnson, Faye / Collaborator ED - Jones, Kelly / Collaborator ED - Karan, Mladen / Collaborator ED - Kolias, Angelos G / Collaborator ED - Kompanje, Erwin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Kornaropoulos, Evgenios / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Kovács, Noémi / Collaborator ED - Kowark, Ana / Collaborator ED - Lagares, Alfonso / Collaborator ED - Lanyon, Linda / Collaborator ED - Laureys, Steven / Collaborator ED - Lecky, Fiona / Collaborator ED - Ledoux, Didier / Collaborator ED - Lefering, Rolf / Collaborator ED - Legrand, Valerie / Collaborator ED - Lejeune, Aurelie / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Lingsma, Hester / Collaborator ED - Maas, Andrew I R / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Maegele, Marc / Collaborator ED - Majdan, Marek / Collaborator ED - Manara, Alex / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martino, Costanza / Collaborator ED - Maréchal, Hugues / Collaborator ED - Mattern, Julia / Collaborator ED - McMahon, Catherine / Collaborator ED - Melegh, Béla / Collaborator ED - Menovsky, Tomas / Collaborator ED - Mikolic, Ana / Collaborator ED - Misset, Benoit / Collaborator ED - Muraleedharan, Visakh / Collaborator ED - Murray, Lynnette / Collaborator ED - Negru, Ancuta / Collaborator ED - Nelson, David / Collaborator ED - Newcombe, Virginia / Collaborator ED - Nieboer, Daan / Collaborator ED - Nyirádi, József / Collaborator ED - Olubukola, Otesile / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Payen, Jean-François / Collaborator ED - Perera, Natascha / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Persona, Paolo / Collaborator ED - Peul, Wilco / Collaborator ED - Piippo-Karjalainen, Anna / Collaborator ED - Pirinen, Matti / Collaborator ED - Ples, Horia / Collaborator ED - Polinder, Suzanne / Collaborator ED - Pomposo, Inigo / Collaborator ED - Posti, Jussi P / Collaborator ED - Puybasset, Louis / Collaborator ED - Radoi, Andreea / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Richter, Sophie / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Roe, Cecilie / Collaborator ED - Roise, Olav / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey V / Collaborator ED - Rosenlund, Christina / Collaborator ED - Rosenthal, Guy / Collaborator ED - Rossaint, Rolf / Collaborator ED - Rossi, Sandra / Collaborator ED - Rueckert, Daniel / Collaborator ED - Rusnák, Martin / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sanchez-Porras, Renan / Collaborator ED - Sándor, János / Collaborator ED - Schäfer, Nadine / Collaborator ED - Schmidt, Silke / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Sewalt, Charlie / Collaborator ED - Skandsen, Toril / Collaborator ED - Smielewski, Peter / Collaborator ED - Sorinola, Abayomi / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Stanworth, Simon / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Stocchetti, Nino / Collaborator ED - Sundström, Nina / Collaborator ED - Takala, Riikka / Collaborator ED - Tamás, Viktória / Collaborator ED - Tamosuitis, Tomas / Collaborator ED - Taylor, Mark Steven / Collaborator ED - Te Ao, Braden / Collaborator ED - Theadom, Alice / Collaborator ED - Thomas, Matt / Collaborator ED - Tibboel, Dick / Collaborator ED - Timmers, Marjolein / Collaborator ED - Tolias, Christos / Collaborator ED - Trapani, Tony / Collaborator ED - Tudora, Cristina Maria / Collaborator ED - Unterberg, Andreas / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Vallance, Shirley / Collaborator ED - Valeinis, Egils / Collaborator ED - Vámos, Zoltán / Collaborator ED - van der Jagt, Mathieu / Collaborator ED - Van der Steen, Gregory / Collaborator ED - van der Naalt, Joukje / Collaborator ED - van Dijck, Jeroen T J M / Collaborator ED - van Essen, Thomas A / Collaborator ED - Van Hecke, Wim / Collaborator ED - van Heugten, Caroline / Collaborator ED - Van Praag, Dominique / Collaborator ED - Vyvere, Thijs Vande / Collaborator ED - van Wijk, Roel P J / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Vega, Emmanuel / Collaborator ED - Velt, Kimberley / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Volovici, Victor / Collaborator ED - von Steinbüchel, Nicole / Collaborator ED - Voormolen, Daphne / Collaborator ED - Vulekovic, Petar / Collaborator ED - Wiegers, Eveline / Collaborator ED - Williams, Guy / Collaborator ED - Wilson, Lindsay / Collaborator ED - Winzeck, Stefan / Collaborator ED - Wolf, Stefan / Collaborator ED - Yang, Zhihui / Collaborator ED - Ylén, Peter / Collaborator ED - Younsi, Alexander / Collaborator ED - Zeiler, Frederick A / Collaborator ED - Zelinkova, Veronika / Collaborator ED - Ziverte, Agate / Collaborator ED - Zoerle, Tommaso / Collaborator TI - Serum metabolome associated with severity of acute traumatic brain injury JF - NATURE COMMUNICATIONS J2 - NAT COMMUN VL - 13 PY - 2022 IS - 1 PG - 15 SN - 2041-1723 DO - 10.1038/s41467-022-30227-5 UR - https://m2.mtmt.hu/api/publication/32819191 ID - 32819191 N1 - Funding Agency and Grant Number: European Union 7th Framework program [602150]; OneMind (US); Hannelore Kohl Foundation (DE); NeuroTrauma Sciences (US); Integra Neurosciences; Swedish Research Council [2018-02629]; Academy of Finland [17379]; Government's Special Financial Transfer tied to academic research in Health Sciences, Finland [11129]; Maire Taponen Foundation; Formas [2018-02629] Funding Source: Formas; Swedish Research Council [2018-02629] Funding Source: Swedish Research Council Funding text: CENTER-TBI was supported by the European Union 7th Framework program (grant no. 602150), with additional project support from OneMind (US), the Hannelore Kohl Foundation (DE), NeuroTrauma Sciences (US), and Integra Neurosciences. The metabolomics study was supported by a grant from Swedish Research Council to M.O. (grant no. 2018-02629). The study was supported by funding from the Academy of Finland to J.P.P. (grant no. 17379), a grant from Government's Special Financial Transfer tied to academic research in Health Sciences, Finland to J.P.P. (grant no. 11129) a grant from Maire Taponen Foundation to J.P.P. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors thank Daniel Duberg, Lisanna Sinisalu, and Vanja Stefanovi for technical assistance in metabolomics analysis and to Dr. Aidan McGlinchey for assistance with language editing. The authors also thank Iftakher Hossain, Janek Frantzen, Mark van Gils, Peter J. Hutchinson, Ari J. Katila, Henna-Riikka Maanpaa, Mehrbod Mohammadian, Virginia F. Newcombe, Jussi Tallus and Riikka S.K. Takala (The TBIcare study group). AB - Complex metabolic disruption is a crucial aspect of the pathophysiology of traumatic brain injury (TBI). Associations between this and systemic metabolism and their potential prognostic value are poorly understood. Here, we aimed to describe the serum metabolome (including lipidome) associated with acute TBI within 24 h post-injury, and its relationship to severity of injury and patient outcome. We performed a comprehensive metabolomics study in a cohort of 716 patients with TBI and non-TBI reference patients (orthopedic, internal medicine, and other neurological patients) from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) cohort. We identified panels of metabolites specifically associated with TBI severity and patient outcomes. Choline phospholipids (lysophosphatidylcholines, ether phosphatidylcholines and sphingomyelins) were inversely associated with TBI severity and were among the strongest predictors of TBI patient outcomes, which was further confirmed in a separate validation dataset of 558 patients. The observed metabolic patterns may reflect different pathophysiological mechanisms, including protective changes of systemic lipid metabolism aiming to maintain lipid homeostasis in the brain. LA - English DB - MTMT ER -