@article{MTMT:34724962,
	title = {Rehabilitation and outcomes after complicated vs uncomplicated mild TBI. results from the CENTER-TBI study.},
	url = {https://m2.mtmt.hu/api/publication/34724962},
	author = {Howe, Emilie Isager and Zeldovich, Marina and Andelic, Nada and von Steinbuechel, Nicole and Fure, Silje C R and Borgen, Ida M H and Forslund, Marit V and Hellstrøm, Torgeir and Søberg, Helene L and Sveen, Unni and Rasmussen, Mari and Kleffelgaard, Ingerid and Tverdal, Cathrine and Helseth, Eirik and Løvstad, Marianne and Lu, Juan and Arango-Lasprilla, Juan Carlos and Tenovuo, Olli and Azouvi, Philippe and Dawes, Helen and Roe, Cecilie and Sándor, János and Tamás, Viktória},
	doi = {10.1186/s12913-022-08908-0},
	journal-iso = {BMC HEALTH SERV RES},
	journal = {BMC HEALTH SERVICES RESEARCH},
	volume = {22},
	unique-id = {34724962},
	issn = {1472-6963},
	abstract = {Despite existing guidelines for managing mild traumatic brain injury (mTBI), evidence-based treatments are still scarce and large-scale studies on the provision and impact of specific rehabilitation services are needed. This study aimed to describe the provision of rehabilitation to patients after complicated and uncomplicated mTBI and investigate factors associated with functional outcome, symptom burden, and TBI-specific health-related quality of life (HRQOL) up to six months after injury.Patients (n = 1379) with mTBI from the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study who reported whether they received rehabilitation services during the first six months post-injury and who participated in outcome assessments were included. Functional outcome was measured with the Glasgow Outcome Scale - Extended (GOSE), symptom burden with the Rivermead Post Concussion Symptoms Questionnaire (RPQ), and HRQOL with the Quality of Life after Brain Injury - Overall Scale (QOLIBRI-OS). We examined whether transition of care (TOC) pathways, receiving rehabilitation services, sociodemographic (incl. geographic), premorbid, and injury-related factors were associated with outcomes using regression models. For easy comparison, we estimated ordinal regression models for all outcomes where the scores were classified based on quantiles.Overall, 43% of patients with complicated and 20% with uncomplicated mTBI reported receiving rehabilitation services, primarily in physical and cognitive domains. Patients with complicated mTBI had lower functional level, higher symptom burden, and lower HRQOL compared to uncomplicated mTBI. Rehabilitation services at three or six months and a higher number of TOC were associated with unfavorable outcomes in all models, in addition to pre-morbid psychiatric problems. Being male and having more than 13 years of education was associated with more favorable outcomes. Sustaining major trauma was associated with unfavorable GOSE outcome, whereas living in Southern and Eastern European regions was associated with lower HRQOL.Patients with complicated mTBI reported more unfavorable outcomes and received rehabilitation services more frequently. Receiving rehabilitation services and higher number of care transitions were indicators of injury severity and associated with unfavorable outcomes. The findings should be interpreted carefully and validated in future studies as we applied a novel analytic approach.ClinicalTrials.gov NCT02210221.},
	keywords = {rehabilitation; PROM; mild TBI},
	year = {2022},
	eissn = {1472-6963}
}

@article{MTMT:33710664,
	title = {EFFECTS OF NAVIGATED RTMS FOR THE HEMIPARETIC UPPER EXTREMITY MOTOR FUNCTION IN STROKE PATIENTS - PILOT STUDY},
	url = {https://m2.mtmt.hu/api/publication/33710664},
	author = {Pinczker, Veronika and Makai, Alexandra and Molics, Bálint and Boncz, Imre and Tamás, Viktória and Járomi, Melinda},
	journal-iso = {VALUE HEALTH},
	journal = {VALUE IN HEALTH},
	volume = {25},
	unique-id = {33710664},
	issn = {1098-3015},
	keywords = {Economics; Health Care Sciences & Services},
	year = {2022},
	eissn = {1524-4733},
	pages = {S487-S487},
	orcid-numbers = {Makai, Alexandra/0000-0002-1907-120X; Boncz, Imre/0000-0003-3699-6236}
}

@article{MTMT:33236529,
	title = {Concomitant spine trauma in patients with traumatic brain injury: Patient characteristics and outcomes},
	url = {https://m2.mtmt.hu/api/publication/33236529},
	author = {Riemann, Lennart and Alhalabi, Obada T. and Unterberg, Andreas W. W. and Younsi, Alexander},
	doi = {10.3389/fneur.2022.861688},
	journal-iso = {FRONT NEUR},
	journal = {FRONTIERS IN NEUROLOGY},
	volume = {13},
	unique-id = {33236529},
	issn = {1664-2295},
	abstract = {ObjectiveSpine injury is highly prevalent in patients with poly-trauma, but data on the co-occurrence of spine trauma in patients with traumatic brain injury (TBI) are scarce. In this study, we used the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) database to assess the prevalence, characteristics, and outcomes of patients with TBI and a concurrent traumatic spinal injury (TSI). MethodsData from the European multi-center CENTER-TBI study were analyzed. Adult patients with TBI (>= 18 years) presenting with a concomitant, isolated TSI of at least serious severity (Abbreviated Injury Scale; AIS >= 3) were included. For outcome analysis, comparison groups of TBI patients with TSI and systemic injuries (non-isolated TSI) and without TSI were created using propensity score matching. Rates of mortality, unfavorable outcomes (Glasgow Outcome Scale Extended; GOSe < 5), and full recovery (GOSe 7-8) of all patients and separately for patients with only mild TBI (mTBI) were compared between groups at 6-month follow-up. ResultsA total of 164 (4%) of the 4,254 CENTER-TBI core study patients suffered from a concomitant isolated TSI. The median age was 53 [interquartile range (IQR): 37-66] years and 71% of patients were men. mTBI was documented in 62% of cases, followed by severe TBI (26%), and spine injuries were mostly cervical (63%) or thoracic (31%). Surgical spine stabilization was performed in 19% of cases and 57% of patients were admitted to the ICU. Mortality at 6 months was 11% and only 36% of patients regained full recovery. There were no significant differences in the 6-month rates of mortality, unfavorable outcomes, or full recovery between TBI patients with and without concomitant isolated TSI. However, concomitant non-isolated TSI was associated with an unfavorable outcome and a higher mortality. In patients with mTBI, a negative association with full recovery could be observed for both concomitant isolated and non-isolated TSI. ConclusionRates of mortality, unfavorable outcomes, and full recovery in TBI patients with and without concomitant, isolated TSIs were comparable after 6 months. However, in patients with mTBI, concomitant TSI was a negative predictor for a full recovery. These findings might indicate that patients with moderate to severe TBI do not necessarily exhibit worse outcomes when having a concomitant TSI, whereas patients with mTBI might be more affected.},
	keywords = {traumatic brain injury; outcome; CENTER-TBI; Spine trauma; traumatic spine injury},
	year = {2022},
	eissn = {1664-2295},
	orcid-numbers = {Younsi, Alexander/0000-0002-8218-9243; Barzó, Pál/0000-0001-8717-748X}
}

@article{MTMT:33195955,
	title = {Measurement invariance of six language versions of the post-traumatic stress disorder checklist for DSM-5 in civilians after traumatic brain injury},
	url = {https://m2.mtmt.hu/api/publication/33195955},
	author = {Bockhop, Fabian and Zeldovich, Marina and Cunitz, Katrin and Van Praag, Dominique and van der Vlegel, Marjolein and Beissbarth, Tim and Hagmayer, York and von Steinbuechel, Nicole},
	doi = {10.1038/s41598-022-20170-2},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {12},
	unique-id = {33195955},
	issn = {2045-2322},
	abstract = {Traumatic brain injury (TBI) is frequently associated with neuropsychiatric impairments such as symptoms of post-traumatic stress disorder (PTSD), which can be screened using self-report instruments such as the Post-Traumatic Stress Disorder Checklist for DSM-5 (PCL-5). The current study aims to inspect the factorial validity and cross-linguistic equivalence of the PCL-5 in individuals after TBI with differential severity. Data for six language groups (n ≥ 200; Dutch, English, Finnish, Italian, Norwegian, Spanish) were extracted from the CENTER-TBI study database. Factorial validity of PTSD was evaluated using confirmatory factor analyses (CFA), and compared between four concurrent structural models. A multi-group CFA approach was utilized to investigate the measurement invariance (MI) of the PCL-5 across languages. All structural models showed satisfactory goodness-of-fit with small between-model variation. The original DSM-5 model for PTSD provided solid evidence of MI across the language groups. The current study underlines the validity of the clinical DSM-5 conceptualization of PTSD and demonstrates the comparability of PCL-5 symptom scores between language versions in individuals after TBI. Future studies should apply MI methods to other sociodemographic (e.g., age, gender) and injury-related (e.g., TBI severity) characteristics to improve the monitoring and clinical care of individuals suffering from PTSD symptoms after TBI.},
	year = {2022},
	eissn = {2045-2322},
	orcid-numbers = {Barzó, Pál/0000-0001-8717-748X; Czeiter, Endre/0000-0002-9578-6944}
}

@article{MTMT:33163294,
	title = {Neurocognitive correlates of probable posttraumatic stress disorder following traumatic brain injury},
	url = {https://m2.mtmt.hu/api/publication/33163294},
	author = {Van Praag, Dominique L G and Wouters, Kristien and Van Den Eede, Filip and Wilson, Lindsay and Maas, Andrew I R},
	doi = {10.1016/j.bas.2021.100854},
	journal-iso = {BRAIN SPINE},
	journal = {BRAIN AND SPINE},
	volume = {2},
	unique-id = {33163294},
	issn = {2772-5294},
	abstract = {Neurocognitive problems associated with posttraumatic stress disorder (PTSD) can interact with impairment resulting from traumatic brain injury (TBI).We aimed to identify neurocognitive problems associated with probable PTSD following TBI in a civilian sample.The study is part of the CENTER-TBI project (Collaborative European Neurotrauma Effectiveness Research) that aims to better characterize TBI. For this cross-sectional study, we included patients of all severities aged over 15, and a Glasgow Outcome Score Extended (GOSE) above 3. Participants were assessed at six months post-injury on the PTSD Checklist-5 (PCL-5), the Trail Making Test (TMT), the Rey Auditory Verbal Learning Test (RAVLT) and the Cambridge Neuropsychological Test Automated Battery (CANTAB). Primary analysis was a complete case analysis. Regression analyses were performed to investigate the association between the PCL-5 and cognition.Of the 1134 participants included in the complete case analysis, 13.5% screened positive for PTSD. Probable PTSD was significantly associated with higher TMT-(B-A) (OR ​= ​1.35, 95% CI: 1.14-1.60, p ​< ​.001) and lower RAVLT-delayed recall scores (OR ​= ​0.74, 95% CI: 0.61-0.91, p ​= ​.004) after controlling for age, sex, psychiatric history, baseline Glasgow Coma Scale and education.Poorer performance on cognitive tests assessing task switching and, to a lesser extent, delayed verbal recall is associated with probable PTSD in civilians who have suffered TBI.},
	keywords = {STRESS; cognition; head injury; neuropsychology; posttraumatic stress disorder},
	year = {2022},
	orcid-numbers = {Barzó, Pál/0000-0001-8717-748X; Czeiter, Endre/0000-0002-9578-6944}
}

@article{MTMT:33121609,
	title = {Neuronavigated theta burst stimulation for achieve safer tumor resection near motor speech area – case study},
	url = {https://m2.mtmt.hu/api/publication/33121609},
	author = {Sebestyén, Gabriella and Lendvai-Emmert, Dominika and Tamás, Viktória and Csendes, Márk Lajos and Magyar-Sümegi, Zsófia Dina and Tóth, Péter József and Büki, András},
	doi = {10.1016/j.clinph.2022.07.384},
	journal-iso = {CLIN NEUROPHYSIOL},
	journal = {CLINICAL NEUROPHYSIOLOGY},
	volume = {141},
	unique-id = {33121609},
	issn = {1388-2457},
	year = {2022},
	eissn = {1872-8952},
	pages = {S145-S146}
}

@article{MTMT:33016765,
	title = {Discrepancy between disability and reported well-being after traumatic brain injury},
	url = {https://m2.mtmt.hu/api/publication/33016765},
	author = {Retel Helmrich, Isabel Rosalie Arianne and van Klaveren, David and Andelic, Nada and Lingsma, Hester and Maas, Andrew and Menon, David and Polinder, Suzanne and Roe, Cecilie and Steyerberg, Ewout W. and Van Veen, Ernest and Wilson, Lindsay},
	doi = {10.1136/jnnp-2021-326615},
	journal-iso = {J NEUROL NEUROSUR PS},
	journal = {JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY},
	volume = {93},
	unique-id = {33016765},
	issn = {0022-3050},
	abstract = {Background Following traumatic brain injury (TBI), the clinical focus is often on disability. However, patients' perceptions of well-being can be discordant with their disability level, referred to as the 'disability paradox'. We aimed to examine the relationship between disability and health-related quality of life (HRQoL) following TBI, while taking variation in personal, injury-related and environment factors into account. Methods We used data from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury study. Disability was assessed 6 months post-injury by the Glasgow Outcome Scale-Extended (GOSE). HRQoL was assessed by the SF-12v2 physical and mental component summary scores and the Quality of Life after Traumatic Brain Injury overall scale. We examined mean total and domain HRQoL scores by GOSE. We quantified variance in HRQoL explained by GOSE, personal, injury-related and environment factors with multivariable regression. Results Six-month outcome assessments were completed in 2075 patients, of whom 78% had mild TBI (Glasgow Coma Scale 13-15). Patients with severe disability had higher HRQoL than expected on the basis of GOSE alone, particularly after mild TBI. Up to 50% of patients with severe disability reported HRQoL scores within the normative range. GOSE, personal, injury-related and environment factors explained a limited amount of variance in HRQoL (up to 29%). Conclusion Contrary to the idea that discrepancies are unusual, many patients with poor functional outcomes reported well-being that was at or above the boundary considered satisfactory for the normative sample. These findings challenge the idea that satisfactory HRQoL in patients with disability should be described as 'paradoxical' and question common views of what constitutes 'unfavourable' outcome.},
	keywords = {Quality of Life; traumatic brain injury; neuropsychology},
	year = {2022},
	eissn = {1468-330X},
	pages = {785-796},
	orcid-numbers = {Barzó, Pál/0000-0001-8717-748X}
}

@article{MTMT:33016757,
	title = {Tailoring Multi-Dimensional Outcomes to Level of Functional Recovery after Traumatic Brain Injury},
	url = {https://m2.mtmt.hu/api/publication/33016757},
	author = {Wilson, Lindsay and Horton, Lindsay and Polinder, Suzanne and Newcombe, Virginia F. J. and von Steinbuechel, Nicole and Maas, Andrew I. R. and Menon, David K.},
	doi = {10.1089/neu.2022.0013},
	journal-iso = {J NEUROTRAUM},
	journal = {JOURNAL OF NEUROTRAUMA},
	volume = {39},
	unique-id = {33016757},
	issn = {0897-7151},
	abstract = {There is increasing emphasis on assessing multi-dimensional outcomes in traumatic brain injury (TBI), but achieving this aim is hampered by a plethora of overlapping assessment tools. There is a clear need for advice on the choice of outcomes and we examined level of functional recovery as a framework to guide selection of assessments. In this cohort study we analysed cross-sectional data from 2604 patients enrolled in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) project. Patients were followed up 6 months after injury and assessed on the Glasgow Outcome Scale-Extended (GOSE), cognitive tests, and patient-reported outcomes. We describe assessment completeness and prevalence of impairment. Relationships between outcomes were visualized using UpSet plots and hierarchical cluster analysis. GOSE categories varied markedly for both completion rates, 34-91% for patient-reported outcomes and 9-81% for cognitive tests, and prevalence of impairment, 3-82% for patient-reported outcomes and 9-59% for cognitive tests. In complete case samples, the GOSE identified impairment in 59-61%, whereas the most impaired patient-reported outcome was the Short Form-12 version 2 (SF-12v2) Physical Component Summary (28% overall), and the most impaired cognitive test was Trail Making Test (TMT) Part A (19% overall). The findings show that degree of disability is a key context of use for cognitive tests and patient-reported outcomes. Level of functional recovery provides a guide to the feasibility of different types of assessment and the likelihood of impairment, and can help tailor suitable assessment approaches in clinical practice and research studies.},
	keywords = {traumatic brain injury; outcome measures; common data elements},
	year = {2022},
	eissn = {1557-9042},
	pages = {1363-1381},
	orcid-numbers = {Barzó, Pál/0000-0001-8717-748X}
}

@article{MTMT:32899084,
	title = {Health care utilization and outcomes in older adults after Traumatic Brain Injury : A CENTER-TBI study},
	url = {https://m2.mtmt.hu/api/publication/32899084},
	author = {van der Vlegel, Marjolein and Mikolić, Ana and Lee, Hee Quentin and Kaplan, Z L Rana and Retel, Helmrich Isabel R A and van Veen, Ernest and Andelic, Nada and Steinbuechel, Nicole V and Plass, Anne Marie and Zeldovich, Marina and Wilson, Lindsay and Maas, Andrew I R and Haagsma, Juanita A and Polinder, Suzanne},
	doi = {10.1016/j.injury.2022.05.009},
	journal-iso = {INJURY},
	journal = {INJURY: INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED},
	volume = {53},
	unique-id = {32899084},
	issn = {0020-1383},
	abstract = {The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in older adults who sustained a TBI.We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care utilization and outcomes were described for patients aged ≥65 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury.Of 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six-month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with functional impairment, lower generic and disease-specific HRQoL and mental health symptoms.The rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive.},
	keywords = {OLDER ADULTS; traumatic brain injury; health-related quality of life; OUTCOMES; mental health; health care utilization},
	year = {2022},
	eissn = {1879-0267},
	pages = {2774-2782},
	orcid-numbers = {Barzó, Pál/0000-0001-8717-748X; Czeiter, Endre/0000-0002-9578-6944}
}

@article{MTMT:32819191,
	title = {Serum metabolome associated with severity of acute traumatic brain injury},
	url = {https://m2.mtmt.hu/api/publication/32819191},
	author = {Thomas, Ilias and Dickens, Alex M and Posti, Jussi P and Czeiter, Endre and Duberg, Daniel and Sinioja, Tim and Kråkström, Matilda and Retel Helmrich, Isabel R A and Wang, Kevin K W and Maas, Andrew I R and Steyerberg, Ewout W and Menon, David K and Tenovuo, Olli and Hyötyläinen, Tuulia and Büki, András and Orešič, Matej},
	doi = {10.1038/s41467-022-30227-5},
	journal-iso = {NAT COMMUN},
	journal = {NATURE COMMUNICATIONS},
	volume = {13},
	unique-id = {32819191},
	issn = {2041-1723},
	abstract = {Complex metabolic disruption is a crucial aspect of the pathophysiology of traumatic brain injury (TBI). Associations between this and systemic metabolism and their potential prognostic value are poorly understood. Here, we aimed to describe the serum metabolome (including lipidome) associated with acute TBI within 24 h post-injury, and its relationship to severity of injury and patient outcome. We performed a comprehensive metabolomics study in a cohort of 716 patients with TBI and non-TBI reference patients (orthopedic, internal medicine, and other neurological patients) from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) cohort. We identified panels of metabolites specifically associated with TBI severity and patient outcomes. Choline phospholipids (lysophosphatidylcholines, ether phosphatidylcholines and sphingomyelins) were inversely associated with TBI severity and were among the strongest predictors of TBI patient outcomes, which was further confirmed in a separate validation dataset of 558 patients. The observed metabolic patterns may reflect different pathophysiological mechanisms, including protective changes of systemic lipid metabolism aiming to maintain lipid homeostasis in the brain.},
	year = {2022},
	eissn = {2041-1723},
	orcid-numbers = {Czeiter, Endre/0000-0002-9578-6944; Barzó, Pál/0000-0001-8717-748X}
}