@article{MTMT:34124819,
	title = {In Vitro and In Vivo Efficacy of Topical Dosage Forms Containing Self-Nanoemulsifying Drug Delivery System Loaded with Curcumin},
	url = {https://m2.mtmt.hu/api/publication/34124819},
	author = {Frei, Gréta and Haimhoffer, Ádám and Csapó, Enikő and Bodnár, Krisztina and Vasvári, Gábor and Nemes, Dániel and Lekli, István and Gyöngyösi, Alexandra and Bácskay, Ildikó and Siposné Fehér, Pálma and Józsa, Liza},
	doi = {10.3390/pharmaceutics15082054},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {15},
	unique-id = {34124819},
	issn = {1999-4923},
	abstract = {The external use of curcumin is rare, although it can be a valuable active ingredient in the treatment of certain inflammatory diseases. The aim of our experimental work was to formulate topical dosage forms containing curcumin for the treatment of atopic dermatitis. Curcumin has extremely poor solubility and bioavailability, so we have tried to increase it with the usage of self-emulsifying drug delivery systems. Creams and gels were formulated using penetration-enhancing surfactants and gelling agents. The release of the drug from the vehicle and its penetration through the membrane were determined using a Franz diffusion cell. An MTT cytotoxicity and in vitro antioxidant assays were performed on HaCaT cell line. The in vivo anti-inflammatory effect of the preparations was tested by measuring rat paw edema. In addition, we examined the degree of inflammation induced by UV radiation after pretreatment with the cream and the gel on rats. For the gels containing SNEDDS, the highest penetration was measured after half an hour, while for the cream, it took one hour to reach the maximum concentration. The gel containing Pemulen TR-1 showed the highest drug release. It was determined that the curcumin-containing preparations can be safely applied on the skin and have antioxidant effects. The animal experiments have proven the effectiveness of curcumin-containing topical preparations.},
	year = {2023},
	eissn = {1999-4923},
	pages = {2054},
	orcid-numbers = {Nemes, Dániel/0000-0002-5477-0540}
}

@{MTMT:34046049,
	title = {Formulation of buccal films in Parkinson’s disease},
	url = {https://m2.mtmt.hu/api/publication/34046049},
	author = {Pamlényi, Krisztián and Regdon, Géza (ifj.) and Jójártné Laczkovich, Orsolya and Nemes, Dániel and Bácskay, Ildikó and Kristó, Katalin},
	booktitle = {V. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science},
	doi = {10.14232/syrptbrs.2023.34},
	unique-id = {34046049},
	year = {2023},
	pages = {34-34},
	orcid-numbers = {Regdon, Géza (ifj.)/0000-0002-6921-3069; Nemes, Dániel/0000-0002-5477-0540; Bácskay, Ildikó/0000-0001-8663-2890}
}

@article{MTMT:34008857,
	title = {Formulation and characterization of pramipexole containing buccal films for using in Parkinson's disease},
	url = {https://m2.mtmt.hu/api/publication/34008857},
	author = {Pamlényi, Krisztián and Regdon, Géza (ifj.) and Jójártné Laczkovich, Orsolya and Nemes, Dániel and Bácskay, Ildikó and Kristó, Katalin},
	doi = {10.1016/j.ejps.2023.106491},
	journal-iso = {EUR J PHARM SCI},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {187},
	unique-id = {34008857},
	issn = {0928-0987},
	year = {2023},
	eissn = {1879-0720},
	orcid-numbers = {Regdon, Géza (ifj.)/0000-0002-6921-3069; Nemes, Dániel/0000-0002-5477-0540}
}

@book{MTMT:33880764,
	title = {Book of abstracts: Conference on Therapeutical Purposes Research and Development III. = Absztrakt kötet : III. Terápiás Célú Kutatások és Fejlesztések Konferenciája},
	url = {https://m2.mtmt.hu/api/publication/33880764},
	editor = {Bácskay, Ildikó and Józsa, Liza and Vasvári, Gábor and Nemes, Dániel and Haimhoffer, Ádám},
	publisher = {University of Debrecen},
	unique-id = {33880764},
	year = {2023},
	orcid-numbers = {Nemes, Dániel/0000-0002-5477-0540}
}

@article{MTMT:33851340,
	title = {Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae Flos},
	url = {https://m2.mtmt.hu/api/publication/33851340},
	author = {Neagu, Oana Mihaela and Ghitea, Timea and Marian, Eleonora and Vlase, Laurian and Vlase, Ana-Maria and Ciavoi, Gabriela and Fehér, Pálma and Pallag, Annamária and Bácskay, Ildikó and Nemes, Dániel and Vicaș, Laura Grațiela and Teușdea, Alin and Jurca, Tünde},
	doi = {10.3390/molecules28104002},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {28},
	unique-id = {33851340},
	issn = {1420-3049},
	abstract = {Taraxaci folium and Matricariae flos plant extracts contain a wide range of bioactive compounds with antioxidant and anti-inflammatory effects. The aim of the study was to evaluate the phytochemical and antioxidant profile of the two plant extracts to obtain a mucoadhesive polymeric film with beneficial properties in acute gingivitis. The chemical composition of the two plant extracts was determined by high-performance liquid chromatography coupled with mass spectrometry. To establish a favourable ratio in the combination of the two extracts, the antioxidant capacity was determined by the method of reduction of copper ions Cu2+ from neocuprein and by reduction of the compound 1.1-diphenyl-2-2picril-hydrazyl. Following preliminary analysis, we selected the plant mixture Taraxaci folium/matricariae flos in the ratio of 1:2 (m/m), having an antioxidant capacity of 83.92% ± 0.02 reduction of free nitrogen radical of 1.1-diphenyl-2-2picril-hydrazyl reagent. Subsequently, bioadhesive films of 0.2 mm thickness were obtained using various concentrations of polymer and plant extract. The mucoadhesive films obtained were homogeneous and flexible, with pH ranging from 6.634 to 7.016 and active ingredient release capacity ranging from 85.94–89.52%. Based on in vitro analysis, the film containing 5% polymer and 10% plant extract was selected for in vivo study. The study involved 50 patients undergoing professional oral hygiene followed by a 7-day treatment with the chosen mucoadhesive polymeric film. The study showed that the film used helped accelerate the healing of acute gingivitis after treatment, with anti-inflammatory and protective action.},
	year = {2023},
	eissn = {1420-3049},
	orcid-numbers = {Ghitea, Timea/0000-0001-8981-1958; Marian, Eleonora/0000-0002-6181-1590; Vlase, Laurian/0000-0002-0664-3387; Vlase, Ana-Maria/0000-0003-4865-0777; Ciavoi, Gabriela/0000-0003-1417-5963; Nemes, Dániel/0000-0002-5477-0540; Vicaș, Laura Grațiela/0000-0001-5328-333X; Teușdea, Alin/0000-0002-3570-7271}
}

@article{MTMT:33742959,
	title = {Recent Options and Techniques to Assess Improved Bioavailability: In Vitro and Ex Vivo Methods},
	url = {https://m2.mtmt.hu/api/publication/33742959},
	author = {Józsa, Liza and Nemes, Dániel and Pető, Ágota and Kósa, Dóra and Révész, Réka and Bácskay, Ildikó and Haimhoffer, Ádám and Vasvári, Gábor},
	doi = {10.3390/pharmaceutics15041146},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {15},
	unique-id = {33742959},
	issn = {1999-4923},
	abstract = {Bioavailability assessment in the development phase of a drug product is vital to reveal the disadvantageous properties of the substance and the possible technological interventions. However, in vivo pharmacokinetic studies provide strong evidence for drug approval applications. Human and animal studies must be designed on the basis of preliminary biorelevant experiments in vitro and ex vivo. In this article, the authors have reviewed the recent methods and techniques from the last decade that are in use for assessing the bioavailability of drug molecules and the effects of technological modifications and drug delivery systems. Four main administration routes were selected: oral, transdermal, ocular, and nasal or inhalation. Three levels of methodologies were screened for each category: in vitro techniques with artificial membranes; cell culture, including monocultures and co-cultures; and finally, experiments where tissue or organ samples were used. Reproducibility, predictability, and level of acceptance by the regulatory organizations are summarized for the readers.},
	year = {2023},
	eissn = {1999-4923},
	pages = {1-25},
	orcid-numbers = {Nemes, Dániel/0000-0002-5477-0540; Révész, Réka/0009-0000-6686-3771}
}

@article{MTMT:33727451,
	title = {Effect of Molecular Weight on the Dissolution Profiles of PEG Solid Dispersions Containing Ketoprofen},
	url = {https://m2.mtmt.hu/api/publication/33727451},
	author = {Le Khanh, Ha Pham and Haimhoffer, Ádám and Nemes, Dániel and Józsa, Liza and Vasvári, Gábor and Budai, István and Bényei, Attila Csaba and Ujhelyi, Zoltán and Siposné Fehér, Pálma and Bácskay, Ildikó},
	doi = {10.3390/polym15071758},
	journal-iso = {POLYMERS-BASEL},
	journal = {POLYMERS},
	volume = {15},
	unique-id = {33727451},
	abstract = {Solid dispersions are typically binary systems with a hydrophilic matrix polymer and a lipophilic active substance. During formulation, the drug undergoes a crystalline to amorphous phase transition, which leads to a supersaturated solution providing enhanced bioavailability. The interaction of the active substance and the polymer is unique and influences the level of supersaturation. We aimed to investigate the relationship between low molecular weight polyethylene glycol derivates PEG 1000, 1500, and 2000 and ketoprofen regarding the effect of molecular weight. The physicochemical properties of solid dispersions prepared with hot melt homogenization and their respective physical mixtures were investigated with Fourier transform infrared spectroscopy, powder X-ray diffraction and scanning electron microscopy techniques. A phase solubility study was carried out in hydrochloric acid media which showed no difference between the three polymers, but the dissolution curves differed considerably. PEG 1000 had higher percentage of released drug than PEG 1500 and 2000, which had similar results. These results indicate that when multiple low molecular weight PEGs are suitable as matrix polymers of solid dispersions, the molecular weight has only limited impact on physicochemical characteristics and interactions and further investigation is needed to select the most applicable candidate.},
	year = {2023},
	eissn = {2073-4360},
	pages = {1-15},
	orcid-numbers = {Le Khanh, Ha Pham/0000-0003-4172-2184; Nemes, Dániel/0000-0002-5477-0540; Budai, István/0000-0002-8966-3817}
}

@misc{MTMT:33550300,
	title = {Pramipexolt tartalmazó innovatív bukkális polimer film formulálása és vizsgálata},
	url = {https://m2.mtmt.hu/api/publication/33550300},
	author = {Pamlényi, Krisztián and Regdon, Géza (ifj.) and Bácskay, Ildikó and Nemes, Dániel and Kristó, Katalin},
	unique-id = {33550300},
	year = {2022},
	orcid-numbers = {Regdon, Géza (ifj.)/0000-0002-6921-3069; Nemes, Dániel/0000-0002-5477-0540}
}

@{MTMT:33550245,
	title = {Preparation of buccal films in Parkinson’s Diseasee},
	url = {https://m2.mtmt.hu/api/publication/33550245},
	author = {Pamlényi, Krisztián and Regdon, Géza (ifj.) and Nemes, Dániel and Bácskay, Ildikó and Kristó, Katalin},
	booktitle = {9th BBBB International Conference on Pharmaceutical Sciences - Pharma Sciences of Tomorrow: Book of Abstracts},
	unique-id = {33550245},
	year = {2022},
	pages = {105-106},
	orcid-numbers = {Regdon, Géza (ifj.)/0000-0002-6921-3069; Nemes, Dániel/0000-0002-5477-0540}
}

@article{MTMT:33135106,
	title = {Enhanced Antioxidant and Anti-Inflammatory Effects of Self-Nano and Microemulsifying Drug Delivery Systems Containing Curcumin},
	url = {https://m2.mtmt.hu/api/publication/33135106},
	author = {Józsa, Liza and Vasvári, Gábor and Sinka, Dávid and Nemes, Dániel and Ujhelyi, Zoltán and Vecsernyés, Miklós and Váradi, Judit and Fenyvesi, Ferenc and Lekli, István and Gyöngyösi, Alexandra and Bácskay, Ildikó and Siposné Fehér, Pálma},
	doi = {10.3390/molecules27196652},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {27},
	unique-id = {33135106},
	issn = {1420-3049},
	abstract = {Turmeric has been used for decades for its antioxidant and anti-inflammatory effect, which is due to an active ingredient isolated from the plant, called curcumin. However, the extremely poor water-solubility of curcumin often limits the bioavailability of the drug. The aim of our experimental work was to improve the solubility and thus bioavailability of curcumin by developing self-nano/microemulsifying drug delivery systems (SN/MEDDS). Labrasol and Cremophor RH 40 as nonionic surfactants, Transcutol P as co-surfactant and isopropyl myristate as the oily phase were used during the formulation. The average droplet size of SN/MEDDS containing curcumin was between 32 and 405 nm. It was found that the higher oil content resulted in larger particle size. The drug loading efficiency was between 93.11% and 99.12% and all formulations were thermodynamically stable. The curcumin release was studied at pH 6.8, and the release efficiency ranged between 57.3% and 80.9% after 180 min. The results of the MTT cytotoxicity assay on human keratinocyte cells (HaCaT) and colorectal adenocarcinoma cells (Caco-2) showed that the curcumin-containing preparations were non-cytotoxic at 5 w/v%. According to the results of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide dismutase (SOD) assays, SNEDDS showed significantly higher antioxidant activity. The anti-inflammatory effect of the SN/MEDDS was screened by enzyme-linked immunosorbent assay (ELISA). SNEDDS formulated with Labrasol as surfactant, reduced tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) levels below 60% at a concentration of 10 w/w%. Our results verified the promising use of SN/MEDDS for the delivery of curcumin. This study demonstrates that the SN/MEDDS could be promising alternatives for the formulation of poorly soluble lipophilic compounds with low bioavailability.},
	year = {2022},
	eissn = {1420-3049},
	orcid-numbers = {Nemes, Dániel/0000-0002-5477-0540}
}