@article{MTMT:34724100,
	title = {Moderate-Intensity Swimming Alleviates Oxidative Injury in Ischemic Heart},
	url = {https://m2.mtmt.hu/api/publication/34724100},
	author = {Börzsei, Denise and Kiss, Viktória and Nagy, András and Hoffmann, Alexandra and Török, Szilvia and Almási, Nikoletta and Veszelka, Médea and Varga, Csaba and Szabó, Renáta},
	doi = {10.3390/app14052073},
	journal-iso = {APPL SCI-BASEL},
	journal = {APPLIED SCIENCES-BASEL},
	volume = {14},
	unique-id = {34724100},
	abstract = {The global burden of cardiovascular diseases is indisputable, as it claims nearly 18 million lives a year. In this current study, we aimed to prove that exercise, a cornerstone in cardiovascular disease management, emerges as a powerful tool in the pathology of myocardial ischemia. Male rats were divided into three groups: pre-swimming training + isoproterenol (ISO) treated, isoproterenol-treated, and control-sedentary. Myocardial infarction was induced by the subcutaneous injection of 1.0 mg/kg ISO. After the subsequent rest period, the animals swam for 3 weeks, every day for 25 min. At the end of the experiment, the serum levels of atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), as well as the cardiac concentrations of reactive oxygen species (ROS), catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) were determined. Our results indicate that both cardiac injury biomarkers (ANP, BNP) and ROS levels were significantly lower in swimming rats compared to the sedentary animals. Moreover, the level of enzymatic components of the intracellular antioxidant system, CAT, SOD, and GPx were increased in swimming animals after ISO-induced myocardial infarction. Our findings support the fact that moderate-intensity swimming training can be efficiently used to prevent myocardial infarction-induced ischemic injury, by inhibiting ROS production and strengthening intracellular antioxidant defense.},
	year = {2024},
	eissn = {2076-3417},
	pages = {2073},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272}
}

@{MTMT:34136657,
	title = {Effects of lifestyle on adipokine pattern changes in stroke-prone spontaneously hypertensive rat model},
	url = {https://m2.mtmt.hu/api/publication/34136657},
	author = {Kiss, Viktória and Szabó, Renáta and Börzsei, Denise and Nagyné Hoffmann, Alexandra and Nagy, András Levente and Almási, Nikoletta and Török, Szilvia and Veszelka, Médea and Varga, Csaba},
	booktitle = {A Magyar Szabadgyökkutató Társaság XII. Kongresszusa},
	unique-id = {34136657},
	year = {2023},
	pages = {34-34},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X}
}

@{MTMT:34136645,
	title = {Examination of imatinib-induced cardiotoxicity in a rat model},
	url = {https://m2.mtmt.hu/api/publication/34136645},
	author = {Szabó, Renáta and Börzsei, Denise and Nagyné Hoffmann, Alexandra and Kiss, Viktória and Sugár, Anna and Nagy, András and Toldi, Éva and Almási, Nikoletta and Török, Szilvia and Veszelka, Médea and Neuperger, Patrícia and Szebeni, Gábor and Varga, Csaba},
	booktitle = {A Magyar Szabadgyökkutató Társaság XII. Kongresszusa},
	unique-id = {34136645},
	year = {2023},
	pages = {57-57},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X}
}

@{MTMT:34136606,
	title = {A PCOS gyulladásos hátterének vizsgálata és terápiás megközelítése},
	url = {https://m2.mtmt.hu/api/publication/34136606},
	author = {Börzsei, Denise and Nagyné Hoffmann, Alexandra and Kiss, Viktória and Sugár, Anna and Neuperger, Patrícia and Szebeni, Gábor and Bagyánszki, Mária and Barta, Bence Pál and Almási, Nikoletta and Veszelka, Médea and Török, Szilvia and Varga, Csaba and Szabó, Renáta},
	booktitle = {A Magyar Szabadgyökkutató Társaság XII. Kongresszusa},
	unique-id = {34136606},
	year = {2023},
	pages = {16-16},
	orcid-numbers = {Szebeni, Gábor/0000-0002-6998-5632; Bagyánszki, Mária/0000-0003-3533-9461; Barta, Bence Pál/0000-0002-5309-8633; Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X}
}

@{MTMT:34136601,
	title = {The effect of H2S treatment on the antioxidant system in a colitis model},
	url = {https://m2.mtmt.hu/api/publication/34136601},
	author = {Török, Szilvia and Almási, Nikoletta and Veszelka, Médea and Börzsei, Denise and Szabó, Renáta and Varga, Csaba},
	booktitle = {A Magyar Szabadgyökkutató Társaság XII. Kongresszusa},
	unique-id = {34136601},
	year = {2023},
	pages = {78-615-6203-02-1},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X}
}

@CONFERENCE{MTMT:34136600,
	title = {Physical activity induced protection in TNBS rat colitis: focus on NETosis},
	url = {https://m2.mtmt.hu/api/publication/34136600},
	author = {Almási, Nikoletta and Török, Szilvia and Veszelka, Médea and Börzsei, Denise and Szabó, Renáta and Varga, Csaba},
	unique-id = {34136600},
	year = {2023},
	pages = {ISBN 978-615-6203-02-1},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X}
}

@{MTMT:34136566,
	title = {Resveratrol hatásának vizsgálata IBD patkánymodellben},
	url = {https://m2.mtmt.hu/api/publication/34136566},
	author = {Veszelka, Médea and Almási, Nikoletta and Török, Szilvia and Bagyánszki, Mária and Barta, Bence Pál and Bódi, Nikolett and Szabó, Renáta and Börzsei, Denise and Varga, Csaba},
	booktitle = {A Magyar Szabadgyökkutató Társaság XII. Kongresszusa},
	unique-id = {34136566},
	year = {2023},
	pages = {67-67},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Bagyánszki, Mária/0000-0003-3533-9461; Barta, Bence Pál/0000-0002-5309-8633; Bódi, Nikolett/0000-0002-9774-1387; Varga, Csaba/0000-0002-2678-665X}
}

@article{MTMT:34081631,
	title = {Voluntary Exercise-Mediated Protection in TNBS-Induced Rat Colitis: The Involvement of NETosis and Prdx Antioxidants},
	url = {https://m2.mtmt.hu/api/publication/34081631},
	author = {Almási, Nikoletta and Török, Szilvia and Al-Awar, Amin and Veszelka, Médea and Király, László and Börzsei, Denise and Szabó, Renáta and Varga, Csaba},
	doi = {10.3390/antiox12081531},
	journal-iso = {ANTIOXIDANTS-BASEL},
	journal = {ANTIOXIDANTS},
	volume = {12},
	unique-id = {34081631},
	abstract = {Inflammatory bowel diseases (IBDs) are autoimmune disorders of the gut. It is increasingly clear that voluntary exercise (VE) may exert protection against IBDs, but the exact background mechanism needs to be elucidated. In the present study, we aimed to investigate the possible role of NETosis and the antioxidant peroxiredoxin (Prdx) enzyme family in VE-induced protection. Wistar Han rats were randomly divided into two groups: sedentary (SED) and VE. After the 6-week voluntary wheel running, animals were treated with 2,4,6-trinitrobenzene sulphonic acid (TNBS) as a model of colitis. Here, we found that VE significantly decreased inflammation and ulceration of the colon in the VE TNBS group compared with SED TNBS. We also found that VE significantly decreased the expression of protein arginine deiminase 4 (PAD4) and myeloperoxidase (MPO), and markedly reduced citrullinated histone H3 (citH3) compared with SED TNBS. Furthermore, VE caused a significant increase in the levels of Prdx6 in the control and TNBS groups. Taken together, we found that a prior 6-week VE effectively reduces inflammation in TNBS-induced colitis, and we suggest that the protective effect of VE may be mediated via the inhibition of NETosis and upregulation of Prdx6 antioxidant.},
	year = {2023},
	eissn = {2076-3921},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X}
}

@article{MTMT:34071290,
	title = {The Interplay of Lifestyle and Adipokines in the Non-Obese Stroke-Prone Spontaneously Hypertensive Rats},
	url = {https://m2.mtmt.hu/api/publication/34071290},
	author = {Szabó, Renáta and Börzsei, Denise and Nagyné Hoffmann, Alexandra and Kiss, Viktória and Nagy, András Levente and Török, Szilvia and Veszelka, Médea and Almási, Nikoletta and Varga, Csaba},
	doi = {10.3390/antiox12071450},
	journal-iso = {ANTIOXIDANTS-BASEL},
	journal = {ANTIOXIDANTS},
	volume = {12},
	unique-id = {34071290},
	abstract = {Although the morphological features and functions of adipose tissue are well-described in obesity-prone animal models, less information is available on animals such as the stroke-prone spontaneously hypertensive (SHRSP) strain with cardiovascular abnormalities, which is not characterized by excessive adiposity. Our aim was to focus on lifestyle-induced (type of diet and physical exercise) effects on adipokine profile and lipid peroxidation in SHRSP rats. In our study, male Wistar-kyoto (control) and SHRSP rats were used. SHRSP rats were fed either standard chow or a high-fat diet with 40% fat content (HFD). One group of the animals was placed into cages fitted with a running-wheel; thus, the dietary and training period started at the same time and lasted for 12 weeks. At the end of the experimental period, adiponectin, leptin, omentin, and chemerin concentrations were determined from adipose tissue and serum. Besides adipokines, malondialdehyde (MDA) levels were also measured. Twelve weeks of HFD significantly decreased adiponectin and omentin concentrations of both adipose tissue and serum, which were ameliorated by physical exercise. Serum leptin, chemerin, and MDA values were elevated in HFD groups; however, physical exercise was able to mitigate these adverse changes. Our results underpin the crosstalk between lifestyle changes and dysfunctional adipose tissue in SHRSP rats.},
	year = {2023},
	eissn = {2076-3921},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X}
}

@article{MTMT:34007150,
	title = {Protective Effects of H2S Donor Treatment in Experimental Colitis: A Focus on Antioxidants},
	url = {https://m2.mtmt.hu/api/publication/34007150},
	author = {Török, Szilvia and Almási, Nikoletta and Veszelka, Médea and Börzsei, Denise and Szabó, Renáta and Varga, Csaba},
	doi = {10.3390/antiox12051025},
	journal-iso = {ANTIOXIDANTS-BASEL},
	journal = {ANTIOXIDANTS},
	volume = {12},
	unique-id = {34007150},
	abstract = {Inflammatory bowel diseases (IBD) are chronic, inflammatory disorders of the gastrointestinal (GI) system, which have become a global disease over the past few decades. It has become increasingly clear that oxidative stress plays a role in the pathogenesis of IBD. Even though several effective therapies exist against IBD, these might have serious side effects. It has been proposed that hydrogen sulfide (H2S), as a novel gasotransmitter, has several physiological and pathological effects on the body. Our present study aimed to investigate the effects of H2S administration on antioxidant molecules in experimental rat colitis. As a model of IBD, 2,4,6-trinitrobenzenesulfonic acid (TNBS) was used intracolonically (i.c.) to induce colitis in male Wistar–Hannover rats. Animals were orally treated (2 times/day) with H2S donor Lawesson’s reagent (LR). Our results showed that H2S administration significantly decreased the severity of inflammation in the colons. Furthermore, LR significantly suppressed the level of oxidative stress marker 3-nitrotyrosine (3-NT) and caused a significant elevation in the levels of antioxidant GSH, Prdx1, Prdx6, and the activity of SOD compared to TNBS. In conclusion, our results suggest that these antioxidants may offer potential therapeutic targets and H2S treatment through the activation of antioxidant defense mechanisms and may provide a promising strategy against IBD.},
	year = {2023},
	eissn = {2076-3921},
	orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Varga, Csaba/0000-0002-2678-665X}
}