TY - JOUR AU - Rétfalvi, G AU - Németh, Balázs AU - Kovács, V AU - Durcsán, H AU - Pécsi, Dániel AU - Almási, K AU - Pécsi, G TI - A DIAGNÓZIS RÖGÖS ÚTJA. WHIPPLE-KÓR DIAGNOSZTIZÁLÁSA 18 ÉVES KÓRLEFOLYÁS UTÁN JF - MAGYAR BELORVOSI ARCHIVUM J2 - MBA VL - 76 PY - 2023 IS - 5-6 SP - 330 EP - 330 PG - 1 SN - 0133-5464 UR - https://m2.mtmt.hu/api/publication/34566778 ID - 34566778 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kovács, Norbert AU - Pécsi, Dániel AU - Sipos, Zoltán AU - Borbásné Farkas, Kornélia AU - Földi, Mária AU - Hegyi, Péter AU - Bajor, Judit AU - Erőss, Bálint Mihály AU - Márta, Katalin AU - Mikó, Alexandra AU - Rakonczay, Zoltán AU - Sarlós, Patrícia AU - Ábrahám, Szabolcs AU - Vincze, Áron TI - Suprapapillary Biliary Stents Have Longer Patency Times than Transpapillary Stents-A Systematic Review and Meta-Analysis. JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 12 PY - 2023 IS - 3 PG - 16 SN - 2077-0383 DO - 10.3390/jcm12030898 UR - https://m2.mtmt.hu/api/publication/33636629 ID - 33636629 N1 - * Megosztott szerzőség AB - Endoscopic biliary stent placement is a minimally invasive intervention for patients with biliary strictures. Stent patency and function time are crucial factors. Suprapapillary versus transpapillary stent positioning may contribute to stent function time, so a meta-analysis was performed in this comparison.A comprehensive literature search was conducted in the CENTRAL, Embase, and MEDLINE databases to find data on suprapapillary stent placement compared to the transpapillary method via endoscopic retrograde cholangiopancreatography in cases of biliary stenosis of any etiology and any stent type until December 2020. We carried out a meta-analysis focusing on the following outcomes: stent patency, stent migration, rate of cholangitis and pancreatitis, and other reported complications.Three prospective and ten retrospective studies involving 1028 patients were included. Suprapapillary stent placement appeared to be superior to transpapillary stent positioning in patency (weighted mean difference = 50.23 days, 95% CI: 8.56, 91.98; p = 0.0.018). In a subgroup analysis of malignant indications, suprapapillary positioning showed a lower rate of cholangitis (OR: 0.34, 95% CI: 0.13, 0.93; p = 0.036). Another subgroup analysis investigating metal stents in a suprapapillary position resulted in a lower rate of pancreatitis (OR: 0.16, 95% CI: 0.03, 0.95; p = 0.043) compared to transpapillary stent placement. There was no difference in stent migration rates between the two groups (OR: 0.67, 95% CI: 0.17, 2.72; p = 0.577).Based on our results, suprapapillary biliary stenting has longer stent patency. Moreover, the stent migration rate did not differ between the suprapapillary and transpapillary groups. LA - English DB - MTMT ER - TY - JOUR AU - Nagy, Rita AU - Ocskay, Klementina AU - Váradi, Alex AU - Papp, Mária AU - Vitális, Zsuzsanna AU - Izbéki, Ferenc AU - Boros, Eszter AU - Gajdán, László AU - Szentesi, Andrea Ildikó AU - Erőss, Bálint Mihály AU - Hegyi, Péter Jenő AU - Vincze, Áron AU - Bajor, Judit AU - Sarlós, Patrícia AU - Mikó, Alexandra AU - Márta, Katalin AU - Pécsi, Dániel AU - Párniczky, Andrea AU - Hegyi, Péter TI - In-Hospital Patient Education Markedly Reduces Alcohol Consumption after Alcohol-Induced Acute Pancreatitis. JF - NUTRIENTS J2 - NUTRIENTS VL - 14 PY - 2022 IS - 10 PG - 9 SN - 2072-6643 DO - 10.3390/nu14102131 UR - https://m2.mtmt.hu/api/publication/32849790 ID - 32849790 N1 - * Megosztott szerzőség AB - Although excessive alcohol consumption is by far the most frequent cause of recurrent acute pancreatitis (AP) cases, specific therapy is still not well established to prevent recurrence. Generally, psychological therapy (e.g., brief intervention (BI)) is the cornerstone of cessation programs; however, it is not yet widely used in everyday practice. We conducted a post-hoc analysis of a prospectively collected database. Patients suffering from alcohol-induced AP between 2016 and 2021 received 30 min BI by a physician. Patient-reported alcohol consumption, serum gamma-glutamyl-transferase (GGT) level, and mean corpuscular volume (MCV) of red blood cells were collected on admission and at the 1-month follow-up visit to monitor patients' drinking habits. Ninety-nine patients with alcohol-induced AP were enrolled in the study (mean age: 50 ± 11, 89% male). A significant decrease was detected both in mean GGT value (294 ± 251 U/L vs. 103 ± 113 U/L, p < 0.001) and in MCV level (93.7 ± 5.3 U/L vs. 92.1 ± 5.1 U/L, p < 0.001) in patients with elevated on-admission GGT levels. Notably, 79% of the patients (78/99) reported alcohol abstinence at the 1-month control visit. Brief intervention is an effective tool to reduce alcohol consumption and to prevent recurrent AP. Longitudinal randomized clinical studies are needed to identify the adequate structure and frequency of BIs in alcohol-induced AP. LA - English DB - MTMT ER - TY - THES AU - Pécsi, Dániel TI - Analysis of the quality indicators, advanced biliary cannulation techniques and difficulty of endoscopic retrograde cholangiopancreatography (ERCP) PB - University of Pécs PY - 2021 SP - 141 UR - https://m2.mtmt.hu/api/publication/32619863 ID - 32619863 LA - English DB - MTMT ER - TY - JOUR AU - Janka, Eszter Anna AU - Várvölgyi, Tünde AU - Sipos, Zoltán AU - Soós, Alexandra AU - Hegyi, Péter AU - Kiss, Szabolcs AU - Dembrovszky, Fanni AU - Csupor, Dezső AU - Kéringer, Patrik AU - Pécsi, Dániel AU - Varjú-Solymár, Margit AU - Emri, Gabriella TI - Predictive Performance of Serum S100B Versus LDH in Melanoma Patients: a Systematic Review and Meta-Analysis JF - FRONTIERS IN ONCOLOGY J2 - FRONT ONCOL VL - 11 PY - 2021 PG - 11 SN - 2234-943X DO - 10.3389/fonc.2021.772165 UR - https://m2.mtmt.hu/api/publication/32602475 ID - 32602475 AB - Currently, no consensus on the use of blood tests for monitoring disease recurrence in patients with resected melanoma exists. The only meta-analysis conducted in 2008 found that elevated serum S100B levels were associated with significantly worse survival in melanoma patients. Serum LDH is an established prognostic factor in patients with advanced melanoma.To compare the discriminative and prognostic ability of serum S100B with that of serum LDH in patients with melanoma.This systematic review and meta-analysis were reported in accordance with the PRISMA Statement. The study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42019137138).A quantitative analysis of data from 6 eligible studies included 1,033 patients with cutaneous melanoma. The discriminative ability of serum S100B at identifying disease relapse [pooled Area Under the ROC (AUROC) 78.64 (95% CI 70.28; 87.01)] was significantly greater than the discriminative ability of serum LDH [AUROC 64.41 (95% CI 56.05; 7278)] (p=0.013). Ten eligible studies with 1,987 patients were included in the risk of death analysis. The prognostic performance of serum S100B [pooled estimate of adjusted hazard ratio (HR) 1.78 (95% CI 1.38; 2.29)] was independent but not superior to that of serum LDH [HR 1.60 (95% CI 1.36; 2.29)].A relatively small number of articles were eligible and there was considerable heterogeneity across the included studies.Serum biomarkers may provide relevant information on melanoma patient status and should be further researched. Serum S100B is a valid marker for diagnosis of melanoma recurrence.The study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42019137138). LA - English DB - MTMT ER - TY - JOUR AU - Nagy, Anikó AU - Juhász, Márk Félix AU - Görbe, Anikó AU - Váradi, Alex AU - Izbéki, Ferenc AU - Vincze, Áron AU - Sarlós, Patrícia AU - Czimmer, József AU - Szepes, Zoltán AU - Takács, Tamás AU - Papp, Mária AU - Fehér, Eszter AU - Hamvas, József AU - Kárász, Klaudia AU - Török, Imola AU - Stimac, Davor AU - Poropat, Goran AU - Ince, Ali Tüzün AU - Erőss, Bálint Mihály AU - Márta, Katalin AU - Pécsi, Dániel AU - Illés, Dóra AU - Váncsa, Szilárd AU - Földi, Mária AU - Faluhelyi, Nándor AU - Farkas, Orsolya AU - Nagy, Tamás AU - Kanizsai, Péter László AU - Márton, Zsolt AU - Szentesi, Andrea Ildikó AU - Hegyi, Péter AU - Párniczky, Andrea TI - Glucose levels show independent and dose-dependent association with worsening acute pancreatitis outcomes: Post-hoc analysis of a prospective, international cohort of 2250 acute pancreatitis cases JF - PANCREATOLOGY J2 - PANCREATOLOGY VL - 21 PY - 2021 IS - 7 SP - 1237 EP - 1246 PG - 10 SN - 1424-3903 DO - 10.1016/j.pan.2021.06.003 UR - https://m2.mtmt.hu/api/publication/32091062 ID - 32091062 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Csiki, Endre AU - Szabó, Hanna AU - Hanák, Lilla AU - Szakács, Zsolt AU - Kiss, Szabolcs AU - Vörhendi, Nóra AU - Pécsi, Dániel AU - Hegyi, Eszter AU - Hegyi, Péter AU - Erőss, Bálint Mihály TI - Oral Proton Pump Inhibitors May Be as Effective as Intravenous in Peptic Ulcer Bleeding : A Systematic Review and Meta-analysis JF - CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY J2 - CLIN TRANSLAT GASTROENT VL - 12 PY - 2021 IS - 4 PG - 10 SN - 2155-384X DO - 10.14309/ctg.0000000000000341 UR - https://m2.mtmt.hu/api/publication/32021654 ID - 32021654 AB - Current guidelines recommend intravenous (IV) proton pump inhibitor (PPI) therapy in peptic ulcer bleeding (PUB). We aimed to compare the efficacy of oral and IV administration of PPIs in PUB.We performed a systematic search in 4 databases for randomized controlled trials, which compared the outcomes of oral PPI therapy with IV PPI therapy for PUB. The primary outcomes were 30-day recurrent bleeding and 30-day mortality. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for dichotomous outcomes, while weighted mean differences (WMDs) with CI were calculated for continuous outcomes in meta-analysis. The protocol was registered a priori onto PROSPERO (CRD42020155852).A total of 14 randomized controlled trials reported 1,951 peptic ulcer patients, 977 and 974 of which were in the control and intervention groups, respectively. There were no statistically significant differences between oral and IV administration regarding 30-day rebleeding rate (OR = 0.96, CI: 0.65-1.44); 30-day mortality (OR = 0.70, CI: 0.35-1.40); length of hospital stay (WMD = -0.25, CI: -0.93 to -0.42); transfusion requirements (WMD = -0.09, CI: -0.07 to 0.24); need for surgery (OR = 0.91, CI: 0.40-2.07); further endoscopic therapy (OR = 1.04, CI: 0.56-1.93); and need for re-endoscopy (OR = 0.81, CI: 0.52-1.28). Heterogeneity was negligible in all analysis, except for the analysis on the length of hospitalization (I2 = 82.3%, P = 0.001).Recent evidence suggests that the oral administration of PPI is not inferior to the IV PPI treatment in PUB after endoscopic management, but further studies are warranted. LA - English DB - MTMT ER - TY - JOUR AU - Hegyi, Péter Jenő AU - Soós, Alexandra AU - Tóth, Emese AU - Ébert, Attila AU - Venglovecz, Viktória AU - Márta, Katalin AU - Mátrai, Péter AU - Mikó, Alexandra AU - Bajor, Judit AU - Sarlós, Patrícia AU - Vincze, Áron AU - Szabó-Halász, Adrienn AU - Izbéki, Ferenc AU - Szepes, Zoltán AU - Czakó, László AU - Kovács, György AU - Papp, Mária AU - Dubravcsik, Zsolt AU - Varga, Márta AU - Hamvas, József AU - Németh, Balázs AU - Macarie, Melania AU - Ince, Ali Tüzün AU - Bordin, Dmitry S AU - Dubtsova, Elena A AU - Kiryukova, Mariya A AU - Khatkov, Igor E AU - Bideeva, Tanya AU - Mickevicius, Artautas AU - Ramírez-Maldonado, Elena AU - Sallinen, Ville AU - Erőss, Bálint Mihály AU - Pécsi, Dániel AU - Szentesi, Andrea Ildikó AU - Párniczky, Andrea AU - Tiszlavicz, László AU - Hegyi, Péter TI - Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 11 PY - 2021 IS - 1 PG - 14 SN - 2045-2322 DO - 10.1038/s41598-020-80532-6 UR - https://m2.mtmt.hu/api/publication/31815619 ID - 31815619 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office [K116634, FK131864, FK124632, K128222]; Economic Development and Innovation Operative Programme Grant from the National Research, Development and Innovation Office [GINOP 2.3.2-15-2016-00048]; Human Resources Development Operational Programme Grant from the National Research, Development and Innovation Office [EFOP-3.6.2-16-2017-00006]; Hungarian Academy of Sciences [LP2014-10/2014]; Hungarian Academy of Sciences; Ministry for Innovation and Technology [UNKP-20-5] Funding text: The study was funded by Project Grants (K116634 to PH, FK131864 to AM, FK124632 to BCN and K128222 to LC), an Economic Development and Innovation Operative Programme Grant (GINOP 2.3.2-15-2016-00048 to PH) and a Human Resources Development Operational Programme Grant (EFOP-3.6.2-16-2017-00006 to PH) from the National Research, Development and Innovation Office, as well as a Momentum Grant from the Hungarian Academy of Sciences (LP2014-10/2014 to PH). Supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences (to AM) and by the UNKP-20-5 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund (to AM). AB - Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n = 983), recurrent AP (RAP, n = 270) and CP (n = 62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5 + was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3 + do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare. LA - English DB - MTMT ER - TY - JOUR AU - Pécsi, Dániel AU - Gódi, Szilárd AU - Hegyi, Péter AU - Hanák, Lilla AU - Szentesi, Andrea Ildikó AU - Altorjay, István AU - Bakucz, Tamás AU - Czakó, László AU - Kovács, György AU - Orbán-Szilágyi, Ákos AU - Pakodi, Ferenc AU - Patai, Árpád AU - Szepes, Zoltán AU - Gyökeres, Tibor Zoltán AU - Fejes, Roland AU - Dubravcsik, Zsolt AU - Vincze, Áron TI - ERCP is more challenging in cases of acute biliary pancreatitis than in acute cholangitis - Analysis of the Hungarian ERCP registry data JF - PANCREATOLOGY J2 - PANCREATOLOGY VL - 21 PY - 2021 IS - 1 SP - 59 EP - 63 PG - 5 SN - 1424-3903 DO - 10.1016/j.pan.2020.11.025 UR - https://m2.mtmt.hu/api/publication/31782996 ID - 31782996 N1 - Institute for Translational Medicine, Szentágothai Research Center, Medical School, University of Pécs, Pécs, Hungary Division of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary Second Department of Medicine, University of Debrecen, Debrecen, Hungary Department of Gastroenterology, Medical Centre Hungarian Defence Forces, Budapest, Hungary First Department of Medicine, University of Szeged, Szeged, Hungary First Department of Gastroenterology and Medicine, Markusovszky University Teaching Hospital, Szombathely, Hungary First Department of Medicine, Szent György University Teaching Hospital of County Fejér, Székesfehérvár, Hungary Bács-Kiskun County University Teaching Hospital, Kecskemét, Hungary Cited By :3 Export Date: 13 October 2023 CODEN: PANCC Correspondence Address: Vincze, Á.Ifjúság u. 13., Hungary; email: vincze.aron@pte.hu Chemicals/CAS: clopidogrel, 113665-84-2, 120202-66-6, 90055-48-4, 94188-84-8 Tradenames: SPSS, IBM, United States Manufacturers: IBM, United States AB - Endoscopic retrograde cholangiopancreatography (ERCP) is an important therapeutic modality in acute biliary pancreatitis (ABP) cases with cholangitis or ongoing common bile duct obstruction. Theoretically, inflammation of the surrounding tissues would result in a more difficult procedure. No previous studies examined this hypothesis.ABP and acute cholangitis (AC) without ABP cases were compared to assess difficulty of ERCP.The rate of successful biliary access, advanced cannulation method, adverse events, cannulation and fluoroscopy time were compared in 240 ABP cases and 250 AC cases without ABP. Previous papillotomy, altered gastroduodenal anatomy, and cases with biliary stricture were excluded.Significantly more pancreatic guidewire manipulation (adjusted odds ratio (aOR) 1.921 [1.241-2.974]) and prophylactic pancreatic stent use (aOR 4.687 [2.415-9.098]) were seen in the ABP than in AC group. Average cannulation time in the ABP patients (248 vs. 185 s; p = 0.043) were longer than in AC cases. No difference was found between biliary cannulation and adverse events rates.ERCP in ABP cases seem to be more challenging than in AC. Difficult biliary access is more frequent in the ABP cases which warrants the involvement of an experienced endoscopist. LA - English DB - MTMT ER - TY - JOUR AU - Pécsi, Dániel AU - Szakó, L AU - Altorjay, I AU - Czakó, L AU - Gódi, S AU - Gyökeres, Tibor Zoltán AU - Szepes, Z AU - Vincze, Á TI - ANALYSIS OF POST-ERCP PANCREATITIS RATES IN THE HUNGARIAN ERCP REGISTRY JF - ENDOSCOPY J2 - ENDOSCOPY VL - 52 PY - 2020 IS - S 01 SN - 0013-726X UR - https://m2.mtmt.hu/api/publication/32635519 ID - 32635519 LA - English DB - MTMT ER -