@article{MTMT:34566778, title = {A DIAGNÓZIS RÖGÖS ÚTJA. WHIPPLE-KÓR DIAGNOSZTIZÁLÁSA 18 ÉVES KÓRLEFOLYÁS UTÁN}, url = {https://m2.mtmt.hu/api/publication/34566778}, author = {Rétfalvi, G and Németh, Balázs and Kovács, V and Durcsán, H and Pécsi, Dániel and Almási, K and Pécsi, G}, journal-iso = {MBA}, journal = {MAGYAR BELORVOSI ARCHIVUM}, volume = {76}, unique-id = {34566778}, issn = {0133-5464}, year = {2023}, pages = {330-330}, orcid-numbers = {Németh, Balázs/0000-0001-5338-7577; Pécsi, Dániel/0000-0003-0499-6004} } @article{MTMT:33636629, title = {Suprapapillary Biliary Stents Have Longer Patency Times than Transpapillary Stents-A Systematic Review and Meta-Analysis.}, url = {https://m2.mtmt.hu/api/publication/33636629}, author = {Kovács, Norbert and Pécsi, Dániel and Sipos, Zoltán and Borbásné Farkas, Kornélia and Földi, Mária and Hegyi, Péter and Bajor, Judit and Erőss, Bálint Mihály and Márta, Katalin and Mikó, Alexandra and Rakonczay, Zoltán and Sarlós, Patrícia and Ábrahám, Szabolcs and Vincze, Áron}, doi = {10.3390/jcm12030898}, journal-iso = {J CLIN MED}, journal = {JOURNAL OF CLINICAL MEDICINE}, volume = {12}, unique-id = {33636629}, abstract = {Endoscopic biliary stent placement is a minimally invasive intervention for patients with biliary strictures. Stent patency and function time are crucial factors. Suprapapillary versus transpapillary stent positioning may contribute to stent function time, so a meta-analysis was performed in this comparison.A comprehensive literature search was conducted in the CENTRAL, Embase, and MEDLINE databases to find data on suprapapillary stent placement compared to the transpapillary method via endoscopic retrograde cholangiopancreatography in cases of biliary stenosis of any etiology and any stent type until December 2020. We carried out a meta-analysis focusing on the following outcomes: stent patency, stent migration, rate of cholangitis and pancreatitis, and other reported complications.Three prospective and ten retrospective studies involving 1028 patients were included. Suprapapillary stent placement appeared to be superior to transpapillary stent positioning in patency (weighted mean difference = 50.23 days, 95% CI: 8.56, 91.98; p = 0.0.018). In a subgroup analysis of malignant indications, suprapapillary positioning showed a lower rate of cholangitis (OR: 0.34, 95% CI: 0.13, 0.93; p = 0.036). Another subgroup analysis investigating metal stents in a suprapapillary position resulted in a lower rate of pancreatitis (OR: 0.16, 95% CI: 0.03, 0.95; p = 0.043) compared to transpapillary stent placement. There was no difference in stent migration rates between the two groups (OR: 0.67, 95% CI: 0.17, 2.72; p = 0.577).Based on our results, suprapapillary biliary stenting has longer stent patency. Moreover, the stent migration rate did not differ between the suprapapillary and transpapillary groups.}, keywords = {endoscopy; Stent; ERCP; intraductal; inside}, year = {2023}, eissn = {2077-0383}, orcid-numbers = {Pécsi, Dániel/0000-0003-0499-6004; Sipos, Zoltán/0000-0001-7845-8116; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427; Márta, Katalin/0000-0002-2213-4865; Rakonczay, Zoltán/0000-0002-1499-3416; Sarlós, Patrícia/0000-0002-5086-9455; Ábrahám, Szabolcs/0000-0002-2191-1714; Vincze, Áron/0000-0003-2217-7686} } @article{MTMT:32849790, title = {In-Hospital Patient Education Markedly Reduces Alcohol Consumption after Alcohol-Induced Acute Pancreatitis.}, url = {https://m2.mtmt.hu/api/publication/32849790}, author = {Nagy, Rita and Ocskay, Klementina and Váradi, Alex and Papp, Mária and Vitális, Zsuzsanna and Izbéki, Ferenc and Boros, Eszter and Gajdán, László and Szentesi, Andrea Ildikó and Erőss, Bálint Mihály and Hegyi, Péter Jenő and Vincze, Áron and Bajor, Judit and Sarlós, Patrícia and Mikó, Alexandra and Márta, Katalin and Pécsi, Dániel and Párniczky, Andrea and Hegyi, Péter}, doi = {10.3390/nu14102131}, journal-iso = {NUTRIENTS}, journal = {NUTRIENTS}, volume = {14}, unique-id = {32849790}, abstract = {Although excessive alcohol consumption is by far the most frequent cause of recurrent acute pancreatitis (AP) cases, specific therapy is still not well established to prevent recurrence. Generally, psychological therapy (e.g., brief intervention (BI)) is the cornerstone of cessation programs; however, it is not yet widely used in everyday practice. We conducted a post-hoc analysis of a prospectively collected database. Patients suffering from alcohol-induced AP between 2016 and 2021 received 30 min BI by a physician. Patient-reported alcohol consumption, serum gamma-glutamyl-transferase (GGT) level, and mean corpuscular volume (MCV) of red blood cells were collected on admission and at the 1-month follow-up visit to monitor patients' drinking habits. Ninety-nine patients with alcohol-induced AP were enrolled in the study (mean age: 50 ± 11, 89% male). A significant decrease was detected both in mean GGT value (294 ± 251 U/L vs. 103 ± 113 U/L, p < 0.001) and in MCV level (93.7 ± 5.3 U/L vs. 92.1 ± 5.1 U/L, p < 0.001) in patients with elevated on-admission GGT levels. Notably, 79% of the patients (78/99) reported alcohol abstinence at the 1-month control visit. Brief intervention is an effective tool to reduce alcohol consumption and to prevent recurrent AP. Longitudinal randomized clinical studies are needed to identify the adequate structure and frequency of BIs in alcohol-induced AP.}, keywords = {Recurrence; ALCOHOL; Acute pancreatitis; Brief intervention; gamma-glutamyl transferase}, year = {2022}, eissn = {2072-6643}, orcid-numbers = {Nagy, Rita/0000-0002-2663-4912; Ocskay, Klementina/0000-0001-5848-2506; Váradi, Alex/0000-0001-8229-6340; Papp, Mária/0000-0003-3662-4010; Vitális, Zsuzsanna/0000-0001-8198-5312; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Erőss, Bálint Mihály/0000-0003-3658-8427; Vincze, Áron/0000-0003-2217-7686; Sarlós, Patrícia/0000-0002-5086-9455; Márta, Katalin/0000-0002-2213-4865; Pécsi, Dániel/0000-0003-0499-6004; Hegyi, Péter/0000-0003-0399-7259} } @mastersthesis{MTMT:32619863, title = {Analysis of the quality indicators, advanced biliary cannulation techniques and difficulty of endoscopic retrograde cholangiopancreatography (ERCP)}, url = {https://m2.mtmt.hu/api/publication/32619863}, author = {Pécsi, Dániel}, publisher = {Pécsi Tudományegyetem}, unique-id = {32619863}, year = {2021}, orcid-numbers = {Pécsi, Dániel/0000-0003-0499-6004} } @article{MTMT:32602475, title = {Predictive Performance of Serum S100B Versus LDH in Melanoma Patients: a Systematic Review and Meta-Analysis}, url = {https://m2.mtmt.hu/api/publication/32602475}, author = {Janka, Eszter Anna and Várvölgyi, Tünde and Sipos, Zoltán and Soós, Alexandra and Hegyi, Péter and Kiss, Szabolcs and Dembrovszky, Fanni and Csupor, Dezső and Kéringer, Patrik and Pécsi, Dániel and Varjú-Solymár, Margit and Emri, Gabriella}, doi = {10.3389/fonc.2021.772165}, journal-iso = {FRONT ONCOL}, journal = {FRONTIERS IN ONCOLOGY}, volume = {11}, unique-id = {32602475}, issn = {2234-943X}, abstract = {Currently, no consensus on the use of blood tests for monitoring disease recurrence in patients with resected melanoma exists. The only meta-analysis conducted in 2008 found that elevated serum S100B levels were associated with significantly worse survival in melanoma patients. Serum LDH is an established prognostic factor in patients with advanced melanoma.To compare the discriminative and prognostic ability of serum S100B with that of serum LDH in patients with melanoma.This systematic review and meta-analysis were reported in accordance with the PRISMA Statement. The study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42019137138).A quantitative analysis of data from 6 eligible studies included 1,033 patients with cutaneous melanoma. The discriminative ability of serum S100B at identifying disease relapse [pooled Area Under the ROC (AUROC) 78.64 (95% CI 70.28; 87.01)] was significantly greater than the discriminative ability of serum LDH [AUROC 64.41 (95% CI 56.05; 7278)] (p=0.013). Ten eligible studies with 1,987 patients were included in the risk of death analysis. The prognostic performance of serum S100B [pooled estimate of adjusted hazard ratio (HR) 1.78 (95% CI 1.38; 2.29)] was independent but not superior to that of serum LDH [HR 1.60 (95% CI 1.36; 2.29)].A relatively small number of articles were eligible and there was considerable heterogeneity across the included studies.Serum biomarkers may provide relevant information on melanoma patient status and should be further researched. Serum S100B is a valid marker for diagnosis of melanoma recurrence.The study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42019137138).}, keywords = {Meta-analysis; S100B; Melanoma; COX; ROC; LDH}, year = {2021}, eissn = {2234-943X}, orcid-numbers = {Janka, Eszter Anna/0000-0003-0724-5281; Sipos, Zoltán/0000-0001-7845-8116; Hegyi, Péter/0000-0003-0399-7259; Dembrovszky, Fanni/0000-0001-6953-3591; Csupor, Dezső/0000-0002-4088-3333; Pécsi, Dániel/0000-0003-0499-6004; Varjú-Solymár, Margit/0000-0001-6667-6263} } @article{MTMT:32091062, title = {Glucose levels show independent and dose-dependent association with worsening acute pancreatitis outcomes: Post-hoc analysis of a prospective, international cohort of 2250 acute pancreatitis cases}, url = {https://m2.mtmt.hu/api/publication/32091062}, author = {Nagy, Anikó and Juhász, Márk Félix and Görbe, Anikó and Váradi, Alex and Izbéki, Ferenc and Vincze, Áron and Sarlós, Patrícia and Czimmer, József and Szepes, Zoltán and Takács, Tamás and Papp, Mária and Fehér, Eszter and Hamvas, József and Kárász, Klaudia and Török, Imola and Stimac, Davor and Poropat, Goran and Ince, Ali Tüzün and Erőss, Bálint Mihály and Márta, Katalin and Pécsi, Dániel and Illés, Dóra and Váncsa, Szilárd and Földi, Mária and Faluhelyi, Nándor and Farkas, Orsolya and Nagy, Tamás and Kanizsai, Péter László and Márton, Zsolt and Szentesi, Andrea Ildikó and Hegyi, Péter and Párniczky, Andrea}, doi = {10.1016/j.pan.2021.06.003}, journal-iso = {PANCREATOLOGY}, journal = {PANCREATOLOGY}, volume = {21}, unique-id = {32091062}, issn = {1424-3903}, year = {2021}, eissn = {1424-3911}, pages = {1237-1246}, orcid-numbers = {Váradi, Alex/0000-0001-8229-6340; Izbéki, Ferenc/0000-0001-7767-4319; Vincze, Áron/0000-0003-2217-7686; Sarlós, Patrícia/0000-0002-5086-9455; Czimmer, József/0000-0001-7831-3523; Szepes, Zoltán/0000-0002-9466-8719; Papp, Mária/0000-0003-3662-4010; Ince, Ali Tüzün/0000-0002-1627-4829; Erőss, Bálint Mihály/0000-0003-3658-8427; Márta, Katalin/0000-0002-2213-4865; Pécsi, Dániel/0000-0003-0499-6004; Váncsa, Szilárd/0000-0002-9347-8163; Nagy, Tamás/0000-0001-5437-1411; Kanizsai, Péter László/0000-0001-7896-2857; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:32021654, title = {Oral Proton Pump Inhibitors May Be as Effective as Intravenous in Peptic Ulcer Bleeding : A Systematic Review and Meta-analysis}, url = {https://m2.mtmt.hu/api/publication/32021654}, author = {Csiki, Endre and Szabó, Hanna and Hanák, Lilla and Szakács, Zsolt and Kiss, Szabolcs and Vörhendi, Nóra and Pécsi, Dániel and Hegyi, Eszter and Hegyi, Péter and Erőss, Bálint Mihály}, doi = {10.14309/ctg.0000000000000341}, journal-iso = {CLIN TRANSLAT GASTROENT}, journal = {CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY}, volume = {12}, unique-id = {32021654}, abstract = {Current guidelines recommend intravenous (IV) proton pump inhibitor (PPI) therapy in peptic ulcer bleeding (PUB). We aimed to compare the efficacy of oral and IV administration of PPIs in PUB.We performed a systematic search in 4 databases for randomized controlled trials, which compared the outcomes of oral PPI therapy with IV PPI therapy for PUB. The primary outcomes were 30-day recurrent bleeding and 30-day mortality. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for dichotomous outcomes, while weighted mean differences (WMDs) with CI were calculated for continuous outcomes in meta-analysis. The protocol was registered a priori onto PROSPERO (CRD42020155852).A total of 14 randomized controlled trials reported 1,951 peptic ulcer patients, 977 and 974 of which were in the control and intervention groups, respectively. There were no statistically significant differences between oral and IV administration regarding 30-day rebleeding rate (OR = 0.96, CI: 0.65-1.44); 30-day mortality (OR = 0.70, CI: 0.35-1.40); length of hospital stay (WMD = -0.25, CI: -0.93 to -0.42); transfusion requirements (WMD = -0.09, CI: -0.07 to 0.24); need for surgery (OR = 0.91, CI: 0.40-2.07); further endoscopic therapy (OR = 1.04, CI: 0.56-1.93); and need for re-endoscopy (OR = 0.81, CI: 0.52-1.28). Heterogeneity was negligible in all analysis, except for the analysis on the length of hospitalization (I2 = 82.3%, P = 0.001).Recent evidence suggests that the oral administration of PPI is not inferior to the IV PPI treatment in PUB after endoscopic management, but further studies are warranted.}, year = {2021}, eissn = {2155-384X}, orcid-numbers = {Szakács, Zsolt/0000-0002-7035-941X; Pécsi, Dániel/0000-0003-0499-6004; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427} } @article{MTMT:31815619, title = {Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model}, url = {https://m2.mtmt.hu/api/publication/31815619}, author = {Hegyi, Péter Jenő and Soós, Alexandra and Tóth, Emese and Ébert, Attila and Venglovecz, Viktória and Márta, Katalin and Mátrai, Péter and Mikó, Alexandra and Bajor, Judit and Sarlós, Patrícia and Vincze, Áron and Szabó-Halász, Adrienn and Izbéki, Ferenc and Szepes, Zoltán and Czakó, László and Kovács, György and Papp, Mária and Dubravcsik, Zsolt and Varga, Márta and Hamvas, József and Németh, Balázs and Macarie, Melania and Ince, Ali Tüzün and Bordin, Dmitry S and Dubtsova, Elena A and Kiryukova, Mariya A and Khatkov, Igor E and Bideeva, Tanya and Mickevicius, Artautas and Ramírez-Maldonado, Elena and Sallinen, Ville and Erőss, Bálint Mihály and Pécsi, Dániel and Szentesi, Andrea Ildikó and Párniczky, Andrea and Tiszlavicz, László and Hegyi, Péter}, doi = {10.1038/s41598-020-80532-6}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {11}, unique-id = {31815619}, issn = {2045-2322}, abstract = {Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n = 983), recurrent AP (RAP, n = 270) and CP (n = 62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5 + was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3 + do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare.}, year = {2021}, eissn = {2045-2322}, orcid-numbers = {Venglovecz, Viktória/0000-0002-2316-7247; Márta, Katalin/0000-0002-2213-4865; Sarlós, Patrícia/0000-0002-5086-9455; Vincze, Áron/0000-0003-2217-7686; Izbéki, Ferenc/0000-0001-7767-4319; Szepes, Zoltán/0000-0002-9466-8719; Czakó, László/0000-0002-6331-0802; Papp, Mária/0000-0003-3662-4010; Dubravcsik, Zsolt/0000-0002-7231-3300; Németh, Balázs/0000-0001-5338-7577; Erőss, Bálint Mihály/0000-0003-3658-8427; Pécsi, Dániel/0000-0003-0499-6004; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Tiszlavicz, László/0000-0003-1134-6587; Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:31782996, title = {ERCP is more challenging in cases of acute biliary pancreatitis than in acute cholangitis - Analysis of the Hungarian ERCP registry data}, url = {https://m2.mtmt.hu/api/publication/31782996}, author = {Pécsi, Dániel and Gódi, Szilárd and Hegyi, Péter and Hanák, Lilla and Szentesi, Andrea Ildikó and Altorjay, István and Bakucz, Tamás and Czakó, László and Kovács, György and Orbán-Szilágyi, Ákos and Pakodi, Ferenc and Patai, Árpád and Szepes, Zoltán and Gyökeres, Tibor Zoltán and Fejes, Roland and Dubravcsik, Zsolt and Vincze, Áron}, doi = {10.1016/j.pan.2020.11.025}, journal-iso = {PANCREATOLOGY}, journal = {PANCREATOLOGY}, volume = {21}, unique-id = {31782996}, issn = {1424-3903}, abstract = {Endoscopic retrograde cholangiopancreatography (ERCP) is an important therapeutic modality in acute biliary pancreatitis (ABP) cases with cholangitis or ongoing common bile duct obstruction. Theoretically, inflammation of the surrounding tissues would result in a more difficult procedure. No previous studies examined this hypothesis.ABP and acute cholangitis (AC) without ABP cases were compared to assess difficulty of ERCP.The rate of successful biliary access, advanced cannulation method, adverse events, cannulation and fluoroscopy time were compared in 240 ABP cases and 250 AC cases without ABP. Previous papillotomy, altered gastroduodenal anatomy, and cases with biliary stricture were excluded.Significantly more pancreatic guidewire manipulation (adjusted odds ratio (aOR) 1.921 [1.241-2.974]) and prophylactic pancreatic stent use (aOR 4.687 [2.415-9.098]) were seen in the ABP than in AC group. Average cannulation time in the ABP patients (248 vs. 185 s; p = 0.043) were longer than in AC cases. No difference was found between biliary cannulation and adverse events rates.ERCP in ABP cases seem to be more challenging than in AC. Difficult biliary access is more frequent in the ABP cases which warrants the involvement of an experienced endoscopist.}, keywords = {endoscopic retrograde cholangiopancreatography; acute biliary pancreatitis; DIFFICULTY; acute cholangitis; Advanced cannulation}, year = {2021}, eissn = {1424-3911}, pages = {59-63}, orcid-numbers = {Pécsi, Dániel/0000-0003-0499-6004; Hegyi, Péter/0000-0003-0399-7259; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Czakó, László/0000-0002-6331-0802; Szepes, Zoltán/0000-0002-9466-8719; Dubravcsik, Zsolt/0000-0002-7231-3300; Vincze, Áron/0000-0003-2217-7686} } @article{MTMT:32635519, title = {ANALYSIS OF POST-ERCP PANCREATITIS RATES IN THE HUNGARIAN ERCP REGISTRY}, url = {https://m2.mtmt.hu/api/publication/32635519}, author = {Pécsi, Dániel and Szakó, L and Altorjay, I and Czakó, L and Gódi, S and Gyökeres, Tibor Zoltán and Szepes, Z and Vincze, Á}, journal-iso = {ENDOSCOPY}, journal = {ENDOSCOPY}, volume = {52}, unique-id = {32635519}, issn = {0013-726X}, year = {2020}, eissn = {1438-8812}, orcid-numbers = {Pécsi, Dániel/0000-0003-0499-6004} }