TY - JOUR AU - Eszlári, Nóra AU - Hullám, Gábor István AU - Gál, Zsófia AU - Török, Dóra AU - Nagy, Tamás AU - Millinghoffer, András Dániel AU - Baksa, Dániel AU - Gonda, Xénia AU - Antal, Péter AU - Bagdy, György AU - Juhász, Gabriella TI - Olfactory genes affect major depression in highly educated, emotionally stable, lean women: a bridge between animal models and precision medicine JF - TRANSLATIONAL PSYCHIATRY J2 - TRANSL PSYCHIAT VL - 14 PY - 2024 IS - 1 PG - 10 SN - 2158-3188 DO - 10.1038/s41398-024-02867-2 UR - https://m2.mtmt.hu/api/publication/34779723 ID - 34779723 N1 - Funding Agency and Grant Number: Hungarian National Research, Development, and Innovation Office [K 139330, K 143391, PD 146014, 2019-2.1.7-ERA-NET-2020-00005, ERAPERMED2019-108]; Hungarian Brain Research Program [2017-1.2.1-NKP-2017-00002]; Hungarian Brain Research Program 3.0 [NAP2022-I-4/2022, TKP2021-EGA-25]; Ministry of Innovation and Technology of Hungary National Research, Development and Innovation Fund [TKP2021-EGA-25]; National Research, Development, and Innovation Fund of Hungary [TKP2021-EGA-02]; European Union [RRF-2.3.1-21-2022-00004]; New National Excellence Program of the Ministry for Culture and Innovation National Research, Development and Innovation Fund [UNKP-23-4-II-SE-2]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences; Semmelweis University; [UNKP-22-4-II-SE-1] Funding text: This study was supported by the Hungarian National Research, Development, and Innovation Office, with grants K 139330, K 143391, and PD 146014, as well as 2019-2.1.7-ERA-NET-2020-00005 under the frame of ERA PerMed (ERAPERMED2019-108); by the Hungarian Brain Research Program (grant: 2017-1.2.1-NKP-2017-00002) and the Hungarian Brain Research Program 3.0 (NAP2022-I-4/2022); and by TKP2021-EGA-25, implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme. It was also supported by the National Research, Development, and Innovation Fund of Hungary under Grant TKP2021-EGA-02 and the European Union project RRF-2.3.1-21-2022-00004 within the framework of the Artificial Intelligence National Laboratory. NE was supported by the UNKP-22-4-II-SE-1, and DB by the UNKP-23-4-II-SE-2 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. NE is supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. This work uses data provided by patients and collected by the NHS as part of their care and support. Copyright (c) (2019), NHS England. Re-used with the permission of the UK Biobank (Application Number 1602). All rights reserved.Open access funding provided by Semmelweis University. AB - Most current approaches to establish subgroups of depressed patients for precision medicine aim to rely on biomarkers that require highly specialized assessment. Our present aim was to stratify participants of the UK Biobank cohort based on three readily measurable common independent risk factors, and to investigate depression genomics in each group to discover common and separate biological etiology. Two-step cluster analysis was run separately in males ( n = 149,879) and females ( n = 174,572), with neuroticism (a tendency to experience negative emotions), body fat percentage, and years spent in education as input variables. Genome-wide association analyses were implemented within each of the resulting clusters, for the lifetime occurrence of either a depressive episode or recurrent depressive disorder as the outcome. Variant-based, gene-based, gene set-based, and tissue-specific gene expression test were applied. Phenotypically distinct clusters with high genetic intercorrelations in depression genomics were found. A two-cluster solution was the best model in each sex with some differences including the less important role of neuroticism in males. In females, in case of a protective pattern of low neuroticism, low body fat percentage, and high level of education, depression was associated with pathways related to olfactory function. While also in females but in a risk pattern of high neuroticism, high body fat percentage, and less years spent in education, depression showed association with complement system genes. Our results, on one hand, indicate that alteration of olfactory pathways, that can be paralleled to the well-known rodent depression models of olfactory bulbectomy, might be a novel target towards precision psychiatry in females with less other risk factors for depression. On the other hand, our results in multi-risk females may provide a special case of immunometabolic depression. LA - English DB - MTMT ER - TY - JOUR AU - Kumar, Sahel AU - Gecse, Kinga AU - Baksa, Dániel AU - Bagdy, György AU - Juhász, Gabriella AU - Petschner, Péter TI - Uncovering Potential Interictal Suppression of ERK Cascade and miR-21 in Migraine Patients: Insights from RNA-Seq Analysis JF - CEPHALALGIA J2 - CEPHALALGIA VL - 43 PY - 2023 IS - IHC Abstracts SP - 76 EP - 77 PG - 2 SN - 0333-1024 UR - https://m2.mtmt.hu/api/publication/34631775 ID - 34631775 LA - English DB - MTMT ER - TY - JOUR AU - Dobos, Dóra AU - Gecse, Kinga AU - Szabó, Edina AU - Baksa, Dániel AU - Kocsel, Natália AU - Galambos, Attila AU - Kökönyei, Gyöngyi AU - Juhász, Gabriella TI - Headache-Related Quality of Life Associates Differently with Emotional Processing in Migraine and Tension-Type Headache Patients – an fMRI Study JF - CEPHALALGIA J2 - CEPHALALGIA VL - 43 PY - 2023 IS - IHC Abstracts SP - 196 EP - 197 PG - 2 SN - 0333-1024 UR - https://m2.mtmt.hu/api/publication/34631657 ID - 34631657 LA - English DB - MTMT ER - TY - JOUR AU - Dobos, Dóra AU - Kökönyei, Gyöngyi AU - Gyebnár, Gyula AU - Szabó, Edina AU - Kocsel, Natália AU - Galambos, Attila AU - Gecse, Kinga AU - Baksa, Dániel AU - Kozák, Lajos Rudolf AU - Juhász, Gabriella TI - Microstructural differences in migraine: A diffusion-tensor imaging study JF - CEPHALALGIA J2 - CEPHALALGIA VL - 43 PY - 2023 IS - 12 PG - 9 SN - 0333-1024 DO - 10.1177/03331024231216456 UR - https://m2.mtmt.hu/api/publication/34474549 ID - 34474549 LA - English DB - MTMT ER - TY - JOUR AU - Juhász, Gabriella AU - Gecse, Kinga AU - Baksa, Dániel TI - Towards precision medicine in migraine: Recent therapeutic advances and potential biomarkers to understand heterogeneity and treatment response JF - PHARMACOLOGY & THERAPEUTICS J2 - PHARMACOL THERAPEUT VL - 250 PY - 2023 PG - 23 SN - 0163-7258 DO - 10.1016/j.pharmthera.2023.108523 UR - https://m2.mtmt.hu/api/publication/34129172 ID - 34129172 N1 - Equally contributed: Gecse Kinga, Baksa Dániel LA - English DB - MTMT ER - TY - GEN AU - Kumar, Sahel AU - Gecse, Kinga AU - Baksa, Dániel AU - Bagdy, György AU - Juhász, Gabriella AU - Petschner, Péter TI - Exploring the Effects of Citalopram on Gene Expression and the Serotonergic Receptor Pathway: A Neuroendocrine Challenge Study PY - 2023 UR - https://m2.mtmt.hu/api/publication/34091518 ID - 34091518 LA - English DB - MTMT ER - TY - GEN AU - Eszlári, Nóra AU - Hullam, Gabor AU - Gál, Zsófia AU - Török, Dóra AU - Nagy, Tamás AU - Millinghoffer, Andras AU - Baksa, Dániel AU - Antal, Péter AU - Bagdy, György AU - Juhász, Gabriella TI - Olfactory Receptors as a Potential Pathomechanism for Depression When No Classic Risk Factors Are Present in Women? Genomic Results from the UK Biobank Cohort PY - 2023 UR - https://m2.mtmt.hu/api/publication/34091468 ID - 34091468 LA - English DB - MTMT ER - TY - GEN AU - Dobos, Dóra AU - Kökönyei, Gyöngyi AU - G., Gyebnár AU - Gecse, Kinga AU - Szabó, Edina AU - Baksa, Dániel AU - Kocsel, Natália AU - Galambos, Attila AU - Zsombók, Terézia Ibolya AU - L. R., Kozák AU - Juhász, Gabriella TI - Microstructural Differences in Migraine: a Diffusion-Tensor Imaging Study PY - 2023 UR - https://m2.mtmt.hu/api/publication/34091434 ID - 34091434 LA - English DB - MTMT ER - TY - GEN AU - Baksa, Dániel AU - Eszlári, Nóra AU - Török, Dóra AU - Juhász, Gabriella TI - Chronotype Affects Physical and Mental Health Status of Migraineurs PY - 2023 UR - https://m2.mtmt.hu/api/publication/34091418 ID - 34091418 LA - English DB - MTMT ER - TY - JOUR AU - Dobos, Dóra AU - Kökönyei, Gyöngyi AU - Gyebnár, G. AU - Gecse, Kinga AU - Szabó, Edina AU - Baksa, Dániel AU - Kocsel, Natália AU - Galambos, Attila AU - Zsombók, Terézia Ibolya AU - Kozák, L.R. AU - Juhász, Gabriella TI - Microstructural differences in migraine: a diffusion tensor imaging study JF - NEUROSCIENCE APPLIED J2 - NEUROSCI APPL VL - 2 PY - 2023 IS - Supplement 1 SP - P.331 SN - 2772-4085 DO - 10.1016/j.nsa.2023.101105 UR - https://m2.mtmt.hu/api/publication/34004707 ID - 34004707 N1 - European Neuropsychopharmacology Workshop for Early Career Scientists in Europe 2023.03.16.-2023.03.19. France, Nice LA - English DB - MTMT ER -