@article{MTMT:34779723, title = {Olfactory genes affect major depression in highly educated, emotionally stable, lean women: a bridge between animal models and precision medicine}, url = {https://m2.mtmt.hu/api/publication/34779723}, author = {Eszlári, Nóra and Hullám, Gábor István and Gál, Zsófia and Török, Dóra and Nagy, Tamás and Millinghoffer, András Dániel and Baksa, Dániel and Gonda, Xénia and Antal, Péter and Bagdy, György and Juhász, Gabriella}, doi = {10.1038/s41398-024-02867-2}, journal-iso = {TRANSL PSYCHIAT}, journal = {TRANSLATIONAL PSYCHIATRY}, volume = {14}, unique-id = {34779723}, issn = {2158-3188}, abstract = {Most current approaches to establish subgroups of depressed patients for precision medicine aim to rely on biomarkers that require highly specialized assessment. Our present aim was to stratify participants of the UK Biobank cohort based on three readily measurable common independent risk factors, and to investigate depression genomics in each group to discover common and separate biological etiology. Two-step cluster analysis was run separately in males ( n = 149,879) and females ( n = 174,572), with neuroticism (a tendency to experience negative emotions), body fat percentage, and years spent in education as input variables. Genome-wide association analyses were implemented within each of the resulting clusters, for the lifetime occurrence of either a depressive episode or recurrent depressive disorder as the outcome. Variant-based, gene-based, gene set-based, and tissue-specific gene expression test were applied. Phenotypically distinct clusters with high genetic intercorrelations in depression genomics were found. A two-cluster solution was the best model in each sex with some differences including the less important role of neuroticism in males. In females, in case of a protective pattern of low neuroticism, low body fat percentage, and high level of education, depression was associated with pathways related to olfactory function. While also in females but in a risk pattern of high neuroticism, high body fat percentage, and less years spent in education, depression showed association with complement system genes. Our results, on one hand, indicate that alteration of olfactory pathways, that can be paralleled to the well-known rodent depression models of olfactory bulbectomy, might be a novel target towards precision psychiatry in females with less other risk factors for depression. On the other hand, our results in multi-risk females may provide a special case of immunometabolic depression.}, year = {2024}, eissn = {2158-3188}, orcid-numbers = {Eszlári, Nóra/0000-0003-4913-028X; Hullám, Gábor István/0000-0002-4765-2351; Gál, Zsófia/0000-0002-9441-1497; Török, Dóra/0000-0001-9213-4345; Nagy, Tamás/0000-0002-0137-4341; Baksa, Dániel/0000-0002-7826-9179; Gonda, Xénia/0000-0001-9015-4203; Bagdy, György/0000-0001-8141-3410; Juhász, Gabriella/0000-0002-5975-4267} } @article{MTMT:34631775, title = {Uncovering Potential Interictal Suppression of ERK Cascade and miR-21 in Migraine Patients: Insights from RNA-Seq Analysis}, url = {https://m2.mtmt.hu/api/publication/34631775}, author = {Kumar, Sahel and Gecse, Kinga and Baksa, Dániel and Bagdy, György and Juhász, Gabriella and Petschner, Péter}, journal-iso = {CEPHALALGIA}, journal = {CEPHALALGIA}, volume = {43}, unique-id = {34631775}, issn = {0333-1024}, year = {2023}, eissn = {1468-2982}, pages = {76-77}, orcid-numbers = {Kumar, Sahel/0000-0003-2108-2992; Gecse, Kinga/0000-0002-3512-2572; Baksa, Dániel/0000-0002-7826-9179; Bagdy, György/0000-0001-8141-3410; Juhász, Gabriella/0000-0002-5975-4267; Petschner, Péter/0000-0002-3198-858X} } @article{MTMT:34631657, title = {Headache-Related Quality of Life Associates Differently with Emotional Processing in Migraine and Tension-Type Headache Patients – an fMRI Study}, url = {https://m2.mtmt.hu/api/publication/34631657}, author = {Dobos, Dóra and Gecse, Kinga and Szabó, Edina and Baksa, Dániel and Kocsel, Natália and Galambos, Attila and Kökönyei, Gyöngyi and Juhász, Gabriella}, journal-iso = {CEPHALALGIA}, journal = {CEPHALALGIA}, volume = {43}, unique-id = {34631657}, issn = {0333-1024}, year = {2023}, eissn = {1468-2982}, pages = {196-197}, orcid-numbers = {Dobos, Dóra/0000-0002-2291-8854; Gecse, Kinga/0000-0002-3512-2572; Szabó, Edina/0000-0003-4087-5373; Baksa, Dániel/0000-0002-7826-9179; Kocsel, Natália/0000-0001-6892-796X; Galambos, Attila/0000-0002-4587-9288; Kökönyei, Gyöngyi/0000-0001-6750-2644; Juhász, Gabriella/0000-0002-5975-4267} } @article{MTMT:34474549, title = {Microstructural differences in migraine: A diffusion-tensor imaging study}, url = {https://m2.mtmt.hu/api/publication/34474549}, author = {Dobos, Dóra and Kökönyei, Gyöngyi and Gyebnár, Gyula and Szabó, Edina and Kocsel, Natália and Galambos, Attila and Gecse, Kinga and Baksa, Dániel and Kozák, Lajos Rudolf and Juhász, Gabriella}, doi = {10.1177/03331024231216456}, journal-iso = {CEPHALALGIA}, journal = {CEPHALALGIA}, volume = {43}, unique-id = {34474549}, issn = {0333-1024}, year = {2023}, eissn = {1468-2982}, orcid-numbers = {Dobos, Dóra/0000-0002-2291-8854; Kökönyei, Gyöngyi/0000-0001-6750-2644; Szabó, Edina/0000-0003-4087-5373; Kocsel, Natália/0000-0001-6892-796X; Galambos, Attila/0000-0002-4587-9288; Gecse, Kinga/0000-0002-3512-2572; Baksa, Dániel/0000-0002-7826-9179; Kozák, Lajos Rudolf/0000-0003-0368-3663; Juhász, Gabriella/0000-0002-5975-4267} } @article{MTMT:34129172, title = {Towards precision medicine in migraine: Recent therapeutic advances and potential biomarkers to understand heterogeneity and treatment response}, url = {https://m2.mtmt.hu/api/publication/34129172}, author = {Juhász, Gabriella and Gecse, Kinga and Baksa, Dániel}, doi = {10.1016/j.pharmthera.2023.108523}, journal-iso = {PHARMACOL THERAPEUT}, journal = {PHARMACOLOGY & THERAPEUTICS}, volume = {250}, unique-id = {34129172}, issn = {0163-7258}, year = {2023}, eissn = {1879-016X}, orcid-numbers = {Juhász, Gabriella/0000-0002-5975-4267; Gecse, Kinga/0000-0002-3512-2572; Baksa, Dániel/0000-0002-7826-9179} } @misc{MTMT:34091518, title = {Exploring the Effects of Citalopram on Gene Expression and the Serotonergic Receptor Pathway: A Neuroendocrine Challenge Study}, url = {https://m2.mtmt.hu/api/publication/34091518}, author = {Kumar, Sahel and Gecse, Kinga and Baksa, Dániel and Bagdy, György and Juhász, Gabriella and Petschner, Péter}, unique-id = {34091518}, year = {2023}, orcid-numbers = {Kumar, Sahel/0000-0003-2108-2992; Gecse, Kinga/0000-0002-3512-2572; Baksa, Dániel/0000-0002-7826-9179; Bagdy, György/0000-0001-8141-3410; Juhász, Gabriella/0000-0002-5975-4267; Petschner, Péter/0000-0002-3198-858X} } @misc{MTMT:34091468, title = {Olfactory Receptors as a Potential Pathomechanism for Depression When No Classic Risk Factors Are Present in Women? Genomic Results from the UK Biobank Cohort}, url = {https://m2.mtmt.hu/api/publication/34091468}, author = {Eszlári, Nóra and Hullam, Gabor and Gál, Zsófia and Török, Dóra and Nagy, Tamás and Millinghoffer, Andras and Baksa, Dániel and Antal, Péter and Bagdy, György and Juhász, Gabriella}, unique-id = {34091468}, year = {2023}, orcid-numbers = {Eszlári, Nóra/0000-0003-4913-028X; Gál, Zsófia/0000-0002-9441-1497; Török, Dóra/0000-0001-9213-4345; Nagy, Tamás/0000-0002-0137-4341; Baksa, Dániel/0000-0002-7826-9179; Bagdy, György/0000-0001-8141-3410; Juhász, Gabriella/0000-0002-5975-4267} } @misc{MTMT:34091434, title = {Microstructural Differences in Migraine: a Diffusion-Tensor Imaging Study}, url = {https://m2.mtmt.hu/api/publication/34091434}, author = {Dobos, Dóra and Kökönyei, Gyöngyi and G., Gyebnár and Gecse, Kinga and Szabó, Edina and Baksa, Dániel and Kocsel, Natália and Galambos, Attila and Zsombók, Terézia Ibolya and L. R., Kozák and Juhász, Gabriella}, unique-id = {34091434}, year = {2023}, orcid-numbers = {Dobos, Dóra/0000-0002-2291-8854; Kökönyei, Gyöngyi/0000-0001-6750-2644; Gecse, Kinga/0000-0002-3512-2572; Szabó, Edina/0000-0003-4087-5373; Baksa, Dániel/0000-0002-7826-9179; Kocsel, Natália/0000-0001-6892-796X; Galambos, Attila/0000-0002-4587-9288; Zsombók, Terézia Ibolya/0000-0002-7535-0465; Juhász, Gabriella/0000-0002-5975-4267} } @misc{MTMT:34091418, title = {Chronotype Affects Physical and Mental Health Status of Migraineurs}, url = {https://m2.mtmt.hu/api/publication/34091418}, author = {Baksa, Dániel and Eszlári, Nóra and Török, Dóra and Juhász, Gabriella}, unique-id = {34091418}, year = {2023}, orcid-numbers = {Baksa, Dániel/0000-0002-7826-9179; Eszlári, Nóra/0000-0003-4913-028X; Török, Dóra/0000-0001-9213-4345; Juhász, Gabriella/0000-0002-5975-4267} } @article{MTMT:34004707, title = {Microstructural differences in migraine: a diffusion tensor imaging study}, url = {https://m2.mtmt.hu/api/publication/34004707}, author = {Dobos, Dóra and Kökönyei, Gyöngyi and Gyebnár, G. and Gecse, Kinga and Szabó, Edina and Baksa, Dániel and Kocsel, Natália and Galambos, Attila and Zsombók, Terézia Ibolya and Kozák, L.R. and Juhász, Gabriella}, doi = {10.1016/j.nsa.2023.101105}, journal-iso = {NEUROSCI APPL}, journal = {NEUROSCIENCE APPLIED}, volume = {2}, unique-id = {34004707}, issn = {2772-4085}, year = {2023}, pages = {P.331}, orcid-numbers = {Dobos, Dóra/0000-0002-2291-8854; Kökönyei, Gyöngyi/0000-0001-6750-2644; Gecse, Kinga/0000-0002-3512-2572; Szabó, Edina/0000-0003-4087-5373; Baksa, Dániel/0000-0002-7826-9179; Kocsel, Natália/0000-0001-6892-796X; Galambos, Attila/0000-0002-4587-9288; Zsombók, Terézia Ibolya/0000-0002-7535-0465; Juhász, Gabriella/0000-0002-5975-4267} }