TY  - THES
AU  - Farkas, Balázs
TI  - Váltóáramú elektrosztatikus szálképzés gyógyszertechnológiai alkalmazása
PB  - Budapesti Műszaki és Gazdaságtudományi Egyetem
PY  - 2021
SP  - 133
UR  - https://m2.mtmt.hu/api/publication/32217334
ID  - 32217334
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Farkas, Balázs
AU  - Balogh, Attila
AU  - Farkas, Attila
AU  - Marosi, György
AU  - Nagy, Zsombor Kristóf
TI  - Frequency and waveform dependence of alternating current electrospinning and their uses for drug dissolution enhancement
JF  - INTERNATIONAL JOURNAL OF PHARMACEUTICS
J2  - INT J PHARM
VL  - 586
PY  - 2020
PG  - 9
SN  - 0378-5173
DO  - 10.1016/j.ijpharm.2020.119593
UR  - https://m2.mtmt.hu/api/publication/31451305
ID  - 31451305
N1  - Funding Agency and Grant Number: National Research Development and Innovation (Higher Education and Industrial Cooperation Center) project [FIEK_16-1-2016-0007]; OTKAOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [121051, 132133]; New National Excellence Program of the Ministry of Human Capacities [UNKP-18-3, UNKP-18-4-BME-95]; Janos Bolyai Research ScholarshipHungarian Academy of Sciences; PREMIUM post-doctorate research program of the Hungarian Academy of Sciences; Gedeon Richter's Talentum Foundation
            Funding text: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, OTKA 132133, UNKP-18-3, UNKP-18-4-BME-95, New National Excellence Program of the Ministry of Human Capacities, the Janos Bolyai Research Scholarship and the PREMIUM post-doctorate research program of the Hungarian Academy of Sciences. Supported by Gedeon Richter's Talentum Foundation.
Export Date: 23 April 2021            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.1111 Budapest, Budafoki út 8, Hungary; email: baloghattila5@gmail.com
Export Date: 26 April 2021            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.1111 Budapest, Budafoki út 8, Hungary; email: baloghattila5@gmail.com
Cited By :1            
            Export Date: 6 September 2021            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.1111 Budapest, Budafoki út 8, Hungary; email: baloghattila5@gmail.com            
            Chemicals/CAS: dodecyl sulfate sodium, 151-21-3; macrogol, 25322-68-3; povidone, 9003-39-8; spironolactone, 52-01-7; vinyl acetate, 108-05-4; Polyethylene Glycols; Polymers; Povidone            
            Manufacturers: Sigma Aldrich, Hungary            
            Funding details: 121051, OTKA 132133, ÚNKP-18-3, ÚNKP-18-4-BME-95            
            Funding details: Hungarian Scientific Research Fund, OTKA, 132133            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI            
            Funding details: Richter Gedeon Talentum Alapítvány            
            Funding text 1: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, OTKA 132133, ÚNKP-18-3, ÚNKP-18-4-BME-95, New National Excellence Program of the Ministry of Human Capacities, the János Bolyai Research Scholarship and the PREMIUM post-doctorate research program of the Hungarian Academy of Sciences. Supported by Gedeon Richter’s Talentum Foundation.            
            Funding text 2: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, OTKA 132133, ?NKP-18-3, ?NKP-18-4-BME-95, New National Excellence Program of the Ministry of Human Capacities, the J?nos Bolyai Research Scholarship and the PREMIUM post-doctorate research program of the Hungarian Academy of Sciences. Supported by Gedeon Richter's Talentum Foundation.
Cited By :1            
            Export Date: 7 September 2021            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.1111 Budapest, Budafoki út 8, Hungary; email: baloghattila5@gmail.com            
            Chemicals/CAS: dodecyl sulfate sodium, 151-21-3; macrogol, 25322-68-3; povidone, 9003-39-8; spironolactone, 52-01-7; vinyl acetate, 108-05-4; Polyethylene Glycols; Polymers; Povidone            
            Manufacturers: Sigma Aldrich, Hungary            
            Funding details: 121051, OTKA 132133, ÚNKP-18-3, ÚNKP-18-4-BME-95            
            Funding details: Hungarian Scientific Research Fund, OTKA, 132133            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI            
            Funding details: Richter Gedeon Talentum Alapítvány            
            Funding text 1: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, OTKA 132133, ÚNKP-18-3, ÚNKP-18-4-BME-95, New National Excellence Program of the Ministry of Human Capacities, the János Bolyai Research Scholarship and the PREMIUM post-doctorate research program of the Hungarian Academy of Sciences. Supported by Gedeon Richter’s Talentum Foundation.            
            Funding text 2: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, OTKA 132133, ?NKP-18-3, ?NKP-18-4-BME-95, New National Excellence Program of the Ministry of Human Capacities, the J?nos Bolyai Research Scholarship and the PREMIUM post-doctorate research program of the Hungarian Academy of Sciences. Supported by Gedeon Richter's Talentum Foundation.
Cited By :1            
            Export Date: 8 September 2021            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.1111 Budapest, Budafoki út 8, Hungary; email: baloghattila5@gmail.com            
            Chemicals/CAS: dodecyl sulfate sodium, 151-21-3; macrogol, 25322-68-3; povidone, 9003-39-8; spironolactone, 52-01-7; vinyl acetate, 108-05-4; Polyethylene Glycols; Polymers; Povidone            
            Manufacturers: Sigma Aldrich, Hungary            
            Funding details: 121051, OTKA 132133, ÚNKP-18-3, ÚNKP-18-4-BME-95            
            Funding details: Hungarian Scientific Research Fund, OTKA, 132133            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI            
            Funding details: Richter Gedeon Talentum Alapítvány            
            Funding text 1: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, OTKA 132133, ÚNKP-18-3, ÚNKP-18-4-BME-95, New National Excellence Program of the Ministry of Human Capacities, the János Bolyai Research Scholarship and the PREMIUM post-doctorate research program of the Hungarian Academy of Sciences. Supported by Gedeon Richter’s Talentum Foundation.            
            Funding text 2: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, OTKA 132133, ?NKP-18-3, ?NKP-18-4-BME-95, New National Excellence Program of the Ministry of Human Capacities, the J?nos Bolyai Research Scholarship and the PREMIUM post-doctorate research program of the Hungarian Academy of Sciences. Supported by Gedeon Richter's Talentum Foundation.
AB  - The effect of different frequencies and waveforms was investigated for the first time on alternating current electrospinning (ACES). PVPVA64, a polyvinylpyrrolidone-vinyl acetate copolymer was selected for the experiments as an important matrix for amorphous solid dispersions but never processed with ACES. It has been proved that ACES could be operated in a wide range of frequencies (40-250 Hz) and using different waveforms (sinusoidal, square, triangle, saw tooth) without significant changes in fiber morphology. Nevertheless, deterioration of the fiber formation process could be also observed especially at high frequencies. The developed PVPVA64-based fibers containing small amounts of additives (polyethylene oxide (PEO) and sodium dodecyl sulfate (SDS)) served as an excellent carrier for spironolactone (SPIR), a poorly soluble antihypertensive drug. As a result of the amorphously dispersed SPIR and the large surface area of the AC electrospun fibers immediate drug release could be achieved.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - He, Haijun
AU  - Wang, Yimeng
AU  - Farkas, Balázs
AU  - Nagy, Zsombor Kristóf
AU  - Molnár, Kolos
TI  - Analysis and prediction of the diameter and orientation of AC electrospun nanofibers by response surface methodology
JF  - MATERIALS AND DESIGN
J2  - MATER DESIGN
VL  - 194
PY  - 2020
PG  - 11
SN  - 0264-1275
DO  - 10.1016/j.matdes.2020.108902
UR  - https://m2.mtmt.hu/api/publication/31371973
ID  - 31371973
N1  - Department of Polymer Engineering, Faculty of Mechanical Engineering, Budapest University of Technology and Economics, Műegyetem rkp. 3-9, Budapest, H-1111, Hungary            
            Department of Organic Chemistry and Technology, Faculty of Chemical Engineering, Budapest University of Technology and Economics, Műegyetem rkp. 3-9, Budapest, H-1111, Hungary            
            MTA–BME Research Group for Composite Science and Technology, Műegyetem rkp. 3, Budapest, H-1111, Hungary         
            Correspondence Address: Molnar, K.; Department of Polymer Engineering, Műegyetem rkp. 3-9, Hungary; email: molnar@pt.bme.hu            
            Funding details: Budapesti Műszaki és Gazdaságtudományi Egyetem, BME            
            Funding details: Hungarian Scientific Research Fund, OTKA, FK 131882            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding details: China Scholarship Council, CSC, 201700500073            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI            
            Funding details: Tempus Közalapítvány, TPF            
            Funding details: Ministry for Innovation and Technology            
            Funding text 1: This work was supported by the BME -Nanonotechnology FIKP grant (BME FIKP-NAT), the Hungarian Research Fund ( OTKA FK 131882 ), the ÚNKP-17-4-I New National Excellence Program of the Ministry of Human Capacities , the ÚNKP-19-4 New National Excellence Program of the Ministry for Innovation and Technology and BME-KKP. This paper was also supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences (K. Molnár), Stipendium Hungaricum Scholarship of Tempus Public Foundation , and China Scholarship Council ( 201700500073 ).
AB  - In this study, we analyzed the influence of process parameters on the diameter and orientation of nanofibers electrospun with alternating current (AC), using surface response methodology. The design of experiment was adopted with four main process parameters: solution concentration, collection distance, voltage and collection speed. The morphology of nanofibers was examined with a scanning electron microscope. Nanofiber orientation was characterized by the fast Fourier transform method. We used the Box-Behnken design model to predict the diameter and orientation of the nanofibers, and the results showed good agreement with the measured results. The results also indicated that solution concentration and collection speed have a similar influence on fiber diameter and orientation, as in the case of direct current electrospinning. Furthermore, in this study, we optimized the process parameters to generate thinner nanofibers with better alignment, and it also can be used as a reference to make nanofiber yarns with AC electrospinning.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Vass, Panna
AU  - Szabó, Edina
AU  - Domokos, András
AU  - Hirsch, Edit
AU  - Galata, Dorián László
AU  - Farkas, Balázs
AU  - Démuth, Balázs
AU  - Andersen, Sune K.
AU  - Vigh, Tamás
AU  - Verreck, Geert
AU  - Marosi, György
AU  - Nagy, Zsombor Kristóf
TI  - Scale‐up of electrospinning technology: Applications in the pharmaceutical industry
JF  - WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
J2  - WIRES NANOMED NANOBI
VL  - 12
PY  - 2020
IS  - 4
SN  - 1939-5116
DO  - 10.1002/wnan.1611
UR  - https://m2.mtmt.hu/api/publication/31018223
ID  - 31018223
N1  - Összes idézések száma a WoS-ban: 0
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Budapest, Hungary            
            Oral Solids Development, Janssen R&D, Beerse, Belgium            
            Export Date: 4 February 2020            
            Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME)Hungary; email: zsknagy@oct.bme.hu
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Budapest, Hungary            
            Oral Solids Development, Janssen R&D, Beerse, Belgium            
            Export Date: 5 February 2020            
            Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME)Hungary; email: zsknagy@oct.bme.hu
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Budapest, Hungary            
            Oral Solids Development, Janssen R&D, Beerse, Belgium            
            Cited By :10            
            Export Date: 9 September 2020            
            Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME)Hungary; email: zsknagy@oct.bme.hu
Funding Agency and Grant Number: Emberi Eroforrasok Miniszteriuma (BME FIKP-BIO, New National Excellence Program) [UNKP-19-3]; Orszagos Tudomanyos Kutatasi AlapprogramokOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [K-132133]
            Funding text: Emberi Eroforrasok Miniszteriuma, Grant/Award Numbers: BME FIKP-BIO, UNKP-19-3 New National Excellence Program; Orszagos Tudomanyos Kutatasi Alapprogramok, Grant/Award Number: K-132133
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Budapest, Hungary            
            Oral Solids Development, Janssen R&D, Beerse, Belgium            
            Cited By :29            
            Export Date: 18 March 2021            
            Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, Hungary; email: zsknagy@oct.bme.hu            
            Funding details: Hungarian Scientific Research Fund, OTKA, K‐132133            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA grant K-132133) and by the ?NKP-19-3 New National Excellence Program of the Ministry of Human Capacities. Support of grant BME FIKP-BIO by EMMI is kindly acknowledged.            
            Funding text 2: This work was supported by the Hungarian Scientific Research Fund (OTKA grant K‐132133) and by the ÚNKP‐19‐3 New National Excellence Program of the Ministry of Human Capacities. Support of grant BME FIKP‐BIO by EMMI is kindly acknowledged.
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Budapest, Hungary            
            Oral Solids Development, Janssen R&D, Beerse, Belgium            
            Cited By :32            
            Export Date: 22 April 2021            
            Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, Hungary; email: zsknagy@oct.bme.hu
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Budapest, Hungary            
            Oral Solids Development, Janssen R&D, Beerse, Belgium            
            Cited By :32            
            Export Date: 23 April 2021            
            Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, Hungary; email: zsknagy@oct.bme.hu
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Budapest, Hungary            
            Oral Solids Development, Janssen R&D, Beerse, Belgium            
            Cited By :32            
            Export Date: 26 April 2021            
            Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, Hungary; email: zsknagy@oct.bme.hu
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Budapest, Hungary            
            Oral Solids Development, Janssen R&D, Beerse, Belgium            
            Cited By :34            
            Export Date: 30 May 2021            
            Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, Hungary; email: zsknagy@oct.bme.hu            
            Funding details: Hungarian Scientific Research Fund, OTKA, K‐132133            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA grant K-132133) and by the ?NKP-19-3 New National Excellence Program of the Ministry of Human Capacities. Support of grant BME FIKP-BIO by EMMI is kindly acknowledged.            
            Funding text 2: This work was supported by the Hungarian Scientific Research Fund (OTKA grant K‐132133) and by the ÚNKP‐19‐3 New National Excellence Program of the Ministry of Human Capacities. Support of grant BME FIKP‐BIO by EMMI is kindly acknowledged.
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Budapest, Hungary            
            Oral Solids Development, Janssen R&D, Beerse, Belgium            
            Cited By :34            
            Export Date: 31 May 2021            
            Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, Hungary; email: zsknagy@oct.bme.hu            
            Funding details: Hungarian Scientific Research Fund, OTKA, K‐132133            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA grant K-132133) and by the ?NKP-19-3 New National Excellence Program of the Ministry of Human Capacities. Support of grant BME FIKP-BIO by EMMI is kindly acknowledged.            
            Funding text 2: This work was supported by the Hungarian Scientific Research Fund (OTKA grant K‐132133) and by the ÚNKP‐19‐3 New National Excellence Program of the Ministry of Human Capacities. Support of grant BME FIKP‐BIO by EMMI is kindly acknowledged.
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Budapest, Hungary            
            Oral Solids Development, Janssen R&D, Beerse, Belgium            
            Cited By :41            
            Export Date: 6 September 2021            
            Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, Hungary; email: zsknagy@oct.bme.hu            
            Funding details: Hungarian Scientific Research Fund, OTKA, K‐132133            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA grant K-132133) and by the ?NKP-19-3 New National Excellence Program of the Ministry of Human Capacities. Support of grant BME FIKP-BIO by EMMI is kindly acknowledged.            
            Funding text 2: This work was supported by the Hungarian Scientific Research Fund (OTKA grant K‐132133) and by the ÚNKP‐19‐3 New National Excellence Program of the Ministry of Human Capacities. Support of grant BME FIKP‐BIO by EMMI is kindly acknowledged.
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Budapest, Hungary            
            Oral Solids Development, Janssen R&D, Beerse, Belgium            
            Cited By :41            
            Export Date: 7 September 2021            
            Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, Hungary; email: zsknagy@oct.bme.hu            
            Funding details: Hungarian Scientific Research Fund, OTKA, K‐132133            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA grant K-132133) and by the ?NKP-19-3 New National Excellence Program of the Ministry of Human Capacities. Support of grant BME FIKP-BIO by EMMI is kindly acknowledged.            
            Funding text 2: This work was supported by the Hungarian Scientific Research Fund (OTKA grant K‐132133) and by the ÚNKP‐19‐3 New National Excellence Program of the Ministry of Human Capacities. Support of grant BME FIKP‐BIO by EMMI is kindly acknowledged.
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Budapest, Hungary            
            Oral Solids Development, Janssen R&D, Beerse, Belgium            
            Cited By :41            
            Export Date: 8 September 2021            
            Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, Hungary; email: zsknagy@oct.bme.hu            
            Funding details: Hungarian Scientific Research Fund, OTKA, K‐132133            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA grant K-132133) and by the ?NKP-19-3 New National Excellence Program of the Ministry of Human Capacities. Support of grant BME FIKP-BIO by EMMI is kindly acknowledged.            
            Funding text 2: This work was supported by the Hungarian Scientific Research Fund (OTKA grant K‐132133) and by the ÚNKP‐19‐3 New National Excellence Program of the Ministry of Human Capacities. Support of grant BME FIKP‐BIO by EMMI is kindly acknowledged.
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Budapest, Hungary            
            Oral Solids Development, Janssen R&D, Beerse, Belgium            
            Cited By :41            
            Export Date: 9 September 2021            
            Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, Hungary; email: zsknagy@oct.bme.hu            
            Funding details: Hungarian Scientific Research Fund, OTKA, K‐132133            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI            
            Funding text 1: This work was supported by the Hungarian Scientific Research Fund (OTKA grant K-132133) and by the ?NKP-19-3 New National Excellence Program of the Ministry of Human Capacities. Support of grant BME FIKP-BIO by EMMI is kindly acknowledged.            
            Funding text 2: This work was supported by the Hungarian Scientific Research Fund (OTKA grant K‐132133) and by the ÚNKP‐19‐3 New National Excellence Program of the Ministry of Human Capacities. Support of grant BME FIKP‐BIO by EMMI is kindly acknowledged.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Casian, Tibor
AU  - Borbás, Enikő
AU  - Ilyés, Kinga
AU  - Démuth, Balázs
AU  - Farkas, Attila
AU  - Rapi, Zsolt
AU  - Bogdan, Cătălina
AU  - Iurian, Sonia
AU  - Toma, Valentin
AU  - Știufiuc, Rares
AU  - Farkas, Balázs
AU  - Balogh, Attila
AU  - Marosi, György
AU  - Tomuță, Ioan
AU  - Nagy, Zsombor Kristóf
TI  - Electrospun amorphous solid dispersions of meloxicam: Influence of polymer type and downstream processing to orodispersible dosage forms
JF  - INTERNATIONAL JOURNAL OF PHARMACEUTICS
J2  - INT J PHARM
VL  - 569
PY  - 2019
SN  - 0378-5173
DO  - 10.1016/j.ijpharm.2019.118593
UR  - https://m2.mtmt.hu/api/publication/30810238
ID  - 30810238
N1  - Összes idézések száma a WoS-ban: 0
Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 400012, Romania            
            Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, H-1111, Hungary            
            MedFuture Research Center for Advanced Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania            
            Export Date: 4 February 2020            
            CODEN: IJPHD            
            Correspondence Address: Casian, T.; University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 41 V. Babes, Romania; email: casian.tibor@umfcluj.ro
Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 400012, Romania            
            Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, H-1111, Hungary            
            MedFuture Research Center for Advanced Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania            
            Export Date: 5 February 2020            
            CODEN: IJPHD            
            Correspondence Address: Casian, T.; University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 41 V. Babes, Romania; email: casian.tibor@umfcluj.ro
Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 400012, Romania            
            Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, H-1111, Hungary            
            MedFuture Research Center for Advanced Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania            
            Cited By :6            
            Export Date: 9 September 2020            
            CODEN: IJPHD            
            Correspondence Address: Casian, T.; University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 41 V. Babes, Romania; email: casian.tibor@umfcluj.ro            
            Chemicals/CAS: alcohol, 64-17-5; eudragit, 24938-16-7, 51822-44-7, 9065-11-6, 9010-88-2; meloxicam, 71125-38-7; Anti-Inflammatory Agents, Non-Steroidal; Meloxicam; Polymers; Tablets            
            Manufacturers: unichem laboratories, India
Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 400012, Romania            
            Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, H-1111, Hungary            
            MedFuture Research Center for Advanced Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania            
            Cited By :8            
            Export Date: 18 March 2021            
            CODEN: IJPHD            
            Correspondence Address: Casian, T.; University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 41 V. Babes, Romania; email: casian.tibor@umfcluj.ro            
            Chemicals/CAS: alcohol, 64-17-5; eudragit, 24938-16-7, 51822-44-7, 9065-11-6, 9010-88-2; meloxicam, 71125-38-7; Anti-Inflammatory Agents, Non-Steroidal; Meloxicam; Polymers; Tablets            
            Manufacturers: unichem laboratories, India
Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 400012, Romania            
            Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, H-1111, Hungary            
            MedFuture Research Center for Advanced Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania            
            Cited By :8            
            Export Date: 26 April 2021            
            CODEN: IJPHD            
            Correspondence Address: Casian, T.; University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 41 V. Babes, Romania; email: casian.tibor@umfcluj.ro
Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 400012, Romania            
            Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, H-1111, Hungary            
            MedFuture Research Center for Advanced Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania            
            Cited By :11            
            Export Date: 7 September 2021            
            CODEN: IJPHD            
            Correspondence Address: Casian, T.; University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 41 V. Babes, Romania; email: casian.tibor@umfcluj.ro            
            Chemicals/CAS: alcohol, 64-17-5; eudragit, 24938-16-7, 51822-44-7, 9065-11-6, 9010-88-2; meloxicam, 71125-38-7; Anti-Inflammatory Agents, Non-Steroidal; Meloxicam; Polymers; Tablets            
            Manufacturers: unichem laboratories, India
Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 400012, Romania            
            Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, H-1111, Hungary            
            MedFuture Research Center for Advanced Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania            
            Cited By :11            
            Export Date: 8 September 2021            
            CODEN: IJPHD            
            Correspondence Address: Casian, T.; University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 41 V. Babes, Romania; email: casian.tibor@umfcluj.ro            
            Chemicals/CAS: alcohol, 64-17-5; eudragit, 24938-16-7, 51822-44-7, 9065-11-6, 9010-88-2; meloxicam, 71125-38-7; Anti-Inflammatory Agents, Non-Steroidal; Meloxicam; Polymers; Tablets            
            Manufacturers: unichem laboratories, India
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Casian, Tibor
AU  - Farkas, Attila
AU  - Ilyés, Kinga
AU  - Démuth, Balázs
AU  - Borbás, Enikő
AU  - Madarász, Lajos
AU  - Rapi, Zsolt
AU  - Farkas, Balázs
AU  - Balogh, Attila
AU  - Domokos, András
AU  - Marosi, György
AU  - Tomută, Ioan
AU  - Nagy, Zsombor Kristóf
TI  - Data fusion strategies for performance improvement of a Process Analytical Technology platform consisting of four instruments: An electrospinning case study
JF  - INTERNATIONAL JOURNAL OF PHARMACEUTICS
J2  - INT J PHARM
VL  - 567
PY  - 2019
SN  - 0378-5173
DO  - 10.1016/j.ijpharm.2019.118473
UR  - https://m2.mtmt.hu/api/publication/30723467
ID  - 30723467
N1  - Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 400012, Romania            
            Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, H-1111, Hungary            
            Export Date: 9 July 2019            
            CODEN: IJPHD            
            Correspondence Address: Casian, T.; University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 41 V. Babes, Romania; email: casian.tibor@umfcluj.ro
Összes idézések száma a WoS-ban: 0
Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 400012, Romania            
            Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, H-1111, Hungary            
            Export Date: 5 February 2020            
            CODEN: IJPHD            
            Correspondence Address: Casian, T.; University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 41 V. Babes, Romania; email: casian.tibor@umfcluj.ro
Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 400012, Romania            
            Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, H-1111, Hungary            
            Cited By :3            
            Export Date: 9 September 2020            
            CODEN: IJPHD            
            Correspondence Address: Casian, T.; University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 41 V. Babes, Romania; email: casian.tibor@umfcluj.ro            
            Chemicals/CAS: meloxicam, 71125-38-7; Meloxicam            
            Manufacturers: Unichem, India
Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 400012, Romania            
            Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, H-1111, Hungary            
            Cited By :6            
            Export Date: 18 March 2021            
            CODEN: IJPHD            
            Correspondence Address: Casian, T.; University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 41 V. Babes, Romania; email: casian.tibor@umfcluj.ro            
            Chemicals/CAS: meloxicam, 71125-38-7; Meloxicam            
            Manufacturers: Unichem, India
Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 400012, Romania            
            Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, H-1111, Hungary            
            Cited By :6            
            Export Date: 26 April 2021            
            CODEN: IJPHD            
            Correspondence Address: Casian, T.; University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 41 V. Babes, Romania; email: casian.tibor@umfcluj.ro
Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 400012, Romania            
            Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, H-1111, Hungary            
            Cited By :6            
            Export Date: 29 May 2021            
            CODEN: IJPHD            
            Correspondence Address: Casian, T.; University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 41 V. Babes, Romania; email: casian.tibor@umfcluj.ro            
            Chemicals/CAS: meloxicam, 71125-38-7; Meloxicam            
            Manufacturers: Unichem, India
Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 400012, Romania            
            Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, H-1111, Hungary            
            Cited By :8            
            Export Date: 7 September 2021            
            CODEN: IJPHD            
            Correspondence Address: Casian, T.; University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 41 V. Babes, Romania; email: casian.tibor@umfcluj.ro            
            Chemicals/CAS: meloxicam, 71125-38-7; Meloxicam            
            Manufacturers: Unichem, India
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Farkas, Balázs
AU  - Balogh, Attila
AU  - Cselkó, Richárd
AU  - Molnár, Kolos
AU  - Farkas, Attila
AU  - Borbás, Enikő
AU  - Marosi, György
AU  - Nagy, Zsombor Kristóf
TI  - Corona alternating current electrospinning: A combined approach for increasing the productivity of electrospinning
JF  - INTERNATIONAL JOURNAL OF PHARMACEUTICS
J2  - INT J PHARM
VL  - 561
PY  - 2019
SP  - 219
EP  - 227
PG  - 9
SN  - 0378-5173
DO  - 10.1016/j.ijpharm.2019.03.005
UR  - https://m2.mtmt.hu/api/publication/30623553
ID  - 30623553
N1  - Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Electric Power Engineering, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Polymer Engineering, Budapest, H-1111, Hungary            
            MTA–BME Research Group for Composite Science and Technology, Budapest, H-1111, Hungary            
            Cited By :1            
            Export Date: 4 June 2019            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.Budafoki út 8, Hungary; email: baloghattila5@gmail.com
Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Electric Power Engineering, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Polymer Engineering, Budapest, H-1111, Hungary            
            MTA–BME Research Group for Composite Science and Technology, Budapest, H-1111, Hungary            
            Cited By :1            
            Export Date: 9 July 2019            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.Budafoki út 8, Hungary; email: baloghattila5@gmail.com
Összes idézések száma a WoS-ban: 0
Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Electric Power Engineering, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Polymer Engineering, Budapest, H-1111, Hungary            
            MTA–BME Research Group for Composite Science and Technology, Budapest, H-1111, Hungary            
            Cited By :5            
            Export Date: 4 February 2020            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.Budafoki út 8, Hungary; email: baloghattila5@gmail.com
Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Electric Power Engineering, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Polymer Engineering, Budapest, H-1111, Hungary            
            MTA–BME Research Group for Composite Science and Technology, Budapest, H-1111, Hungary            
            Cited By :5            
            Export Date: 5 February 2020            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.Budafoki út 8, Hungary; email: baloghattila5@gmail.com
Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Electric Power Engineering, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Polymer Engineering, Budapest, H-1111, Hungary            
            MTA–BME Research Group for Composite Science and Technology, Budapest, H-1111, Hungary            
            Cited By :5            
            Export Date: 12 February 2020            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.Budafoki út 8, Hungary; email: baloghattila5@gmail.com
Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Electric Power Engineering, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Polymer Engineering, Budapest, H-1111, Hungary            
            MTA–BME Research Group for Composite Science and Technology, Budapest, H-1111, Hungary            
            Cited By :13            
            Export Date: 9 September 2020            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.Budafoki út 8, Hungary; email: baloghattila5@gmail.com            
            Chemicals/CAS: dodecyl sulfate sodium, 151-21-3; povidone, 9003-39-8; spironolactone, 52-01-7; Drug Carriers; Povidone; Spironolactone
Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Electric Power Engineering, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Polymer Engineering, Budapest, H-1111, Hungary            
            MTA–BME Research Group for Composite Science and Technology, Budapest, H-1111, Hungary            
            Cited By :15            
            Export Date: 27 October 2020            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.Budafoki út 8, Hungary; email: baloghattila5@gmail.com
Funding Agency and Grant Number: National Research Development and Innovation [FIEK_16-1-2016-0007]; OTKAOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [121051, UNKP-18-3, UNKP-18-4-BME-95]; Gedeon Richter's Talentum Foundation
            Funding text: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, UNKP-18-3, UNKP-18-4-BME-95. New National Excellence Program of the Ministry of Human Capacities and the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. Supported by Gedeon Richter's Talentum Foundation.
Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Electric Power Engineering, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Polymer Engineering, Budapest, H-1111, Hungary            
            MTA–BME Research Group for Composite Science and Technology, Budapest, H-1111, Hungary            
            Cited By :16            
            Export Date: 18 March 2021            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.Budafoki út 8, Hungary; email: baloghattila5@gmail.com            
            Chemicals/CAS: dodecyl sulfate sodium, 151-21-3; povidone, 9003-39-8; spironolactone, 52-01-7; Drug Carriers; Povidone; Spironolactone            
            Funding details: Gedeon Richter            
            Funding details: Hungarian Scientific Research Fund, OTKA, 121051, ÚNKP-18-3, ÚNKP-18-4-BME-95            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI            
            Funding details: Richter Gedeon Talentum Alapítvány            
            Funding text 1: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, ÚNKP-18-3, ÚNKP-18-4-BME-95. New National Excellence Program of the Ministry of Human Capacities and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Supported by Gedeon Richter's Talentum Foundation.            
            Funding text 2: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, ÚNKP-18-3, ÚNKP-18-4-BME-95. New National Excellence Program of the Ministry of Human Capacities and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences . Supported by Gedeon Richter’s Talentum Foundation .
Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Electric Power Engineering, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Polymer Engineering, Budapest, H-1111, Hungary            
            MTA–BME Research Group for Composite Science and Technology, Budapest, H-1111, Hungary            
            Cited By :18            
            Export Date: 22 April 2021            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.Budafoki út 8, Hungary; email: baloghattila5@gmail.com
Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Electric Power Engineering, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Polymer Engineering, Budapest, H-1111, Hungary            
            MTA–BME Research Group for Composite Science and Technology, Budapest, H-1111, Hungary            
            Cited By :18            
            Export Date: 23 April 2021            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.Budafoki út 8, Hungary; email: baloghattila5@gmail.com
Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Electric Power Engineering, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Polymer Engineering, Budapest, H-1111, Hungary            
            MTA–BME Research Group for Composite Science and Technology, Budapest, H-1111, Hungary            
            Cited By :19            
            Export Date: 26 April 2021            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.Budafoki út 8, Hungary; email: baloghattila5@gmail.com
Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Electric Power Engineering, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Polymer Engineering, Budapest, H-1111, Hungary            
            MTA–BME Research Group for Composite Science and Technology, Budapest, H-1111, Hungary            
            Cited By :19            
            Export Date: 31 May 2021            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.Budafoki út 8, Hungary; email: baloghattila5@gmail.com            
            Chemicals/CAS: dodecyl sulfate sodium, 151-21-3; povidone, 9003-39-8; spironolactone, 52-01-7; Drug Carriers; Povidone; Spironolactone            
            Funding details: Gedeon Richter            
            Funding details: Hungarian Scientific Research Fund, OTKA, 121051, ÚNKP-18-3, ÚNKP-18-4-BME-95            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI            
            Funding details: Richter Gedeon Talentum Alapítvány            
            Funding text 1: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, ÚNKP-18-3, ÚNKP-18-4-BME-95. New National Excellence Program of the Ministry of Human Capacities and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Supported by Gedeon Richter's Talentum Foundation.            
            Funding text 2: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, ÚNKP-18-3, ÚNKP-18-4-BME-95. New National Excellence Program of the Ministry of Human Capacities and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences . Supported by Gedeon Richter’s Talentum Foundation .
Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Electric Power Engineering, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Polymer Engineering, Budapest, H-1111, Hungary            
            MTA–BME Research Group for Composite Science and Technology, Budapest, H-1111, Hungary            
            Cited By :21            
            Export Date: 6 September 2021            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.Budafoki út 8, Hungary; email: baloghattila5@gmail.com            
            Chemicals/CAS: dodecyl sulfate sodium, 151-21-3; povidone, 9003-39-8; spironolactone, 52-01-7; Drug Carriers; Povidone; Spironolactone            
            Funding details: Gedeon Richter            
            Funding details: Hungarian Scientific Research Fund, OTKA, 121051, ÚNKP-18-3, ÚNKP-18-4-BME-95            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI            
            Funding details: Richter Gedeon Talentum Alapítvány            
            Funding text 1: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, ÚNKP-18-3, ÚNKP-18-4-BME-95. New National Excellence Program of the Ministry of Human Capacities and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Supported by Gedeon Richter's Talentum Foundation.            
            Funding text 2: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, ÚNKP-18-3, ÚNKP-18-4-BME-95. New National Excellence Program of the Ministry of Human Capacities and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences . Supported by Gedeon Richter’s Talentum Foundation .
Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Electric Power Engineering, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Polymer Engineering, Budapest, H-1111, Hungary            
            MTA–BME Research Group for Composite Science and Technology, Budapest, H-1111, Hungary            
            Cited By :21            
            Export Date: 7 September 2021            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.Budafoki út 8, Hungary; email: baloghattila5@gmail.com            
            Chemicals/CAS: dodecyl sulfate sodium, 151-21-3; povidone, 9003-39-8; spironolactone, 52-01-7; Drug Carriers; Povidone; Spironolactone            
            Funding details: Gedeon Richter            
            Funding details: Hungarian Scientific Research Fund, OTKA, 121051, ÚNKP-18-3, ÚNKP-18-4-BME-95            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI            
            Funding details: Richter Gedeon Talentum Alapítvány            
            Funding text 1: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, ÚNKP-18-3, ÚNKP-18-4-BME-95. New National Excellence Program of the Ministry of Human Capacities and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Supported by Gedeon Richter's Talentum Foundation.            
            Funding text 2: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, ÚNKP-18-3, ÚNKP-18-4-BME-95. New National Excellence Program of the Ministry of Human Capacities and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences . Supported by Gedeon Richter’s Talentum Foundation .
Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Electric Power Engineering, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Polymer Engineering, Budapest, H-1111, Hungary            
            MTA–BME Research Group for Composite Science and Technology, Budapest, H-1111, Hungary            
            Cited By :21            
            Export Date: 8 September 2021            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.Budafoki út 8, Hungary; email: baloghattila5@gmail.com            
            Chemicals/CAS: dodecyl sulfate sodium, 151-21-3; povidone, 9003-39-8; spironolactone, 52-01-7; Drug Carriers; Povidone; Spironolactone            
            Funding details: Gedeon Richter            
            Funding details: Hungarian Scientific Research Fund, OTKA, 121051, ÚNKP-18-3, ÚNKP-18-4-BME-95            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI            
            Funding details: Richter Gedeon Talentum Alapítvány            
            Funding text 1: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, ÚNKP-18-3, ÚNKP-18-4-BME-95. New National Excellence Program of the Ministry of Human Capacities and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Supported by Gedeon Richter's Talentum Foundation.            
            Funding text 2: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, ÚNKP-18-3, ÚNKP-18-4-BME-95. New National Excellence Program of the Ministry of Human Capacities and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences . Supported by Gedeon Richter’s Talentum Foundation .
Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Electric Power Engineering, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Polymer Engineering, Budapest, H-1111, Hungary            
            MTA–BME Research Group for Composite Science and Technology, Budapest, H-1111, Hungary            
            Cited By :21            
            Export Date: 9 September 2021            
            CODEN: IJPHD            
            Correspondence Address: Balogh, A.Budafoki út 8, Hungary; email: baloghattila5@gmail.com            
            Chemicals/CAS: dodecyl sulfate sodium, 151-21-3; povidone, 9003-39-8; spironolactone, 52-01-7; Drug Carriers; Povidone; Spironolactone            
            Funding details: Gedeon Richter            
            Funding details: Hungarian Scientific Research Fund, OTKA, 121051, ÚNKP-18-3, ÚNKP-18-4-BME-95            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding details: Emberi Eroforrások Minisztériuma, EMMI            
            Funding details: Richter Gedeon Talentum Alapítvány            
            Funding text 1: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, ÚNKP-18-3, ÚNKP-18-4-BME-95. New National Excellence Program of the Ministry of Human Capacities and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Supported by Gedeon Richter's Talentum Foundation.            
            Funding text 2: This work was supported by the National Research Development and Innovation in the frame of FIEK_16-1-2016-0007 (Higher Education and Industrial Cooperation Center) project. Supported by OTKA 121051, ÚNKP-18-3, ÚNKP-18-4-BME-95. New National Excellence Program of the Ministry of Human Capacities and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences . Supported by Gedeon Richter’s Talentum Foundation .
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Domokos, András
AU  - Balogh, Attila
AU  - Denes, Daniel
AU  - Nyerges, Gyula
AU  - Zodi, Levente
AU  - Farkas, Balázs
AU  - Marosi, György
AU  - Nagy, Zsombor Kristóf
TI  - Continuous manufacturing of orally dissolving webs containing a poorly soluble drug via electrospinning
JF  - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
J2  - EUR J PHARM SCI
VL  - 130
PY  - 2019
SP  - 91
EP  - 99
PG  - 9
SN  - 0928-0987
DO  - 10.1016/j.ejps.2019.01.026
UR  - https://m2.mtmt.hu/api/publication/30547041
ID  - 30547041
N1  - Összes idézések száma a WoS-ban: 0
Budapest University of Technology and Economics, Organic Chemistry and Technology Department, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Inorganic Chemistry, Budapest, H-1111, Hungary            
            Cited By :6            
            Export Date: 4 February 2020            
            CODEN: EPSCE            
            Correspondence Address: Balogh, A.1111 Budapest, Budafoki út 8, Hungary; email: baloghattila5@gmail.com
Budapest University of Technology and Economics, Organic Chemistry and Technology Department, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Inorganic Chemistry, Budapest, H-1111, Hungary            
            Cited By :6            
            Export Date: 5 February 2020            
            CODEN: EPSCE            
            Correspondence Address: Balogh, A.1111 Budapest, Budafoki út 8, Hungary; email: baloghattila5@gmail.com
Budapest University of Technology and Economics, Organic Chemistry and Technology Department, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Inorganic Chemistry, Budapest, H-1111, Hungary            
            Cited By :6            
            Export Date: 12 February 2020            
            CODEN: EPSCE            
            Correspondence Address: Balogh, A.1111 Budapest, Budafoki út 8, Hungary; email: baloghattila5@gmail.com
Budapest University of Technology and Economics, Organic Chemistry and Technology Department, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Inorganic Chemistry, Budapest, H-1111, Hungary            
            Cited By :11            
            Export Date: 9 September 2020            
            CODEN: EPSCE            
            Correspondence Address: Balogh, A.1111 Budapest, Budafoki út 8, Hungary; email: baloghattila5@gmail.com            
            Chemicals/CAS: 2 hydroxypropyl beta cyclodextrin, 94035-02-6, 128446-35-5; alcohol, 64-17-5; carvedilol, 72956-09-3; citric acid, 126-44-3, 5949-29-1, 77-92-9, 8002-14-0; n,n dimethylformamide, 68-12-2; povidone, 9003-39-8; pullulan, 9057-02-7; glucan, 9012-72-0, 9037-91-6; 2-Hydroxypropyl-beta-cyclodextrin; Carvedilol; Citric Acid; Glucans; pullulan            
            Manufacturers: Sigma Aldrich, Hungary
Budapest University of Technology and Economics, Organic Chemistry and Technology Department, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Inorganic Chemistry, Budapest, H-1111, Hungary            
            Cited By :11            
            Export Date: 27 October 2020            
            CODEN: EPSCE            
            Correspondence Address: Balogh, A.1111 Budapest, Budafoki út 8, Hungary; email: baloghattila5@gmail.com
Funding Agency and Grant Number: New Szechenyi Plan [TAMOP-4.2.1/B-09/1/KMR-2010-0002]; OTKAOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [K-112644, PD-121051, FIEK_16-1-2016-0007]; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences
            Funding text: This work was supported by the New Szechenyi Plan (project ID: TAMOP-4.2.1/B-09/1/KMR-2010-0002), OTKA grants K-112644, PD-121051, FIEK_16-1-2016-0007, and the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. We thank Janos Madarasz for his excellent support in the XRPD measurements.
Budapest University of Technology and Economics, Organic Chemistry and Technology Department, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Inorganic Chemistry, Budapest, H-1111, Hungary            
            Cited By :13            
            Export Date: 18 March 2021            
            CODEN: EPSCE            
            Correspondence Address: Balogh, A.1111 Budapest, Budafoki út 8, Hungary; email: baloghattila5@gmail.com            
            Chemicals/CAS: 2 hydroxypropyl beta cyclodextrin, 94035-02-6, 128446-35-5; alcohol, 64-17-5; carvedilol, 72956-09-3; citric acid, 126-44-3, 5949-29-1, 77-92-9, 8002-14-0; n,n dimethylformamide, 68-12-2; povidone, 9003-39-8; pullulan, 9057-02-7; glucan, 9012-72-0, 9037-91-6; 2-Hydroxypropyl-beta-cyclodextrin; Carvedilol; Citric Acid; Glucans; pullulan            
            Manufacturers: Sigma Aldrich, Hungary            
            Funding details: TÁMOP-4.2.1/B-09/1/KMR-2010-0002            
            Funding details: Hungarian Scientific Research Fund, OTKA, FIEK_16-1-2016-0007, K-112644, PD-121051            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding text 1: This work was supported by the New Széchenyi Plan (project ID: TÁMOP-4.2.1/B-09/1/KMR-2010-0002 ), OTKA grants K-112644 , PD-121051 , FIEK_16-1-2016-0007 , and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences . We thank János Madarász for his excellent support in the XRPD measurements.
Budapest University of Technology and Economics, Organic Chemistry and Technology Department, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Inorganic Chemistry, Budapest, H-1111, Hungary            
            Cited By :15            
            Export Date: 22 April 2021            
            CODEN: EPSCE            
            Correspondence Address: Balogh, A.1111 Budapest, Budafoki út 8, Hungary; email: baloghattila5@gmail.com
Budapest University of Technology and Economics, Organic Chemistry and Technology Department, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Inorganic Chemistry, Budapest, H-1111, Hungary            
            Cited By :18            
            Export Date: 7 September 2021            
            CODEN: EPSCE            
            Correspondence Address: Balogh, A.1111 Budapest, Budafoki út 8, Hungary; email: baloghattila5@gmail.com            
            Chemicals/CAS: 2 hydroxypropyl beta cyclodextrin, 94035-02-6, 128446-35-5; alcohol, 64-17-5; carvedilol, 72956-09-3; citric acid, 126-44-3, 5949-29-1, 77-92-9, 8002-14-0; n,n dimethylformamide, 68-12-2; povidone, 9003-39-8; pullulan, 9057-02-7; glucan, 9012-72-0, 9037-91-6; 2-Hydroxypropyl-beta-cyclodextrin; Carvedilol; Citric Acid; Glucans; pullulan            
            Manufacturers: Sigma Aldrich, Hungary            
            Funding details: TÁMOP-4.2.1/B-09/1/KMR-2010-0002            
            Funding details: Hungarian Scientific Research Fund, OTKA, FIEK_16-1-2016-0007, K-112644, PD-121051            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding text 1: This work was supported by the New Széchenyi Plan (project ID: TÁMOP-4.2.1/B-09/1/KMR-2010-0002 ), OTKA grants K-112644 , PD-121051 , FIEK_16-1-2016-0007 , and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences . We thank János Madarász for his excellent support in the XRPD measurements.
Budapest University of Technology and Economics, Organic Chemistry and Technology Department, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Inorganic Chemistry, Budapest, H-1111, Hungary            
            Cited By :18            
            Export Date: 8 September 2021            
            CODEN: EPSCE            
            Correspondence Address: Balogh, A.1111 Budapest, Budafoki út 8, Hungary; email: baloghattila5@gmail.com            
            Chemicals/CAS: 2 hydroxypropyl beta cyclodextrin, 94035-02-6, 128446-35-5; alcohol, 64-17-5; carvedilol, 72956-09-3; citric acid, 126-44-3, 5949-29-1, 77-92-9, 8002-14-0; n,n dimethylformamide, 68-12-2; povidone, 9003-39-8; pullulan, 9057-02-7; glucan, 9012-72-0, 9037-91-6; 2-Hydroxypropyl-beta-cyclodextrin; Carvedilol; Citric Acid; Glucans; pullulan            
            Manufacturers: Sigma Aldrich, Hungary            
            Funding details: TÁMOP-4.2.1/B-09/1/KMR-2010-0002            
            Funding details: Hungarian Scientific Research Fund, OTKA, FIEK_16-1-2016-0007, K-112644, PD-121051            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding text 1: This work was supported by the New Széchenyi Plan (project ID: TÁMOP-4.2.1/B-09/1/KMR-2010-0002 ), OTKA grants K-112644 , PD-121051 , FIEK_16-1-2016-0007 , and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences . We thank János Madarász for his excellent support in the XRPD measurements.
Budapest University of Technology and Economics, Organic Chemistry and Technology Department, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Inorganic Chemistry, Budapest, H-1111, Hungary            
            Cited By :18            
            Export Date: 9 September 2021            
            CODEN: EPSCE            
            Correspondence Address: Balogh, A.1111 Budapest, Budafoki út 8, Hungary; email: baloghattila5@gmail.com            
            Chemicals/CAS: 2 hydroxypropyl beta cyclodextrin, 94035-02-6, 128446-35-5; alcohol, 64-17-5; carvedilol, 72956-09-3; citric acid, 126-44-3, 5949-29-1, 77-92-9, 8002-14-0; n,n dimethylformamide, 68-12-2; povidone, 9003-39-8; pullulan, 9057-02-7; glucan, 9012-72-0, 9037-91-6; 2-Hydroxypropyl-beta-cyclodextrin; Carvedilol; Citric Acid; Glucans; pullulan            
            Manufacturers: Sigma Aldrich, Hungary            
            Funding details: TÁMOP-4.2.1/B-09/1/KMR-2010-0002            
            Funding details: Hungarian Scientific Research Fund, OTKA, FIEK_16-1-2016-0007, K-112644, PD-121051            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding text 1: This work was supported by the New Széchenyi Plan (project ID: TÁMOP-4.2.1/B-09/1/KMR-2010-0002 ), OTKA grants K-112644 , PD-121051 , FIEK_16-1-2016-0007 , and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences . We thank János Madarász for his excellent support in the XRPD measurements.
Budapest University of Technology and Economics, Organic Chemistry and Technology Department, Budapest, H-1111, Hungary            
            Budapest University of Technology and Economics, Department of Inorganic Chemistry, Budapest, H-1111, Hungary            
            Cited By :18            
            Export Date: 13 September 2021            
            CODEN: EPSCE            
            Correspondence Address: Balogh, A.1111 Budapest, Budafoki út 8, Hungary; email: baloghattila5@gmail.com            
            Chemicals/CAS: 2 hydroxypropyl beta cyclodextrin, 94035-02-6, 128446-35-5; alcohol, 64-17-5; carvedilol, 72956-09-3; citric acid, 126-44-3, 5949-29-1, 77-92-9, 8002-14-0; n,n dimethylformamide, 68-12-2; povidone, 9003-39-8; pullulan, 9057-02-7; glucan, 9012-72-0, 9037-91-6; 2-Hydroxypropyl-beta-cyclodextrin; Carvedilol; Citric Acid; Glucans; pullulan            
            Manufacturers: Sigma Aldrich, Hungary            
            Funding details: TÁMOP-4.2.1/B-09/1/KMR-2010-0002            
            Funding details: Hungarian Scientific Research Fund, OTKA, FIEK_16-1-2016-0007, K-112644, PD-121051            
            Funding details: Magyar Tudományos Akadémia, MTA            
            Funding text 1: This work was supported by the New Széchenyi Plan (project ID: TÁMOP-4.2.1/B-09/1/KMR-2010-0002 ), OTKA grants K-112644 , PD-121051 , FIEK_16-1-2016-0007 , and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences . We thank János Madarász for his excellent support in the XRPD measurements.
AB  - An orally dissolving web (ODW) formulation of poorly soluble carvedilol (CAR) was developed and manufactured continuously using electrospinning (ES) as a key technology. Phase solubility tests revealed that hydroxypropyl-beta-cyclodextrin (HP beta CD) solubilizer alone cannot ensure sufficient solubility (6.25 mg CAR in 20 mL) in the oral cavity even if citric acid was present to ionize the basic drug. In turn, electrospun amorphous nanofibers of polyvinylpyrrolidone K30 (PVPK30) and CAR exhibited notable supersaturation of the drug in the presence of citric acid. Differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD) confirmed the amorphous state of CAR. The final ODW was prepared by layering the nanofibers onto pullulan, a well-soluble polysaccharide film carrying citric acid. The double-layered formulation showed ultrafast disintegration and dissolution modeling the oral cavity meeting regulatory requirements ( < 30 s). The continuous production was accomplished using our recently developed continuous model system by controlled deposition of the nanofibers onto the carrier film strained to a wheel collector and followed by cutting into final dosage units. Performance tests of the continuous system revealed satisfactory content uniformity over time (average acceptance value = 9.45), while residual solvent content measurements showed trace amounts of ethanol (EtOH) after production and acceptable dimethyl-formamide (DMF) content with secondary drying at room temperature. The presented work demonstrates how ES can be part of a continuous manufacturing system as an advanced drying tool during the formulation of challenging drugs.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Ilyés, Kinga
AU  - Kovács, Norbert Krisztián
AU  - Balogh, Attila
AU  - Borbás, Enikő
AU  - Farkas, Balázs
AU  - Casian, Tibor
AU  - Marosi, György
AU  - Tomuță, Ioan
AU  - Nagy, Zsombor Kristóf
TI  - Evaluarea imprimabilității 3D-FDM prin intermediul polimerilor farmaceutici
JF  - Medicine and Pharmacy Reports
J2  - Medicine Pharm Rep
VL  - 92
PY  - 2019
IS  - Supl. 1.
SP  - S87
EP  - S88
SN  - 2602-0807
UR  - https://m2.mtmt.hu/api/publication/30415856
ID  - 30415856
N1  - Paper 14 Pharmaceutical Specialities. In: Zilele UMF 2018
LA  - Romanian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Ilyés, Kinga
AU  - Kovács, Norbert Krisztián
AU  - Balogh, Attila
AU  - Borbás, Enikő
AU  - Farkas, Balázs
AU  - Casian, Tibor
AU  - Marosi, György
AU  - Tomuță, Ioan
AU  - Nagy, Zsombor Kristóf
TI  - The applicability of pharmaceutical polymeric blends for the fused deposition modelling (FDM) 3D technique: Material considerations–printability–process modulation, with consecutive effects on in vitro release, stability and degradation
JF  - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
J2  - EUR J PHARM SCI
VL  - 129
PY  - 2019
SP  - 110
EP  - 123
PG  - 14
SN  - 0928-0987
DO  - 10.1016/j.ejps.2018.12.019
UR  - https://m2.mtmt.hu/api/publication/30401928
ID  - 30401928
N1  - Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy “Iuliu Hațieganu”, Cluj-Napoca, 400012, Romania            
            Department of Polymer Engineering, Faculty of Mechanical Engineering, Budapest University of Technology and Economics, Budapest, H-1111, Hungary            
            Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Budapest, H-1111, Hungary            
            Cited By :43            
            Export Date: 8 September 2021            
            CODEN: EPSCE            
            Correspondence Address: Tomuță, I.; Department of Pharmaceutical Technology and Biopharmacy, 41 Victor Babeș street, Romania; email: tomutaioan@umfcluj.ro            
            Chemicals/CAS: carvedilol, 72956-09-3; hydroxypropylcellulose, 9004-64-2; hydroxypropylmethylcellulose, 9004-65-3; polyvinyl acetate, 9003-20-7; polyvinyl alcohol, 37380-95-3, 9002-89-5; povidone, 9003-39-8; Excipients; Polymers; Tablets            
            Funding details: 1300/32/13.01.2017            
            Funding text 1: The authors would like to acknowledge the technical support of Madarász János in the XRD measurement. This project was supported by “Iuliu Hațieganu” University of Medicine and Pharmacy , Romania - internal doctoral research grant 1300/32/13.01.2017 and by the Sapientia Hungariae Organization , Hungary - Collegium Talentum 2018 Programme of Hungary.
AB  - The three dimensional printing (3DP) in the pharmaceutical domain constitutes an alternative, innovative approach compared to the conventional production methods. Fused deposition modelling (FDM), is a simple, cost-effective 3DP technique, however the range of pharmaceutical excipients that can be applied for this methodology is restricted. The study set to define the requirements of the FDM printability, using as technical support custom made, pharmaceutical polymer based filaments and to evaluate if these new dosage forms can live up to the current GMP/GCP quality standards. Formulation rationale was assessed in accordance to the apparatus functionality. Blends were pre-screened based on the processability under the API (carvedilol) thermogravimetric analysis determined critical limit. The technological process implied the use of FDM coupled with hot melt extrusion (HME), while printability was defined by means of thermal, rheological and mechanical measurements. From the pharmaceutical standpoint, the consistency of the in vitro dissolution kinetics was monitored ‘at release’ and ‘in stability’, while the print process impact was evaluated based on the previously determined processability potential. Results showed that FDM printability is multifactorial, with brittleness and melt viscosity as primary limitation factors. The increase in shear-thinning and flexural modulus can enable broader processability intervals, which in turn proved to be essential in limiting degradation product formation. The 3DP tablets released the API in an extended rate, however the temperature and humidity along production and storage should be carefully considered as it may affect the final product quality in time. In conclusion, HME + FDM can be considered as an alternative production methodology, with prospects of applicability in the clinical sector, however for some formulations extensive packaging development will be necessary before confirming their suitability.
LA  - English
DB  - MTMT
ER  -