@mastersthesis{MTMT:32217334,
	title = {Váltóáramú elektrosztatikus szálképzés gyógyszertechnológiai alkalmazása},
	url = {https://m2.mtmt.hu/api/publication/32217334},
	author = {Farkas, Balázs},
	publisher = {Budapest University of Technology and Economics},
	unique-id = {32217334},
	year = {2021}
}

@article{MTMT:31451305,
	title = {Frequency and waveform dependence of alternating current electrospinning and their uses for drug dissolution enhancement},
	url = {https://m2.mtmt.hu/api/publication/31451305},
	author = {Farkas, Balázs and Balogh, Attila and Farkas, Attila and Marosi, György and Nagy, Zsombor Kristóf},
	doi = {10.1016/j.ijpharm.2020.119593},
	journal-iso = {INT J PHARM},
	journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS},
	volume = {586},
	unique-id = {31451305},
	issn = {0378-5173},
	abstract = {The effect of different frequencies and waveforms was investigated for the first time on alternating current electrospinning (ACES). PVPVA64, a polyvinylpyrrolidone-vinyl acetate copolymer was selected for the experiments as an important matrix for amorphous solid dispersions but never processed with ACES. It has been proved that ACES could be operated in a wide range of frequencies (40-250 Hz) and using different waveforms (sinusoidal, square, triangle, saw tooth) without significant changes in fiber morphology. Nevertheless, deterioration of the fiber formation process could be also observed especially at high frequencies. The developed PVPVA64-based fibers containing small amounts of additives (polyethylene oxide (PEO) and sodium dodecyl sulfate (SDS)) served as an excellent carrier for spironolactone (SPIR), a poorly soluble antihypertensive drug. As a result of the amorphously dispersed SPIR and the large surface area of the AC electrospun fibers immediate drug release could be achieved.},
	keywords = {Nanotechnology; Oral drug delivery; waveform; Frequency dependence; Amorphous solid dispersion; Dissolution enhancement; Alternating current electrospinning},
	year = {2020},
	eissn = {1873-3476},
	orcid-numbers = {Farkas, Attila/0000-0002-8877-2587; Marosi, György/0000-0002-4774-2023}
}

@article{MTMT:31371973,
	title = {Analysis and prediction of the diameter and orientation of AC electrospun nanofibers by response surface methodology},
	url = {https://m2.mtmt.hu/api/publication/31371973},
	author = {He, Haijun and Wang, Yimeng and Farkas, Balázs and Nagy, Zsombor Kristóf and Molnár, Kolos},
	doi = {10.1016/j.matdes.2020.108902},
	journal-iso = {MATER DESIGN},
	journal = {MATERIALS AND DESIGN},
	volume = {194},
	unique-id = {31371973},
	issn = {0264-1275},
	abstract = {In this study, we analyzed the influence of process parameters on the diameter and orientation of nanofibers electrospun with alternating current (AC), using surface response methodology. The design of experiment was adopted with four main process parameters: solution concentration, collection distance, voltage and collection speed. The morphology of nanofibers was examined with a scanning electron microscope. Nanofiber orientation was characterized by the fast Fourier transform method. We used the Box-Behnken design model to predict the diameter and orientation of the nanofibers, and the results showed good agreement with the measured results. The results also indicated that solution concentration and collection speed have a similar influence on fiber diameter and orientation, as in the case of direct current electrospinning. Furthermore, in this study, we optimized the process parameters to generate thinner nanofibers with better alignment, and it also can be used as a reference to make nanofiber yarns with AC electrospinning.},
	year = {2020},
	eissn = {1873-4197},
	orcid-numbers = {He, Haijun/0000-0002-8201-0979; Molnár, Kolos/0000-0002-9331-4652}
}

@article{MTMT:31018223,
	title = {Scale‐up of electrospinning technology: Applications in the pharmaceutical industry},
	url = {https://m2.mtmt.hu/api/publication/31018223},
	author = {Vass, Panna and Szabó, Edina and Domokos, András and Hirsch, Edit and Galata, Dorián László and Farkas, Balázs and Démuth, Balázs and Andersen, Sune K. and Vigh, Tamás and Verreck, Geert and Marosi, György and Nagy, Zsombor Kristóf},
	doi = {10.1002/wnan.1611},
	journal-iso = {WIRES NANOMED NANOBI},
	journal = {WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY},
	volume = {12},
	unique-id = {31018223},
	issn = {1939-5116},
	year = {2020},
	eissn = {1939-0041},
	orcid-numbers = {Vass, Panna/0000-0003-2206-565X; Szabó, Edina/0000-0001-9616-5122; Domokos, András/0000-0003-1968-4679; Démuth, Balázs/0000-0002-2918-0899; Marosi, György/0000-0002-4774-2023; Nagy, Zsombor Kristóf/0000-0003-2651-7756}
}

@article{MTMT:30810238,
	title = {Electrospun amorphous solid dispersions of meloxicam: Influence of polymer type and downstream processing to orodispersible dosage forms},
	url = {https://m2.mtmt.hu/api/publication/30810238},
	author = {Casian, Tibor and Borbás, Enikő and Ilyés, Kinga and Démuth, Balázs and Farkas, Attila and Rapi, Zsolt and Bogdan, Cătălina and Iurian, Sonia and Toma, Valentin and Știufiuc, Rares and Farkas, Balázs and Balogh, Attila and Marosi, György and Tomuță, Ioan and Nagy, Zsombor Kristóf},
	doi = {10.1016/j.ijpharm.2019.118593},
	journal-iso = {INT J PHARM},
	journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS},
	volume = {569},
	unique-id = {30810238},
	issn = {0378-5173},
	year = {2019},
	eissn = {1873-3476},
	orcid-numbers = {Casian, Tibor/0000-0003-2651-7756; Farkas, Attila/0000-0002-8877-2587; Rapi, Zsolt/0000-0002-6035-5482; Marosi, György/0000-0002-4774-2023}
}

@article{MTMT:30723467,
	title = {Data fusion strategies for performance improvement of a Process Analytical Technology platform consisting of four instruments: An electrospinning case study},
	url = {https://m2.mtmt.hu/api/publication/30723467},
	author = {Casian, Tibor and Farkas, Attila and Ilyés, Kinga and Démuth, Balázs and Borbás, Enikő and Madarász, Lajos and Rapi, Zsolt and Farkas, Balázs and Balogh, Attila and Domokos, András and Marosi, György and Tomută, Ioan and Nagy, Zsombor Kristóf},
	doi = {10.1016/j.ijpharm.2019.118473},
	journal-iso = {INT J PHARM},
	journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS},
	volume = {567},
	unique-id = {30723467},
	issn = {0378-5173},
	year = {2019},
	eissn = {1873-3476},
	orcid-numbers = {Casian, Tibor/0000-0003-4984-8216; Farkas, Attila/0000-0002-8877-2587; Rapi, Zsolt/0000-0002-6035-5482; Balogh, Attila/0000-0001-8058-5392; Domokos, András/0000-0003-1968-4679; Marosi, György/0000-0002-4774-2023}
}

@article{MTMT:30623553,
	title = {Corona alternating current electrospinning: A combined approach for increasing the productivity of electrospinning},
	url = {https://m2.mtmt.hu/api/publication/30623553},
	author = {Farkas, Balázs and Balogh, Attila and Cselkó, Richárd and Molnár, Kolos and Farkas, Attila and Borbás, Enikő and Marosi, György and Nagy, Zsombor Kristóf},
	doi = {10.1016/j.ijpharm.2019.03.005},
	journal-iso = {INT J PHARM},
	journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS},
	volume = {561},
	unique-id = {30623553},
	issn = {0378-5173},
	year = {2019},
	eissn = {1873-3476},
	pages = {219-227},
	orcid-numbers = {Balogh, Attila/0000-0001-8058-5392; Cselkó, Richárd/0000-0003-3145-1667; Molnár, Kolos/0000-0002-9331-4652; Farkas, Attila/0000-0002-8877-2587; Borbás, Enikő/0000-0003-2651-7756; Marosi, György/0000-0002-4774-2023}
}

@article{MTMT:30547041,
	title = {Continuous manufacturing of orally dissolving webs containing a poorly soluble drug via electrospinning},
	url = {https://m2.mtmt.hu/api/publication/30547041},
	author = {Domokos, András and Balogh, Attila and Denes, Daniel and Nyerges, Gyula and Zodi, Levente and Farkas, Balázs and Marosi, György and Nagy, Zsombor Kristóf},
	doi = {10.1016/j.ejps.2019.01.026},
	journal-iso = {EUR J PHARM SCI},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {130},
	unique-id = {30547041},
	issn = {0928-0987},
	abstract = {An orally dissolving web (ODW) formulation of poorly soluble carvedilol (CAR) was developed and manufactured continuously using electrospinning (ES) as a key technology. Phase solubility tests revealed that hydroxypropyl-beta-cyclodextrin (HP beta CD) solubilizer alone cannot ensure sufficient solubility (6.25 mg CAR in 20 mL) in the oral cavity even if citric acid was present to ionize the basic drug. In turn, electrospun amorphous nanofibers of polyvinylpyrrolidone K30 (PVPK30) and CAR exhibited notable supersaturation of the drug in the presence of citric acid. Differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD) confirmed the amorphous state of CAR. The final ODW was prepared by layering the nanofibers onto pullulan, a well-soluble polysaccharide film carrying citric acid. The double-layered formulation showed ultrafast disintegration and dissolution modeling the oral cavity meeting regulatory requirements ( < 30 s). The continuous production was accomplished using our recently developed continuous model system by controlled deposition of the nanofibers onto the carrier film strained to a wheel collector and followed by cutting into final dosage units. Performance tests of the continuous system revealed satisfactory content uniformity over time (average acceptance value = 9.45), while residual solvent content measurements showed trace amounts of ethanol (EtOH) after production and acceptable dimethyl-formamide (DMF) content with secondary drying at room temperature. The presented work demonstrates how ES can be part of a continuous manufacturing system as an advanced drying tool during the formulation of challenging drugs.},
	keywords = {Oral drug delivery; Electrospinning; continuous manufacturing; Dissolution enhancement; Orally dissolving web; Poorly soluble drug},
	year = {2019},
	eissn = {1879-0720},
	pages = {91-99},
	orcid-numbers = {Domokos, András/0000-0003-1968-4679; Marosi, György/0000-0002-4774-2023}
}

@article{MTMT:30415856,
	title = {Evaluarea imprimabilității 3D-FDM prin intermediul polimerilor farmaceutici},
	url = {https://m2.mtmt.hu/api/publication/30415856},
	author = {Ilyés, Kinga and Kovács, Norbert Krisztián and Balogh, Attila and Borbás, Enikő and Farkas, Balázs and Casian, Tibor and Marosi, György and Tomuță, Ioan and Nagy, Zsombor Kristóf},
	journal-iso = {Medicine Pharm Rep},
	journal = {Medicine and Pharmacy Reports},
	volume = {92},
	unique-id = {30415856},
	issn = {2602-0807},
	year = {2019},
	eissn = {2668-0572},
	pages = {S87-S88},
	orcid-numbers = {Marosi, György/0000-0002-4774-2023}
}

@article{MTMT:30401928,
	title = {The applicability of pharmaceutical polymeric blends for the fused deposition modelling (FDM) 3D technique: Material considerations–printability–process modulation, with consecutive effects on in vitro release, stability and degradation},
	url = {https://m2.mtmt.hu/api/publication/30401928},
	author = {Ilyés, Kinga and Kovács, Norbert Krisztián and Balogh, Attila and Borbás, Enikő and Farkas, Balázs and Casian, Tibor and Marosi, György and Tomuță, Ioan and Nagy, Zsombor Kristóf},
	doi = {10.1016/j.ejps.2018.12.019},
	journal-iso = {EUR J PHARM SCI},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {129},
	unique-id = {30401928},
	issn = {0928-0987},
	abstract = {The three dimensional printing (3DP) in the pharmaceutical domain constitutes an alternative, innovative approach compared to the conventional production methods. Fused deposition modelling (FDM), is a simple, cost-effective 3DP technique, however the range of pharmaceutical excipients that can be applied for this methodology is restricted. The study set to define the requirements of the FDM printability, using as technical support custom made, pharmaceutical polymer based filaments and to evaluate if these new dosage forms can live up to the current GMP/GCP quality standards. Formulation rationale was assessed in accordance to the apparatus functionality. Blends were pre-screened based on the processability under the API (carvedilol) thermogravimetric analysis determined critical limit. The technological process implied the use of FDM coupled with hot melt extrusion (HME), while printability was defined by means of thermal, rheological and mechanical measurements. From the pharmaceutical standpoint, the consistency of the in vitro dissolution kinetics was monitored ‘at release’ and ‘in stability’, while the print process impact was evaluated based on the previously determined processability potential. Results showed that FDM printability is multifactorial, with brittleness and melt viscosity as primary limitation factors. The increase in shear-thinning and flexural modulus can enable broader processability intervals, which in turn proved to be essential in limiting degradation product formation. The 3DP tablets released the API in an extended rate, however the temperature and humidity along production and storage should be carefully considered as it may affect the final product quality in time. In conclusion, HME + FDM can be considered as an alternative production methodology, with prospects of applicability in the clinical sector, however for some formulations extensive packaging development will be necessary before confirming their suitability.},
	keywords = {STABILITY; Amorphous solid dispersion; 3D tablets; Printability; Fused deposition modelling; Polymeric blend},
	year = {2019},
	eissn = {1879-0720},
	pages = {110-123},
	orcid-numbers = {Marosi, György/0000-0002-4774-2023}
}