TY - CONF AU - Igaz, Nóra AU - Szőke, Krisztina AU - Bocz, Csenge AU - Kovács, Dávid AU - Rónavári, Andrea AU - Szabó, Emilia Rita AU - Polanek, Róbert AU - Buhala, Andrea AU - Vizler, Csaba AU - Tiszlavicz, László AU - Rázga, Zsolt AU - Hideghéty, Katalin AU - Kónya, Zoltán AU - Csontné Kiricsi, Mónika TI - Radiosensitizing effect of metal nanoparticles in combination with histone deacetylase inhibitors T2 - FAMÉ 2023 PY - 2023 SP - 75 EP - 76 PG - 2 UR - https://m2.mtmt.hu/api/publication/34154565 ID - 34154565 LA - English DB - MTMT ER - TY - JOUR AU - Lécz, Zsolt AU - Polanek, Róbert AU - Andreev, Alexander AU - Sharma, Ashutosh AU - Papp, Dániel AU - Hafiz, Nasr Abdelrahman Mohamed AU - Kamperidis, Christos TI - Hybrid acceleration of compact ion bunches by few-cycle laser pulses in gas jets of two atomic species JF - PHYSICAL REVIEW RESEARCH J2 - PRRESEARCH VL - 5 PY - 2023 IS - 2 PG - 11 SN - 2643-1564 DO - 10.1103/PhysRevResearch.5.023169 UR - https://m2.mtmt.hu/api/publication/34028192 ID - 34028192 N1 - ELI-ALPS, ELI-HU Non-Profit Ltd., Wolfgang Sadner str 3., Szeged, 6728, Hungary Doctoral School of Physics, Faculty of Science and Informatics, University of Szeged, Dóm tér 9, Szeged, 6720, Hungary Max-Born Institute for Nonlinear Optics, Berlin, 12489, Germany Export Date: 7 August 2023 Funding details: European Commission, EC Funding details: European Regional Development Fund, ERDF, 2020-1.2.4-TÉT-IPARI-2021-00018 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding text 1: We acknowledge support of the Department of Information Services and Computing, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany, for providing access to the Compute Cluster Hemera. We acknowledge KIFÜ/NIIF for awarding us access to HPC resource based in Debrecen, Hungary. The ELI-ALPS project (Project No. GINOP-2.3.6-15-2015-00001) is supported by the European Union and cofinanced by the European Regional Development Fund. The authors also acknowledge the Project No. 2020-1.2.4-TÉT-IPARI-2021-00018, named as HUN-CHI TéT, which is supported by the National Research, Development and Innovation Fund of Hungary. LA - English DB - MTMT ER - TY - JOUR AU - H. Kovács, Bálint Barna AU - Varga, Dániel AU - Sebők, Dániel AU - Majoros, Hajnalka AU - Polanek, Róbert AU - Pankotai, Tibor AU - Hideghéty, Katalin AU - Kukovecz, Ákos AU - Erdélyi, Miklós TI - Application of Lacunarity for Quantification of Single Molecule Localization Microscopy Images JF - CELLS J2 - CELLS-BASEL VL - 11 PY - 2022 IS - 19 PG - 14 SN - 2073-4409 DO - 10.3390/cells11193105 UR - https://m2.mtmt.hu/api/publication/33134572 ID - 33134572 N1 - Department of Optics and Quantum Electronics, University of Szeged, Szeged, 6720, Hungary Department of Applied and Environmental Chemistry, University of Szeged, Szeged, 6720, Hungary Institute of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, 6725, Hungary Centre of Excellence for Interdisciplinary Research, Development and Innovation, University of Szeged, Szeged, 6723, Hungary Biomedical Applications Group, ELI-ALPS Research Institute, ELI-HU Non-Profit Ltd., Szeged, 6728, Hungary Department of Oncotherapy, University of Szeged, Szeged, 6720, Hungary Genome Integrity and DNA Repair Group, Hungarian Centre of Excellence for Molecular Medicine (HCEMM), University of Szeged, Szeged, 6728, Hungary Export Date: 31 March 2023 Correspondence Address: Kovács, B.B.H.; Department of Optics and Quantum Electronics, Hungary; email: hkbalint@gmail.com Correspondence Address: Erdélyi, M.; Department of Optics and Quantum Electronics, Hungary; email: erdelyim@physx.u-szeged.hu Funding details: 739593 Funding details: National Renewable Energy Laboratory, NREL, RRF-2.3.1-21-2022-00009 Funding details: European Commission, EC Funding details: Magyar Tudományos Akadémia, MTA, BO/27/20, UNKP-21-5-SZTE-563, UNKP-22-5-SZTE-318 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA, TKP2021-NVA-19 Funding text 1: This research was partially supported by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-NVA funding scheme (no. TKP2021-NVA-19); the Bolyai János Research Scholarship of the Hungarian Academy of Sciences (BO/27/20); the UNKP-22-5-SZTE-318 and UNKP-21-5-SZTE-563 grants; the Recovery and Resilience Facility of the European Union within the framework of the Széchenyi Plan Plus programme (National Laboratory for Renewable Energy project, no. RRF-2.3.1-21-2022-00009). The project has received funding from the EU’s Horizon 2020 research and innovation program under grant agreement No. 739593. AB - The quantitative analysis of datasets achieved by single molecule localization microscopy is vital for studying the structure of subcellular organizations. Cluster analysis has emerged as a multi-faceted tool in the structural analysis of localization datasets. However, the results it produces greatly depend on the set parameters, and the process can be computationally intensive. Here we present a new approach for structural analysis using lacunarity. Unlike cluster analysis, lacunarity can be calculated quickly while providing definitive information about the structure of the localizations. Using simulated data, we demonstrate how lacunarity results can be interpreted. We use these interpretations to compare our lacunarity analysis with our previous cluster analysis-based results in the field of DNA repair, showing the new algorithm’s efficiency. LA - English DB - MTMT ER - TY - JOUR AU - Brunner, Szilvia AU - Varga, Dániel AU - Bozó, Renáta AU - Polanek, Róbert AU - Tőkés, Tünde AU - Szabó, Emilia Rita AU - Molnár, Réka AU - Gémes, Nikolett AU - Szebeni, Gábor AU - Puskás, László AU - Erdélyi, Miklós AU - Hideghéty, Katalin TI - Analysis of Ionizing Radiation Induced DNA Damage by Superresolution dSTORM Microscopy JF - PATHOLOGY AND ONCOLOGY RESEARCH J2 - PATHOL ONCOL RES VL - 27 PY - 2021 PG - 13 SN - 1219-4956 DO - 10.3389/pore.2021.1609971 UR - https://m2.mtmt.hu/api/publication/32487977 ID - 32487977 N1 - Funding details: Laserlab-Europe Funding details: European Commission, EC Funding details: Horizon 2020, 2017-1.2.1-NKP-2017-00002, 871124, NTP-NFTÖ-20-B-0354 Funding details: European Regional Development Fund, ERDF, GINOP-2.3.6-15-2015-00001 Funding text 1: This work was supported in part by the European Union and co-financed by the European Regional Development Fund through the ELI-ALPS project (GINOP-2.3.6-15-2015-00001), and in part by Horizon 2020, the EU Framework Programme for Research and Innovation under Grant Agreement No. 871124 Laserlab-Europe. The Confocal and superresolution dSTORM experiments and their evaluation were funded by the Hungarian BrainResearch Program (2017-1.2.1-NKP-2017-00002) and the National Young Talent Scholarship programme (NTP-NFTÖ-20-B-0354). LA - English DB - MTMT ER - TY - JOUR AU - Hideghéty, Katalin AU - Tőkés, Tünde AU - Polanek, Róbert AU - Szabó, Emilia Rita TI - Ígéretes sugárkezelési technikák a klinikai bevezetés küszöbén: mikronyaláb- és villanás besugárzás JF - KLINIKAI ONKOLÓGIA J2 - KLINIKAI ONKOLÓGIA VL - 8 PY - 2021 IS - 1 SP - 71 EP - 78 PG - 8 SN - 2064-5058 UR - https://m2.mtmt.hu/api/publication/32013749 ID - 32013749 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Polanek, Róbert AU - Hafiz, Nasr Abdelrahman Mohamed AU - Lécz, Zsolt AU - Papp, Dániel AU - Kamperidis, Christos AU - Brunner, Szilvia AU - Szabó, Emilia Rita AU - Tőkés, Tünde AU - Hideghéty, Katalin TI - 1 kHz laser accelerated electron beam feasible for radiotherapy uses: A PIC–Monte Carlo based study JF - NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT J2 - NUCL INSTRUM METH A VL - 987 PY - 2021 PG - 7 SN - 0168-9002 DO - 10.1016/j.nima.2020.164841 UR - https://m2.mtmt.hu/api/publication/31791845 ID - 31791845 N1 - ELI-ALPS, ELI-HU Non-Profit Ltd. Wolfgang Sandner u. 3, Szeged, H-6728, Hungary National Laboratory on High Power Laser and Physics, SIOM, CAS, Shanghai, 201800, China Department of Plasma and Nuclear Fusion, Nuclear Research Center, Atomic Energy Authority, Abu-Zabal, 13759, Egypt University of Szeged, Faculty of Medicine, Department of Oncotherapy, Korányi fasor 12., Szeged, H-6720, Hungary Cited By :10 Export Date: 15 May 2023 CODEN: NIMAE Correspondence Address: Polanek, R.; ELI-ALPS, Hungary; email: robert.polanek@eli-alps.hu Funding details: Horizon 2020 Framework Programme, H2020 Funding details: College of Arts and Sciences, University of Nebraska-Lincoln, CAS Funding details: European Commission, EC Funding details: Chinese Academy of Sciences, CAS, 181231KYSB20170022 Funding details: Horizon 2020, 654148, 871124 Funding details: European Regional Development Fund, FEDER, GINOP-2.3.6-15-2015-00001 Funding text 1: This work was supported in part by the European Union and co-financed by the European Regional Development Fund through the ELI-ALPS project (GINOP-2.3.6-15-2015-00001), and in part by Horizon 2020, the EU Framework Programme for Research and Innovation under Grant Agreement No. 654148 and No. 871124 Laserlab-Europe. N. A. M. H. acknowledges the President International Fellowship Initiative (PIFI) of the Chinese Academy of Sciences; the International Partnership Program (181231KYSB20170022) of CAS; the Inter-Governmental Science and Technology Cooperation of MOST. Funding text 2: This work was supported in part by the European Union and co-financed by the European Regional Development Fund through the ELI-ALPS project (GINOP-2.3.6-15-2015-00001), and in part by Horizon 2020 , the EU Framework Programme for Research and Innovation under Grant Agreement No. 654148 and No. 871124 Laserlab-Europe. Funding text 3: N. A. M. H. acknowledges the President International Fellowship Initiative (PIFI) of the Chinese Academy of Sciences; the International Partnership Program (181231KYSB20170022) of CAS; the Inter-Governmental Science and Technology Cooperation of MOST. LA - English DB - MTMT ER - TY - THES AU - Polanek, Róbert TI - Dosimetric Analysis of a Laser Accelerated Electron Beam and Optimization of FBX Chemical Dosimeter [Lézer-plazma gyorsította elektronnyaláb dozimetriai jellemzése valamint egy az FBX típusú kémiai doziméter továbbfejlesztése] PB - Szegedi Tudományegyetem (SZTE) PY - 2020 SP - 73 DO - 10.14232/phd.10712 UR - https://m2.mtmt.hu/api/publication/31956663 ID - 31956663 LA - English DB - MTMT ER - TY - JOUR AU - Brunner, Szilvia AU - Tőkés, Tünde AU - Szabó, Emilia Rita AU - Polanek, Róbert AU - Szabó, Zoltán Imre AU - Reisz, Zita AU - Konczné Gubán, Barbara AU - Szijártó, András Lajos AU - Michael, Brand AU - Stefan, Hans AU - Leonhard, Karsch AU - Elisabeth, Lessmann AU - Jörg, Pawelke AU - Michael, Schürer AU - Elke, Beyreuther AU - Hideghéty, Katalin TI - Dose-dependent Changes After Proton and Photon Irradiation in a Zebrafish Model JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 40 PY - 2020 IS - 11 SP - 6123 EP - 6135 PG - 13 SN - 0250-7005 DO - 10.21873/anticanres.14633 UR - https://m2.mtmt.hu/api/publication/31655754 ID - 31655754 N1 - ELI-ALPS, ELI-HU Non-Profit Ltd., Szeged, Hungary Department of Pathology, University of Szeged, Szeged, Hungary Department of Clinical Neuropathology, King’s College Hospital, London, United Kingdom Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Dresden, Germany OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany Helmholtz-Zentrum Dresden–Rossendorf, Dresden, Germany National Center for Tumor Diseases (NCT), Dresden, Germany Department of Oncotherapy, University of Szeged, Szeged, Hungary Export Date: 11 February 2022 CODEN: ANTRD Correspondence Address: Brunner, S.; ELI-ALPS, Wolfgang Sandner Str. 3., Hungary; email: Szilvia.Brunner@elialps.hu LA - English DB - MTMT ER - TY - JOUR AU - Polanek, Róbert AU - Varga, Zoltán AU - Fodor, Emese AU - Brunner, Szilvia AU - Szabó, Emilia Rita AU - Tőkés, Tünde AU - Hideghéty, Katalin TI - Improved FBX chemical dosimeter system with enhanced radiochemical yield for reference dosimetry in radiobiology and radiotherapy research JF - RADIATION PHYSICS AND CHEMISTRY: THE JOURNAL FOR RADIATION PHYSICS RADIATION CHEMISTRY AND RADIATION PROCESSING J2 - RADIAT PHYS CHEM VL - 174 PY - 2020 PG - 8 SN - 0969-806X DO - 10.1016/j.radphyschem.2020.108899 UR - https://m2.mtmt.hu/api/publication/31392882 ID - 31392882 AB - Radiation dosimetry plays important role in the reproducibility of radiobiology experiments, in the replicability of results, as well as in the successful and safe use of radiotherapy procedures. The consistency and accuracy of the applied dosimetry methods pre-define the outcomes of these applications. This paper presents a version of the well-known ferrous sulphate – benzoic acid – xylenol orange (FBX) chemical dosimeter with improved sensitivity, accuracy and precision. Sensitivity is increased due to a slight modification in composition and the preparation procedures. We use stock solutions for the preparation of the dosimeter solution, which consists of 1 mM ferrous sulphate and 16 mM benzoic acid with 0.25 mM xylenol orange added post-irradiation. The nonlinear response to the absorbed dose of this system is eliminated by the increased ferrous sulphate concentration, permitting the calculation of the absorbed dose by a linear relationship between the absorbed dose and the optical absorbance of the solution. The measured chemical yield of our dosimeter is 9.08⋅10−6mol/J for 6 MV photon beams and 6.42⋅10−6mol/J for 250 kVp x-rays. This is a 24% enhancement over the original FBX solution, which permits a finer dose resolution. The accuracy and precision of our method is assured by a well-designed and consistently used practice. A custom designed multipurpose PMMA slab phantom was used for irradiation in reference conditions. This phantom can be used for irradiation in reference conditions of dosimetric solutions, dosimetric films and chemical or biological samples. The combined standard uncertainty of this system is 1.12%, which can be improved by using an appropriate temperature correction factor. Furthermore, a working protocol has been established which allows dosimetry measurements using less than 1 mL dosimetric solutions. LA - English DB - MTMT ER - TY - JOUR AU - Rösch, Thomas F. AU - Szabó, Zoltán Imre AU - Haffa, Daniel AU - Bin, Jianhui AU - Brunner, Szilvia AU - Englbrecht, Franz S. AU - Friedl, Anna A. AU - Gao, Ying AU - Hartmann, Jens AU - Hilz, Peter AU - Kreuzer, Christian AU - Lindner, Florian H. AU - Ostermayr, Tobias M. AU - Polanek, Róbert AU - Speicher, Martin AU - Szabó, Emilia Rita AU - Taray, Derya AU - Tőkés, Tünde AU - Würl, Matthias AU - Parodi, Katia AU - Hideghéty, Katalin AU - Schreiber, Jörg TI - A feasibility study of zebrafish embryo irradiation with laser-accelerated protons JF - REVIEW OF SCIENTIFIC INSTRUMENTS J2 - REV SCI INSTRUM VL - 91 PY - 2020 IS - 6 PG - 8 SN - 0034-6748 DO - 10.1063/5.0008512 UR - https://m2.mtmt.hu/api/publication/31339600 ID - 31339600 N1 - Department of Medical Physics, Faculty of Physics, Ludwig-Maximilians-Universität München, Garching bei München, 85748, Germany ELI-ALPS, ELI-HU Non-Profit Ltd., Wolfgang Sandner utca 3., Szeged, H-6728, Hungary Accelerator Technology and Applied Physics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States Department of Radiation Oncology, University Hospital, LMU München, München, 80337, Germany Oncotherapy Department, University Szeged, Szeged, 6728, Hungary Cited By :7 Export Date: 14 February 2022 CODEN: RSINA Correspondence Address: Rösch, T.F.; Department of Medical Physics, Germany; email: t.roesch@physik.lmu.de LA - English DB - MTMT ER -