TY - JOUR AU - Ezer, Erzsébet AU - Schrick, Diana Zsuzsanna AU - Tőkés-Füzesi, Margit AU - Papp, István AU - Réger, Barbara AU - Molnár, Abigél AU - Ábrahám, Hajnalka AU - Koller, Ákos AU - Hársfalvi, Jolán AU - Kellermayer, Miklós AU - Molnár, Tihamér TI - Gravity sedimentation reveals functionally and morphologically different platelets in human blood JF - PLATELETS J2 - PLATELETS VL - 35 PY - 2024 IS - 1 PG - 10 SN - 0953-7104 DO - 10.1080/09537104.2023.2298341 UR - https://m2.mtmt.hu/api/publication/34493390 ID - 34493390 LA - English DB - MTMT ER - TY - BOOK AU - Bátai, István AU - Bogár, Lajos AU - Csontos, Csaba AU - Ezer, Erzsébet AU - Molnár, Tihamér AU - Mühl, Diána AU - Almási, Róbert Gyula AU - Kövesi, Tamás AU - Márton, Sándor TI - ANAESTHESIOLOGY AND INTENSIVE CARE THERAPY UNIVERSITY COURSE BOOK PB - PTE ÁOK CY - Pécs PY - 2022 UR - https://m2.mtmt.hu/api/publication/34118867 ID - 34118867 LA - German DB - MTMT ER - TY - JOUR AU - Bockhop, Fabian AU - Zeldovich, Marina AU - Cunitz, Katrin AU - Van Praag, Dominique AU - van der Vlegel, Marjolein AU - Beissbarth, Tim AU - Hagmayer, York AU - von Steinbuechel, Nicole ED - Åkerlund, Cecilia / Collaborator ED - Amrein, Krisztina / Collaborator ED - Andelic, Nada / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Antoni, Anna / Collaborator ED - Audibert, Gérard / Collaborator ED - Azouvi, Philippe / Collaborator ED - Azzolini, Maria Luisa / Collaborator ED - Bartels, Ronald / Collaborator ED - Barzó, Pál / Collaborator ED - Beauvais, Romuald / Collaborator ED - Beer, Ronny / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Benali, Habib / Collaborator ED - Berardino, Maurizio / Collaborator ED - Beretta, Luigi / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Brinck, Vibeke / Collaborator ED - Brooker, Joanne / Collaborator ED - Brorsson, Camilla / Collaborator ED - Büki, András / Collaborator ED - Bullinger, Monika / Collaborator ED - Cabeleira, Manuel / Collaborator ED - Caccioppola, Alessio / Collaborator ED - Calappi, Emiliana / Collaborator ED - Calvi, Maria Rosa / Collaborator ED - Cameron, Peter / Collaborator ED - Carbayo Lozano, Guillermo / Collaborator ED - Carbonara, Marco / Collaborator ED - Cavallo, Simona / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Clusmann, Hans / Collaborator ED - Coburn, Mark / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, Jamie D / Collaborator ED - Correia, Marta / Collaborator ED - Čović, Amra / Collaborator ED - Curry, Nicola / Collaborator ED - Czeiter, Endre / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Dark, Paul / Collaborator ED - Dawes, Helen / Collaborator ED - De Keyser, Véronique / Collaborator ED - Degos, Vincent / Collaborator ED - Della Corte, Francesco / Collaborator ED - den Boogert, Hugo / Collaborator ED - Depreitere, Bart / Collaborator ED - Đilvesi, Đula / Collaborator ED - Dixit, Abhishek / Collaborator ED - Donoghue, Emma / Collaborator ED - Dreier, Jens / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Ercole, Ari / Collaborator ED - Esser, Patrick / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Fabricius, Martin / Collaborator ED - Feigin, Valery L / Collaborator ED - Foks, Kelly / Collaborator ED - Frisvold, Shirin / Collaborator ED - Furmanov, Alex / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Galanaud, Damien / Collaborator ED - Gantner, Dashiell / Collaborator ED - Guoyi, Gao / Collaborator ED - George, Pradeep / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giga, Lelde / Collaborator ED - Glocker, Ben / Collaborator ED - Golubovic, Jagoš / Collaborator ED - A Gomez, Pedro / Collaborator ED - Gratz, Johannes / Collaborator ED - Gravesteijn, Benjamin / Collaborator ED - Grossi, Francesca / Collaborator ED - L Gruen, Russell / Collaborator ED - Gupta, Deepak / Collaborator ED - A Haagsma, Juanita / Collaborator ED - Haitsma, Iain / Collaborator ED - Helbok, Raimund / Collaborator ED - Helseth, Eirik / Collaborator ED - Horton, Lindsay / Collaborator ED - Huijben, Jilske / Collaborator ED - J Hutchinson, Peter / Collaborator ED - Jacobs, Bram / Collaborator ED - Jankowski, Stefan / Collaborator ED - Jarrett, Mike / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Johnson, Faye / Collaborator ED - Jones, Kelly / Collaborator ED - Karan, Mladen / Collaborator ED - G Kolias, Angelos / Collaborator ED - Kompanje, Erwin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Kornaropoulos, Evgenios / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Kovács, Noémi / Collaborator ED - Kowark, Ana / Collaborator ED - Lagares, Alfonso / Collaborator ED - Lanyon, Linda / Collaborator ED - Laureys, Steven / Collaborator ED - Lecky, Fiona / Collaborator ED - Ledoux, Didier / Collaborator ED - Lefering, Rolf / Collaborator ED - Legrand, Valerie / Collaborator ED - Lejeune, Aurelie / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Lingsma, Hester / Collaborator ED - I R Maas, Andrew / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Maegele, Marc / Collaborator ED - Majdan, Marek / Collaborator ED - Manara, Alex / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martino, Costanza / Collaborator ED - Maréchal, Hugues / Collaborator ED - Mattern, Julia / Collaborator ED - McMahon, Catherine / Collaborator ED - Melegh, Béla / Collaborator ED - Menon, David / Collaborator ED - Menovsky, Tomas / Collaborator ED - Mikolic, Ana / Collaborator ED - Misset, Benoit / Collaborator ED - Muraleedharan, Visakh / Collaborator ED - Murray, Lynnette / Collaborator ED - Negru, Ancuta / Collaborator ED - Nelson, David / Collaborator ED - Newcombe, Virginia / Collaborator ED - Nieboer, Daan / Collaborator ED - Nyirádi, József / Collaborator ED - Olubukola, Otesile / Collaborator ED - Oresic, Matej / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Payen, Jean-François / Collaborator ED - Perera, Natascha / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Persona, Paolo / Collaborator ED - Peul, Wilco / Collaborator ED - Piippo-Karjalainen, Anna / Collaborator ED - Pirinen, Matti / Collaborator ED - Pisica, Dana / Collaborator ED - Ples, Horia / Collaborator ED - Polinder, Suzanne / Collaborator ED - Pomposo, Inigo / Collaborator ED - Posti, Jussi P / Collaborator ED - Puybasset, Louis / Collaborator ED - Radoi, Andreea / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Helmrich, Isabel Retel / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Richter, Sophie / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Roe, Cecilie / Collaborator ED - Roise, Olav / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey V / Collaborator ED - Rosenlund, Christina / Collaborator ED - Rosenthal, Guy / Collaborator ED - Rossaint, Rolf / Collaborator ED - Rossi, Sandra / Collaborator ED - RueckertMartin Rusnák, Daniel / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sanchez-Porras, Renan / Collaborator ED - Sándor, János / Collaborator ED - Schäfer, Nadine / Collaborator ED - Schmidt, Silke / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Sewalt, Charlie / Collaborator ED - Singh, Ranjit D / Collaborator ED - Skandsen, Toril / Collaborator ED - Smielewski, Peter / Collaborator ED - Sorinola, Abayomi Akinrinsola / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Stanworth, Simon / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Steyerberg, Ewout W / Collaborator ED - Stocchetti, Nino / Collaborator ED - Sundström, Nina / Collaborator ED - Takala, Riikka / Collaborator ED - Tamás, Viktória / Collaborator ED - Tamosuitis, Tomas / Collaborator ED - Steven Taylor, Mark / Collaborator ED - Te Ao, Braden / Collaborator ED - Tenovuo, Olli / Collaborator ED - Theadom, Alice / Collaborator ED - Thomas, Matt / Collaborator ED - Tibboel, Dick / Collaborator ED - Timmers, Marjolein / Collaborator ED - Tolias, Christos / Collaborator ED - Trapani, Tony / Collaborator ED - Maria Tudora, Cristina / Collaborator ED - Unterberg, Andreas / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Vallance, Shirley / Collaborator ED - Valeinis, Egils / Collaborator ED - Vámos, Zoltán / Collaborator ED - van der Jagt, Mathieu / Collaborator ED - Van der Steen, Gregory / Collaborator ED - Naalt, Joukje van der / Collaborator ED - T J M van Dijck, Jeroen / Collaborator ED - van Erp, Inge A M / Collaborator ED - van Essen, Thomas A / Collaborator ED - Hecke, Wim Van / Collaborator ED - van Heugten, Caroline / Collaborator ED - Van Praag, Dominique / Collaborator ED - van Veen, Ernest / Collaborator ED - Vande Vyvere, Thijs / Collaborator ED - van Wijk, Roel P J / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Vega, Emmanuel / Collaborator ED - Velt, Kimberley / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Volovici, Victor / Collaborator ED - von Steinbüchel, Nicole / Collaborator ED - Voormolen, Daphne / Collaborator ED - Vulekovic, Petar / Collaborator ED - K W Wang, Kevin / Collaborator ED - Whitehouse, Daniel / Collaborator ED - Wiegers, Eveline / Collaborator ED - Williams, Guy / Collaborator ED - Wilson, Lindsay / Collaborator ED - Winzeck, Stefan / Collaborator ED - Wolf, Stefan / Collaborator ED - Yang, Zhihui / Collaborator ED - Ylén, Peter / Collaborator ED - Younsi, Alexander / Collaborator ED - Zeiler, Frederick A / Collaborator ED - Zelinkova, Veronika / Collaborator ED - Ziverte, Agate / Collaborator ED - Zoerle, Tommaso / Collaborator TI - Measurement invariance of six language versions of the post-traumatic stress disorder checklist for DSM-5 in civilians after traumatic brain injury JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 12 PY - 2022 IS - 1 PG - 15 SN - 2045-2322 DO - 10.1038/s41598-022-20170-2 UR - https://m2.mtmt.hu/api/publication/33195955 ID - 33195955 N1 - Funding Agency and Grant Number: European Union [602150]; Hannelore Kohl Stiftung (Germany); OneMind (USA); Integra LifeSciences Corporation (USA); Projekt DEAL Funding text: Open Access funding enabled and organized by Projekt DEAL. CENTER-TBI was supported by the European Union 7th Framework programme (EC Grant 602150). Additional funding was obtained from the Hannelore Kohl Stiftung (Germany), from OneMind (USA), and from Integra LifeSciences Corporation (USA). The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. AB - Traumatic brain injury (TBI) is frequently associated with neuropsychiatric impairments such as symptoms of post-traumatic stress disorder (PTSD), which can be screened using self-report instruments such as the Post-Traumatic Stress Disorder Checklist for DSM-5 (PCL-5). The current study aims to inspect the factorial validity and cross-linguistic equivalence of the PCL-5 in individuals after TBI with differential severity. Data for six language groups (n ≥ 200; Dutch, English, Finnish, Italian, Norwegian, Spanish) were extracted from the CENTER-TBI study database. Factorial validity of PTSD was evaluated using confirmatory factor analyses (CFA), and compared between four concurrent structural models. A multi-group CFA approach was utilized to investigate the measurement invariance (MI) of the PCL-5 across languages. All structural models showed satisfactory goodness-of-fit with small between-model variation. The original DSM-5 model for PTSD provided solid evidence of MI across the language groups. The current study underlines the validity of the clinical DSM-5 conceptualization of PTSD and demonstrates the comparability of PCL-5 symptom scores between language versions in individuals after TBI. Future studies should apply MI methods to other sociodemographic (e.g., age, gender) and injury-related (e.g., TBI severity) characteristics to improve the monitoring and clinical care of individuals suffering from PTSD symptoms after TBI. LA - English DB - MTMT ER - TY - JOUR AU - Van Praag, Dominique L G AU - Wouters, Kristien AU - Van Den Eede, Filip AU - Wilson, Lindsay AU - Maas, Andrew I R ED - Åkerlund, Cecilia / Collaborator ED - Amrein, Krisztina / Collaborator ED - Andelic, Nada / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Antoni, Anna / Collaborator ED - Audibert, Gérard / Collaborator ED - Azouvi, Philippe / Collaborator ED - Azzolini, Maria Luisa / Collaborator ED - Bartels, Ronald / Collaborator ED - Barzó, Pál / Collaborator ED - Beauvais, Romuald / Collaborator ED - Beer, Ronny / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Benali, Habib / Collaborator ED - Berardino, Maurizio / Collaborator ED - Beretta, Luigi / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Brinck, Vibeke / Collaborator ED - Brooker, Joanne / Collaborator ED - Brorsson, Camilla / Collaborator ED - Büki, András / Collaborator ED - Bullinger, Monika / Collaborator ED - Cabeleira, Manuel / Collaborator ED - Caccioppola, Alessio / Collaborator ED - Calappi, Emiliana / Collaborator ED - Calvi, Maria Rosa / Collaborator ED - Cameron, Peter / Collaborator ED - Lozano, Guillermo Carbayo / Collaborator ED - Carbonara, Marco / Collaborator ED - Cavallo, Simona / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Ceyisakar, Iris / Collaborator ED - Clusmann, Hans / Collaborator ED - Coburn, Mark / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, Jamie D / Collaborator ED - Correia, Marta / Collaborator ED - Čović, Amra / Collaborator ED - Curry, Nicola / Collaborator ED - Czeiter, Endre / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Dark, Paul / Collaborator ED - Dawes, Helen / Collaborator ED - De Keyser, Véronique / Collaborator ED - Degos, Vincent / Collaborator ED - Della Corte, Francesco / Collaborator ED - Boogert, Hugo den / Collaborator ED - Depreitere, Bart / Collaborator ED - Đilvesi, Đula / Collaborator ED - Dixit, Abhishek / Collaborator ED - Donoghue, Emma / Collaborator ED - Dreier, Jens / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Ercole, Ari / Collaborator ED - Esser, Patrick / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Fabricius, Martin / Collaborator ED - Feigin, Valery L / Collaborator ED - Foks, Kelly / Collaborator ED - Frisvold, Shirin / Collaborator ED - Furmanov, Alex / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Galanaud, Damien / Collaborator ED - Gantner, Dashiell / Collaborator ED - Gao, Guoyi / Collaborator ED - George, Pradeep / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giga, Lelde / Collaborator ED - Glocker, Ben / Collaborator ED - Golubovic, Jagoš / Collaborator ED - Gomez, Pedro A / Collaborator ED - Gratz, Johannes / Collaborator ED - Gravesteijn, Benjamin / Collaborator ED - Grossi, Francesca / Collaborator ED - Gruen, Russell L / Collaborator ED - Gupta, Deepak / Collaborator ED - Haagsma, Juanita A / Collaborator ED - Haitsma, Iain / Collaborator ED - Helbok, Raimund / Collaborator ED - Helseth, Eirik / Collaborator ED - Horton, Lindsay / Collaborator ED - Huijben, Jilske / Collaborator ED - Hutchinson, Peter J / Collaborator ED - Jacobs, Bram / Collaborator ED - Jankowski, Stefan / Collaborator ED - Jarrett, Mike / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Johnson, Faye / Collaborator ED - Jones, Kelly / Collaborator ED - Karan, Mladen / Collaborator ED - Kolias, Angelos G / Collaborator ED - Kompanje, Erwin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Koraropoulos, Evgenios / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Kovács, Noémi / Collaborator ED - Kowark, Ana / Collaborator ED - Lagares, Alfonso / Collaborator ED - Lanyon, Linda / Collaborator ED - Laureys, Steven / Collaborator ED - Lecky, Fiona / Collaborator ED - Ledoux, Didier / Collaborator ED - Lefering, Rolf / Collaborator ED - Legrand, Valerie / Collaborator ED - Lejeune, Aurelie / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Lingsma, Hester / Collaborator ED - Maas, Andrew Ir / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Maegele, Marc / Collaborator ED - Majdan, Marek / Collaborator ED - Manara, Alex / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martino, Costanza / Collaborator ED - Maréchal, Hugues / Collaborator ED - Mattern, Julia / Collaborator ED - McMahon, Catherine / Collaborator ED - Melegh, Béla / Collaborator ED - Menon, David / Collaborator ED - Menovsky, Tomas / Collaborator ED - Mikolic, Ana / Collaborator ED - Misset, Benoit / Collaborator ED - Muraleedharan, Visakh / Collaborator ED - Murray, Lynnette / Collaborator ED - Negru, Ancuta / Collaborator ED - Nelson, David / Collaborator ED - Newcombe, Virginia / Collaborator ED - Nieboer, Daan / Collaborator ED - Nyirádi, József / Collaborator ED - Olubukola, Otesile / Collaborator ED - Oresic, Matej / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Payen, Jean-François / Collaborator ED - Perera, Natascha / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Persona, Paolo / Collaborator ED - Peul, Wilco / Collaborator ED - Piippo-Karjalainen, Anna / Collaborator ED - Pirinen, Matti / Collaborator ED - Ples, Horia / Collaborator ED - Polinder, Suzanne / Collaborator ED - Pomposo, Inigo / Collaborator ED - Posti, Jussi P / Collaborator ED - Puybasset, Louis / Collaborator ED - Radoi, Andreea / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Richter, Sophie / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Roe, Cecilie / Collaborator ED - Roise, Olav / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey V / Collaborator ED - Rosenlund, Christina / Collaborator ED - Rosenthal, Guy / Collaborator ED - Rossaint, Rolf / Collaborator ED - Rossi, Sandra / Collaborator ED - Rueckert, Daniel / Collaborator ED - Rusnák, Martin / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sanchez-Porras, Renan / Collaborator ED - Sandor, Janos / Collaborator ED - Schäfer, Nadine / Collaborator ED - Schmidt, Silke / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Sewalt, Charlie / Collaborator ED - Skandsen, Toril / Collaborator ED - Smielewski, Peter / Collaborator ED - Sorinola, Abayomi Akinrinsola / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Stanworth, Simon / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Steyerberg, Ewout W / Collaborator ED - Stocchetti, Nino / Collaborator ED - Sundström, Nina / Collaborator ED - Synnot, Anneliese / Collaborator ED - Takala, Riikka / Collaborator ED - Tamás, Viktória / Collaborator ED - Tamosuitis, Tomas / Collaborator ED - Taylor, Mark Steven / Collaborator ED - Ao, Braden Te / Collaborator ED - Tenovuo, Olli / Collaborator ED - Theadom, Alice / Collaborator ED - Thomas, Matt / Collaborator ED - Tibboel, Dick / Collaborator ED - Timmers, Marjolein / Collaborator ED - Tolias, Christos / Collaborator ED - Trapani, Tony / Collaborator ED - Tudora, Cristina Maria / Collaborator ED - Unterberg, Andreas / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Vallance, Shirley / Collaborator ED - Valeinis, Egils / Collaborator ED - Vámos, Zoltán / Collaborator ED - van der Jagt, Mathieu / Collaborator ED - Van der Steen, Gregory / Collaborator ED - van der Naalt, Joukje / Collaborator ED - van Dijck, Jeroen Tjm / Collaborator ED - van Essen, Thomas A / Collaborator ED - Van Hecke, Wim / Collaborator ED - van Heugten, Caroline / Collaborator ED - Van Praag, Dominique / Collaborator ED - Vyvere, Thijs Vande / Collaborator ED - van Wijk, Roel Pj / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Vega, Emmanuel / Collaborator ED - Velt, Kimberley / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Volovici, Victor / Collaborator ED - von Steinbüchel, Nicole / Collaborator ED - Voormolen, Daphne / Collaborator ED - Vulekovic, Petar / Collaborator ED - Wang, Kevin Kw / Collaborator ED - Wiegers, Eveline / Collaborator ED - Williams, Guy / Collaborator ED - Wilson, Lindsay / Collaborator ED - Winzeck, Stefan / Collaborator ED - Wolf, Stefan / Collaborator ED - Yang, Zhihui / Collaborator ED - Ylén, Peter / Collaborator ED - Younsi, Alexander / Collaborator ED - Zeiler, Frederick A / Collaborator ED - Zelinkova, Veronika / Collaborator ED - Ziverte, Agate / Collaborator ED - Zoerle, Tommaso / Collaborator TI - Neurocognitive correlates of probable posttraumatic stress disorder following traumatic brain injury JF - BRAIN AND SPINE J2 - BRAIN SPINE VL - 2 PY - 2022 PG - 11 SN - 2772-5294 DO - 10.1016/j.bas.2021.100854 UR - https://m2.mtmt.hu/api/publication/33163294 ID - 33163294 N1 - Funding Agency and Grant Number: European Union [602150]; Hannelore Kohl Stiftung (Germany); OneMind (USA); Integra LifeSciences Corporation (USA) Funding text: The data used in preparation of this manuscript was obtained in the context of CENTER-TBI, a large collaborative research project funded by the European Union 7th Framework program (EC grant 602150) . Additional funding was obtained from the Hannelore Kohl Stiftung (Germany) , from OneMind (USA) and from Integra LifeSciences Corporation (USA) . AB - Neurocognitive problems associated with posttraumatic stress disorder (PTSD) can interact with impairment resulting from traumatic brain injury (TBI).We aimed to identify neurocognitive problems associated with probable PTSD following TBI in a civilian sample.The study is part of the CENTER-TBI project (Collaborative European Neurotrauma Effectiveness Research) that aims to better characterize TBI. For this cross-sectional study, we included patients of all severities aged over 15, and a Glasgow Outcome Score Extended (GOSE) above 3. Participants were assessed at six months post-injury on the PTSD Checklist-5 (PCL-5), the Trail Making Test (TMT), the Rey Auditory Verbal Learning Test (RAVLT) and the Cambridge Neuropsychological Test Automated Battery (CANTAB). Primary analysis was a complete case analysis. Regression analyses were performed to investigate the association between the PCL-5 and cognition.Of the 1134 participants included in the complete case analysis, 13.5% screened positive for PTSD. Probable PTSD was significantly associated with higher TMT-(B-A) (OR ​= ​1.35, 95% CI: 1.14-1.60, p ​< ​.001) and lower RAVLT-delayed recall scores (OR ​= ​0.74, 95% CI: 0.61-0.91, p ​= ​.004) after controlling for age, sex, psychiatric history, baseline Glasgow Coma Scale and education.Poorer performance on cognitive tests assessing task switching and, to a lesser extent, delayed verbal recall is associated with probable PTSD in civilians who have suffered TBI. LA - English DB - MTMT ER - TY - JOUR AU - van der Vlegel, Marjolein AU - Mikolić, Ana AU - Lee, Hee Quentin AU - Kaplan, Z L Rana AU - Retel, Helmrich Isabel R A AU - van Veen, Ernest AU - Andelic, Nada AU - Steinbuechel, Nicole V AU - Plass, Anne Marie AU - Zeldovich, Marina AU - Wilson, Lindsay AU - Maas, Andrew I R AU - Haagsma, Juanita A AU - Polinder, Suzanne ED - Åkerlund, Cecilia / Collaborator ED - George, Pradeep / Collaborator ED - Lanyon, Linda / Collaborator ED - Muraleedharan, Visakh / Collaborator ED - Nelson, David / Collaborator ED - Amrein, Krisztina / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Kovács, Noémi / Collaborator ED - Melegh, Béla / Collaborator ED - Nyirádi, József / Collaborator ED - Tamás, Viktória / Collaborator ED - Vámos, Zoltán / Collaborator ED - Sorinola, Abayomi Akinrinsola / Collaborator ED - Andelic, Nada / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Frisvold, Shirin / Collaborator ED - Antoni, Anna / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Audibert, Gérard / Collaborator ED - Azouvi, Philippe / Collaborator ED - Azzolini, Maria Luisa / Collaborator ED - Beretta, Luigi / Collaborator ED - Calvi, Maria Rosa / Collaborator ED - Bartels, Ronald / Collaborator ED - Boogert, Hugo den / Collaborator ED - Barzó, Pál / Collaborator ED - Beauvais, Romuald / Collaborator ED - Perera, Natascha / Collaborator ED - Beer, Ronny / Collaborator ED - Helbok, Raimund / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Benali, Habib / Collaborator ED - Degos, Vincent / Collaborator ED - Galanaud, Damien / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Berardino, Maurizio / Collaborator ED - Cavallo, Simona / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Rosenlund, Christina / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Majdan, Marek / Collaborator ED - Taylor, Mark Steven / Collaborator ED - Zelinkova, Veronika / Collaborator ED - Brinck, Vibeke / Collaborator ED - Jarrett, Mike / Collaborator ED - Brooker, Joanne / Collaborator ED - Donoghue, Emma / Collaborator ED - Synnot, Anneliese / Collaborator ED - Brorsson, Camilla / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Sundström, Nina / Collaborator ED - Büki, András / Collaborator ED - Czeiter, Endre / Collaborator ED - Bullinger, Monika / Collaborator ED - Cabeleira, Manuel / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dixit, Abhishek / Collaborator ED - Ercole, Ari / Collaborator ED - Koraropoulos, Evgenios / Collaborator ED - Menon, David / Collaborator ED - Newcombe, Virginia / Collaborator ED - Richter, Sophie / Collaborator ED - Smielewski, Peter / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Williams, Guy / Collaborator ED - Winzeck, Stefan / Collaborator ED - Zeiler, Frederick A / Collaborator ED - Caccioppola, Alessio / Collaborator ED - Calappi, Emiliana / Collaborator ED - Carbonara, Marco / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Zoerle, Tommaso / Collaborator ED - Stocchetti, Nino / Collaborator ED - Cameron, Peter / Collaborator ED - Gantner, Dashiell / Collaborator ED - Murray, Lynnette / Collaborator ED - Trapani, Tony / Collaborator ED - Vallance, Shirley / Collaborator ED - Lozano, Guillermo Carbayo / Collaborator ED - Pomposo, Inigo / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Gomez, Pedro A / Collaborator ED - Lagares, Alfonso / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Ceyisakar, Iris / Collaborator ED - Gravesteijn, Benjamin / Collaborator ED - Haagsma, Juanita A / Collaborator ED - Huijben, Jilske / Collaborator ED - Lingsma, Hester / Collaborator ED - Nieboer, Daan / Collaborator ED - Mikolic, Ana / Collaborator ED - Polinder, Suzanne / Collaborator ED - Sewalt, Charlie / Collaborator ED - Steyerberg, Ewout W / Collaborator ED - Velt, Kimberley / Collaborator ED - Voormolen, Daphne / Collaborator ED - Wiegers, Eveline / Collaborator ED - Peul, Wilco / Collaborator ED - van Dijck, Jeroen T J M / Collaborator ED - van Essen, Thomas A / Collaborator ED - van Wijk, Roel P J / Collaborator ED - Clusmann, Hans / Collaborator ED - Coburn, Mark / Collaborator ED - Kowark, Ana / Collaborator ED - Rossaint, Rolf / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, Jamie D / Collaborator ED - Correia, Marta / Collaborator ED - Čovid, Amra / Collaborator ED - von Steinbüchel, Nicole / Collaborator ED - Curry, Nicola / Collaborator ED - Stanworth, Simon / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Dark, Paul / Collaborator ED - Johnson, Faye / Collaborator ED - Dawes, Helen / Collaborator ED - Esser, Patrick / Collaborator ED - van Heugten, Caroline / Collaborator ED - De Keyser, Véronique / Collaborator ED - Maas, Andrew I R / Collaborator ED - Menovsky, Tomas / Collaborator ED - Van, der Steen Gregory / Collaborator ED - Corte, Francesco Della / Collaborator ED - Grossi, Francesca / Collaborator ED - Depreitere, Bart / Collaborator ED - Đilvesi, Đula / Collaborator ED - Golubovic, Jagoš / Collaborator ED - Karan, Mladen / Collaborator ED - Vulekovic, Petar / Collaborator ED - Dreier, Jens / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Wolf, Stefan / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Maréchal, Hugues / Collaborator ED - Fabricius, Martin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Feigin, Valery L / Collaborator ED - Jones, Kelly / Collaborator ED - Ao, Braden Te / Collaborator ED - Theadom, Alice / Collaborator ED - Foks, Kelly / Collaborator ED - Haitsma, Iain / Collaborator ED - Volovici, Victor / Collaborator ED - Furmanov, Alex / Collaborator ED - Rosenthal, Guy / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Gao, Guoyi / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giga, Lelde / Collaborator ED - Valeinis, Egils / Collaborator ED - Ziverte, Agate / Collaborator ED - Glocker, Ben / Collaborator ED - Rueckert, Daniel / Collaborator ED - Gratz, Johannes / Collaborator ED - Gruen, Russell L / Collaborator ED - Gupta, Deepak / Collaborator ED - Roe, Cecilie / Collaborator ED - Helseth, Eirik / Collaborator ED - Roise, Olav / Collaborator ED - Horton, Lindsay / Collaborator ED - Wilson, Lindsay / Collaborator ED - Hutchinson, Peter J / Collaborator ED - Kolias, Angelos G / Collaborator ED - Jacobs, Bram / Collaborator ED - van der Naalt, Joukje / Collaborator ED - Jankowski, Stefan / Collaborator ED - Kompanje, Erwin / Collaborator ED - Timmers, Marjolein / Collaborator ED - Laureys, Steven / Collaborator ED - Ledoux, Didier / Collaborator ED - Misset, Benoit / Collaborator ED - Lecky, Fiona / Collaborator ED - Olubukola, Otesile / Collaborator ED - Lefering, Rolf / Collaborator ED - Schäfer, Nadine / Collaborator ED - Legrand, Valerie / Collaborator ED - Lejeune, Aurelie / Collaborator ED - Vega, Emmanuel / Collaborator ED - Mattern, Julia / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Maegele, Marc / Collaborator ED - Manara, Alex / Collaborator ED - Thomas, Matt / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martino, Costanza / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sanchez-Porras, Renan / Collaborator ED - Younsi, Alexander / Collaborator ED - McMahon, Catherine / Collaborator ED - Negru, Ancuta / Collaborator ED - Oresic, Matej / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Payen, Jean-François / Collaborator ED - Persona, Paolo / Collaborator ED - Piippo-Karjalainen, Anna / Collaborator ED - Pirinen, Matti / Collaborator ED - Ples, Horia / Collaborator ED - Posti, Jussi P / Collaborator ED - Puybasset, Louis / Collaborator ED - Radoi, Andreea / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey V / Collaborator ED - Rossi, Sandra / Collaborator ED - Rusnák, Martin / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sándor, János / Collaborator ED - Schmidt, Silke / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Skandsen, Toril / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Takala, Riikka / Collaborator ED - Tamosuitis, Tomas / Collaborator ED - Tenovuo, Olli / Collaborator ED - Tibboel, Dick / Collaborator ED - Tolias, Christos / Collaborator ED - Tudora, Cristina Maria / Collaborator ED - van der Jagt, Mathieu / Collaborator ED - Van, Hecke Wim / Collaborator ED - Van, Praag Dominique / Collaborator ED - Vyvere, Thijs Vande / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Wang, Kevin K W / Collaborator ED - Yang, Zhihui / Collaborator ED - Ylén, Peter / Collaborator TI - Health care utilization and outcomes in older adults after Traumatic Brain Injury : A CENTER-TBI study JF - INJURY: INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED J2 - INJURY VL - 53 PY - 2022 IS - 8 SP - 2774 EP - 2782 PG - 9 SN - 0020-1383 DO - 10.1016/j.injury.2022.05.009 UR - https://m2.mtmt.hu/api/publication/32899084 ID - 32899084 N1 - Funding Agency and Grant Number: CENTER-TBI study Funding text: We are grateful to all patients and investigators who partici-pated in the CENTER-TBI study. AB - The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in older adults who sustained a TBI.We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care utilization and outcomes were described for patients aged ≥65 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury.Of 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six-month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with functional impairment, lower generic and disease-specific HRQoL and mental health symptoms.The rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive. LA - English DB - MTMT ER - TY - JOUR AU - Abada, Alan AU - Csécsei, Péter AU - Ezer, Erzsébet AU - Lenzsér, Gábor AU - Hegyi, Péter AU - Szolics, Alex AU - Mérei, Ákos AU - Szentesi, Andrea Ildikó AU - Molnár, Tihamér TI - General Anesthesia-Related Drop in Diastolic Blood Pressure May Impact the Long-Term Outcome in Stroke Patients Undergoing Thrombectomy JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 11 PY - 2022 IS - 11 PG - 10 SN - 2077-0383 DO - 10.3390/jcm11112997 UR - https://m2.mtmt.hu/api/publication/32843086 ID - 32843086 N1 - Department of Anesthesiology and Intensive Care, Medical School, University of Pecs, Pecs, 7624, Hungary Centre for Translational Medicine, Semmelweiss University, Budapest, 1085, Hungary Department of Neurosurgery, Medical School, University of Pecs, Pecs, 7624, Hungary Department of Radiology, Örebro University Hospital, Örebro, 70281, Sweden Export Date: 13 November 2023 Correspondence Address: Csecsei, P.; Department of Neurosurgery, Hungary; email: csecsei.peter@pte.hu AB - Background: Several factors affect the efficacy of endovascular thrombectomy (EVT); however, the anesthesia-related factors have not been fully explored. We aimed to identify independent predictors of outcome by analyzing procedural factors based on a multicentric stroke registry. Methods: Data of consecutive patients with acute ischemic stroke (AIS) were extracted from the prospective STAY ALIVE stroke registry. Demographic, clinical, and periprocedural factors including hemodynamic values were analyzed in patients undergoing thrombectomy with either general anesthesia (GA) or conscious sedation (CS). Independent predictors of outcome both at 30 and 90 days based on the modified Rankin Scale (mRS: 0–2 as favorable outcome) were also explored. Results: A total of 199 patients (GA: 76 (38%) vs. CS: 117 (59%); in addition, six patients were converted from CS to GA) were included. The minimum value of systolic, diastolic, and mean arterial pressure was significantly lower in the GA compared to the CS group, and GA was associated with a longer onset to EVT time and a higher drop in all hemodynamic variables (all, p < 0.001). A higher drop in diastolic blood pressure (DBP) was even independently associated with a poor 90-day outcome (p = 0.024). Conclusion: A GA-related drop in DBP may independently predict a poor long-term outcome in stroke patients undergoing thrombectomy. LA - English DB - MTMT ER - TY - JOUR AU - Schrick, Diana Zsuzsanna AU - Molnár, Tihamér AU - Tőkés-Füzesi, Margit AU - Molnár, Abigél AU - Ezer, Erzsébet TI - Circulating Microvesicles in Convalescent Ischemic Stroke Patients: A Contributor to High-On-Treatment Residual Platelet Reactivity? JF - FRONTIERS IN BIOSCIENCE-LANDMARK J2 - FRONT BIOSCI-LANDMARK VL - 27 PY - 2022 IS - 5 PG - 7 SN - 2768-6701 DO - 10.31083/j.fbl2705158 UR - https://m2.mtmt.hu/api/publication/32832892 ID - 32832892 N1 - * Megosztott szerzőség AB - Exploration of novel and effective antiplatelet strategies for the secondary prevention of ischemic stroke is utmost. Some platelet derived microparticles (PMVs) in convalescent stroke subjects were found to be predictive for the next vascular event. Patients with high-on-treatment platelet reactivity (HTPR) had a significantly higher risk for ischemic stroke. Here, we aimed to explore associations among circulating microparticles and responsivness to antiplatelet (clopidogrel) therapy.A total of 18 patients on clopidogrel therapy due to secondary stroke prevention were rospectively recruited into this study. Twenty age-matched healthy subjects served as controls. Flow cytometric measurements of microparicles (MVs) and data analysis were performed on Beckman-Coulter FC-500 cytometer with CXP software. Besides, platelet aggregometry data were revealed. Both measurements were performed in whole blood and from the lower and upper blood fractions separated after 1-hour gravity sedimentation by the analogy with erythrocyte sedimentation rate.The total number of circulating MVs, and particularly the platelet derived CD42+ and PAC-1+ were significantly higher in post-stroke patients (p < 0.001). The platelet aggregation in the whole blood (area under the curve, AUC) showed a significant negative correlation with the total number of MPs in the lower blood sample after 1-hour gravity sedimentation (r = -0.650, p = 0.005). Next, we analyzed associations among MPs and aggregometry data obtained from clopidogrel responders and non-responders. Both, area under the curve (AUC) and velocity in the whole blood showed opposite correlation with the total number of MVs in the lower blood sample after 1-hour gravity sedimentation. Importantly, a significant negative correlation was observed for the velocity (r = -0.801, p = 0.005), but not for the AUC in responders. Platelet derived CD42+ and PAC-1+ MVs showed positive correlations with neutrophils in the lower blood sample (p = 0.008 and p = 0.006 respectively).Circulating MVs may allow to monitor the response to antiplatelet therapy in post-stroke patients. In addition, the link between platelet derived MVs and neutrophil granulocytes might become therapeutic targets in the future. LA - English DB - MTMT ER - TY - JOUR AU - Böhm, Julia K AU - Güting, Helge AU - Thorn, Sophie AU - Schäfer, Nadine AU - Rambach, Victoria AU - Schöchl, Herbert AU - Grottke, Oliver AU - Rossaint, Rolf AU - Stanworth, Simon AU - Curry, Nicola AU - Lefering, Rolf AU - Maegele, Marc ED - Åkerlund, Cecilia / Collaborator ED - Amrein, Krisztina / Collaborator ED - Andelic, Nada / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Antoni, Anna / Collaborator ED - Audibert, Gérard / Collaborator ED - Azouvi, Philippe / Collaborator ED - Azzolini, Maria Luisa / Collaborator ED - Bartels, Ronald / Collaborator ED - Barzó, Pál / Collaborator ED - Beauvais, Romuald / Collaborator ED - Beer, Ronny / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Benali, Habib / Collaborator ED - Berardino, Maurizio / Collaborator ED - Beretta, Luigi / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Brinck, Vibeke / Collaborator ED - Brooker, Joanne / Collaborator ED - Brorsson, Camilla / Collaborator ED - Büki, András / Collaborator ED - Bullinger, Monika / Collaborator ED - Cabeleira, Manuel / Collaborator ED - Caccioppola, Alessio / Collaborator ED - Calappi, Emiliana / Collaborator ED - Calvi, Maria Rosa / Collaborator ED - Cameron, Peter / Collaborator ED - Lozano, Guillermo Carbayo / Collaborator ED - Carbonara, Marco / Collaborator ED - Cavallo, Simona / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Ceyisakar, Iris / Collaborator ED - Clusmann, Hans / Collaborator ED - Coburn, Mark / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, Jamie D / Collaborator ED - Correia, Marta / Collaborator ED - Čović, Amra / Collaborator ED - Curry, Nicola / Collaborator ED - Czeiter, Endre / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Dark, Paul / Collaborator ED - Dawes, Helen / Collaborator ED - De Keyser, Véronique / Collaborator ED - Degos, Vincent / Collaborator ED - Corte, Francesco Della / Collaborator ED - Boogert, Hugo den / Collaborator ED - Depreitere, Bart / Collaborator ED - Đilvesi, Đula / Collaborator ED - Dixit, Abhishek / Collaborator ED - Donoghue, Emma / Collaborator ED - Dreier, Jens / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Ercole, Ari / Collaborator ED - Esser, Patrick / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Fabricius, Martin / Collaborator ED - Feigin, Valery L / Collaborator ED - Foks, Kelly / Collaborator ED - Frisvold, Shirin / Collaborator ED - Furmanov, Alex / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Galanaud, Damien / Collaborator ED - Gantner, Dashiell / Collaborator ED - Gao, Guoyi / Collaborator ED - George, Pradeep / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giga, Lelde / Collaborator ED - Glocker, Ben / Collaborator ED - Golubovic, Jagoš / Collaborator ED - Gomez, Pedro A / Collaborator ED - Gratz, Johannes / Collaborator ED - Gravesteijn, Benjamin / Collaborator ED - Grossi, Francesca / Collaborator ED - Gruen, Russell L / Collaborator ED - Gupta, Deepak / Collaborator ED - Haagsma, Juanita A / Collaborator ED - Haitsma, Iain / Collaborator ED - Helbok, Raimund / Collaborator ED - Helseth, Eirik / Collaborator ED - Horton, Lindsay / Collaborator ED - Huijben, Jilske / Collaborator ED - Hutchinson, Peter J / Collaborator ED - Jacobs, Bram / Collaborator ED - Jankowski, Stefan / Collaborator ED - Jarrett, Mike / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Johnson, Faye / Collaborator ED - Jones, Kelly / Collaborator ED - Karan, Mladen / Collaborator ED - Kolias, Angelos G / Collaborator ED - Kompanje, Erwin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Koraropoulos, Evgenios / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Kovács, Noémi / Collaborator ED - Kowark, Ana / Collaborator ED - Lagares, Alfonso / Collaborator ED - Lanyon, Linda / Collaborator ED - Laureys, Steven / Collaborator ED - Lecky, Fiona / Collaborator ED - Ledoux, Didier / Collaborator ED - Lefering, Rolf / Collaborator ED - Legrand, Valerie / Collaborator ED - Lejeune, Aurelie / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Lingsma, Hester / Collaborator ED - Maas, Andrew I R / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Maegele, Marc / Collaborator ED - Majdan, Marek / Collaborator ED - Manara, Alex / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martino, Costanza / Collaborator ED - Maréchal, Hugues / Collaborator ED - Mattern, Julia / Collaborator ED - McMahon, Catherine / Collaborator ED - Melegh, Béla / Collaborator ED - Menon, David / Collaborator ED - Menovsky, Tomas / Collaborator ED - Mikolic, Ana / Collaborator ED - Misset, Benoit / Collaborator ED - Muraleedharan, Visakh / Collaborator ED - Murray, Lynnette / Collaborator ED - Negru, Ancuta / Collaborator ED - Nelson, David / Collaborator ED - Newcombe, Virginia / Collaborator ED - Nieboer, Daan / Collaborator ED - Nyirádi, József / Collaborator ED - Olubukola, Otesile / Collaborator ED - Oresic, Matej / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Payen, Jean-François / Collaborator ED - Perera, Natascha / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Persona, Paolo / Collaborator ED - Peul, Wilco / Collaborator ED - Piippo-Karjalainen, Anna / Collaborator ED - Pirinen, Matti / Collaborator ED - Ples, Horia / Collaborator ED - Polinder, Suzanne / Collaborator ED - Pomposo, Inigo / Collaborator ED - Posti, Jussi P / Collaborator ED - Puybasset, Louis / Collaborator ED - Radoi, Andreea / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Richter, Sophie / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Roe, Cecilie / Collaborator ED - Roise, Olav / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey V / Collaborator ED - Rosenlund, Christina / Collaborator ED - Rosenthal, Guy / Collaborator ED - Rossaint, Rolf / Collaborator ED - Rossi, Sandra / Collaborator ED - Rueckert, Daniel / Collaborator ED - Rusnák, Martin / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sanchez-Porras, Renan / Collaborator ED - Sándor, János / Collaborator ED - Schäfer, Nadine / Collaborator ED - Schmidt, Silke / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Sewalt, Charlie / Collaborator ED - Skandsen, Toril / Collaborator ED - Smielewski, Peter / Collaborator ED - Sorinola, Abayomi Akinrinsola / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Stanworth, Simon / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Steyerberg, Ewout W / Collaborator ED - Stocchetti, Nino / Collaborator ED - Sundström, Nina / Collaborator ED - Synnot, Anneliese / Collaborator ED - Takala, Riikka / Collaborator ED - Tamás, Viktória / Collaborator ED - Tamosuitis, Tomas / Collaborator ED - Taylor, Mark Steven / Collaborator ED - Ao, Braden Te / Collaborator ED - Tenovuo, Olli / Collaborator ED - Theadom, Alice / Collaborator ED - Thomas, Matt / Collaborator ED - Tibboel, Dick / Collaborator ED - Timmers, Marjolein / Collaborator ED - Tolias, Christos / Collaborator ED - Trapani, Tony / Collaborator ED - Tudora, Cristina Maria / Collaborator ED - Unterberg, Andreas / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Vallance, Shirley / Collaborator ED - Valeinis, Egils / Collaborator ED - Vámos, Zoltán / Collaborator ED - van der Jagt, Mathieu / Collaborator ED - Van der Steen, Gregory / Collaborator ED - van der Naalt, Joukje / Collaborator ED - van Dijck, Jeroen T J M / Collaborator ED - van Essen, Thomas A / Collaborator ED - Van Hecke, Wim / Collaborator ED - van Heugten, Caroline / Collaborator ED - Van Praag, Dominique / Collaborator ED - Vyvere, Thijs Vande / Collaborator ED - van Wijk, Roel P J / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Vega, Emmanuel / Collaborator ED - Velt, Kimberley / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Volovici, Victor / Collaborator ED - von Steinbüchel, Nicole / Collaborator ED - Voormolen, Daphne / Collaborator ED - Vulekovic, Petar / Collaborator ED - Wang, Kevin K W / Collaborator ED - Wiegers, Eveline / Collaborator ED - Williams, Guy / Collaborator ED - Wilson, Lindsay / Collaborator ED - Winzeck, Stefan / Collaborator ED - Wolf, Stefan / Collaborator ED - Yang, Zhihui / Collaborator ED - Ylén, Peter / Collaborator ED - Younsi, Alexander / Collaborator ED - Zeiler, Frederick A / Collaborator ED - Zelinkova, Veronika / Collaborator ED - Ziverte, Agate / Collaborator ED - Zoerle, Tommaso / Collaborator TI - Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI) : A CENTER-TBI Analysis JF - NEUROCRITICAL CARE J2 - NEUROCRIT CARE VL - 35 PY - 2021 IS - 1 SP - 184 EP - 196 PG - 13 SN - 1541-6933 DO - 10.1007/s12028-020-01151-7 UR - https://m2.mtmt.hu/api/publication/32668374 ID - 32668374 N1 - Funding Agency and Grant Number: European Union [602150]; Projekt DEAL Funding text: Open Access funding enabled and organized by Projekt DEAL. The research described above was supported by the European Union's Seventh Framework Programme (FP7/2007-2013) under Grant Agreement No. 602150 (CENTER-TBI). AB - Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associated with high rates of complications, unfavourable outcomes and mortality. The mechanism of the development of TBI-associated coagulopathy is poorly understood.This analysis, embedded in the prospective, multi-centred, observational Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, aimed to characterise the coagulopathy of TBI. Emphasis was placed on the acute phase following TBI, primary on subgroups of patients with abnormal coagulation profile within 4 h of admission, and the impact of pre-injury anticoagulant and/or antiplatelet therapy. In order to minimise confounding factors, patients with isolated TBI (iTBI) (n = 598) were selected for this analysis.Haemostatic disorders were observed in approximately 20% of iTBI patients. In a subgroup analysis, patients with pre-injury anticoagulant and/or antiplatelet therapy had a twice exacerbated coagulation profile as likely as those without premedication. This was in turn associated with increased rates of mortality and unfavourable outcome post-injury. A multivariate analysis of iTBI patients without pre-injury anticoagulant therapy identified several independent risk factors for coagulopathy which were present at hospital admission. Glasgow Coma Scale (GCS) less than or equal to 8, base excess (BE) less than or equal to - 6, hypothermia and hypotension increased risk significantly.Consideration of these factors enables early prediction and risk stratification of acute coagulopathy after TBI, thus guiding clinical management. LA - English DB - MTMT ER - TY - CHAP AU - Futó, Judit AU - Ezer, Erzsébet ED - Bogár, Lajos TI - Központi Idegrendszeri kórképek T2 - Aneszteziológia és intenzív terápia PB - Medicina Könyvkiadó CY - Budapest SN - 9789632268026 PY - 2021 SP - 451 EP - 488 PG - 38 UR - https://m2.mtmt.hu/api/publication/32502755 ID - 32502755 N1 - 4.1.1. fejezet LA - Hungarian DB - MTMT ER - TY - JOUR AU - Sewalt, Charlie Aletta AU - Gravesteijn, Benjamin Yaël AU - Menon, David AU - Lingsma, Hester Floor AU - Maas, Andrew I R AU - Stocchetti, Nino AU - Venema, Esmee AU - Lecky, Fiona E ED - Åkerlund, Cecilia / Collaborator ED - Amrein, Krisztina / Collaborator ED - Andelic, Nada / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Antoni, Anna / Collaborator ED - Audibert, Gérard / Collaborator ED - Azouvi, Philippe / Collaborator ED - Azzolini, Maria Luisa / Collaborator ED - Bartels, Ronald / Collaborator ED - Barzó, Pál / Collaborator ED - Beauvais, Romuald / Collaborator ED - Beer, Ronny / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Benali, Habib / Collaborator ED - Berardino, Maurizio / Collaborator ED - Beretta, Luigi / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Brinck, Vibeke / Collaborator ED - Brooker, Joanne / Collaborator ED - Brorsson, Camilla / Collaborator ED - Büki, András / Collaborator ED - Bullinger, Monika / Collaborator ED - Cabeleira, Manuel / Collaborator ED - Caccioppola, Alessio / Collaborator ED - Calappi, Emiliana / Collaborator ED - Calvi, Maria Rosa / Collaborator ED - Cameron, Peter / Collaborator ED - Lozano, Guillermo Carbayo / Collaborator ED - Carbonara, Marco / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Cnossen, Maryse / Collaborator ED - Coburn, Mark / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, D Jamie / Collaborator ED - Correia, Marta / Collaborator ED - Čović, Amra / Collaborator ED - Curry, Nicola / Collaborator ED - Czeiter, Endre / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Dawes, Helen / Collaborator ED - De Keyser, Véronique / Collaborator ED - Degos, Vincent / Collaborator ED - Corte, Francesco Della / Collaborator ED - Boogert, Hugo den / Collaborator ED - Depreitere, Bart / Collaborator ED - Đilvesi, Đula / Collaborator ED - Dixit, Abhishek / Collaborator ED - Donoghue, Emma / Collaborator ED - Dreier, Jens / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Ercole, Ari / Collaborator ED - Esser, Patrick / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Fabricius, Martin / Collaborator ED - Feigin, Valery L / Collaborator ED - Foks, Kelly / Collaborator ED - Frisvold, Shirin / Collaborator ED - Furmanov, Alex / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Galanaud, Damien / Collaborator ED - Gantner, Dashiell / Collaborator ED - Gao, Guoyi / Collaborator ED - George, Pradeep / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giga, Lelde / Collaborator ED - Glocker, Ben / Collaborator ED - Golubovic, Jagoš / Collaborator ED - Gomez, Pedro A / Collaborator ED - Gratz, Johannes / Collaborator ED - Gravesteijn, Benjamin / Collaborator ED - Grossi, Francesca / Collaborator ED - Gruen, Russell L / Collaborator ED - Gupta, Deepak / Collaborator ED - Haagsma, Juanita A / Collaborator ED - Haitsma, Iain / Collaborator ED - Helbok, Raimund / Collaborator ED - Helseth, Eirik / Collaborator ED - Horton, Lindsay / Collaborator ED - Huijben, Jilske / Collaborator ED - Hutchinson, Peter J / Collaborator ED - Jacobs, Bram / Collaborator ED - Jankowski, Stefan / Collaborator ED - Jarrett, Mike / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Jones, Kelly / Collaborator ED - Karan, Mladen / Collaborator ED - Kolias, Angelos G / Collaborator ED - Kompanje, Erwin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Koraropoulos, Evgenios / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Kovács, Noémi / Collaborator ED - Lagares, Alfonso / Collaborator ED - Lanyon, Linda / Collaborator ED - Laureys, Steven / Collaborator ED - Lecky, Fiona / Collaborator ED - Lefering, Rolf / Collaborator ED - Legrand, Valerie / Collaborator ED - Lejeune, Aurelie / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Lingsma, Hester / Collaborator ED - Maas, Andrew I R / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Maegele, Marc / Collaborator ED - Majdan, Marek / Collaborator ED - Manara, Alex / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martino, Costanza / Collaborator ED - Maréchal, Hugues / Collaborator ED - Mattern, Julia / Collaborator ED - McMahon, Catherine / Collaborator ED - Melegh, Béla / Collaborator ED - Menon, David / Collaborator ED - Menovsky, Tomas / Collaborator ED - Mulazzi, Davide / Collaborator ED - Muraleedharan, Visakh / Collaborator ED - Murray, Lynnette / Collaborator ED - Nair, Nandesh / Collaborator ED - Negru, Ancuta / Collaborator ED - Nelson, David / Collaborator ED - Newcombe, Virginia / Collaborator ED - Nieboer, Daan / Collaborator ED - Noirhomme, Quentin / Collaborator ED - Nyirádi, József / Collaborator ED - Olubukola, Otesile / Collaborator ED - Oresic, Matej / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Payen, Jean-François / Collaborator ED - Perera, Natascha / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Persona, Paolo / Collaborator ED - Peul, Wilco / Collaborator ED - Piippo-Karjalainen, Anna / Collaborator ED - Pirinen, Matti / Collaborator ED - Ples, Horia / Collaborator ED - Polinder, Suzanne / Collaborator ED - Pomposo, Inigo / Collaborator ED - Posti, Jussi P / Collaborator ED - Puybasset, Louis / Collaborator ED - Radoi, Andreea / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Real, Ruben / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Richter, Sophie / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Roe, Cecilie / Collaborator ED - Roise, Olav / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey V / Collaborator ED - Rosenlund, Christina / Collaborator ED - Rosenthal, Guy / Collaborator ED - Rossaint, Rolf / Collaborator ED - Rossi, Sandra / Collaborator ED - Rueckert, Daniel / Collaborator ED - Rusnák, Martin / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sanchez-Porras, Renan / Collaborator ED - Sándor, János / Collaborator ED - Schäfer, Nadine / Collaborator ED - Schmidt, Silke / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Sewalt, Charlie / Collaborator ED - Skandsen, Toril / Collaborator ED - Smielewski, Peter / Collaborator ED - Sorinola, Abayomi Akinrinsola / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Stanworth, Simon / Collaborator ED - Kowark, Ana / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Steyerberg, Ewout W / Collaborator ED - Stocchetti, Nino / Collaborator ED - Sundström, Nina / Collaborator ED - Synnot, Anneliese / Collaborator ED - Takala, Riikka / Collaborator ED - Tamás, Viktória / Collaborator ED - Tamosuitis, Tomas / Collaborator ED - Taylor, Mark Steven / Collaborator ED - Ao, Braden Te / Collaborator ED - Tenovuo, Olli / Collaborator ED - Theadom, Alice / Collaborator ED - Thomas, Matt / Collaborator ED - Tibboel, Dick / Collaborator ED - Timmers, Marjolein / Collaborator ED - Tolias, Christos / Collaborator ED - Trapani, Tony / Collaborator ED - Tudora, Cristina Maria / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Vallance, Shirley / Collaborator ED - Valeinis, Egils / Collaborator ED - Vámos, Zoltán / Collaborator ED - Van der Steen, Gregory / Collaborator ED - van der Naalt, Joukje / Collaborator ED - van Dijck, Jeroen T J M / Collaborator ED - van Essen, Thomas A / Collaborator ED - Van Hecke, Wim / Collaborator ED - van Heugten, Caroline / Collaborator ED - Van Praag, Dominique / Collaborator ED - Vyvere, Thijs Vande / Collaborator ED - Vanhaudenhuyse, Audrey / Collaborator ED - van Wijk, Roel P J / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Vega, Emmanuel / Collaborator ED - Velt, Kimberley / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Volovici, Victor / Collaborator ED - von Steinbüchel, Nicole / Collaborator ED - Voormolen, Daphne / Collaborator ED - Vulekovic, Petar / Collaborator ED - Wang, Kevin K W / Collaborator ED - Wiegers, Eveline / Collaborator ED - Williams, Guy / Collaborator ED - Wilson, Lindsay / Collaborator ED - Winzeck, Stefan / Collaborator ED - Wolf, Stefan / Collaborator ED - Yang, Zhihui / Collaborator ED - Ylén, Peter / Collaborator ED - Younsi, Alexander / Collaborator ED - Zeiler, Frederik A / Collaborator ED - Zelinkova, Veronika / Collaborator ED - Ziverte, Agate / Collaborator ED - Zoerle, Tommaso / Collaborator TI - Primary versus early secondary referral to a specialized neurotrauma center in patients with moderate/severe traumatic brain injury : a CENTER TBI study JF - SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION AND EMERGENCY MEDICINE J2 - SCAND J TRAUMA RESUS VL - 29 PY - 2021 IS - 1 PG - 11 SN - 1757-7241 DO - 10.1186/s13049-021-00930-1 UR - https://m2.mtmt.hu/api/publication/32164324 ID - 32164324 N1 - Funding Agency and Grant Number: European Union 7th Framework program (EC Grant) [602150]; Hannelore Kohl Stiftung (Germany); OneMind (USA); Integra LifeSciences Corporation (USA) Funding text: CENTER-TBI was supported by the European Union 7th Framework program (EC Grant 602150). Additional funding was obtained from the Hannelore Kohl Stiftung (Germany), from OneMind (USA) and from Integra LifeSciences Corporation (USA). AB - Prehospital care for patients with traumatic brain injury (TBI) varies with some emergency medical systems recommending direct transport of patients with moderate to severe TBI to hospitals with specialist neurotrauma care (SNCs). The aim of this study is to assess variation in levels of early secondary referral within European SNCs and to compare the outcomes of directly admitted and secondarily transferred patients.Patients with moderate and severe TBI (Glasgow Coma Scale < 13) from the prospective European CENTER-TBI study were included in this study. All participating hospitals were specialist neuroscience centers. First, adjusted between-country differences were analysed using random effects logistic regression where early secondary referral was the dependent variable, and a random intercept for country was included. Second, the adjusted effect of early secondary referral on survival to hospital discharge and functional outcome [6 months Glasgow Outcome Scale Extended (GOSE)] was estimated using logistic and ordinal mixed effects models, respectively.A total of 1347 moderate/severe TBI patients from 53 SNCs in 18 European countries were included. Of these 1347 patients, 195 (14.5%) were admitted after early secondary referral. Secondarily referred moderate/severe TBI patients presented more often with a CT abnormality: mass lesion (52% vs. 34%), midline shift (54% vs. 36%) and acute subdural hematoma (77% vs. 65%). After adjusting for case-mix, there was a large European variation in early secondary referral, with a median OR of 1.69 between countries. Early secondary referral was not associated with functional outcome (adjusted OR 1.07, 95% CI 0.78-1.69), nor with survival at discharge (1.05, 0.58-1.90).Across Europe, substantial practice variation exists in the proportion of secondarily referred TBI patients at SNCs that is not explained by case mix. Within SNCs early secondary referral does not seem to impact functional outcome and survival after stabilisation in a non-specialised hospital. Future research should identify which patients with TBI truly benefit from direct transportation. LA - English DB - MTMT ER -