TY - JOUR AU - Mezei, Gabriella AU - Batár, Péter AU - Kozma, Laura AU - Illés, Árpád AU - Kappelmayer, János AU - Bekéné Debreceni, Ildikó TI - Ponatinib Exerts an Inhibitory Effect on Collagen-induced Platelet Aggregation and Generation of Coated-Platelets JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 41 PY - 2021 IS - 10 SP - 4867 EP - 4874 PG - 8 SN - 0250-7005 DO - 10.21873/anticanres.15300 UR - https://m2.mtmt.hu/api/publication/32575842 ID - 32575842 AB - Background/Aim: BCR-ABL tyrosine kinase inhibitors (TKIs) are exceptionally effective drugs in the treatment of chronic myeloid leukemia, nevertheless, TKIs have also an effect on platelets. We aimed to investigate the effect of a third-generation TKI, ponatinib on platelet functions. Materials and Methods: Collagen-induced platelet aggregation and coated-platelet formation were examined using in vitro and in ex vivo samples of patients on ponatinib therapy. Results: In platelet rich plasma of healthy volunteers, ponatinib at a supra- therapeutic concentration (1,000 nM) significantly impaired collagen induced platelet aggregation (p <= 0.01) and reduced the formation of coated-platelets at 150 nM ponatinib concentration ( p <= 0.05). In addition, upon glycoprotein VI (GPVI) receptor activation, a significantly lower percentage of PAC1 binding platelets (p <= 0.05) was observed at 1,000 nM final concentration of ponatinib. Platelets, isolated from patients on ponatinib therapy showed impaired collagen elicited aggregation response, already in pre-dose samples compared to healthy donors. Conclusion: The therapeutic concentration of ponatinib impairs platelet activation processes elicited by GPVI receptor agonists. LA - English DB - MTMT ER - TY - JOUR AU - Mezei, Gabriella AU - Illés, Árpád AU - Batár, Péter TI - A krónikus myeloid leukaemia tirozin-kináz-gátló kezelésének mellékhatásai és azok gyakorlati ellátása = Practical management of side effects of tyrosine kinase inhibitor therapy in chronic myeloid leukemia JF - ORVOSI HETILAP J2 - ORV HETIL VL - 162 PY - 2021 IS - 30 SP - 1198 EP - 1207 PG - 10 SN - 0030-6002 DO - 10.1556/650.2021.32177 UR - https://m2.mtmt.hu/api/publication/32285360 ID - 32285360 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kotogány, Edit AU - Balog, József Ágoston AU - Nagy, Lajos I. AU - Alföldi, Róbert AU - Bertagnolo, Valeria AU - Brugnoli, Federica AU - Demjén, András AU - Kovács, Anita Kármen AU - Batár, Péter AU - Mezei, Gabriella AU - Szabó, Renáta AU - Kanizsai, Iván AU - Varga, Csaba AU - Puskás, László AU - Szebeni, Gábor TI - Imidazo[1,2-b]pyrazole-7-Carboxamide Derivative Induces Differentiation-Coupled Apoptosis of Immature Myeloid Cells Such as Acute Myeloid Leukemia and Myeloid-Derived Suppressor Cells JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 21 PY - 2020 IS - 14 PG - 27 SN - 1661-6596 DO - 10.3390/ijms21145135 UR - https://m2.mtmt.hu/api/publication/31385279 ID - 31385279 N1 - Laboratory of Functional Genomics, Institute of Genetics, Biological Research Centre, Temesvári krt. 62, Szeged, H6726, Hungary School in Biology, University of Szeged, Szeged, H6726, Hungary Avidin Ltd., Alsó kikötő sor 11/D, Szeged, H6726, Hungary AstridBio Technologies Ltd., Wimmer Fülöp u. 1, Szeged, H6728, Hungary Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, Ferrara, 44121, Italy Department of Hematology, Faculty of Medicine, University of Debrecen, Nagyerdei körút 98, Debrecen, H4032, Hungary Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H6726, Hungary Export Date: 29 August 2020 Correspondence Address: Szebeni, G.J.; Laboratory of Functional Genomics, Institute of Genetics, Biological Research Centre, Avidin Ltd., Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Temesvári krt. 62, Hungary; email: szebeni.gabor@brc.hu Chemicals/CAS: amide, 17655-31-1; lactate dehydrogenase, 9001-60-9; lactate dehydrogenase A; mitogen activated protein kinase 3, 137632-07-6; stress activated protein kinase, 155215-87-5 Funding details: Magyar Tudományos Akadémia, MTA, UNKP-19-4-SZTE-36, BO/00139/17/8 Funding text 1: Funding: This research was funded by the following grants, GINOP-2.3.2-15-2016-00001 and GINOP-2.3.2-15-2016-00030 by the National Research, Development and Innovation Office, Hungary; Gábor J. Szebeni was supported by János Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00139/17/8) and by the UNKP-19-4-SZTE-36 New National Excellence Program of the Ministry for Innovation and Technology. Laboratory of Functional Genomics, Institute of Genetics, Biological Research Centre, Temesvári krt. 62, Szeged, H6726, Hungary School in Biology, University of Szeged, Szeged, H6726, Hungary Avidin Ltd., Alsó kikötő sor 11/D, Szeged, H6726, Hungary AstridBio Technologies Ltd., Wimmer Fülöp u. 1, Szeged, H6728, Hungary Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, Ferrara, 44121, Italy Department of Hematology, Faculty of Medicine, University of Debrecen, Nagyerdei körút 98, Debrecen, H4032, Hungary Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H6726, Hungary Export Date: 10 January 2021 Correspondence Address: Szebeni, G.J.; Laboratory of Functional Genomics, Institute of Genetics, Biological Research Centre, Avidin Ltd., Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Temesvári krt. 62, Hungary; email: szebeni.gabor@brc.hu Chemicals/CAS: amide, 17655-31-1; lactate dehydrogenase, 9001-60-9; lactate dehydrogenase A; mitogen activated protein kinase 3, 137632-07-6; stress activated protein kinase, 155215-87-5 Funding details: Magyar Tudományos Akadémia, MTA, UNKP-19-4-SZTE-36, BO/00139/17/8 Funding details: Ministry for Innovation and Technology Funding details: National Research, Development and Innovation Office Funding text 1: Funding: This research was funded by the following grants, GINOP-2.3.2-15-2016-00001 and GINOP-2.3.2-15-2016-00030 by the National Research, Development and Innovation Office, Hungary; Gábor J. Szebeni was supported by János Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00139/17/8) and by the UNKP-19-4-SZTE-36 New National Excellence Program of the Ministry for Innovation and Technology. Laboratory of Functional Genomics, Institute of Genetics, Biological Research Centre, Temesvári krt. 62, Szeged, H6726, Hungary School in Biology, University of Szeged, Szeged, H6726, Hungary Avidin Ltd., Alsó kikötő sor 11/D, Szeged, H6726, Hungary AstridBio Technologies Ltd., Wimmer Fülöp u. 1, Szeged, H6728, Hungary Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, Ferrara, 44121, Italy Department of Hematology, Faculty of Medicine, University of Debrecen, Nagyerdei körút 98, Debrecen, H4032, Hungary Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H6726, Hungary Export Date: 10 February 2021 Correspondence Address: Szebeni, G.J.; Laboratory of Functional Genomics, Temesvári krt. 62, Hungary; email: szebeni.gabor@brc.hu Correspondence Address: Szebeni, G.J.; Avidin Ltd., Alsó kikötő sor 11/D, Hungary; email: szebeni.gabor@brc.hu Correspondence Address: Szebeni, G.J.; Department of Physiology, Közép fasor 52, Hungary; email: szebeni.gabor@brc.hu Funding Agency and Grant Number: National Research, Development and Innovation Office, Hungary [GINOP-2.3.2-15-2016-00001, GINOP-2.3.2-15-2016-00030]; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences [BO/00139/17/8]; New National Excellence Program of the Ministry for Innovation and Technology [UNKP-19-4-SZTE-36] Funding text: This research was funded by the following grants, GINOP-2.3.2-15-2016-00001 and GINOP-2.3.2-15-2016-00030 by the National Research, Development and Innovation Office, Hungary; Gabor J. Szebeni was supported by Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00139/17/8) and by the UNKP-19-4-SZTE-36 New National Excellence Program of the Ministry for Innovation and Technology. Laboratory of Functional Genomics, Institute of Genetics, Biological Research Centre, Temesvári krt. 62, Szeged, H6726, Hungary School in Biology, University of Szeged, Szeged, H6726, Hungary Avidin Ltd., Alsó kikötő sor 11/D, Szeged, H6726, Hungary AstridBio Technologies Ltd., Wimmer Fülöp u. 1, Szeged, H6728, Hungary Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, Ferrara, 44121, Italy Department of Hematology, Faculty of Medicine, University of Debrecen, Nagyerdei körút 98, Debrecen, H4032, Hungary Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, H6726, Hungary Export Date: 12 March 2021 Correspondence Address: Szebeni, G.J.; Laboratory of Functional Genomics, Temesvári krt. 62, Hungary; email: szebeni.gabor@brc.hu Correspondence Address: Szebeni, G.J.; Avidin Ltd., Alsó kikötő sor 11/D, Hungary; email: szebeni.gabor@brc.hu Correspondence Address: Szebeni, G.J.; Department of Physiology, Közép fasor 52, Hungary; email: szebeni.gabor@brc.hu Chemicals/CAS: amide, 17655-31-1; lactate dehydrogenase, 9001-60-9; lactate dehydrogenase A; mitogen activated protein kinase 3, 137632-07-6; stress activated protein kinase, 155215-87-5 Funding details: Magyar Tudományos Akadémia, MTA, BO/00139/17/8, UNKP-19-4-SZTE-36 Funding details: Ministry for Innovation and Technology Funding details: National Research, Development and Innovation Office Funding text 1: This research was funded by the following grants, GINOP-2.3.2-15-2016-00001 and GINOP-2.3.2-15-2016-00030 by the National Research, Development and Innovation Office, Hungary; G?bor J. Szebeni was supported by J?nos Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00139/17/8) and by the UNKP-19-4-SZTE-36 New National Excellence Program of the Ministry for Innovation and Technology. Funding text 2: Funding: This research was funded by the following grants, GINOP-2.3.2-15-2016-00001 and GINOP-2.3.2-15-2016-00030 by the National Research, Development and Innovation Office, Hungary; Gábor J. Szebeni was supported by János Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00139/17/8) and by the UNKP-19-4-SZTE-36 New National Excellence Program of the Ministry for Innovation and Technology. LA - English DB - MTMT ER - TY - JOUR AU - Mezei, Gabriella AU - Bekéné Debreceni, Ildikó AU - Kerenyi, Adrienne AU - Reményi, Gyula AU - Szász, Róbert AU - Illés, Árpád AU - Kappelmayer, János AU - Batár, Péter TI - Dasatinib inhibits coated-platelet generation in patients with chronic myeloid leukemia JF - PLATELETS J2 - PLATELETS VL - 30 PY - 2019 IS - 7 SP - 836 EP - 843 PG - 8 SN - 0953-7104 DO - 10.1080/09537104.2018.1501470 UR - https://m2.mtmt.hu/api/publication/32005205 ID - 32005205 LA - English DB - MTMT ER - TY - JOUR AU - Bekéné Debreceni, Ildikó AU - Mezei, Gabriella AU - Batár, Péter AU - Illés, Árpád AU - Kappelmayer, János TI - Dasatinib Inhibits Procoagulant and Clot Retracting Activities of Human Platelets JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 20 PY - 2019 IS - 21 SN - 1661-6596 DO - 10.3390/ijms20215430 UR - https://m2.mtmt.hu/api/publication/31189289 ID - 31189289 LA - English DB - MTMT ER - TY - JOUR AU - Telek, Béla AU - Rejtő, László AU - Batár, Péter AU - Miltényi, Zsófia AU - Reményi, Gyula AU - Simon, Zsófia Zsuzsanna AU - Ujj, Zsófia Ágnes AU - Mezei, Gabriella AU - Szász, Róbert AU - Kiss, Attila AU - Udvardy, Miklós AU - Illés, Árpád TI - Az akut myeloid leukaemia gyógyszeres kezelése. Jelenlegi lehetőségek, jövőbeli kilátások JF - ORVOSI HETILAP J2 - ORV HETIL VL - 157 PY - 2016 IS - 22 SP - 843 EP - 848 PG - 6 SN - 0030-6002 DO - 10.1556/650.2016.30433 UR - https://m2.mtmt.hu/api/publication/3111420 ID - 3111420 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Papp, Mária AU - Mezei, Gabriella AU - Udvardy, Miklós AU - Altorjay, István TI - Haematológiai és haemostasis paraméterek változása transjugularis intrahepaticus portosystemas shunt (TIPS) hatására JF - ORVOSI HETILAP J2 - ORV HETIL VL - 144 PY - 2003 IS - 27 SP - 1341 EP - 1345 PG - 5 SN - 0030-6002 UR - https://m2.mtmt.hu/api/publication/1463342 ID - 1463342 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Telek, Béla AU - Rejtő, László AU - Mezei, Gabriella AU - Karászi, Éva AU - Kappelmayer, János AU - Balázs, Margit AU - Kiss, Attila AU - Ujj, G AU - Rak, K AU - Udvardy, Miklós TI - Molekuláris biológiai vizsgálatok kronikus lymphoid leukaemiában [Molecular biology examination in chronic lymphocytic leukemia] JF - ORVOSI HETILAP J2 - ORV HETIL VL - 142 PY - 2001 IS - 16 SP - 833 EP - 837 PG - 5 SN - 0030-6002 UR - https://m2.mtmt.hu/api/publication/1138705 ID - 1138705 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Mezei, Gabriella AU - Karászi, Éva AU - Telek, Béla AU - Ujj, György AU - Rejtő, László AU - Kiss, Attila AU - Rácz, Klára AU - Udvardy, Miklós AU - Rák, Kálmán TI - A krónikus lymphoid leukaemia biológiája JF - MAGYAR BELORVOSI ARCHIVUM J2 - MBA VL - 53 PY - 2000 IS - 2 SP - 103 EP - 107 PG - 5 SN - 0133-5464 UR - https://m2.mtmt.hu/api/publication/34484146 ID - 34484146 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Rejtő, László AU - Balázs, Margit AU - Ádány, Róza AU - Rak, K AU - Telek, Béla AU - Kiss, Attila AU - Ujj, G AU - Mezei, Gabriella AU - Balogh, E AU - Udvardy, Miklós TI - Fluoreszcencia in situ hibridizációval szerzett tapasztalataink a krónikus myeloid leukaemia diagnosztikájában és követésében JF - ORVOSI HETILAP J2 - ORV HETIL VL - 141 PY - 2000 IS - 39 SP - 2133 EP - 2137 PG - 5 SN - 0030-6002 UR - https://m2.mtmt.hu/api/publication/1138698 ID - 1138698 LA - Hungarian DB - MTMT ER -