@article{MTMT:35467844, title = {Reduced circulating CD63+ extracellular vesicle levels associate with atherosclerosis in hypercholesterolaemic mice and humans}, url = {https://m2.mtmt.hu/api/publication/35467844}, author = {Kestecher, Brachyahu Meir and Németh, Krisztina and Ghosal, Sayam and Sayour, Viktor Nabil and Gergely, Tamás G and Bodnár, Bernadett Réka and Försönits, András and Sódar, Barbara and Oesterreicher, Johannes and Holnthoner, Wolfgang and Varga, Zoltán and Giricz, Zoltán and Ferdinandy, Péter and Buzás, Edit Irén and Osteikoetxea, Xabier}, doi = {10.1186/s12933-024-02459-w}, journal-iso = {CARDIOVASC DIABETOL}, journal = {CARDIOVASCULAR DIABETOLOGY}, volume = {23}, unique-id = {35467844}, issn = {1475-2840}, year = {2024}, eissn = {1475-2840}, orcid-numbers = {Németh, Krisztina/0000-0002-3825-2137; Ghosal, Sayam/0000-0001-6618-930X; Bodnár, Bernadett Réka/0000-0003-3347-9225; Försönits, András/0000-0002-9298-8890; Sódar, Barbara/0000-0002-8803-7304; Varga, Zoltán/0000-0002-2758-0784; Giricz, Zoltán/0000-0003-2036-8665; Ferdinandy, Péter/0000-0002-6424-6806; Buzás, Edit Irén/0000-0002-3744-206X; Osteikoetxea, Xabier/0000-0003-3628-0174} } @article{MTMT:34567532, title = {Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches}, url = {https://m2.mtmt.hu/api/publication/34567532}, author = {Welsh, Joshua A. and Goberdhan, Deborah C. I. and O'Driscoll, Lorraine and Buzás, Edit Irén and Blenkiron, Cherie and Bussolati, Benedetta and Cai, Houjian and Di Vizio, Dolores and Driedonks, Tom A. P. and Erdbrügger, Uta and Falcon‐Perez, Juan M. and Fu, Qing‐Ling and Hill, Andrew F. and Lenassi, Metka and Lim, Sai Kiang and Mahoney, Mỹ G. and Mohanty, Sujata and Möller, Andreas and Nieuwland, Rienk and Ochiya, Takahiro and Sahoo, Susmita and Torrecilhas, Ana C. and Zheng, Lei and Zijlstra, Andries and Abuelreich, Sarah and Bagabas, Reem and Bergese, Paolo and Bridges, Esther M. and Brucale, Marco and Burger, Dylan and Carney, Randy P. and Cocucci, Emanuele and Colombo, Federico and Crescitelli, Rossella and Hanser, Edveena and Harris, Adrian L. and Haughey, Norman J. and Hendrix, An and Ivanov, Alexander R. and Jovanovic‐Talisman, Tijana and Kruh‐Garcia, Nicole A. and Ku'ulei‐Lyn Faustino, Vroniqa and Kyburz, Diego and Lässer, Cecilia and Lennon, Kathleen M. and Lötvall, Jan and Maddox, Adam L. and Martens‐Uzunova, Elena S. and Mizenko, Rachel R. and Newman, Lauren A. and Ridolfi, Andrea and Rohde, Eva and Rojalin, Tatu and Rowland, Andrew and Saftics, Andras and Sandau, Ursula S. and Saugstad, Julie A. and Shekari, Faezeh and Swift, Simon and Ter‐Ovanesyan, Dmitry and Tosar, Juan P. and Useckaite, Zivile and Valle, Francesco and Varga, Zoltán and van der Pol, Edwin and van Herwijnen, Martijn J. C. and Wauben, Marca H. M. and Wehman, Ann M. and Williams, Sarah and Zendrini, Andrea and Zimmerman, Alan J. and Théry, Clotilde and Witwer, Kenneth W. and Beke-Somfai, Tamás and Szigyártó, Imola Csilla and Haseeb, Zubair}, doi = {10.1002/jev2.12404}, journal-iso = {J EXTRACELLULAR VESICL}, journal = {JOURNAL OF EXTRACELLULAR VESICLES}, volume = {13}, unique-id = {34567532}, abstract = {Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year‐on‐year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non‐vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly.}, year = {2024}, eissn = {2001-3078}, orcid-numbers = {Welsh, Joshua A./0000-0002-1097-9756; Goberdhan, Deborah C. I./0000-0003-0645-6714; Buzás, Edit Irén/0000-0002-3744-206X; Bussolati, Benedetta/0000-0002-3663-5134; Cai, Houjian/0000-0003-4887-2652; Falcon‐Perez, Juan M./0000-0003-3133-0670; Hill, Andrew F./0000-0001-5581-2354; Lenassi, Metka/0000-0002-9488-6855; Mohanty, Sujata/0000-0002-0047-4914; Nieuwland, Rienk/0000-0002-5671-3400; Ochiya, Takahiro/0000-0002-0776-9918; Sahoo, Susmita/0000-0002-7279-1564; Torrecilhas, Ana C./0000-0001-5724-2199; Zheng, Lei/0000-0003-2576-8780; Zijlstra, Andries/0000-0001-8460-8803; Brucale, Marco/0000-0001-7244-4389; Carney, Randy P./0000-0001-8193-1664; Crescitelli, Rossella/0000-0002-1714-3169; Haughey, Norman J./0000-0001-5194-4122; Martens‐Uzunova, Elena S./0000-0002-5363-2525; Newman, Lauren A./0000-0003-3303-1666; Rohde, Eva/0000-0001-8692-886X; Sandau, Ursula S./0000-0002-3646-7089; Saugstad, Julie A./0000-0002-2996-9611; Shekari, Faezeh/0000-0001-6026-5412; Tosar, Juan P./0000-0002-2021-2479; Varga, Zoltán/0000-0002-5741-2669; Wauben, Marca H. M./0000-0003-0360-0311; Wehman, Ann M./0000-0001-9826-4132; Zimmerman, Alan J./0000-0001-6280-4790; Théry, Clotilde/0000-0001-8294-6884; Witwer, Kenneth W./0000-0003-1664-4233; Bodnár, Bernadett Réka/0000-0003-3347-9225; Bukva, Mátyás/0000-0002-5225-0285; Buzás, Edit Irén/0000-0002-3744-206X; Buzás, Krisztina/0000-0001-8933-2033; Dobra, Gabriella/0000-0002-2814-7720; Försönits, András/0000-0002-9298-8890; Ghosal, Sayam/0000-0001-6618-930X; Gyukity-Sebestyén, Edina/0000-0003-1383-6301; Koncz, Anna/0000-0003-2511-2394; Lőrincz, Márton Ákos/0000-0002-2819-5116; Németh, Krisztina/0000-0002-3825-2137; Oláh, Attila/0000-0003-4122-5639; Osteikoetxea, Xabier/0000-0003-3628-0174; Pálóczi, Krisztina/0000-0001-7065-3582; Stepanova, Ganna/0000-0002-8285-2762; Visnovitz, Tamás/0000-0002-7962-5083; Wiener, Zoltán/0000-0001-7056-4926; Harmati, Mária/0000-0002-4875-5723; Hegyesi, Hargita/0000-0002-8800-5169} } @article{MTMT:32980579, title = {A citokinek mint terápiás célpontok}, url = {https://m2.mtmt.hu/api/publication/32980579}, author = {Tóth, Eszter Ágnes and Försönits, András and Nagy, György}, journal-iso = {IMMUNOLÓGIAI SZEMLE}, journal = {IMMUNOLÓGIAI SZEMLE}, volume = {14}, unique-id = {32980579}, issn = {2061-0203}, abstract = {A szervezetünk hírközlésében kiemelt szerepet betöltő citokinek számos megbetegedésben játszanak szerepet, így fontos célpontjai lehetnek napjaink terápiáinak. Az alábbi összefoglalóban röviden bemutatjuk a jelátviteli mechanizmusuk alapján elkülönített citokincsaládokat, majd sorra vesszük a terápiás beavatkozási lehetőségeket, részletesebben bemutatva a reumatológia-immunológia területén legfontosabb, kifejezetten a citokineket célzó terápiákat, valamint röviden érintjük a citokinek intracelluláris jelátvitelét befolyásoló szereket és a legmodernebb génterápiás eljárásokat is. Kulcsszavak: citokin, citokincsalád, célzott terápia, JAK/STAT, TNF, IL-1, IL-17}, keywords = {terápia; CYTOKINEK}, year = {2022}, pages = {31-41}, orcid-numbers = {Försönits, András/0000-0002-9298-8890; Nagy, György/0000-0003-1198-3228} } @article{MTMT:32189675, title = {Formation of a protein corona on the surface of extracellular vesicles in blood plasma}, url = {https://m2.mtmt.hu/api/publication/32189675}, author = {Tóth, Eszter Ágnes and Turiák, Lilla and Visnovitz, Tamás and Cserép, Csaba and Türk-Mázló, Anett and Sódar, Barbara and Försönits, András and Petővári, Gábor and Sebestyén, Anna and Komlósi, Zsolt and Drahos, László and Kittel, Ágnes and Nagy, György and Bácsi, Attila and Dénes, Ádám and Song Gho, Yong and Szabó-Taylor, Katalin and Buzás, Edit Irén}, doi = {10.1002/jev2.12140}, journal-iso = {J EXTRACELLULAR VESICL}, journal = {JOURNAL OF EXTRACELLULAR VESICLES}, volume = {10}, unique-id = {32189675}, year = {2021}, eissn = {2001-3078}, orcid-numbers = {Visnovitz, Tamás/0000-0002-7962-5083; Cserép, Csaba/0000-0001-5513-2471; Sódar, Barbara/0000-0002-8803-7304; Försönits, András/0000-0002-9298-8890; Petővári, Gábor/0000-0002-1957-2864; Sebestyén, Anna/0000-0001-8814-4794; Komlósi, Zsolt/0000-0002-4149-1497; Drahos, László/0000-0001-9589-6652; Nagy, György/0000-0003-1198-3228; Szabó-Taylor, Katalin/0000-0002-4763-3521; Buzás, Edit Irén/0000-0002-3744-206X} } @article{MTMT:31808664, title = {An implanted device enables in vivo monitoring of extracellular vesicle-mediated spread of pro-inflammatory mast cell response in mice}, url = {https://m2.mtmt.hu/api/publication/31808664}, author = {Visnovitzné Dr Vukman, Krisztina and Ferencz, Andrea and Fehér, Daniella and Berner-Juhos, Krisztina and Lőrincz, Péter and Visnovitz, Tamás and Koncz, Anna and Pálóczi, Krisztina and Seregélyes, Gábor and Försönits, András and Khamari, Delaram and Galinsoga, Alicia and Drahos, László and Buzás, Edit Irén}, doi = {10.1002/jev2.12023}, journal-iso = {J EXTRACELLULAR VESICL}, journal = {JOURNAL OF EXTRACELLULAR VESICLES}, volume = {10}, unique-id = {31808664}, abstract = {Abstract Mast cells have been shown to release extracellular vesicles (EVs) in vitro. However, EV-mediated mast cell communication in vivo remains unexplored. Primary mast cells from GFP-transgenic and wild type mice, were grown in the presence or absence of lipopolysaccharide (LPS), and the secreted EVs were separated from the conditioned media. Mast cell-derived EVs were next cultured with LPS-naïve mast cells, and the induction of TNF-α expression was monitored. In addition, primary mast cells were seeded in diffusion chambers that were implanted into the peritoneal cavities of mice. Diffusion chambers enabled the release of GFP+ mast cell-derived EVs in vivo into the peritoneal cavity. Peritoneal lavage cells were assessed for the uptake of GFP+ EVs and for TNF-α production. In vitro, LPS-stimulated mast cell-derived EVs were efficiently taken up by non-stimulated mast cells, and induced TNF-α expression in a TLR4, JNK and P38 MAPK dependent manner. In vivo, using implanted diffusion chambers, we confirmed the release and transmission of mast cell-derived EVs to other mast cells with subsequent induction of TNF-α expression. These data show an EV-mediated spreading of pro-inflammatory response between mast cells, and provide the first in vivo evidence for the biological role of mast cell-derived EVs.}, keywords = {In Vitro; mast cell; In vivo; TNF-α; LPS; Extracellular vesicles}, year = {2020}, eissn = {2001-3078}, orcid-numbers = {Ferencz, Andrea/0000-0002-1623-9783; Berner-Juhos, Krisztina/0000-0002-0585-8239; Lőrincz, Péter/0000-0001-7374-667X; Visnovitz, Tamás/0000-0002-7962-5083; Koncz, Anna/0000-0003-2511-2394; Pálóczi, Krisztina/0000-0001-7065-3582; Försönits, András/0000-0002-9298-8890; Drahos, László/0000-0001-9589-6652; Buzás, Edit Irén/0000-0002-3744-206X} } @article{MTMT:31798713, title = {Continuous in vivo release of mast cell derived extracellular vesicles from an implanted device spreads pro‐inflammatory response in mice}, url = {https://m2.mtmt.hu/api/publication/31798713}, author = {Visnovitzné Dr Vukman, Krisztina and Seregélyes, Gábor and Visnovitz, Tamás and Lőrincz, Péter and Koncz, Anna and Ferencz, Andrea and Fehér, Daniella and Berner-Juhos, Krisztina and Sódar, Barbara and Pálóczi, Krisztina and Tóth, Eszter Ágnes and Försönits, András and Khamari, Delaram and Galinsoga, Alicia and Buzás, Edit Irén}, journal-iso = {J EXTRACELLULAR VESICL}, journal = {JOURNAL OF EXTRACELLULAR VESICLES}, volume = {9}, unique-id = {31798713}, year = {2020}, eissn = {2001-3078}, pages = {85-85}, orcid-numbers = {Visnovitz, Tamás/0000-0002-7962-5083; Lőrincz, Péter/0000-0001-7374-667X; Koncz, Anna/0000-0003-2511-2394; Ferencz, Andrea/0000-0002-1623-9783; Berner-Juhos, Krisztina/0000-0002-0585-8239; Sódar, Barbara/0000-0002-8803-7304; Pálóczi, Krisztina/0000-0001-7065-3582; Försönits, András/0000-0002-9298-8890; Buzás, Edit Irén/0000-0002-3744-206X} } @article{MTMT:31616018, title = {Extracelluláris vezikulákkal folytatott kísérletes módszerek validálása}, url = {https://m2.mtmt.hu/api/publication/31616018}, author = {Királyhidi, Panna and Joóné, Baricza Eszter and Tóth, Eszter and Försönits, András and Visnovitz, Tamás and Nagy, György and Buzás, Edit Irén}, journal-iso = {MAGYAR REUMATOL}, journal = {MAGYAR REUMATOLÓGIA}, volume = {61}, unique-id = {31616018}, issn = {0139-4495}, year = {2020}, pages = {192-192}, orcid-numbers = {Försönits, András/0000-0002-9298-8890; Visnovitz, Tamás/0000-0002-7962-5083; Nagy, György/0000-0003-1198-3228; Buzás, Edit Irén/0000-0002-3744-206X} } @article{MTMT:30338008, title = {Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines}, url = {https://m2.mtmt.hu/api/publication/30338008}, author = {Théry, C. and Witwer, K.W. and Aikawa, E. and Alcaraz, M.J. and Anderson, J.D. and Andriantsitohaina, R. and Antoniou, A. and Arab, T. and Archer, F. and Atkin-Smith, G.K. and Ayre, D.C. and Bach, J.-M. and Bachurski, D. and Baharvand, H. and Balaj, L. and Baldacchino, S. and Bauer, N.N. and Baxter, A.A. and Bebawy, M. and Beckham, C. and Bedina, Zavec A. and Benmoussa, A. and Berardi, A.C. and Bergese, P. and Bielska, E. and Blenkiron, C. and Bobis-Wozowicz, S. and Boilard, E. and Boireau, W. and Bongiovanni, A. and Borràs, F.E. and Bosch, S. and Boulanger, C.M. and Breakefield, X. and Breglio, A.M. and Brennan, M.Á. and Brigstock, D.R. and Brisson, A. and Broekman, M.L.D. and Bromberg, J.F. and Bryl-Górecka, P. and Buch, S. and Buck, A.H. and Burger, D. and Busatto, S. and Buschmann, D. and Bussolati, B. and Buzás, Edit Irén and Byrd, J.B. and Camussi, G. and Carter, D.R.F. and Caruso, S. and Chamley, L.W. and Chang, Y.-T. and Chaudhuri, A.D. and Chen, C. and Chen, S. and Cheng, L. and Chin, A.R. and Clayton, A. and Clerici, S.P. and Cocks, A. and Cocucci, E. and Coffey, R.J. and Cordeiro-da-Silva, A. and Couch, Y. and Coumans, F.A.W. and Coyle, B. and Crescitelli, R. and Criado, M.F. and D’Souza-Schorey, C. and Das, S. and de, Candia P. and De, Santana E.F. Jr. and De, Wever O. and del, Portillo H.A. and Demaret, T. and Deville, S. and Devitt, A. and Dhondt, B. and Di, Vizio D. and Dieterich, L.C. and Dolo, V. and Dominguez, Rubio A.P. and Dominici, M. and Dourado, M.R. and Driedonks, T.A.P. and Duarte, F.V. and Duncan, H.M. and Eichenberger, R.M. and Ekström, K. and EL, Andaloussi S. and Elie-Caille, C. and Erdbrügger, U. and Falcón-Pérez, J.M. and Fatima, F. and Fish, J.E. and Flores-Bellver, M. and Försönits, András and Frelet-Barrand, A. and Fricke, F. and Fuhrmann, G. and Gabrielsson, S. and Gámez-Valero, A. and Gardiner, C. and Gärtner, K. and Gaudin, R. and Gho, Y.S. and Giebel, B. and Gilbert, C. and Gimona, M. and Giusti, I. and Goberdhan, D.C.I. and Görgens, A. and Gorski, S.M. and Greening, D.W. and Gross, J.C. and Gualerzi, A. and Gupta, G.N. and Gustafson, D. and Handberg, A. and Haraszti, R.A. and Harrison, P. and Hegyesi, Hargita and Hendrix, A. and Hill, A.F. and Hochberg, F.H. and Hoffmann, K.F. and Holder, B. and Holthofer, H. and Hosseinkhani, B. and Hu, G. and Huang, Y. and Huber, V. and Hunt, S. and Ibrahim, A.G.-E. and Ikezu, T. and Inal, J.M. and Isin, M. and Ivanova, A. and Jackson, H.K. and Jacobsen, S. and Jay, S.M. and Jayachandran, M. and Jenster, G. and Jiang, L. and Johnson, S.M. and Jones, J.C. and Jong, A. and Jovanovic-Talisman, T. and Jung, S. and Kalluri, R. and Kano, S.-I. and Kaur, S. and Kawamura, Y. and Keller, E.T. and Khamari, Delaram and Khomyakova, E. and Khvorova, A. and Kierulf, P. and Kim, K.P. and Kislinger, T. and Klingeborn, M. and Klinke, D.J. II and Kornek, M. and Kosanović, M.M. and Kovács, Árpád Ferenc and Krämer-Albers, E.-M. and Krasemann, S. and Krause, M. and Kurochkin, I.V. and Kusuma, G.D. and Kuypers, S. and Laitinen, S. and Langevin, S.M. and Languino, L.R. and Lannigan, J. and Lässer, C. and Laurent, L.C. and Lavieu, G. and Lázaro-Ibáñez, E. and Le, Lay S. and Lee, M.-S. and Lee, Y.X.F. and Lemos, D.S. and Lenassi, M. and Leszczynska, A. and Li, I.T.S. and Liao, K. and Libregts, S.F. and Ligeti, Erzsébet and Lim, R. and Lim, S.K. and Linē, A. and Linnemannstöns, K. and Llorente, A. and Lombard, C.A. and Lorenowicz, M.J. and Lőrincz, Márton Ákos and Lötvall, J. and Lovett, J. and Lowry, M.C. and Loyer, X. and Lu, Q. and Lukomska, B. and Lunavat, T.R. and Maas, S.L.N. and Malhi, H. and Marcilla, A. and Mariani, J. and Mariscal, J. and Martens-Uzunova, E.S. and Martin-Jaular, L. and Martinez, M.C. and Martins, V.R. and Mathieu, M. and Mathivanan, S. and Maugeri, M. and McGinnis, L.K. and McVey, M.J. and Meckes, D.G. 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Jr and Veit, T.D. and Vella, L.J. and Velot, É. and Verweij, F.J. and Vestad, B. and Viñas, J.L. and Visnovitz, Tamás and Visnovitzné Dr Vukman, Krisztina and Wahlgren, J. and Watson, D.C. and Wauben, M.H.M. and Weaver, A. and Webber, J.P. and Weber, V. and Wehman, A.M. and Weiss, D.J. and Welsh, J.A. and Wendt, S. and Wheelock, A.M. and Wiener, Zoltán and Witte, L. and Wolfram, J. and Xagorari, A. and Xander, P. and Xu, J. and Yan, X. and Yáñez-Mó, M. and Yin, H. and Yuana, Y. and Zappulli, V. and Zarubova, J. and Žėkas, V. and Zhang, J.-Y. and Zhao, Z. and Zheng, L. and Zheutlin, A.R. and Zickler, A.M. and Zimmermann, P. and Zivkovic, A.M. and Zocco, D. and Zuba-Surma, E.K.}, doi = {10.1080/20013078.2018.1535750}, journal-iso = {J EXTRACELLULAR VESICL}, journal = {JOURNAL OF EXTRACELLULAR VESICLES}, volume = {7}, unique-id = {30338008}, year = {2018}, eissn = {2001-3078}, orcid-numbers = {Buzás, Edit Irén/0000-0002-3744-206X; Försönits, András/0000-0002-9298-8890; Hegyesi, Hargita/0000-0002-8800-5169; Kovács, Árpád Ferenc/0000-0002-7742-160X; Ligeti, Erzsébet/0000-0001-6374-729X; Lőrincz, Márton Ákos/0000-0002-2819-5116; Osteikoetxea, Xabier/0000-0003-3628-0174; Sódar, Barbara/0000-0002-8803-7304; Visnovitz, Tamás/0000-0002-7962-5083; Wiener, Zoltán/0000-0001-7056-4926} } @article{MTMT:3204172, title = {Mast cell secretome: Soluble and vesicular components}, url = {https://m2.mtmt.hu/api/publication/3204172}, author = {Visnovitzné Dr Vukman, Krisztina and Försönits, András and Oszvald, Ádám and Tóth, Eszter Ágnes and Buzás, Edit Irén}, doi = {10.1016/j.semcdb.2017.02.002}, journal-iso = {SEMIN CELL DEV BIOL}, journal = {SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY}, volume = {67}, unique-id = {3204172}, issn = {1084-9521}, abstract = {Mast cells are multifunctional master cells implicated in both innate and adaptive immune responses. Their role has been best characterized in allergy and anaphylaxis; however, emerging evidences support their contribution to a wide variety of human diseases. Mast cells, being capable of both degranulation and subsequent recovery, have recently attracted substantial attention as also being rich sources of secreted extracellular vesicles (including exosomes and microvesicles). Along with secreted de novo synthesized soluble molecules and secreted preformed granules, the membrane-enclosed extracellular vesicles represent a previously unexplored part of the mast cell secretome. In this review article we summarize available data regarding the different soluble molecules and membrane-enclosed structures secreted by mast cells. Furthermore, we provide an overview of the release mechanisms including degranulation, piecemeal degranulation, transgranulation, and secretion of different types of extracellular vesicles. Finally, we aim to give a summary of the known biological functions associated with the different mast cell-derived secretion products. The increasingly recognized complexity of mast cell secretome may provide important novel clues to processes by which mast cells contribute to the development of different pathologies and are capable of orchestrating immune responses both in health and disease.}, year = {2017}, eissn = {1096-3634}, pages = {65-73}, orcid-numbers = {Försönits, András/0000-0002-9298-8890; Oszvald, Ádám/0000-0002-1931-7345; Buzás, Edit Irén/0000-0002-3744-206X} }