TY - JOUR AU - Kormányos, Eszter Sára AU - Illés, Dóra AU - Kui, Balázs AU - Lemes, K AU - Tajti, M AU - Czakó, László TI - GYAKORI TüNETEK RITKA OKAI: MYELOMA MULTIPLEX SZÖVŐDMÉNYEKÉNT KIALAKULT KRÓNIKUS HASMENÉS ÉS SZEKUNDER ADDISON-KÓR JF - MAGYAR BELORVOSI ARCHIVUM J2 - MBA VL - 76 PY - 2023 IS - 5-6 SP - 317 EP - 318 PG - 2 SN - 0133-5464 UR - https://m2.mtmt.hu/api/publication/34543527 ID - 34543527 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Tóth, Illés János AU - Ábrahám, Szabolcs AU - Karamya, Zain Alabedeen AU - Benkő, Ria AU - Matuz, Mária AU - Nagy, András AU - Váczi, Dániel AU - Négyessy, András AU - Czakó, Bálint AU - Illés, Dóra AU - Tajti, Máté AU - Ivány, Emese AU - Lázár, György ifj AU - Czakó, László TI - Multidisciplinary management of acute cholecystitis during the COVID-19 pandemic JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 13 PY - 2023 IS - 1 PG - 7 SN - 2045-2322 DO - 10.1038/s41598-023-43555-3 UR - https://m2.mtmt.hu/api/publication/34162226 ID - 34162226 AB - The coronavirus disease 2019 pandemic had a major impact on most medical services. Our aim was to assess the outcome of acute cholecystitis during the nationwide lockdown period. All patients admitted to our emergency department for AC were analysed. Patient characteristics, performance status, AC severity, treatment modality and outcome of AC were assessed during the lockdown period (Period II: 1 April 2020–30 November 2021) and compared to a historical control period (Period I: 1 May 2017–31 December 2018). AC admissions increased by 72.8% in Period II. Patients were younger (70 vs. 74 years, p = 0.017) and greater in number in the CCI 1 group (20.4% vs. 11.2%, p = 0.043) in Period II. The unplanned readmission rate (6.3 vs. 0%, p = 0.004) and the gallbladder perforation (GP) rate was higher (18.0 vs. 7.3%, p = 0.006) in Period II. Percutaneous transhepatic gallbladder drainage (PTGBD) was more frequent (24.1 vs. 12.8%, p = 0.012) in Period II. In addition to a drop in patient age and CCI, a significant rise in the prevalence of acute cholecystitis, GP and unplanned readmissions was observed during the nationwide lockdown due to the COVID-19 pandemic. PTGBD was more frequent during this period, whereas successful conservative treatment was less frequent. LA - English DB - MTMT ER - TY - JOUR AU - Juhász, Márk Félix AU - Tóháti, Rebeka AU - Jászai, Viktória Adrienn AU - Molnár, Regina AU - Borbásné Farkas, Kornélia AU - Czakó, László AU - Vincze, Áron AU - Erőss, Bálint Mihály AU - Szentesi, Andrea Ildikó AU - Izbéki, Ferenc AU - Papp, Mária AU - Hegyi, Péter AU - Párniczky, Andrea ED - Váncsa, Szilárd / Collaborator ED - Márta, Katalin / Collaborator ED - Földi, Mária / Collaborator ED - Nagy, Rita / Collaborator ED - Hegyi, Péter Jenő / Collaborator ED - Ocskay, Klementina / Collaborator ED - Imrei, Marcell / Collaborator ED - Mikó, Alexandra / Collaborator ED - Gódi, Szilárd / Collaborator ED - Bajor, Judit / Collaborator ED - Hágendorn, Roland / Collaborator ED - Sarlós, Patrícia / Collaborator ED - Szabó, Imre / Collaborator ED - Czimmer, József / Collaborator ED - Faluhelyi, Nándor / Collaborator ED - Kanizsai, Péter / Collaborator ED - Nagy, Tamás / Collaborator ED - Gajdán, László / Collaborator ED - Kui, Balázs / Collaborator ED - Illés, Dóra / Collaborator ED - Takács, Tamás / Collaborator ED - Vitális, Zsuzsanna / Collaborator ED - Hamvas, József / Collaborator ED - Varga, Márta / Collaborator ED - Bod, Barnabás / Collaborator ED - Novák, János / Collaborator ED - Maurovich-Horvat, Pál / Collaborator ED - Doros, Attila / Collaborator ED - Deák, Pál Ákos / Collaborator ED - Varga, Csaba / Collaborator ED - Gaál, Szabolcs / Collaborator ED - Zubek, László / Collaborator ED - Gál, János / Collaborator ED - Lázár, Balázs / Collaborator ED - Hussein, Tamás / Collaborator ED - Kovács, Bea / Collaborator ED - Tarján, Dorottya / Collaborator ED - Lipp, Mónika Bernadett / Collaborator ED - Urbán, Orsolya / Collaborator ED - Tornai, Tamás / Collaborator TI - Invalidity of Tokyo guidelines in acute biliary pancreatitis : A multicenter cohort analysis of 944 pancreatitis cases JF - UNITED EUROPEAN GASTROENTEROLOGY JOURNAL J2 - UEG JOURNAL VL - 11 PY - 2023 IS - 8 SP - 767 EP - 774 PG - 8 SN - 2050-6406 DO - 10.1002/ueg2.12402 UR - https://m2.mtmt.hu/api/publication/34072590 ID - 34072590 N1 - * Megosztott szerzőség AB - There is a noteworthy overlap between the clinical picture of biliary acute pancreatitis (AP) and the 2018 Tokyo guidelines currently used for the diagnosis of cholangitis (AC) and cholecystitis (CC). This can lead to significant antibiotic and endoscopic retrograde cholangiopancreatography (ERCP) overuse.We aimed to assess the on-admission prevalence of AC/CC according to the 2018 Tokyo guidelines (TG18) in a cohort of biliary AP patients, and its association with antibiotic use, ERCP and clinically relevant endpoints.We conducted a secondary analysis of the Hungarian Pancreatic Study Group's prospective multicenter registry of 2195 AP cases. We grouped and compared biliary cases (n = 944) based on the on-admission fulfillment of definite AC/CC according to TG18. Aside from antibiotic use, we evaluated mortality, AC/CC/AP severity, ERCP performance and length of hospitalization. We also conducted a literature review discussing each criteria of the TG18 in the context of AP.27.8% of biliary AP cases fulfilled TG18 for both AC and CC, 22.5% for CC only and 20.8% for AC only. Antibiotic use was high (77.4%). About 2/3 of the AC/CC cases were mild, around 10% severe. Mortality was below 1% in mild and moderate AC/CC patients, but considerably higher in severe cases (12.8% and 21.2% in AC and CC). ERCP was performed in 89.3% of AC cases, common bile duct stones were found in 41.1%.Around 70% of biliary AP patients fulfilled the TG18 for AC/CC, associated with a high rate of antibiotic use. Mortality in presumed mild or moderate AC/CC is low. Each of the laboratory and clinical criteria are commonly fulfilled in biliary AP, single imaging findings are also unspecific-AP specific diagnostic criteria are needed, as the prevalence of AC/CC are likely greatly overestimated. Randomized trials testing antibiotic use are also warranted. LA - English DB - MTMT ER - TY - JOUR AU - Turcsiné Czapári, Dóra AU - Váradi, Alex AU - Borbásné Farkas, Kornélia AU - Nyári, Gergely Róbert AU - Márta, Katalin AU - Váncsa, Szilárd AU - Nagy, Rita AU - Teutsch, Brigitta AU - Bunduc, Stefania AU - Erőss, Bálint Mihály AU - Czakó, László AU - Vincze, Áron AU - Izbéki, Ferenc AU - Papp, Mária AU - Merkely, Béla Péter AU - Szentesi, Andrea Ildikó AU - Hegyi, Péter ED - Péter, Jenő Hegyi / Collaborator ED - Andrea, Párniczky / Collaborator ED - Mária, Földi / Collaborator ED - Klementina, Ocskay / Collaborator ED - Márk, Félix Juhász / Collaborator ED - Imrei, Marcell / Collaborator ED - Szabolcs, Kiss / Collaborator ED - Alexandra, Mikó / Collaborator ED - Szilárd, Gódi / Collaborator ED - Judit, Bajor / Collaborator ED - Roland, Hágendorn / Collaborator ED - Patrícia, Sarlós / Collaborator ED - Imre, Szabó / Collaborator ED - József, Czimmer / Collaborator ED - Nándor, Faluhelyi / Collaborator ED - Péter, Kanizsai / Collaborator ED - Attila, Miseta / Collaborator ED - Tamás, Nagy / Collaborator ED - László, Gajdán / Collaborator ED - Adrienn, Halász / Collaborator ED - Németh, Balázs / Collaborator ED - Kui, Balázs / Collaborator ED - Illés, Dóra / Collaborator ED - Takács, Tamás / Collaborator ED - Tiszlavicz, László / Collaborator ED - Oláh, Orsolya / Collaborator ED - Radics, Bence / Collaborator ED - Vitális, Zsuzsanna / Collaborator ED - József, Hamvas / Collaborator ED - Márta, Varga / Collaborator ED - Barnabás, Bod / Collaborator ED - János, Novák / Collaborator ED - Pál, Maurovich-Horváth / Collaborator ED - Doros, Attila / Collaborator ED - Pál, Ákos Deák / Collaborator ED - Varga, Csaba / Collaborator ED - Szabolcs, Gaál / Collaborator ED - László, Zubek / Collaborator ED - János, Gál / Collaborator ED - Zsolt, Molnár / Collaborator ED - Tamás, Tornai / Collaborator ED - Balázs, Lázár / Collaborator ED - Tamás, Hussein / Collaborator ED - Beáta, Kovács / Collaborator ED - Anna, Németh / Collaborator ED - Tarján, Dorottya / Collaborator ED - Lipp, Mónika Bernadett / Collaborator ED - Orsolya, Urbán / Collaborator ED - Simon, Tóth / Collaborator ED - Dániel, Söti / Collaborator ED - Dávid, Becker / Collaborator TI - Detailed characteristics of post-discharge mortality in acute pancreatitis JF - GASTROENTEROLOGY J2 - GASTROENTEROLOGY VL - 165 PY - 2023 IS - 3 SP - 682 EP - 695 PG - 14 SN - 0016-5085 DO - 10.1053/j.gastro.2023.05.028 UR - https://m2.mtmt.hu/api/publication/33864451 ID - 33864451 N1 - * Megosztott szerzőség AB - The in-hospital survival of patients suffering from acute pancreatitis (AP) is 95-98%. However, there is growing evidence that patients discharged after AP may be at risk of serious morbidity and mortality. Here, we aimed to investigate the risk, causes, and predictors of the most severe consequence of the post-AP period: mortality.2,613, well-characterized patients from twenty-five centers were collected and followed by the Hungarian Pancreatic Study Group between 2012 and 2021. A general and a hospital-based population was used as the control group.After an AP episode patients have an approximately three-fold higher incidence rate of mortality than the general population (0.0404vs.0.0130 person-years). First-year mortality after discharge was almost double than in-hospital mortality (5.5%vs.3.5%), with 3.0% occurring in the first 90-day period. Age, comorbidities, and severity were the most significant independent risk factors for death following AP. Furthermore, multivariate analysis identified creatinine, glucose, and pleural fluid on admission as independent risk factors associated with post-discharge mortality. In the first 90-day period, cardiac failure and AP-related sepsis were among the main causes of death following discharge, while cancer-related cachexia and non-AP-related infection were the key causes in the later phase.Almost as many patients in our cohort die in the first 90-day period after discharge as during their hospital stay. Evaluation of cardiovascular status, follow-up of local complications, and cachexia-preventing oncological care should be an essential part of post-AP patient care. Future study protocols in AP must include at least a 90-day follow-up period after discharge. LA - English DB - MTMT ER - TY - JOUR AU - Czakó, László AU - Gyökeres, Tibor Zoltán AU - Hritz, István AU - Madácsy, László AU - Illés, Dóra AU - Szepes, Zoltán AU - Dubravcsik, Zsolt AU - Péterfi, Zoltán AU - Nagy, András AU - Szűcs, Ákos AU - Vincze, Áron TI - Epeút- és epehólyag-gyulladás: diagnosztikus kritériumok és terápia [Cholangitis and cholecystitis: diagnostic criteria and management] JF - ORVOSI HETILAP J2 - ORV HETIL VL - 164 PY - 2023 IS - 20 SP - 770 EP - 787 PG - 18 SN - 0030-6002 DO - 10.1556/650.2023.32770 UR - https://m2.mtmt.hu/api/publication/33842885 ID - 33842885 N1 - Belgyógyászati Klinika, Gasztroenterológiai Osztály, Általános Orvostudományi Kar, Szegedi Tudományegyetem, Szeged, Hungary Gasztroenterológiai Osztály, ÉSzak-Pesti Centrumkórház - Honvédkórház, Budapest, Hungary Sebészeti, Transzplantációs és Gasztroenterológiai Klinika, Általános Orvostudományi Kar, Semmelweis Egyetem, Budapest, Hungary Endo-Kapszula Magánorvosi Centrum, Székesfehérvár, Hungary Gasztroenterológiai Osztály, Bács-Kiskun Megyei Oktatókórház, Kecskemét, Hungary I. Belgyógyászati Klinika, Általános Orvostudományi Kar, Pécsi Tudományegyetem, Pécs, Hungary Radiológiai Klinika, Általános Orvostudományi Kar, Szegedi Tudományegyetem, Szeged, Hungary Export Date: 7 September 2023 CODEN: ORHEA Correspondence Address: László, C.Pf. 469, Hungary; email: czako.laszlo@med.u-szeged.hu AB - In developed countries, diseases of the gallbladder and the biliary tract count as some of the most frequent gastrointestinal disorders. The inflammation of the gallbladder/biliary tree is a potentially severe, even lethal condition that requires rapid diagnosis and early multidisciplinary approach to be treated. Although the frequency of these diseases is high, the treatment is not unified in Hungary yet. The aim of the evidence-based recommendation is to clarify the diagnostic criteria and severity grading of these diseases and to highlight the indications and rules of proper application of the numerous available therapeutic interventions. The recent guideline is based on the consensus of the Board members of the Endoscopic Section of the Hungarian Gastroenterology Society in contribution with renown experts of surgery, infectology as well as interventional radiology and it counts as a clear and easy applicable guide during the all-day healthcare practice. Our guidelines are based on Tokyo guidelines established on the basis of the consensus reached in the International Consensus Meeting held in Tokyo which were revised in 2013 (TG13) and in 2018 (TG18). Orv Hetil. 2023; 164(20): 770-787. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Váncsa, Szilárd AU - Sipos, Zoltán AU - Váradi, Alex AU - Nagy, Rita AU - Ocskay, Klementina AU - Juhász, Márk Félix AU - Márta, Katalin AU - Teutsch, Brigitta AU - Mikó, Alexandra AU - Hegyi, Péter Jenő AU - Vincze, Áron AU - Izbéki, Ferenc AU - Czakó, László AU - Papp, Mária AU - Hamvas, József AU - Varga, Márta AU - Török, Imola AU - Mickevicius, Artautas AU - Erőss, Bálint Mihály AU - Párniczky, Andrea AU - Szentesi, Andrea Ildikó AU - Pár, Gabriella AU - Hegyi, Péter ED - Imrei, Marcell / Collaborator ED - Földi, Mária / Collaborator ED - Miklós, Emőke / Collaborator ED - Gódi, Szilárd / Collaborator ED - Hágendorn, Roland / Collaborator ED - Sarlós, Patricia / Collaborator ED - Bajor, Judit / Collaborator ED - Szabó, Imre / Collaborator ED - Czimmer, József / Collaborator ED - Faluhelyi, Nándor / Collaborator ED - Farkas, Orsolya / Collaborator ED - Kanizsai, Péter / Collaborator ED - Nagy, Tamás / Collaborator ED - Németh, Balázs / Collaborator ED - Kui, Balázs / Collaborator ED - Illés, Dóra / Collaborator ED - Takács, Tamás / Collaborator ED - Gajdán, László / Collaborator ED - Vitális, Zsuzsanna / Collaborator ED - Bod, Barnabás / Collaborator ED - Novák, János / Collaborator ED - Macarie, Melania / Collaborator ED - Maurovich-Horvat, Pál / Collaborator ED - Doros, Attila / Collaborator ED - Deák, Pál Ákos / Collaborator ED - Varga, Csaba / Collaborator ED - Gaál, Szabolcs / Collaborator ED - Zubek, László / Collaborator ED - Gál, János / Collaborator ED - Patai, Árpád / Collaborator ED - Tornai, Tamás / Collaborator ED - Lázár, Balázs / Collaborator ED - Hussein, Tamás / Collaborator ED - Kovács, Beáta / Collaborator ED - Tarján, Dorottya / Collaborator ED - Lipp, Mónika Bernadett / Collaborator ED - Urbán, Orsolya / Collaborator ED - Emese, Fürst / Collaborator ED - Tari, Edina / Collaborator TI - Metabolic-associated fatty liver disease is associated with acute pancreatitis with more severe course : Post hoc analysis of a prospectively collected international registry JF - UNITED EUROPEAN GASTROENTEROLOGY JOURNAL J2 - UEG JOURNAL VL - 11 PY - 2023 IS - 4 SP - 371 EP - 382 PG - 12 SN - 2050-6406 DO - 10.1002/ueg2.12389 UR - https://m2.mtmt.hu/api/publication/33761635 ID - 33761635 N1 - Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary Centre for Translational Medicine, Semmelweis University, Budapest, Hungary Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary Institute of Bioanalysis, Medical School, University of Pécs, Pécs, Hungary Department of Metagenomics, University of Debrecen, Debrecen, Hungary Department of Laboratory Medicine, Medical School, University of Pécs, Pécs, Hungary Heim Pál National Pediatric Institute, Budapest, Hungary Department of Medical Genetics, Medical School, University of Pécs, Pécs, Hungary Division of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary Szent György University Teaching Hospital of Fejér County, Székesfehérvár, Hungary Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Department of Gastroenterology, Institute of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Peterfy Hospital, Budapest, Hungary Department of Gastroenterology, BMKK Dr. Réthy Pál Hospital, Békéscsaba, Hungary County Emergency Clinical Hospital of Targu Mures - Gastroenterology and George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, Targu Mures, Romania Vilnius University Hospital Santaros Clinics, Vilnius, Lithuania Clinics of Abdominal Surgery, Nephrology and Gastroenterology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania Translational Pancreatology Research Group, Interdisciplinary Centre of Excellence for Research Development and Innovation University of Szeged, Szeged, Hungary Cited By :1 Export Date: 1 October 2023 Correspondence Address: Hegyi, P.Szigeti Street 12, Hungary; email: hegyi2009@gmail.com AB - Non-alcoholic fatty liver disease (NAFLD) is a proven risk factor for acute pancreatitis (AP). However, NAFLD has recently been redefined as metabolic-associated fatty liver disease (MAFLD). In this post hoc analysis, we quantified the effect of MAFLD on the outcomes of AP.We identified our patients from the multicentric, prospective International Acute Pancreatitis Registry of the Hungarian Pancreatic Study Group. Next, we compared AP patients with and without MAFLD and the individual components of MAFLD regarding in-hospital mortality and AP severity based on the revised Atlanta classification. Lastly, we calculated odds ratios (ORs) with 95% confidence intervals (CIs) using multivariate logistic regression analysis.MAFLD had a high prevalence in AP, 39% (801/2053). MAFLD increased the odds of moderate-to-severe AP (OR = 1.43, CI: 1.09-1.89). However, the odds of in-hospital mortality (OR = 0.89, CI: 0.42-1.89) and severe AP (OR = 1.70, CI: 0.97-3.01) were not higher in the MAFLD group. Out of the three diagnostic criteria of MAFLD, the highest odds of severe AP was in the group based on metabolic risk abnormalities (OR = 2.68, CI: 1.39-5.09). In addition, the presence of one, two, and three diagnostic criteria dose-dependently increased the odds of moderate-to-severe AP (OR = 1.23, CI: 0.88-1.70, OR = 1.38, CI: 0.93-2.04, and OR = 3.04, CI: 1.63-5.70, respectively) and severe AP (OR = 1.13, CI: 0.54-2.27, OR = 2.08, CI: 0.97-4.35, and OR = 4.76, CI: 1.50-15.4, respectively). Furthermore, in patients with alcohol abuse and aged ≥60 years, the effect of MAFLD became insignificant.MAFLD is associated with AP severity, which varies based on the components of its diagnostic criteria. Furthermore, MAFLD shows a dose-dependent effect on the outcomes of AP. LA - English DB - MTMT ER - TY - JOUR AU - Gieszinger, G. AU - Tajti, M. AU - Karamya, Zain Alabedeen AU - Szepes, Zoltán AU - Takács, Tamás AU - Kui, Balázs AU - Illés, Dóra AU - Ivány, Emese AU - Czakó, László TI - Endoscopic papillectomy for ampullary adenoma: are we good enough? JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 8 PY - 2022 IS - Suppl. 1 SP - 78 EP - 78 PG - 1 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/34013125 ID - 34013125 LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Szabolcs AU - Pintér, József AU - Molontay, Roland AU - Nagy, Marcell AU - Borbásné Farkas, Kornélia AU - Sipos, Zoltán AU - Fehérvári, Péter AU - Pecze, László AU - Földi, Mária AU - Vincze, Áron AU - Takács, Tamás AU - Czakó, László AU - Szabó-Halász, Adrienn AU - Boros, Eszter AU - Hamvas, József AU - Varga, Márta AU - Mickevicius, Artautas AU - Faluhelyi, Nándor AU - Farkas, Orsolya AU - Váncsa, Szilárd AU - Nagy, Rita AU - Bunduc, Stefania AU - Hegyi, Péter Jenő AU - Márta, Katalin AU - Borka, Katalin AU - Doros, Attila AU - Hosszúfalusi, Nóra AU - Zubek, László AU - Erőss, Bálint Mihály AU - Molnár, Zsolt AU - Párniczky, Andrea AU - Hegyi, Péter AU - Szentesi, Andrea Ildikó ED - Kiss, Szabolcs / Collaborator ED - Farkas, Nelli / Collaborator ED - Sipos, Zoltán / Collaborator ED - Fehérvári, Péter / Collaborator ED - Pecze, László / Collaborator ED - Földi, Mária / Collaborator ED - Vincze, Áron / Collaborator ED - Takács, Tamás / Collaborator ED - Czakó, László / Collaborator ED - Halász, Adrienn / Collaborator ED - Boros, Eszter / Collaborator ED - Hamvas, József / Collaborator ED - Varga, Márta / Collaborator ED - Mickevicius, Artautas / Collaborator ED - Faluhelyi, Nándor / Collaborator ED - Farkas, Orsolya / Collaborator ED - Váncsa, Szilárd / Collaborator ED - Nagy, Rita / Collaborator ED - Bunduc, Stefania / Collaborator ED - Hegyi, Péter Jenő / Collaborator ED - Márta, Katalin / Collaborator ED - Borka, Katalin / Collaborator ED - Doros, Attila / Collaborator ED - Hosszúfalusi, Nóra / Collaborator ED - Zubek, László / Collaborator ED - Erőss, Bálint / Collaborator ED - Molnár, Zsolt / Collaborator ED - Párniczky, Andrea / Collaborator ED - Hegyi, Péter / Collaborator ED - Szentesi, Andrea / Collaborator ED - Bajor, Judit / Collaborator ED - Gódi, Szilárd / Collaborator ED - Sarlós, Patrícia / Collaborator ED - Czimmer, József / Collaborator ED - Szabó, Imre / Collaborator ED - Pár, Gabriella / Collaborator ED - Illés, Anita / Collaborator ED - Hágendorn, Roland / Collaborator ED - Németh, Balázs / Collaborator ED - Kui, Balázs / Collaborator ED - Illés, Dóra / Collaborator ED - Gajdán, László / Collaborator ED - Dunás-Varga, Veronika / Collaborator ED - Fejes, Roland / Collaborator ED - Papp, Mária / Collaborator ED - Vitális, Zsuzsanna / Collaborator ED - Novák, János / Collaborator ED - Török, Imola / Collaborator ED - Macarie, Melania / Collaborator ED - Ramírez-Maldonado, Elena / Collaborator ED - Sallinen, Ville / Collaborator ED - Galeev, Shamil / Collaborator ED - Bod, Barnabás / Collaborator ED - Ince, Ali Tüzün / Collaborator ED - Pécsi, Dániel / Collaborator ED - Varjú, Péter / Collaborator ED - Juhász, Márk Félix / Collaborator ED - Ocskay, Klementina / Collaborator ED - Mikó, Alexandra / Collaborator ED - Szakács, Zsolt / Collaborator AU - Izbéki, Ferenc TI - Early prediction of acute necrotizing pancreatitis by artificial intelligence : a prospective cohort-analysis of 2387 cases JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 12 PY - 2022 IS - 1 PG - 11 SN - 2045-2322 DO - 10.1038/s41598-022-11517-w UR - https://m2.mtmt.hu/api/publication/32823615 ID - 32823615 N1 - * Megosztott szerzőség AB - Pancreatic necrosis is a consistent prognostic factor in acute pancreatitis (AP). However, the clinical scores currently in use are either too complicated or require data that are unavailable on admission or lack sufficient predictive value. We therefore aimed to develop a tool to aid in necrosis prediction. The XGBoost machine learning algorithm processed data from 2387 patients with AP. The confidence of the model was estimated by a bootstrapping method and interpreted via the 10th and the 90th percentiles of the prediction scores. Shapley Additive exPlanations (SHAP) values were calculated to quantify the contribution of each variable provided. Finally, the model was implemented as an online application using the Streamlit Python-based framework. The XGBoost classifier provided an AUC value of 0.757. Glucose, C-reactive protein, alkaline phosphatase, gender and total white blood cell count have the most impact on prediction based on the SHAP values. The relationship between the size of the training dataset and model performance shows that prediction performance can be improved. This study combines necrosis prediction and artificial intelligence. The predictive potential of this model is comparable to the current clinical scoring systems and has several advantages over them. LA - English DB - MTMT ER - TY - JOUR AU - Ocskay, Klementina AU - Juhász, Márk Félix AU - Borbásné Farkas, Kornélia AU - Zádori, Noémi AU - Szakó, Lajos AU - Szakács, Zsolt AU - Szentesi, Andrea Ildikó AU - Erőss, Bálint Mihály AU - Miklós, Emőke AU - Zemplényi, Antal Tamás AU - Birkás, Béla AU - Csathó, Árpád AU - Hartung, István AU - Nagy, Tamás AU - Czopf, László AU - Izbéki, Ferenc AU - Gajdán, László AU - Papp, Mária AU - Czakó, László AU - Illés, Dóra AU - Marino, Marco V AU - Mirabella, Antonello AU - Małecka-Panas, Ewa AU - Zatorski, Hubert AU - Susak, Yaroslav AU - Opalchuk, Kristina AU - Capurso, Gabriele AU - Apadula, Laura AU - Gheorghe, Cristian AU - Saizu, Ionut Adrian AU - Petersen, Ole H AU - de-Madaria, Enrique AU - Rosendahl, Jonas AU - Párniczky, Andrea AU - Hegyi, Péter TI - Recurrent acute pancreatitis prevention by the elimination of alcohol and cigarette smoking (REAPPEAR): protocol of a randomised controlled trial and a cohort study JF - BMJ OPEN J2 - BMJ OPEN VL - 12 PY - 2022 IS - 1 PG - 9 SN - 2044-6055 DO - 10.1136/bmjopen-2021-050821 UR - https://m2.mtmt.hu/api/publication/32582747 ID - 32582747 N1 - Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary Centre for Translational Medicine, Semmelweis University, Budapest, Hungary Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary Medical School, Institute of Bioanalysis, University of Pécs, Pécs, Hungary Faculty of Pharmacy, Division of Pharmacoeconomics, University of Pécs, Pécs, Hungary Center for Health Technology Assessment, University of Pécs, Pécs, Hungary Medical School, Institute of Behavioural Sciences, University of Pécs, Pécs, Hungary Medical School, Department of Laboratory Medicine, University of Pécs, Pécs, Hungary Medical School, First Department of Medicine, Division of Cardiology and Angiology, University of Pécs, Pécs, Hungary First Department of Internal Medicine, Szent György University Teaching Hospital of Fejér County, Hungary Department of Internal Medicine, Division of Gastroenterology, University of Debrecen, Debrecen, Hungary Faculty of Medicine, First Department of Medicine, University of Szeged, Szeged, Hungary General and Emergency Surgery Department, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland Department of Surgery, Bogomolets National Medical University, Kyiv, Ukraine Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy Clinical Institute Fundeni, Bucuresti, Romania Carol Davila University of Medicine and Pharmacy, Bucuresti, Romania Cardiff University, Cardiff, United Kingdom Gastroenterology Department, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain Department of Internal Medicine I, Martin Luther University, Halle, Germany Heim Pál National Pediatric Institute, Budapest, Hungary Cited By :5 Export Date: 16 October 2023 Correspondence Address: Hegyi, P.; Institute for Translational Medicine, Hungary; email: hegyi2009@gmail.com Chemicals/CAS: alcohol, 64-17-5 Funding text 1: 8Medical School, Department of Laboratory Medicine, University of Pécs, Pécs, Hungary 9Medical School, First Department of Medicine, Division of Cardiology and Angiology, University of Pécs, Pécs, Hungary 10First Department of Internal Medicine, Szent György University Teaching Hospital of Fejér County, Székesfehérvár, Hungary 11Department of Internal Medicine, Division of Gastroenterology, University of Debrecen, Debrecen, Hungary 12Faculty of Medicine, First Department of Medicine, University of Szeged, Szeged, Hungary 13General and Emergency Surgery Department, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy 14Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland 15Department of Surgery, Bogomolets National Medical University, Kyiv, Ukraine 16Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy 17Clinical Institute Fundeni, Bucuresti, Romania 18Carol Davila University of Medicine and Pharmacy, Bucuresti, Romania 19Cardiff University, Cardiff, UK 20Gastroenterology Department, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain 21Department of Internal Medicine I, Martin Luther University, Halle, Germany 22Heim Pál National Pediatric Institute, Budapest, Hungary Twitter Ionut Adrian Saizu @saizuadrian and Enrique de-Madaria @DeMadaria Acknowledgements We would like to thank the interdisciplinary team of the Institute for Translational Medicine and the staff from all centres. Contributors All authors were involved in the study design and edited the manuscript. KOc conducted the literature search, conceptualised and wrote the manuscript and prepared the figures. FJ participated in manuscript writing, critical revision, abstract writing and figure preparation. NF performed the sample size calculation and planned the statistical analyses. NZ and LS facilitated the ethical approval and trial registration. ZS provided methodological guidance, critically reviewed and revised the manuscript, EM facilitated patient invovlement and will coordinate data management, BB, AC and IH designed the intervention and chose the questionnaires, AZ will carry out the healthcare cost calculations. LC provided expert opinion and will perform safety monitoring. TN provided expert opinion on laboratory measurements and biological sample collection. FI, LG, MP, LC, DI, MVM, AM, EM-P, HZ, YS, KOp, GC, LA, CG and IAS provided insight on feasibility and will coordinate local enrolment and follow-up. OHP, Ed-M and JR provided expert opinion. PH, AP, AS, BE critically reviewed and revised the manuscript. PH and AP have given significant intellectual input and supervised the work. All authors have read and approved the final version of the manuscript. AP and PH co-supervised this work as joint last authors. Funding Center costs (IT, biostatistics, trial organisation, etc) are covered by the University of Pécs Medical School (grant number: not applicable). This work was supported by 'GINOP-2.3.2-15-2016-00048 - STAY ALIVE' (PH) cofinanced by the European Union (European Regional Development Fund) within the framework of Programme Széchenyi 2020, and by EFOP 3.6.2‐16‐2017‐00006 – LIVE LONGER (PH) Human Resources Development Operational Programme Grant which is cofinanced by the European Union (European Regional Development Fund) within the framework of Programme Széchenyi 2020 as well as the Translational Medicine Foundation. Further grants: a János Bolyai Research Scholarship from the Hungarian Academy of Sciences (AP) and National Research, Development and Innovation Office Project Grants (K116634, (PH);, FK138929 (AP)). LA - English DB - MTMT ER - TY - GEN AU - Németh, Balázs AU - Inczefi, Orsolya AU - Iglói, Gábor AU - Ollé, Georgina AU - Dani, Kristóf Tamás AU - Fejes, Imola AU - Horváth, Ágnes Judit AU - Illés, Dóra AU - Greff, Dorottya AU - Christofi, Alexandros AU - Szalatnyai, Bálint AU - Roczkov, Anett AU - Tajti, Máté AU - Laczkó, Edit AU - Riesz, Tamás János AU - Éberhardt, Gábor AU - Kiss, Nóra Ágnes AU - Kiss, Tamás AU - Visnyovszki, Ádám AU - Nagy, Nóra AU - Orosz, László AU - Farkas, Attila AU - Sepp, Krisztián AU - Róka, Richárd László TI - A COVID-19 SÚLYOSSÁGÁT ELŐRE JELZIK AZ ELSŐ ELLÁTÁS SORÁN MÉRT KLINIKAI TÜNETEK ÉS PARAMÉTEREK – EGYCENTRUMOS, RETROSPEKTÍV KLINIKAI VIZSGÁLAT PY - 2021 UR - https://m2.mtmt.hu/api/publication/32477077 ID - 32477077 LA - Hungarian DB - MTMT ER -