TY - JOUR AU - Erdélyi-Bótor, Szilvia AU - Komáromy, Hedvig AU - Kamson Olayinka, Dávid AU - Kovács, Norbert AU - Perlaki, Gábor AU - Orsi, Gergely AU - Molnár, Tihamér AU - Illés, Zsolt László AU - Nagy, Lajos AU - Kéki, Sándor AU - Deli, Gabriella AU - Bosnyák, Edit AU - Trauninger, Anita AU - Pfund, Zoltán TI - Serum L-arginine and Dimethylarginine Levels in Migraine Patients with Brain White Matter Lesions JF - CEPHALALGIA J2 - CEPHALALGIA VL - 37 PY - 2017 IS - 6 SP - 571 EP - 580 PG - 10 SN - 0333-1024 DO - 10.1177/0333102416651454 UR - https://m2.mtmt.hu/api/publication/3055175 ID - 3055175 LA - English DB - MTMT ER - TY - JOUR AU - Erdélyi-Bótor, Szilvia AU - Aradi, Mihály AU - Kamson Olayinka, Dávid AU - Kovács, Norbert AU - Perlaki, Gábor AU - Orsi, Gergely AU - Nagy, Szilvia Anett AU - Schwarcz, Attila AU - Dóczi, Tamás Péter AU - Komoly, Sámuel AU - Deli, Gabriella AU - Trauninger, Anita AU - Pfund, Zoltán TI - Changes of Migraine-Related White Matter Hyperintensities After 3 Years: A Longitudinal MRI Study. JF - HEADACHE J2 - HEADACHE VL - 55 PY - 2015 IS - 1 SP - 55 EP - 70 PG - 16 SN - 0017-8748 DO - 10.1111/head.12459 UR - https://m2.mtmt.hu/api/publication/2758889 ID - 2758889 AB - OBJECTIVE/BACKGROUND: The aim of this longitudinal study was to investigate changes of migraine-related brain white matter hyperintensities 3 years after an initial study. Baseline quantitative magnetic resonance imaging (MRI) studies of migraine patients with hemispheric white matter hyperintensities performed in 2009 demonstrated signs of tissue damage within the hyperintensities. The hyperintensities appeared most frequently in the deep white matter of the frontal lobe with a similar average hyperintensity size in all hemispheric lobes. Since in this patient group the repeated migraine attacks were the only known risk factors for the development of white matter hyperintensities, the remeasurements of migraineurs after a 3-year long follow-up may show changes in the status of these structural abnormalities as the effects of the repeated headaches. METHODS: The same patient group was reinvestigated in 2012 using the same MRI scanner and acquisition protocol. MR measurements were performed on a 3.0-Tesla clinical MRI scanner. Beyond the routine T1-, T2-weighted, and fluid-attenuated inversion recovery imaging, diffusion and perfusion-weighted imaging, proton magnetic resonance spectroscopy, and T1 and T2 relaxation time measurements were also performed. Findings of the baseline and follow-up studies were compared with each other. RESULTS: The follow-up proton magnetic resonance spectroscopy studies of white matter hyperintensities showed significantly decreased N-acetyl-aspartate (median values 8.133 vs 7.153 mmol/L, P = .009) and creatine/phosphocreatine (median values 4.970 vs 4.641 mmol/L, P = .015) concentrations compared to the baseline, indicating a more severe axonal loss and glial hypocellularity with decreased intracellular energy production. The diffusion values, the T1 and T2 relaxation times, and the cerebral blood flow and volume measurements presented only mild changes between the studies. The number (median values 21 vs 25, P < .001) and volume (median values 0.896 vs 1.140 mL, P < .001) of hyperintensities were significantly higher in the follow-up study. No changes were found in the hemispheric and lobar distribution of hyperintensities. An increase in the hyperintensity size of preexisting lesions was much more common than a decrease (median values 14 vs 5, P = .004). A higher number of newly developed hyperintensities were detected than disappeared ones (130 vs 22), and most of them were small (<.034 mL). Small white matter hyperintensities in patients with a low migraine attack frequency had a higher chance to disappear than large white matter hyperintensities or white matter hyperintensities in patients with a high attack frequency (coefficient: -0.517, P = .034). CONCLUSIONS: This longitudinal MRI study found clinically silent brain white matter hyperintensities to be predominantly progressive in nature. The absence of a control group precludes definitive conclusions about the nature of these changes or if their degree is beyond normal aging. LA - English DB - MTMT ER - TY - CHAP AU - Kellermayer, MS AU - Karsai, Á AU - Murvai, Ü AU - Erdélyi-Bótor, Szilvia AU - Kardos, József AU - Pires, RH ED - Andres, F Oberhauser TI - Single-molecule studies of amyloidogenic proteins T2 - Single-molecule Studies of Proteins PB - Springer New York CY - New York, New York SN - 9781461449218 T3 - Biophysics for the Life Sciences ; 2. PY - 2013 SP - 169 EP - 210 PG - 42 DO - 10.1007/978-1-4614-4921-8_7 UR - https://m2.mtmt.hu/api/publication/3178314 ID - 3178314 LA - English DB - MTMT ER - TY - JOUR AU - Aradi, Mihály AU - Schwarcz, Attila AU - Perlaki, Gábor AU - Orsi, Gergely AU - Kovács, Norbert AU - Trauninger, Anita AU - Kamson Olayinka, Dávid AU - Erdélyi-Bótor, Szilvia AU - Nagy, Ferenc AU - Nagy, Szilvia Anett AU - Dóczi, Tamás Péter AU - Komoly, Sámuel AU - Pfund, Zoltán TI - Quantitative MRI studies of chronic brain white matter hyperintensities in migraine patients JF - HEADACHE J2 - HEADACHE VL - 53 PY - 2013 IS - 5 SP - 752 EP - 763 PG - 12 SN - 0017-8748 DO - 10.1111/head.12013 UR - https://m2.mtmt.hu/api/publication/2074501 ID - 2074501 AB - Objective The aim of this study was to examine chronic brain white matter hyperintensities in migraine and to gain data on the characteristics of the lesions. Background Migraine associates with a higher incidence of magnetic resonance imaging (MRI)-visible white matter signal abnormalities. Several attack-related pathomechanisms have been proposed in the lesion development, including the effect of repeated intracerebral hemodynamic changes. Methods Supratentorial white matter hyperintensities of 17 migraine patients were investigated interictally with quantitative MRI, including quantitative single voxel spectroscopy, diffusion, and perfusion MRI at 3.0-Tesla. The findings were compared with data measured in the contralateral, normal-appearing white matter of migraineurs and in the white matter of 17 healthy subjects. Results Significantly higher apparent diffusion coefficient values, prolonged T2 relaxation times, and decreased N-acetyl-aspartate and creatine/phosphocreatine concentrations were found in the white matter hyperintensities. The cerebral blood flow and blood volume values were mildly decreased inside the hyperintensities. Differences were not present between the migraine patients' normal-appearing white matter and the white matter of healthy subjects. Conclusions The MRI measurements denote tissue damage with axonal loss, low glial cell density, and an enlarged extracellular space with an increased extracellular water fraction. These radiological features might be the consequences of microvascular ischemic changes during migraine attacks. LA - English DB - MTMT ER - TY - JOUR AU - Kamson Olayinka, Dávid AU - Illés, Zsolt László AU - Aradi, Mihály AU - Orsi, Gergely AU - Perlaki, Gábor AU - Leél-Őssy, E AU - Erdélyi-Bótor, Szilvia AU - Pótó, László AU - Trauninger, Anita AU - Pfund, Zoltán TI - Volumetric comparisons of supratentorial white matter hyperintensities on FLAIR MRI in patients with migraine and multiple sclerosis JF - JOURNAL OF CLINICAL NEUROSCIENCE J2 - J CLIN NEUROSCI VL - 19 PY - 2012 IS - 5 SP - 696 EP - 701 PG - 6 SN - 0967-5868 DO - 10.1016/j.jocn.2011.07.044 UR - https://m2.mtmt.hu/api/publication/1943171 ID - 1943171 N1 - Export Date: 27 January 2024; CODEN: JCNUE LA - English DB - MTMT ER - TY - JOUR AU - Trauninger, Anita AU - Leel-Ossy, E AU - Kamson Olayinka, Dávid AU - Pótó, László AU - Aradi, Mihály AU - Kover, F AU - Imre, M AU - Komáromy, Hedvig AU - Erdélyi-Bótor, Szilvia AU - Patzkó, Ágnes AU - Pfund, Zoltán TI - Risk factors of migraine-related brain white matter hyperintensities: an investigation of 186 patients JF - JOURNAL OF HEADACHE AND PAIN J2 - J HEADACHE PAIN VL - 12 PY - 2011 IS - 1 SP - 97 EP - 103 PG - 7 SN - 1129-2369 DO - 10.1007/s10194-011-0299-3 UR - https://m2.mtmt.hu/api/publication/1615693 ID - 1615693 N1 - Export Date: 27 January 2024; CODEN: JHPOA AB - Brain white matter hyperintensities are more prevalent in migraine patients than in the general population, but the pathogenesis and the risk factors of these hyperintensities are not fully elucidated. The authors analyzed the routine clinical data of 186 migraine patients who were referred to the Outpatient Headache Department of the Department of Neurology, Medical School, University of Pecs, Hungary between 2007 and 2009: 58 patients with white matter hyperintensities and 128 patients without white matter hyperintensities on 3 T MRI. Significant associations between the presence of white matter hyperintensities and longer disease duration (14.4 vs. 19.9 years, p = 0.004), higher headache frequency (4.1 vs. 5.5 attacks/month, p = 0.017), hyperhomocysteinemia (incidence of hyperintensity is 9/9 = 100%, p = 0.009) and thyroid gland dysfunction (incidence of hyperintensity is 8/14 = 57.1%, p = 0.038) were found. These data support the theory that both the disease duration and the attack frequency have a key role in the formation of migraine-related brain white matter hyperintensities, but the effects of comorbid diseases may also contribute to the development of the hyperintensities. LA - English DB - MTMT ER -