@article{MTMT:3055175,
	title = {Serum L-arginine and Dimethylarginine Levels in Migraine Patients with Brain White Matter Lesions},
	url = {https://m2.mtmt.hu/api/publication/3055175},
	author = {Erdélyi-Bótor, Szilvia and Komáromy, Hedvig and Kamson Olayinka, Dávid and Kovács, Norbert and Perlaki, Gábor and Orsi, Gergely and Molnár, Tihamér and Illés, Zsolt László and Nagy, Lajos and Kéki, Sándor and Deli, Gabriella and Bosnyák, Edit and Trauninger, Anita and Pfund, Zoltán},
	doi = {10.1177/0333102416651454},
	journal-iso = {CEPHALALGIA},
	journal = {CEPHALALGIA},
	volume = {37},
	unique-id = {3055175},
	issn = {0333-1024},
	keywords = {RISK; NITRIC-OXIDE; INJURY; MIGRAINE; CEREBRAL-BLOOD-FLOW; CARDIOVASCULAR-DISEASE; COMMUNITY; MRI; L-arginine; ASYMMETRIC DIMETHYLARGININE; ADMA; HYPERINTENSITIES; VASCULAR ENDOTHELIAL DYSFUNCTION; SDMA; white matter lesion; Oxidative stress},
	year = {2017},
	eissn = {1468-2982},
	pages = {571-580},
	orcid-numbers = {Kovács, Norbert/0000-0002-7332-9240; Illés, Zsolt László/0000-0001-9655-0450}
}

@article{MTMT:2758889,
	title = {Changes of Migraine-Related White Matter Hyperintensities After 3 Years: A Longitudinal MRI Study.},
	url = {https://m2.mtmt.hu/api/publication/2758889},
	author = {Erdélyi-Bótor, Szilvia and Aradi, Mihály and Kamson Olayinka, Dávid and Kovács, Norbert and Perlaki, Gábor and Orsi, Gergely and Nagy, Szilvia Anett and Schwarcz, Attila and Dóczi, Tamás Péter and Komoly, Sámuel and Deli, Gabriella and Trauninger, Anita and Pfund, Zoltán},
	doi = {10.1111/head.12459},
	journal-iso = {HEADACHE},
	journal = {HEADACHE},
	volume = {55},
	unique-id = {2758889},
	issn = {0017-8748},
	abstract = {OBJECTIVE/BACKGROUND: The aim of this longitudinal study was to investigate changes of migraine-related brain white matter hyperintensities 3 years after an initial study. Baseline quantitative magnetic resonance imaging (MRI) studies of migraine patients with hemispheric white matter hyperintensities performed in 2009 demonstrated signs of tissue damage within the hyperintensities. The hyperintensities appeared most frequently in the deep white matter of the frontal lobe with a similar average hyperintensity size in all hemispheric lobes. Since in this patient group the repeated migraine attacks were the only known risk factors for the development of white matter hyperintensities, the remeasurements of migraineurs after a 3-year long follow-up may show changes in the status of these structural abnormalities as the effects of the repeated headaches. METHODS: The same patient group was reinvestigated in 2012 using the same MRI scanner and acquisition protocol. MR measurements were performed on a 3.0-Tesla clinical MRI scanner. Beyond the routine T1-, T2-weighted, and fluid-attenuated inversion recovery imaging, diffusion and perfusion-weighted imaging, proton magnetic resonance spectroscopy, and T1 and T2 relaxation time measurements were also performed. Findings of the baseline and follow-up studies were compared with each other. RESULTS: The follow-up proton magnetic resonance spectroscopy studies of white matter hyperintensities showed significantly decreased N-acetyl-aspartate (median values 8.133 vs 7.153 mmol/L, P = .009) and creatine/phosphocreatine (median values 4.970 vs 4.641 mmol/L, P = .015) concentrations compared to the baseline, indicating a more severe axonal loss and glial hypocellularity with decreased intracellular energy production. The diffusion values, the T1 and T2 relaxation times, and the cerebral blood flow and volume measurements presented only mild changes between the studies. The number (median values 21 vs 25, P < .001) and volume (median values 0.896 vs 1.140 mL, P < .001) of hyperintensities were significantly higher in the follow-up study. No changes were found in the hemispheric and lobar distribution of hyperintensities. An increase in the hyperintensity size of preexisting lesions was much more common than a decrease (median values 14 vs 5, P = .004). A higher number of newly developed hyperintensities were detected than disappeared ones (130 vs 22), and most of them were small (<.034 mL). Small white matter hyperintensities in patients with a low migraine attack frequency had a higher chance to disappear than large white matter hyperintensities or white matter hyperintensities in patients with a high attack frequency (coefficient: -0.517, P = .034). CONCLUSIONS: This longitudinal MRI study found clinically silent brain white matter hyperintensities to be predominantly progressive in nature. The absence of a control group precludes definitive conclusions about the nature of these changes or if their degree is beyond normal aging.},
	year = {2015},
	eissn = {1526-4610},
	pages = {55-70},
	orcid-numbers = {Kovács, Norbert/0000-0002-7332-9240; Nagy, Szilvia Anett/0000-0001-6483-9209}
}

@{MTMT:3178314,
	title = {Single-molecule studies of amyloidogenic proteins},
	url = {https://m2.mtmt.hu/api/publication/3178314},
	author = {Kellermayer, MS and Karsai, Á and Murvai, Ü and Erdélyi-Bótor, Szilvia and Kardos, József and Pires, RH},
	booktitle = {Single-molecule Studies of Proteins},
	doi = {10.1007/978-1-4614-4921-8_7},
	unique-id = {3178314},
	year = {2013},
	pages = {169-210},
	orcid-numbers = {Kardos, József/0000-0002-2135-2932}
}

@article{MTMT:2074501,
	title = {Quantitative MRI studies of chronic brain white matter hyperintensities in migraine patients},
	url = {https://m2.mtmt.hu/api/publication/2074501},
	author = {Aradi, Mihály and Schwarcz, Attila and Perlaki, Gábor and Orsi, Gergely and Kovács, Norbert and Trauninger, Anita and Kamson Olayinka, Dávid and Erdélyi-Bótor, Szilvia and Nagy, Ferenc and Nagy, Szilvia Anett and Dóczi, Tamás Péter and Komoly, Sámuel and Pfund, Zoltán},
	doi = {10.1111/head.12013},
	journal-iso = {HEADACHE},
	journal = {HEADACHE},
	volume = {53},
	unique-id = {2074501},
	issn = {0017-8748},
	abstract = {Objective
		
		The aim of this study was to examine chronic brain white matter hyperintensities in migraine and to gain data on the characteristics of the lesions.
		Background
		
		Migraine associates with a higher incidence of magnetic resonance imaging (MRI)-visible white matter signal abnormalities. Several attack-related pathomechanisms have been proposed in the lesion development, including the effect of repeated intracerebral hemodynamic changes.
		Methods
		
		Supratentorial white matter hyperintensities of 17 migraine patients were investigated interictally with quantitative MRI, including quantitative single voxel spectroscopy, diffusion, and perfusion MRI at 3.0-Tesla. The findings were compared with data measured in the contralateral, normal-appearing white matter of migraineurs and in the white matter of 17 healthy subjects.
		Results
		
		Significantly higher apparent diffusion coefficient values, prolonged T2 relaxation times, and decreased N-acetyl-aspartate and creatine/phosphocreatine concentrations were found in the white matter hyperintensities. The cerebral blood flow and blood volume values were mildly decreased inside the hyperintensities. Differences were not present between the migraine patients' normal-appearing white matter and the white matter of healthy subjects.
		Conclusions
		
		The MRI measurements denote tissue damage with axonal loss, low glial cell density, and an enlarged extracellular space with an increased extracellular water fraction. These radiological features might be the consequences of microvascular ischemic changes during migraine attacks.},
	year = {2013},
	eissn = {1526-4610},
	pages = {752-763},
	orcid-numbers = {Kovács, Norbert/0000-0002-7332-9240; Nagy, Szilvia Anett/0000-0001-6483-9209}
}

@article{MTMT:1943171,
	title = {Volumetric comparisons of supratentorial white matter hyperintensities on FLAIR MRI in patients with migraine and multiple sclerosis},
	url = {https://m2.mtmt.hu/api/publication/1943171},
	author = {Kamson Olayinka, Dávid and Illés, Zsolt László and Aradi, Mihály and Orsi, Gergely and Perlaki, Gábor and Leél-Őssy, E and Erdélyi-Bótor, Szilvia and Pótó, László and Trauninger, Anita and Pfund, Zoltán},
	doi = {10.1016/j.jocn.2011.07.044},
	journal-iso = {J CLIN NEUROSCI},
	journal = {JOURNAL OF CLINICAL NEUROSCIENCE},
	volume = {19},
	unique-id = {1943171},
	issn = {0967-5868},
	keywords = {Aged; Adult; Female; Middle Aged; Male; Humans; Prospective Studies; Diagnosis, Differential; Young Adult; Brain/blood supply/*pathology; Magnetic Resonance Imaging/*methods; Nerve Fibers, Myelinated/*pathology; Multiple Sclerosis/diagnosis/*pathology/physiopathology; Migraine Disorders/diagnosis/*pathology/physiopathology; Leukoaraiosis/diagnosis/etiology/*pathology},
	year = {2012},
	eissn = {1532-2653},
	pages = {696-701},
	orcid-numbers = {Illés, Zsolt László/0000-0001-9655-0450}
}

@article{MTMT:1615693,
	title = {Risk factors of migraine-related brain white matter hyperintensities: an investigation of 186 patients},
	url = {https://m2.mtmt.hu/api/publication/1615693},
	author = {Trauninger, Anita and Leel-Ossy, E and Kamson Olayinka, Dávid and Pótó, László and Aradi, Mihály and Kover, F and Imre, M and Komáromy, Hedvig and Erdélyi-Bótor, Szilvia and Patzkó, Ágnes and Pfund, Zoltán},
	doi = {10.1007/s10194-011-0299-3},
	journal-iso = {J HEADACHE PAIN},
	journal = {JOURNAL OF HEADACHE AND PAIN},
	volume = {12},
	unique-id = {1615693},
	issn = {1129-2369},
	abstract = {Brain white matter hyperintensities are more prevalent in migraine patients than in the general population, but the pathogenesis and the risk factors of these hyperintensities are not fully elucidated. The authors analyzed the routine clinical data of 186 migraine patients who were referred to the Outpatient Headache Department of the Department of Neurology, Medical School, University of Pecs, Hungary between 2007 and 2009: 58 patients with white matter hyperintensities and 128 patients without white matter hyperintensities on 3 T MRI. Significant associations between the presence of white matter hyperintensities and longer disease duration (14.4 vs. 19.9 years, p = 0.004), higher headache frequency (4.1 vs. 5.5 attacks/month, p = 0.017), hyperhomocysteinemia (incidence of hyperintensity is 9/9 = 100%, p = 0.009) and thyroid gland dysfunction (incidence of hyperintensity is 8/14 = 57.1%, p = 0.038) were found. These data support the theory that both the disease duration and the attack frequency have a key role in the formation of migraine-related brain white matter hyperintensities, but the effects of comorbid diseases may also contribute to the development of the hyperintensities.},
	keywords = {Adult; Adolescent; Female; Middle Aged; Male; Humans; Risk Factors; Young Adult; Nerve Fibers, Myelinated/*pathology; Migraine Disorders/diagnosis/*epidemiology/*pathology; Leukoencephalopathies/diagnosis/*epidemiology/*pathology; Comorbidity/trends; Cerebrum/*pathology},
	year = {2011},
	eissn = {1129-2377},
	pages = {97-103}
}