TY  - JOUR
AU  - Giaccherini, M
AU  - Rende, M
AU  - Gentiluomo, M
AU  - Corradi, C
AU  - Archibugi, L
AU  - Ermini, S
AU  - Maiello, E
AU  - Morelli, L
AU  - van Eijck, C H J
AU  - Cavestro, G M
AU  - Schneider, M
AU  - Mickevicius, A
AU  - Adamonis, K
AU  - Basso, D
AU  - Hlavac, V
AU  - Gioffreda, D
AU  - Talar-Wojnarowska, R
AU  - Schöttker, B
AU  - Lovecek, M
AU  - Vanella, G
AU  - Gazouli, M
AU  - Uno, M
AU  - Malecka-Wojciesko, E
AU  - Vodicka, P
AU  - Goetz, M
AU  - Bijlsma, M F
AU  - Petrone, M C
AU  - Bazzocchi, F
AU  - Kiudelis, M
AU  - Szentesi, Andrea Ildikó
AU  - Carrara, S
AU  - Nappo, G
AU  - Brenner, H
AU  - Milanetto, A C
AU  - Soucek, P
AU  - Katzke, V
AU  - Peduzzi, G
AU  - Rizzato, C
AU  - Pasquali, C
AU  - Chen, X
AU  - Capurso, G
AU  - Hackert, T
AU  - Bueno-de-Mesquita, B
AU  - Uzunoglu, F G G
AU  - Hegyi, Péter
AU  - Greenhalf, W
AU  - Theodoropoulos, G E E
AU  - Sperti, C
AU  - Perri, F
AU  - Oliverius, M
AU  - Mambrini, A
AU  - Tavano, F
AU  - Farinella, R
AU  - Arcidiacono, P G
AU  - Lucchesi, M
AU  - Bunduc, Stefania
AU  - Kupcinskas, J
AU  - Di Franco, G
AU  - Stocker, S
AU  - Neoptolemos, J P
AU  - Bambi, F
AU  - Jamroziak, K
AU  - Testoni, S G G
AU  - Aoki, M N
AU  - Mohelnikova-Duchonova, B
AU  - Izbicki, J R
AU  - Pezzilli, R
AU  - Lawlor, R T
AU  - Kauffmann, E F
AU  - López de Maturana, E
AU  - Malats, N
AU  - Canzian, F
AU  - Campa, D
TI  - A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma
JF  - MUTAGENESIS
J2  - MUTAGENESIS
PY  - 2024
SN  - 0267-8357
DO  - 10.1093/mutage/geae012
UR  - https://m2.mtmt.hu/api/publication/34797929
ID  - 34797929
AB  - Pleiotropic variants (i.e., genetic polymorphisms influencing more than one phenotype) are often associated with cancer risk. A scan of pleiotropic variants was successfully conducted ten years ago in relation to pancreatic ductal adenocarcinoma susceptibility. However, in the last decade, genetic association studies performed on several human traits have greatly increased the number of known pleiotropic variants. Based on the hypothesis that variants already associated with a least one trait have a higher probability of association with other traits, 61,052 variants reported to be associated by at least one genome wide association study (GWAS) with at least one human trait were tested in the present study consisting of two phases (discovery and validation), comprising a total of 16,055 pancreatic ductal adenocarcinoma (PDAC) cases and 212,149 controls. The meta-analysis of the two phases showed two loci (10q21.1-rs4948550 (P=6.52×10-5) and 7q36.3-rs288762 (P=3.03×10-5) potentially associated with PDAC risk. 10q21.1-rs4948550 shows a high degree of pleiotropy and it is also associated with colorectal cancer risk while 7q36.3-rs288762 is situated 28,558 base pairs upstream of the Sonic Hedgehog (SHH) gene, which is involved in the cell differentiation process and PDAC etiopathogenesis. In conclusion, none of the single nucleotide polymorphisms (SNPs) showed a formally statistically significant association after correction for multiple testing. However, given their pleiotropic nature and association with various human traits including colorectal cancer, the two SNPs showing the best associations with PDAC risk merit further investigation through fine mapping and ad hoc functional studies.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Ünal, Pelin
AU  - Lu, Ye
AU  - Bueno-de-Mesquita, Bas
AU  - van Eijck, Casper H J
AU  - Talar-Wojnarowska, Renata
AU  - Szentesi, Andrea Ildikó
AU  - Gazouli, Maria
AU  - Kreivenaite, Edita
AU  - Tavano, Francesca
AU  - Małecka-Wojciesko, Ewa
AU  - Erőss, Bálint Mihály
AU  - Oliverius, Martin
AU  - Bunduc, Stefania
AU  - Nóbrega Aoki, Mateus
AU  - Vodickova, Ludmila
AU  - Boggi, Ugo
AU  - Giaccherini, Matteo
AU  - Kondrackiene, Jurate
AU  - Chammas, Roger
AU  - Palmieri, Orazio
AU  - Theodoropoulos, George E
AU  - Bijlsma, Maarten F
AU  - Basso, Daniela
AU  - Mohelnikova-Duchonova, Beatrice
AU  - Soucek, Pavel
AU  - Izbicki, Jakob R
AU  - Kiudelis, Vytautas
AU  - Vanella, Giuseppe
AU  - Arcidiacono, Paolo Giorgio
AU  - Włodarczyk, Barbara
AU  - Hackert, Thilo
AU  - Schöttker, Ben
AU  - Uzunoglu, Faik G
AU  - Bambi, Franco
AU  - Goetz, Mara
AU  - Hlavac, Viktor
AU  - Brenner, Hermann
AU  - Perri, Francesco
AU  - Carrara, Silvia
AU  - Landi, Stefano
AU  - Hegyi, Péter
AU  - Dijk, Frederike
AU  - Maiello, Evaristo
AU  - Capretti, Giovanni
AU  - Testoni, Sabrina Gloria Giulia
AU  - Petrone, Maria Chiara
AU  - Stocker, Hannah
AU  - Ermini, Stefano
AU  - Archibugi, Livia
AU  - Gentiluomo, Manuel
AU  - Cavestro, Giulia Martina
AU  - Pezzilli, Raffaele
AU  - Di Franco, Gregorio
AU  - Milanetto, Anna Caterina
AU  - Sperti, Cosimo
AU  - Neoptolemos, John P
AU  - Morelli, Luca
AU  - Vokacova, Klara
AU  - Pasquali, Claudio
AU  - Lawlor, Rita T
AU  - Bazzocchi, Francesca
AU  - Kupcinskas, Juozas
AU  - Capurso, Gabriele
AU  - Campa, Daniele
AU  - Canzian, Federico
TI  - Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk
JF  - HUMAN GENOMICS
J2  - HUM GENOMICS
VL  - 18
PY  - 2024
IS  - 1
PG  - 12
SN  - 1473-9542
DO  - 10.1186/s40246-024-00576-x
UR  - https://m2.mtmt.hu/api/publication/34561485
ID  - 34561485
N1  - Genomic Epidemiology Group, German Cancer Research Center, In Neuenheimer Feld 280, Heidelberg, 69120, Germany            
            Department for Determinants of Chronic Diseases, National Institute for Public Health and the Environment, Bilthoven, Netherlands            
            Department of Surgery, Erasmus MC University Medical Center, Rotterdam, Netherlands            
            Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland            
            Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary            
            János Szentágothai Research Center, University of Pécs, Pécs, Hungary            
            Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece            
            Gastroenterology Department and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania            
            Division of Gastroenterology and Research Laboratory, Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital, FG, San Giovanni Rotondo, Italy            
            Center for Translational Medicine, Semmelweis University, Budapest, Hungary            
            Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary            
            Department of Surgery, University Hospital Kralovske Vinohrady, Third Faculty of Medicine, Charles University, Prague, Czech Republic            
            Carol Davila University of Medicine and Pharmacy, Bucharest, Romania            
            Laboratory for Applied Science and Technology in Health, Carlos Chagas Institute, PR, Curitiba, Brazil            
            Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Plzeň, Czech Republic            
            Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic            
            Institute of Biology and Medical Genetics, Institute of Physiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic            
            Division of General and Transplant Surgery, Pisa University Hospital, Pisa, Italy            
            Department of Biology, University of Pisa, Pisa, Italy            
            Department of Radiology and Oncology, Institute of Cancer of São Paulo, São Paulo, Brazil            
            First Propaedeutic University Surgery Clinic, Hippocratio General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece            
            Laboratory for Experimental Oncology and Radiobiology, Center of Experimental Molecular Medicine, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands            
            Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, Netherlands            
            Department of Medicine, Laboratory Medicine, University of Padova, Padua, Italy            
            Department of Oncology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic            
            Department of General Visceral and Thoracic Surgery, University of Hamburg Medical Institutions, Hamburg, Germany            
            PancreatoBiliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy            
            Digestive and Liver Disease Unit, S. Andrea Hospital, Rome, Italy            
            Department of General, Visceral and Transplant Surgery, Heidelberg University Hospital, Heidelberg, Germany            
            Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany            
            Network Aging Research (NAR), Heidelberg University, Heidelberg, Germany            
            Blood Transfusion Service, Meyer Children’s Hospital, Florence, Italy            
            Division of Preventive Oncology, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany            
            German Cancer Consortium (DKTK), German Cancer Research Center, Heidelberg, Germany            
            Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Milan, Italy            
            Department of Pathology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands            
            Department of Oncology, Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital, FG, San Giovanni Rotondo, Italy            
            Pancreatic Unit, IRCCS Humanitas Research Hospital, Milan, Italy            
            Department of Biomedical Sciences, Humanitas University, Milan, Italy            
            Gastroenterology and Gastrointestinal Endoscopy Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy            
            Department of Gastroenterology, San Carlo Hospital, Potenza, Italy            
            General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy            
            Department of Surgery, Oncology and Gastroenterology, University of Padova, Padua, Italy            
            Department of Diagnostics and Public Health, ARC-Net Centre for Applied Research on Cancer, University of Verona, Verona, Italy            
            Department of Surgery, Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital, FG, San Giovanni Rotondo, Italy            
            Export Date: 19 February 2024            
            Correspondence Address: Canzian, F.; Genomic Epidemiology Group, In Neuenheimer Feld 280, Germany; email: f.canzian@dkfz.de
AB  - Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). However, the strict significance threshold commonly used makes it likely that many true risk loci are missed. Functional annotation of GWAS polymorphisms is a proven strategy to identify additional risk loci. We aimed to investigate single-nucleotide polymorphisms (SNP) in regulatory regions [transcription factor binding sites (TFBSs) and enhancers] that could change the expression profile of multiple genes they act upon and thereby modify PDAC risk. We analyzed a total of 12,636 PDAC cases and 43,443 controls from PanScan/PanC4 and the East Asian GWAS (discovery populations), and the PANDoRA consortium (replication population). We identified four associations that reached study-wide statistical significance in the overall meta-analysis: rs2472632(A) (enhancer variant, OR 1.10, 95%CI 1.06,1.13, p = 5.5 × 10-8), rs17358295(G) (enhancer variant, OR 1.16, 95%CI 1.10,1.22, p = 6.1 × 10-7), rs2232079(T) (TFBS variant, OR 0.88, 95%CI 0.83,0.93, p = 6.4 × 10-6) and rs10025845(A) (TFBS variant, OR 1.88, 95%CI 1.50,1.12, p = 1.32 × 10-5). The SNP with the most significant association, rs2472632, is located in an enhancer predicted to target the coiled-coil domain containing 34 oncogene. Our results provide new insights into genetic risk factors for PDAC by a focused analysis of polymorphisms in regulatory regions and demonstrating the usefulness of functional prioritization to identify loci associated with PDAC risk.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Nagy, Rita
AU  - Ocskay, Klementina
AU  - Sipos, Zoltán
AU  - Szentesi, Andrea Ildikó
AU  - Vincze, Áron
AU  - Czakó, László
AU  - Izbéki, Ferenc
AU  - Shirinskaya, Natalia V
AU  - Poluektov, Vladimir L
AU  - Zolotov, Alexandr N
AU  - Zhu, Yin
AU  - Xia, Liang
AU  - He, Wenhua
AU  - Sutton, Robert
AU  - Szatmary, Peter
AU  - Mukherjee, Rajarshi
AU  - Burridge, Isobel Saffron
AU  - Wauchope, Emma
AU  - Francisco, Elsa
AU  - Aparicio, David
AU  - Pinto, Bruno
AU  - Gomes, António
AU  - Nunes, Vitor
AU  - Tantau, Vasile Marcel
AU  - Sagau, Emanuela Denisa
AU  - Tantau, Alina Ioana
AU  - Suceveanu, Andra Iulia
AU  - Tocia, Cristina
AU  - Dumitru, Andrei
AU  - Pando, Elizabeth
AU  - Alberti, Piero
AU  - Cirera, Arturo
AU  - Molero, Xavier
AU  - Lee, Hong Sik
AU  - Jung, Min Kyu
AU  - Kim, Eui Joo
AU  - Lee, Sanghyub
AU  - Rebollo, María Lourdes Ruiz
AU  - Nistal, Reyes Busta
AU  - Santervas, Sandra Izquierdo
AU  - Lesko, Dusan
AU  - Soltes, Marek
AU  - Radonak, Jozef
AU  - Zatorski, Hubert
AU  - Małecka-Panas, Ewa
AU  - Fabisiak, Adam
AU  - Yaroslav, M Susak
AU  - Mykhailo, V Maksymenko
AU  - Olekcandr, A Tkachenko
AU  - Barauskas, Giedrius
AU  - Simanaitis, Vytautas
AU  - Ignatavicius, Povilas
AU  - Jinga, Mariana
AU  - Balaban, Vasile-Daniel
AU  - Patoni, Cristina
AU  - Gong, Liang
AU  - Song, Kai
AU  - Li, Yunlong
AU  - Gonçalves, T Cúrdia
AU  - Freitas, Marta
AU  - Macedo, Vítor
AU  - Vornhuelz, Marlies
AU  - Klauss, Sarah
AU  - Beyer, Georg
AU  - Koksal, Aydin Seref
AU  - Tozlu, Mukaddes
AU  - Eminler, Ahmet Tarik
AU  - Monclús, Nuria Torres
AU  - Comas, Eva Pijoan
AU  - Oballe, Juan Armando Rodriguez
AU  - Nawacki, Łukasz
AU  - Głuszek, Stanisław
AU  - Rama-Fernández, Alberto
AU  - Galego, Marco
AU  - de la Iglesia, Daniel
AU  - Aykut, Umut Emre
AU  - Duman, Deniz Güney
AU  - Aslan, Rahmi
AU  - Gherbon, Adriana
AU  - Deng, Lihui
AU  - Huang, Wei
AU  - Xia, Qing
AU  - Poropat, Goran
AU  - Radovan, Anja
AU  - Vranić, Luka
AU  - Ricci, Claudio
AU  - Ingaldi, Carlo
AU  - Casadei, Riccardo
AU  - Negoi, Ionut
AU  - Ciubotaru, Cezar
AU  - Iordache, Florin Mihail
AU  - Constantinescu, Gabriel
AU  - Sandru, Vasile
AU  - Altintas, Engin
AU  - Balci, Hatice Rizaoglu
AU  - Constantino, Júlio
AU  - Aveiro, Débora
AU  - Pereira, Jorge
AU  - Gunay, Suleyman
AU  - Misirlioglu Sucan, Seda
AU  - Dronov, Oleksiy
AU  - Kovalska, Inna
AU  - Bush, Nikhil
AU  - Rana, Surinder Singh
AU  - Chooklin, Serge
AU  - Chuklin, Serhii
AU  - Saizu, Ionut Adrian
AU  - Gheorghe, Cristian
AU  - Göltl, Philipp
AU  - Hirth, Michael
AU  - Mateescu, Radu Bogdan
AU  - Papuc, Geanina
AU  - Minkov, Georgi Angelov
AU  - Enchev, Emil Tihomirov
AU  - Mastrangelo, Laura
AU  - Jovine, Elio
AU  - Chen, Weiwei
AU  - Zhu, Quping
AU  - Gąsiorowska, Anita
AU  - Fabisiak, Natalia
AU  - Bezmarevic, Mihailo
AU  - Litvin, Andrey
AU  - Mottes, Martina Cattani
AU  - Choi, Eun Kwang
AU  - Bánovčin, Peter
AU  - Nosáková, Lenka
AU  - Kovacheva-Slavova, Mila Dimitrova
AU  - Kchaou, Ali
AU  - Tlili, Ahmed
AU  - Marino, Marco V
AU  - Kusnierz, Katarzyna
AU  - Mickevicius, Artautas
AU  - Hollenbach, Marcus
AU  - Molcan, Pavol
AU  - Ioannidis, Orestis
AU  - Tokarev, Mark Valerievich
AU  - Ince, Ali Tüzün
AU  - Semenenko, Ivan Albertovich
AU  - Galeev, Shamil
AU  - Ramírez-Maldonado, Elena
AU  - Sallinen, Ville
AU  - Pencik, Petr
AU  - Bajor, Judit
AU  - Sarlós, Patrícia
AU  - Hágendorn, Roland
AU  - Gódi, Szilárd
AU  - Szabó, Imre
AU  - Czimmer, József
AU  - Pár, Gabriella
AU  - Illés, Anita
AU  - Faluhelyi, Nándor
AU  - Kanizsai, Péter László
AU  - Nagy, Tamás
AU  - Mikó, Alexandra
AU  - Németh, Balázs
AU  - Hamvas, József
AU  - Bod, Barnabás
AU  - Varga, Márta
AU  - Török, Imola
AU  - Novák, János
AU  - Patai, Árpád
AU  - Sümegi, János
AU  - Góg, Csaba
AU  - Papp, Mária
AU  - Erőss, Bálint Mihály
AU  - Váncsa, Szilárd
AU  - Teutsch, Brigitta
AU  - Márta, Katalin
AU  - Hegyi, Péter Jenő
AU  - Tornai, Tamás
AU  - Lázár, Balázs
AU  - Hussein, Tamás
AU  - Tarján, Dorottya
AU  - Lipp, Mónika Bernadett
AU  - Kovács, Beáta
AU  - Urbán, Orsolya
AU  - Fürst, Emese Rita
AU  - Tari, Edina
AU  - Kocsis, Ibolya
AU  - Maurovich-Horvat, Pál
AU  - Tihanyi, Balázs
AU  - Eperjesi, Orsolya
AU  - Kormos, Zita
AU  - Deák, Pál Ákos
AU  - Párniczky, Andrea
AU  - Hegyi, Péter
TI  - Discharge protocol in acute pancreatitis: an international survey and cohort analysis
JF  - SCIENTIFIC REPORTS
J2  - SCI REP
VL  - 13
PY  - 2023
IS  - 1
PG  - 10
SN  - 2045-2322
DO  - 10.1038/s41598-023-48480-z
UR  - https://m2.mtmt.hu/api/publication/34434496
ID  - 34434496
AB  - There are several overlapping clinical practice guidelines in acute pancreatitis (AP), however, none of them contains suggestions on patient discharge. The Hungarian Pancreatic Study Group (HPSG) has recently developed a laboratory data and symptom-based discharge protocol which needs to be validated. (1) A survey was conducted involving all members of the International Association of Pancreatology (IAP) to understand the characteristics of international discharge protocols. (2) We investigated the safety and effectiveness of the HPSG-discharge protocol. According to our international survey, 87.5% (49/56) of the centres had no discharge protocol. Patients discharged based on protocols have a significantly shorter median length of hospitalization (LOH) (7 (5;10) days vs. 8 (5;12) days) p < 0.001), and a lower rate of readmission due to recurrent AP episodes (p = 0.005). There was no difference in median discharge CRP level among the international cohorts (p = 0.586). HPSG-protocol resulted in the shortest LOH (6 (5;9) days) and highest median CRP (35.40 (13.78; 68.40) mg/l). Safety was confirmed by the low rate of readmittance (n = 35; 5%). Discharge protocol is necessary in AP. The discharge protocol used in this study is the first clinically proven protocol. Developing and testifying further protocols are needed to better standardize patients' care.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Martonosi, Ágnes Rita
AU  - Németh, Balázs Csaba
AU  - Párniczky, Andrea
AU  - Vincze, Áron
AU  - Szentesi, Andrea Ildikó
AU  - Erőss, Bálint Mihály
AU  - Sahin-Tóth, Miklós
AU  - Hegyi, Péter
AU  - Hegyi, Eszter
TI  - CFTR p.F508del Mutation Carrier Status Is Not Associated With Biliary Acute Pancreatitis
JF  - PANCREAS
J2  - PANCREAS
VL  - 52
PY  - 2023
IS  - 4
SP  - e256
EP  - e257
SN  - 0885-3177
DO  - 10.1097/MPA.0000000000002241
UR  - https://m2.mtmt.hu/api/publication/34196830
ID  - 34196830
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Giaccherini, Matteo
AU  - Gori, Leonardo
AU  - Gentiluomo, Manuel
AU  - Farinella, Riccardo
AU  - Cervena, Klara
AU  - Skieceviciene, Jurgita
AU  - Dijk, Frederike
AU  - Capurso, Gabriele
AU  - Vezakis, Antonis
AU  - Archibugi, Livia
AU  - Chammas, Roger
AU  - Hussein, Tamás
AU  - Tavano, Francesca
AU  - Hegyi, Péter
AU  - Lovecek, Martin
AU  - Izbicki, Jakob
AU  - Brenner, Hermann
AU  - Mohelnikova-Duchonova, Beatrice
AU  - Dell'Anna, Giuseppe
AU  - Kupcinskas, Juozas
AU  - Ermini, Stefano
AU  - Aoki, Mateus Nóbrega
AU  - Neoptolemos, John P
AU  - Gazouli, Maria
AU  - Pasquali, Claudio
AU  - Pezzilli, Raffaele
AU  - Talar-Wojnarowska, Renata
AU  - Oliverius, Martin
AU  - Al-Saeedi, Mohammed
AU  - Lucchesi, Maurizio
AU  - Furbetta, Niccolò
AU  - Carrara, Silvia
AU  - van Eijck, Casper H J
AU  - Maleckas, Almantas
AU  - Milanetto, Anna Caterina
AU  - Lawlor, Rita T
AU  - Schöttker, Ben
AU  - Boggi, Ugo
AU  - Morelli, Luca
AU  - Ginocchi, Laura
AU  - Ponz de Leon, Ruggero
AU  - Sperti, Cosimo
AU  - Zerbi, Alessandro
AU  - Arcidiacono, Paolo Giorgio
AU  - Uzunoglu, Faik G
AU  - Bunduc, Stefania
AU  - Holleczek, Bernd
AU  - Gioffreda, Domenica
AU  - Małecka-Wojciesko, Ewa
AU  - Kiudelis, Mindaugas
AU  - Szentesi, Andrea Ildikó
AU  - van Laarhoven, Hanneke W M
AU  - Soucek, Pavel
AU  - Götz, Mara
AU  - Erőss, Bálint Mihály
AU  - Cavestro, Giulia Martina
AU  - Basso, Daniela
AU  - Perri, Francesco
AU  - Landi, Stefano
AU  - Canzian, Federico
AU  - Campa, Daniele
TI  - A scan of all coding region variants of the human genome, identifies 13q12.2-rs9579139 and 15q24.1-rs2277598 as novel risk loci for pancreatic ductal adenocarcinoma
JF  - CARCINOGENESIS
J2  - CARCINOGENESIS
VL  - 44
PY  - 2023
IS  - 8-9
SP  - 642
EP  - 649
PG  - 8
SN  - 0143-3334
DO  - 10.1093/carcin/bgad056
UR  - https://m2.mtmt.hu/api/publication/34133723
ID  - 34133723
N1  - Department of Biology, University of Pisa, Pisa, Italy            
            Department of Molecular Biology of Cancer, Institute of Experimental Medicine, the Czech Academy of Sciences, Prague, Czech Republic            
            First Faculty of Medicine, Institute of Biology and Medical Genetics, Charles University, Prague, Czech Republic            
            Department of Gastroenterology, Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania            
            Department of Pathology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands            
            Digestive and Liver Disease Unit, S. Andrea Hospital, “Sapienza” University of Rome, Rome, Italy            
            Pancreato-Biliary Endoscopy and Endosonography Division, IRCCS San Raffaele Scientific Institute, Pancreas Translational and Clinical Research Center, Vita-Salute San Raffaele University, Milan, Italy            
            Department of Surgery, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, 11528, Greece            
            Departamento de Radiologia e Oncologia, Instituto Do Câncer Do Estado de São Paulo (ICESP), Center for Translational Research in Oncology (LIM24), Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo (HCFMUSP), São Paulo, Brazil            
            Center for Translational Medicine, Semmelweis University, Budapest, Hungary            
            Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary            
            Division of Gastroenterology and Research Laboratory, Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo, Foggia, Italy            
            Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary            
            Department of Surgery I, University Hospital Olomouc, Olomouc, Czech Republic            
            Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany            
            Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany            
            Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany            
            German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany            
            Department of Oncology, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, University Hospital, Olomouc, Czech Republic            
            Pancreatico/Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy            
            Blood Transfusion Service, Azienda Ospedaliero-Universitaria Meyer, Children’s Hospital, Florence, Italy            
            Laboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Curitiba, Brazil            
            Department of General Surgery, University of Heidelberg, Heidelberg, Germany            
            Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece            
            Department of Surgery, Oncology and Gastroenterology-DiSCOG, University of Padova, Padua, Italy            
            Potenza County Medical Association, Potenza, Italy            
            Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland            
            Department of Surgery, University Hospital Kralovske Vinohrady, Third Faculty of Medicine, Charles University, Prague, Czech Republic            
            Department of Medical Oncology, Oncology of Massa Carrara, Azienda USL Toscana Nord Ovest, Carrara, Italy            
            General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy            
            Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research, Milan, Italy            
            Department of Surgery, Erasmus MC University Medical Center, Rotterdam, Netherlands            
            Department of Surgery, Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania            
            ARC-Net Centre for Applied Research on Cancer, Department of Diagnostics and Public Health, University of Verona, Verona, Italy            
            Division of General and Transplant Surgery, Pisa University Hospital, Pisa, Italy            
            Pancreatic Unit, IRCCS Humanitas Research Hospital, Milan, Italy            
            Department of Biomedical Sciences, Humanitas University, Milan, Italy            
            Carol Davila University of Medicine and Pharmacy, Bucharest, Romania            
            Center for Gastroenterology, Hepatology and Liver Transplant, Fundeni Clinical Institute, Bucharest, Romania            
            Saarland Cancer Registry, Saarbrücken, Germany            
            Department of Medicine, Centre for Translational Medicine, University of Szeged, Szeged, Hungary            
            Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands            
            Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic            
            Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy            
            Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany            
            Export Date: 3 January 2024            
            CODEN: CRNGD            
            Correspondence Address: Campa, D.; Department of Biology, Via Derna 1 (PI), Italy; email: daniele.campa@unipi.it
AB  - Coding sequence variants comprise a small fraction of the germline genetic variability of the human genome. However, they often cause deleterious change in protein function and are therefore associated with pathogenic phenotypes. To identify novel pancreatic ductal adenocarcinoma (PDAC) risk loci, we carried out a complete scan of all common missense and synonymous SNPs and analysed them in a case control study comprising four different populations, for a total of 14,538 PDAC cases and 190,657 controls. We observed a statistically significant association between 13q12.2-rs9581957-T and PDAC risk (P=2.46x10 -9), that is in linkage disequilibrium (LD) with a deleterious missense variant (rs9579139) of the URAD gene. Recent findings suggest that this gene is active in peroxisomes. Considering that peroxisomes have a key role as molecular scavengers, especially in eliminating reactive oxygen species, a malfunctioning URAD protein might expose the cell to a higher load of potentially DNA damaging molecules and therefore increase PDAC risk. The association was observed in individuals of European and Asian ethnicity. We also observed the association of the missense variant 15q24.1-rs2277598-T, that belongs to BBS4 gene, with increased PDAC risk (P=1.53x10 -6). rs2277598 is associated with body mass index and is in LD with diabetes susceptibility loci. In conclusion, we identified two missense variants associated with the risk of developing PDAC independently from the ethnicity highlighting the importance of conducting reanalysis of GWAS studies in light of functional data.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Piccardi, Margherita
AU  - Gentiluomo, Manuel
AU  - Bertoncini, Stefania
AU  - Pezzilli, Raffaele
AU  - Erőss, Bálint Mihály
AU  - Bunduc, Stefania
AU  - Uzunoglu, Faik G
AU  - Talar-Wojnarowska, Renata
AU  - Vanagas, Tomas
AU  - Sperti, Cosimo
AU  - Oliverius, Martin
AU  - Aoki, Mateus Nóbrega
AU  - Ermini, Stefano
AU  - Hussein, Tamás
AU  - Boggi, Ugo
AU  - Jamroziak, Krzysztof
AU  - Maiello, Evaristo
AU  - Morelli, Luca
AU  - Vodickova, Ludmila
AU  - Di Franco, Gregorio
AU  - Landi, Stefano
AU  - Szentesi, Andrea Ildikó
AU  - Lovecek, Martin
AU  - Puzzono, Marta
AU  - Tavano, Francesca
AU  - van Laarhoven, Hanneke W M
AU  - Zerbi, Alessandro
AU  - Mohelnikova-Duchonova, Beatrice
AU  - Stocker, Hannah
AU  - Costello, Eithne
AU  - Capurso, Gabriele
AU  - Ginocchi, Laura
AU  - Lawlor, Rita T
AU  - Vanella, Giuseppe
AU  - Bazzocchi, Francesca
AU  - Izbicki, Jakob R
AU  - Latiano, Anna
AU  - Bueno-de-Mesquita, Bas
AU  - Ponz de Leon Pisani, Ruggero
AU  - Schöttker, Ben
AU  - Soucek, Pavel
AU  - Hegyi, Péter
AU  - Gazouli, Maria
AU  - Hackert, Thilo
AU  - Kupcinskas, Juozas
AU  - Poskiene, Lina
AU  - Tacelli, Matteo
AU  - Roth, Susanne
AU  - Carrara, Silvia
AU  - Perri, Francesco
AU  - Hlavac, Viktor
AU  - Theodoropoulos, George E
AU  - Busch, Olivier R
AU  - Mambrini, Andrea
AU  - van Eijck, Casper H J
AU  - Arcidiacono, Paolo
AU  - Scarpa, Aldo
AU  - Pasquali, Claudio
AU  - Basso, Daniela
AU  - Lucchesi, Maurizio
AU  - Milanetto, Anna Caterina
AU  - Neoptolemos, John P
AU  - Cavestro, Giulia Martina
AU  - Janciauskas, Dainius
AU  - Chen, Xuechen
AU  - Chammas, Roger
AU  - Goetz, Mara
AU  - Brenner, Hermann
AU  - Archibugi, Livia
AU  - Dannemann, Michael
AU  - Canzian, Federico
AU  - Tofanelli, Sergio
AU  - Campa, Daniele
TI  - Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians
JF  - BIOLOGICAL RESEARCH
J2  - BIOL RES
VL  - 56
PY  - 2023
IS  - 1
PG  - 9
SN  - 0716-9760
DO  - 10.1186/s40659-023-00457-y
UR  - https://m2.mtmt.hu/api/publication/34103680
ID  - 34103680
N1  - * Megosztott szerzőség
AB  - The genomes of present-day non-Africans are composed of 1-3% of Neandertal-derived DNA as a consequence of admixture events between Neandertals and anatomically modern humans about 50-60 thousand years ago. Neandertal-introgressed single nucleotide polymorphisms (aSNPs) have been associated with modern human disease-related traits, which are risk factors for pancreatic ductal adenocarcinoma (PDAC), such as obesity, type 2 diabetes, and inflammation. In this study, we aimed at investigating the role of aSNPs in PDAC in three Eurasian populations.The high-coverage Vindija Neandertal genome was used to select aSNPs in non-African populations from 1000 Genomes project phase 3 data. Then, the association between aSNPs and PDAC risk was tested independently in Europeans and East Asians, using existing GWAS data on more than 200 000 individuals. We did not find any significant associations between aSNPs and PDAC in samples of European descent, whereas, in East Asians, we observed that the Chr10p12.1-rs117585753-T allele (MAF = 10%) increased the risk to develop PDAC (OR = 1.35, 95%CI 1.19-1.54, P = 3.59 × 10-6), with a P-value close to a threshold that takes into account multiple testing.Our results show only a minimal contribution of Neandertal SNPs to PDAC risk.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Juhász, Márk Félix
AU  - Tóháti, Rebeka
AU  - Jászai, Viktória Adrienn
AU  - Molnár, Regina
AU  - Borbásné Farkas, Kornélia
AU  - Czakó, László
AU  - Vincze, Áron
AU  - Erőss, Bálint Mihály
AU  - Szentesi, Andrea Ildikó
AU  - Izbéki, Ferenc
AU  - Papp, Mária
AU  - Hegyi, Péter
AU  - Párniczky, Andrea
ED  - Váncsa, Szilárd / Collaborator
ED  - Márta, Katalin / Collaborator
ED  - Földi, Mária / Collaborator
ED  - Nagy, Rita / Collaborator
ED  - Hegyi, Péter Jenő / Collaborator
ED  - Ocskay, Klementina / Collaborator
ED  - Imrei, Marcell / Collaborator
ED  - Mikó, Alexandra / Collaborator
ED  - Gódi, Szilárd / Collaborator
ED  - Bajor, Judit / Collaborator
ED  - Hágendorn, Roland / Collaborator
ED  - Sarlós, Patrícia / Collaborator
ED  - Szabó, Imre / Collaborator
ED  - Czimmer, József / Collaborator
ED  - Faluhelyi, Nándor / Collaborator
ED  - Kanizsai, Péter / Collaborator
ED  - Nagy, Tamás / Collaborator
ED  - Gajdán, László / Collaborator
ED  - Kui, Balázs / Collaborator
ED  - Illés, Dóra / Collaborator
ED  - Takács, Tamás / Collaborator
ED  - Vitális, Zsuzsanna / Collaborator
ED  - Hamvas, József / Collaborator
ED  - Varga, Márta / Collaborator
ED  - Bod, Barnabás / Collaborator
ED  - Novák, János / Collaborator
ED  - Maurovich-Horvat, Pál / Collaborator
ED  - Doros, Attila / Collaborator
ED  - Deák, Pál Ákos / Collaborator
ED  - Varga, Csaba / Collaborator
ED  - Gaál, Szabolcs / Collaborator
ED  - Zubek, László / Collaborator
ED  - Gál, János / Collaborator
ED  - Lázár, Balázs / Collaborator
ED  - Hussein, Tamás / Collaborator
ED  - Kovács, Bea / Collaborator
ED  - Tarján, Dorottya / Collaborator
ED  - Lipp, Mónika Bernadett / Collaborator
ED  - Urbán, Orsolya / Collaborator
ED  - Tornai, Tamás / Collaborator
TI  - Invalidity of Tokyo guidelines in acute biliary pancreatitis : A multicenter cohort analysis of 944 pancreatitis cases
JF  - UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
J2  - UEG JOURNAL
VL  - 11
PY  - 2023
IS  - 8
SP  - 767
EP  - 774
PG  - 8
SN  - 2050-6406
DO  - 10.1002/ueg2.12402
UR  - https://m2.mtmt.hu/api/publication/34072590
ID  - 34072590
N1  - * Megosztott szerzőség
AB  - There is a noteworthy overlap between the clinical picture of biliary acute pancreatitis (AP) and the 2018 Tokyo guidelines currently used for the diagnosis of cholangitis (AC) and cholecystitis (CC). This can lead to significant antibiotic and endoscopic retrograde cholangiopancreatography (ERCP) overuse.We aimed to assess the on-admission prevalence of AC/CC according to the 2018 Tokyo guidelines (TG18) in a cohort of biliary AP patients, and its association with antibiotic use, ERCP and clinically relevant endpoints.We conducted a secondary analysis of the Hungarian Pancreatic Study Group's prospective multicenter registry of 2195 AP cases. We grouped and compared biliary cases (n = 944) based on the on-admission fulfillment of definite AC/CC according to TG18. Aside from antibiotic use, we evaluated mortality, AC/CC/AP severity, ERCP performance and length of hospitalization. We also conducted a literature review discussing each criteria of the TG18 in the context of AP.27.8% of biliary AP cases fulfilled TG18 for both AC and CC, 22.5% for CC only and 20.8% for AC only. Antibiotic use was high (77.4%). About 2/3 of the AC/CC cases were mild, around 10% severe. Mortality was below 1% in mild and moderate AC/CC patients, but considerably higher in severe cases (12.8% and 21.2% in AC and CC). ERCP was performed in 89.3% of AC cases, common bile duct stones were found in 41.1%.Around 70% of biliary AP patients fulfilled the TG18 for AC/CC, associated with a high rate of antibiotic use. Mortality in presumed mild or moderate AC/CC is low. Each of the laboratory and clinical criteria are commonly fulfilled in biliary AP, single imaging findings are also unspecific-AP specific diagnostic criteria are needed, as the prevalence of AC/CC are likely greatly overestimated. Randomized trials testing antibiotic use are also warranted.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Berke, Gergő
AU  - Beer, Sebastian
AU  - Gede, Noémi
AU  - Takáts, Amanda
AU  - Szentesi, Andrea Ildikó
AU  - Hegyi, Péter
AU  - Rosendahl, Jonas
AU  - Sahin-Tóth, Miklós
AU  - Németh, Balázs
AU  - Hegyi, Eszter
TI  - Risk of chronic pancreatitis in carriers of the c.180C>T (p.Gly60=) CTRC variant: Case-control studies and meta-analysis
JF  - PANCREATOLOGY
J2  - PANCREATOLOGY
VL  - 23
PY  - 2023
IS  - 5
SP  - 481
EP  - 490
PG  - 10
SN  - 1424-3903
DO  - 10.1016/j.pan.2023.05.013
UR  - https://m2.mtmt.hu/api/publication/34011872
ID  - 34011872
N1  - * Megosztott szerzőség
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Turcsiné Czapári, Dóra
AU  - Váradi, Alex
AU  - Borbásné Farkas, Kornélia
AU  - Nyári, Gergely Róbert
AU  - Márta, Katalin
AU  - Váncsa, Szilárd
AU  - Nagy, Rita
AU  - Teutsch, Brigitta
AU  - Bunduc, Stefania
AU  - Erőss, Bálint Mihály
AU  - Czakó, László
AU  - Vincze, Áron
AU  - Izbéki, Ferenc
AU  - Papp, Mária
AU  - Merkely, Béla Péter
AU  - Szentesi, Andrea Ildikó
AU  - Hegyi, Péter
ED  - Péter, Jenő Hegyi / Collaborator
ED  - Andrea, Párniczky / Collaborator
ED  - Mária, Földi / Collaborator
ED  - Klementina, Ocskay / Collaborator
ED  - Márk, Félix Juhász / Collaborator
ED  - Imrei, Marcell / Collaborator
ED  - Szabolcs, Kiss / Collaborator
ED  - Alexandra, Mikó / Collaborator
ED  - Szilárd, Gódi / Collaborator
ED  - Judit, Bajor / Collaborator
ED  - Roland, Hágendorn / Collaborator
ED  - Patrícia, Sarlós / Collaborator
ED  - Imre, Szabó / Collaborator
ED  - József, Czimmer / Collaborator
ED  - Nándor, Faluhelyi / Collaborator
ED  - Péter, Kanizsai / Collaborator
ED  - Attila, Miseta / Collaborator
ED  - Tamás, Nagy / Collaborator
ED  - László, Gajdán / Collaborator
ED  - Adrienn, Halász / Collaborator
ED  - Németh, Balázs / Collaborator
ED  - Kui, Balázs / Collaborator
ED  - Illés, Dóra / Collaborator
ED  - Takács, Tamás / Collaborator
ED  - Tiszlavicz, László / Collaborator
ED  - Oláh, Orsolya / Collaborator
ED  - Radics, Bence / Collaborator
ED  - Vitális, Zsuzsanna / Collaborator
ED  - József, Hamvas / Collaborator
ED  - Márta, Varga / Collaborator
ED  - Barnabás, Bod / Collaborator
ED  - János, Novák / Collaborator
ED  - Pál, Maurovich-Horváth / Collaborator
ED  - Doros, Attila / Collaborator
ED  - Pál, Ákos Deák / Collaborator
ED  - Varga, Csaba / Collaborator
ED  - Szabolcs, Gaál / Collaborator
ED  - László, Zubek / Collaborator
ED  - János, Gál / Collaborator
ED  - Zsolt, Molnár / Collaborator
ED  - Tamás, Tornai / Collaborator
ED  - Balázs, Lázár / Collaborator
ED  - Tamás, Hussein / Collaborator
ED  - Beáta, Kovács / Collaborator
ED  - Anna, Németh / Collaborator
ED  - Tarján, Dorottya / Collaborator
ED  - Lipp, Mónika Bernadett / Collaborator
ED  - Orsolya, Urbán / Collaborator
ED  - Simon, Tóth / Collaborator
ED  - Dániel, Söti / Collaborator
ED  - Dávid, Becker / Collaborator
TI  - Detailed characteristics of post-discharge mortality in acute pancreatitis
JF  - GASTROENTEROLOGY
J2  - GASTROENTEROLOGY
VL  - 165
PY  - 2023
IS  - 3
SP  - 682
EP  - 695
PG  - 14
SN  - 0016-5085
DO  - 10.1053/j.gastro.2023.05.028
UR  - https://m2.mtmt.hu/api/publication/33864451
ID  - 33864451
N1  - * Megosztott szerzőség
AB  - The in-hospital survival of patients suffering from acute pancreatitis (AP) is 95-98%. However, there is growing evidence that patients discharged after AP may be at risk of serious morbidity and mortality. Here, we aimed to investigate the risk, causes, and predictors of the most severe consequence of the post-AP period: mortality.2,613, well-characterized patients from twenty-five centers were collected and followed by the Hungarian Pancreatic Study Group between 2012 and 2021. A general and a hospital-based population was used as the control group.After an AP episode patients have an approximately three-fold higher incidence rate of mortality than the general population (0.0404vs.0.0130 person-years). First-year mortality after discharge was almost double than in-hospital mortality (5.5%vs.3.5%), with 3.0% occurring in the first 90-day period. Age, comorbidities, and severity were the most significant independent risk factors for death following AP. Furthermore, multivariate analysis identified creatinine, glucose, and pleural fluid on admission as independent risk factors associated with post-discharge mortality. In the first 90-day period, cardiac failure and AP-related sepsis were among the main causes of death following discharge, while cancer-related cachexia and non-AP-related infection were the key causes in the later phase.Almost as many patients in our cohort die in the first 90-day period after discharge as during their hospital stay. Evaluation of cardiovascular status, follow-up of local complications, and cachexia-preventing oncological care should be an essential part of post-AP patient care. Future study protocols in AP must include at least a 90-day follow-up period after discharge.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Campa, Daniele
AU  - Gentiluomo, Manuel
AU  - Stein, Angelika
AU  - Aoki, Mateus Nóbrega
AU  - Oliverius, Martin
AU  - Vodičková, Ludmila
AU  - Jamroziak, Krzysztof
AU  - Theodoropoulos, George
AU  - Pasquali, Claudio
AU  - Greenhalf, William
AU  - Arcidiacono, Paolo Giorgio
AU  - Uzunoglu, Faik
AU  - Pezzilli, Raffaele
AU  - Luchini, Claudio
AU  - Puzzono, Marta
AU  - Loos, Martin
AU  - Giaccherini, Matteo
AU  - Katzke, Verena
AU  - Mambrini, Andrea
AU  - Kiudeliene, Edita
AU  - Federico, Kauffmann Emanuele
AU  - Johansen, Julia
AU  - Hussein, Tamás
AU  - Mohelnikova-Duchonova, Beatrice
AU  - van Eijck, Casper H J
AU  - Brenner, Hermann
AU  - Farinella, Riccardo
AU  - Pérez, Juan Sainz
AU  - Lovecek, Martin
AU  - Büchler, Markus W
AU  - Hlavac, Viktor
AU  - Izbicki, Jakob R
AU  - Hackert, Thilo
AU  - Chammas, Roger
AU  - Zerbi, Alessandro
AU  - Lawlor, Rita
AU  - Felici, Alessio
AU  - Götz, Mara
AU  - Capurso, Gabriele
AU  - Ginocchi, Laura
AU  - Gazouli, Maria
AU  - Kupcinskas, Juozas
AU  - Cavestro, Giulia Martina
AU  - Vodicka, Pavel
AU  - Moz, Stefania
AU  - Neoptolemos, John P
AU  - Kunovsky, Lumir
AU  - Bojesen, Stig E
AU  - Carrara, Silvia
AU  - Gioffreda, Domenica
AU  - Morkunas, Egidijus
AU  - Abian, Olga
AU  - Bunduc, Stefania
AU  - Basso, Daniela
AU  - Boggi, Ugo
AU  - Wlodarczyk, Barbara
AU  - Szentesi, Andrea Ildikó
AU  - Vanella, Giuseppe
AU  - Chen, Inna
AU  - Bijlsma, Maarten F
AU  - Kiudelis, Vytautas
AU  - Landi, Stefano
AU  - Schöttker, Ben
AU  - Corradi, Chiara
AU  - Giese, Nathalia
AU  - Kaaks, Rudolf
AU  - Peduzzi, Giulia
AU  - Hegyi, Péter
AU  - Morelli, Luca
AU  - Furbetta, Niccolò
AU  - Soucek, Pavel
AU  - Latiano, Anna
AU  - Talar-Wojnarowska, Renata
AU  - Lindgaard, Sidsel C
AU  - Dijk, Frederike
AU  - Milanetto, Anna Caterina
AU  - Tavano, Francesca
AU  - Cervena, Klara
AU  - Erőss, Bálint Mihály
AU  - Testoni, Sabrina G
AU  - Verhagen-Oldenampsen, Judith H E
AU  - Małecka-Wojciesko, Ewa
AU  - Costello, Eithne
AU  - Salvia, Roberto
AU  - Maiello, Evaristo
AU  - Ermini, Stefano
AU  - Sperti, Cosimo
AU  - Holleczek, Bernd
AU  - Perri, Francesco
AU  - Skieceviciene, Jurgita
AU  - Archibugi, Livia
AU  - Lucchesi, Maurizio
AU  - Rizzato, Cosmeri
AU  - Canzian, Federico
TI  - The PANcreatic Disease ReseArch (PANDoRA) consortium : ten years' experience of association studies to understand the genetic architecture of pancreatic cancer
JF  - CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
J2  - CRIT REV ONCOL HEMAT
VL  - 186
PY  - 2023
PG  - 13
SN  - 1040-8428
DO  - 10.1016/j.critrevonc.2023.104020
UR  - https://m2.mtmt.hu/api/publication/33813736
ID  - 33813736
N1  - Funding Agency and Grant Number: Associazione Italiana per la Ricerca sul Cancro (AIRC); AZV, The Czech Ministry of Health [23672]; Italian Minister of Health, Ricerca Corrente program; Cancer Research UK [CA21116]; Pancreatic Cancer UK; AMC Foundation; COST (European Cooperation in Science and Technology); Programme EXCELES;  [NU21-07-00247];  [C7690/A26881];  [C18616/A25153];  [26201];  [LX22NPO5102]
            Funding text: The research leading to these results has received funding from Associazione Italiana per la Ricerca sul Cancro (AIRC) under IG 2019-ID. 23672 project-P.I. Campa Daniele and IG 2021 ID - 26201 project P.I. Gabriele Capurso. PV, LV and KC acknowledge the support from the AZV, The Czech Ministry of Health, NU21-07-00247 and from Programme EXCELES, ID Project No. LX22NPO5102. Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo (FG) , Italy has received funding by the Italian Minister of Health, Ricerca Corrente program 2022-2024, and by the and by the "5 x 1000?voluntary contribution. Costello, E and Greenhalf, W are supported bygrants from, Cancer Research UK (C7690/A26881, C18616/A25153) and Pancreatic Cancer UK. Sample accrual at the Amsterdam UMC was supported by the AMC Foundation. This article is based upon work from COST Action TRANSPAN, CA21116, supported by COST (European Cooperation in Science and Technology) .
AB  - Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups. In the last ten years, PANDoRA has contributed to the discovery of 25 susceptibility loci, a feat that will be instrumental in stratifying the population by risk and optimizing preventive strategies.
LA  - English
DB  - MTMT
ER  -