TY - JOUR AU - Szűcsborus, Tamás AU - Sasi, Viktor AU - Katona, András AU - Szántó, Gyula Tamás AU - Andréka, Judit AU - Szabó-Biczók, Antal Norbert AU - Bitay, Miklós AU - Palásty, Z AU - Babik, Barna AU - Ungi, Imre AU - Szili-Török, Tamás AU - Ruzsa, Zoltán TI - Transzkatéteres aortabillentyű implantációjának fejlődése a dél-magyarországi régióban JF - MAGYAR BELORVOSI ARCHIVUM J2 - MBA VL - 76 PY - 2023 IS - 5-6 SP - 335 EP - 336 PG - 2 SN - 0133-5464 UR - https://m2.mtmt.hu/api/publication/34567822 ID - 34567822 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Árpádffy-Lovas, Tamás AU - Mohammed, Aiman AU - Naveed, Muhammad AU - Koncz, Istvan AU - Baláti, Beáta AU - Bitay, Miklós AU - Jost, Norbert László AU - Nagy, Norbert AU - Baczkó, István AU - Virág, László AU - Varró, András TI - Species-dependent differences in the inhibition of various potassium currents and in their effects on repolarization in cardiac ventricular muscle JF - CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY J2 - CAN J PHYSIOL PHARM VL - 100 PY - 2022 IS - 9 SP - 880 EP - 889 PG - 10 SN - 0008-4212 DO - 10.1139/cjpp-2022-0028 UR - https://m2.mtmt.hu/api/publication/33124707 ID - 33124707 N1 - Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, H-6721, Hungary Department of Cardiac Surgery, Second Department of Internal Medicine and Cardiology Center, Albert Szent-Györgyi Health Center, University of Szeged, Szeged, H-6725, Hungary ELKH-SZTE Research Group of Cardiovascular Pharmacology, Szeged, H-6721, Hungary Export Date: 7 October 2022 CODEN: CJPPA Correspondence Address: Varró, A.; Department of Pharmacology and Pharmacotherapy, Hungary; email: varro.andras@med.u-szeged.hu Chemicals/CAS: potassium, 7440-09-7; Potassium; Potassium Channels AB - Even though rodents are accessible model animals, their electrophysiological properties are deeply different from those of humans, making the translation of rat studies to humans rather difficult. We compared the mechanisms of ventricular repolarization in various animal models to those of humans by measuring cardiac ventricular action potentials from ventricular papillary muscle preparations using conventional microelectrodes and applying selective inhibitors of various potassium transmembrane ion currents. Inhibition of the IK1 current (10 μmol/L barium chloride) significantly prolonged rat ventricular repolarization, but only slightly prolonged it in dogs, and did not affect it in humans. On the contrary, IKr inhibition (50 nmol/L dofetilide) significantly prolonged repolarization in humans, rabbits, and dogs, but not in rats. Inhibition of the IKur current (1 μmol/L XEN-D0101) only prolonged rat ventricular repolarization and had no effect in humans or dogs. Inhibition of the IKs (500 nmol/L HMR-1556) and Ito currents (100 μmol/L chromanol-293B) elicited similar effects in all investigated species. We conclude that dog ventricular preparations have the strongest translational value and rat ventricular preparations have the weakest translational value in cardiac electrophysiological experiments. © 2022 The Author(s). LA - English DB - MTMT ER - TY - JOUR AU - Bitay, Miklós AU - Shadmanian, A AU - Kovacev, M AU - Szűcs, Sz AU - Varga, Sándor AU - Szabó-Biczók, Antal Norbert AU - Bari, Gábor TI - „Off -pump”, teljes artériás revaszkularizáció kétoldali belső mellkasi érrel: 15 éves után követés = Off -Pump Total Arterial Revascularization With Bilateral Internal Thoracic Arteries (Aortic No-Touch Technique): 15 Follow-Up JF - CARDIOLOGIA HUNGARICA J2 - CARDIOL HUNG VL - 51 PY - 2021 IS - Suppl B SP - B357 EP - B358 SN - 0133-5596 UR - https://m2.mtmt.hu/api/publication/32601757 ID - 32601757 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bari, Gábor AU - Szabó-Biczók, Antal Norbert AU - Varga, Sándor AU - Iglói, Gábor AU - Kovacev, M AU - Shadmanian, A AU - Szűcs, Sz AU - Bitay, Miklós AU - Hegedűs, Zoltán TI - Az aortaív rekonstrukciós műtétei „branch-graft” érprotézissel: a szegedi stratégia = Aortic arch reconstruction using branched vascular grafts: the operative strategy in Szeged JF - CARDIOLOGIA HUNGARICA J2 - CARDIOL HUNG VL - 51 PY - 2021 IS - Suppl B SP - B357 SN - 0133-5596 UR - https://m2.mtmt.hu/api/publication/32601740 ID - 32601740 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bitay, Miklós AU - Shadmanian, Ali AU - Kovacev, Marko AU - Szabó-Biczók, Antal Norbert AU - Iglói, Gábor TI - Arrow Shaped Ministernotomy Approach for the Ross Procedure JF - STRUCTURAL HEART J2 - STRUCT HEART VL - 5 PY - 2021 IS - sup1 SP - 19 EP - 19 PG - 1 SN - 2474-8706 DO - 10.1080/24748706.2021.1898904 UR - https://m2.mtmt.hu/api/publication/32510023 ID - 32510023 LA - English DB - MTMT ER - TY - JOUR AU - Árpádffy-Lovas, Tamás AU - Naveed, Muhammad AU - Mohammed, Aiman AU - Baláti, B AU - Bitay, Miklós AU - Jost, Norbert László AU - Nagy, Norbert AU - Baczkó, István AU - Virág, László AU - Varró, András TI - Ioncsatorna-gátló vegyületek humán, kutya, nyúl, tengerimalac és patkány kamrai akciós potenciálra gyakorolt hatásainak összehasonlítása = Comparison of effects of ion channel blocking substances on human, dog, rabbit, and guinea-pig cardiac ventricular preparations JF - CARDIOLOGIA HUNGARICA J2 - CARDIOL HUNG VL - 51 PY - 2021 IS - Suppl B SP - B248 EP - B248 SN - 0133-5596 UR - https://m2.mtmt.hu/api/publication/32462718 ID - 32462718 LA - English DB - MTMT ER - TY - JOUR AU - Trosclair, Krystle AU - Si, Man AU - Watts, Megan AU - Gautier, Nicole M AU - Voigt, Niels AU - Traylor, James AU - Bitay, Miklós AU - Baczkó, István AU - Dobrev, Dobromir AU - Hamilton, Kathryn A AU - Bhuiyan, Md Shenuarin AU - Dominic, Paari AU - Glasscock, Edward TI - Kv1.1 potassium channel subunit deficiency alters ventricular arrhythmia susceptibility, contractility, and repolarization JF - PHYSIOLOGICAL REPORTS J2 - PHYSIOL REPORTS VL - 9 PY - 2021 IS - 1 PG - 12 SN - 2051-817X DO - 10.14814/phy2.14702 UR - https://m2.mtmt.hu/api/publication/31807185 ID - 31807185 AB - Epilepsy-associated Kv1.1 voltage-gated potassium channel subunits encoded by the Kcna1 gene have traditionally been considered absent in heart, but recent studies reveal they are expressed in cardiomyocytes where they could regulate intrinsic cardiac electrophysiology. Although Kv1.1 now has a demonstrated functional role in atria, its role in the ventricles has never been investigated. In this work, electrophysiological, histological, and gene expression approaches were used to explore the consequences of Kv1.1 deficiency in the ventricles of Kcna1 knockout (KO) mice at the organ, cellular, and molecular levels to determine whether the absence of Kv1.1 leads to ventricular dysfunction that increases the risk of premature or sudden death. When subjected to intracardiac pacing, KO mice showed normal baseline susceptibility to inducible ventricular arrhythmias (VA) but resistance to VA under conditions of sympathetic challenge with isoproterenol. Echocardiography revealed cardiac contractile dysfunction manifesting as decreased ejection fraction and fractional shortening. In whole-cell patch-clamp recordings, KO ventricular cardiomyocytes exhibited action potential prolongation indicative of impaired repolarization. Imaging, histological, and transcript analyses showed no evidence of structural or channel gene expression remodeling, suggesting that the observed deficits are likely electrogenic due to Kv1.1 deficiency. Immunoblots of patient heart samples detected the presence of Kv1.1 at relatively high levels, implying that Kv1.1 contributes to human cardiac electrophysiology. Taken together, this work describes an important functional role for Kv1.1 in ventricles where its absence causes repolarization and contractility deficits but reduced susceptibility to arrhythmia under conditions of sympathetic drive. LA - English DB - MTMT ER - TY - JOUR AU - Árpádffy-Lovas, Tamás AU - Baláti, B AU - Bitay, Miklós AU - Jost, Norbert László AU - Nagy, Norbert AU - Baczkó, István AU - Virág, László AU - Varró, András TI - Ioncsatorna-gátló­ vegyületek­ humán­ és­ rágcsáló­ kamrai­ akciós­ potenciálra­ gyakorolt­ hatásainak­ összehasonlítása = Comparison­ of­ ion­ channel­ inhibitor­ effects ­in­ human­ and­ rat­ cardiac­ ventricular­ action­ potentials JF - CARDIOLOGIA HUNGARICA J2 - CARDIOL HUNG VL - 50 PY - 2020 IS - Suppl. D SP - 166 EP - 166 PG - 1 SN - 0133-5596 UR - https://m2.mtmt.hu/api/publication/31974293 ID - 31974293 LA - English DB - MTMT ER - TY - JOUR AU - Árpádffy-Lovas, Tamás AU - Baczkó, István AU - Baláti, Beáta AU - Bitay, Miklós AU - Jost, Norbert László AU - Lengyel, Csaba Attila AU - Nagy, Norbert AU - Takács, János AU - Varró, András AU - Virág, László TI - Electrical Restitution and Its Modifications by Antiarrhythmic Drugs in Undiseased Human Ventricular Muscle JF - FRONTIERS IN PHARMACOLOGY J2 - FRONT PHARMACOL VL - 11 PY - 2020 PG - 7 SN - 1663-9812 DO - 10.3389/fphar.2020.00479 UR - https://m2.mtmt.hu/api/publication/31295810 ID - 31295810 N1 - Funding Agency and Grant Number: National Research Development and Innovation Office [NKFIH K-119992, K-128851, FK-129117, GINOP-2.3.2.-15-2016-00047]; Ministry of Human Capacities Hungary [20391-3/2018/FEKUSTRAT, EFOP-3.6.2-16-2017-00006]; New National Excellence Program of the Ministry for Innovation and Technology [UNKP-19-3-SZTE-5]; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences; European UnionEuropean Union (EU); European Regional Development FundEuropean Union (EU) Funding text: This work was funded by the National Research Development and Innovation Office (NKFIH K-119992 (for AV), K-128851 (for IB), FK-129117 (for NN), and GINOP-2.3.2.-15-2016-00047), the Ministry of Human Capacities Hungary (20391-3/2018/FEKUSTRAT and EFOP-3.6.2-16-2017-00006), the UNKP-19-3-SZTE-5 (New National Excellence Program of the Ministry for Innovation and Technology; for TA '-L) and Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences (for NN). The GINOP and EFOP projects are co-financed by the European Union and the European Regional Development Fund. AB - Introduction: Re-entry is a basic mechanism of ventricular fibrillation, which can be elicited by extrasystolic activity, but the timing of an extrasystole can be critical. The action potential duration (APD) of an extrasystole depends on the proximity of the preceding beat, and the relation between its timing and its APD is called electrical restitution. The aim of the present work was to study and compare the effect of several antiarrhythmic drugs on restitution in preparations from undiseased human ventricular muscle, and other mammalian species. Methods: Action potentials were recorded in preparations obtained from rat, guinea pig, rabbit, and dog hearts; and from undiseased human donor hearts using the conventional microelectrode technique. Preparations were stimulated with different basic cycle lengths (BCLs) ranging from 300 to 5,000 ms. To study restitution, single test pulses were applied at every 20th beat while the preparation was driven at 1,000 ms BCL. Results: Marked differences were found between the animal and human preparations regarding restitution and steady-state frequency dependent curves. In human ventricular muscle, restitution kinetics were slower in preparations with large phase 1 repolarization with shorter APDs at 1000 ms BCL compared to preparations with small phase 1. Preparations having APD longer than 300 ms at 1000 ms BCL had slower restitution kinetics than those having APD shorter than 250 ms. The selective IKr inhibitors E-4031 and sotalol increased overall APD and slowed the restitution kinetics, while IKs inhibition did not influence APD and electrical restitution. Mexiletine and nisoldipine shortened APD, but only mexiletine slowed restitution kinetics. Discussion: Frequency dependent APD changes, including electrical restitution, were partly determined by the APD at the BCL. Small phase 1 associated with slower restitution suggests a role of Ito in restitution. APD prolonging drugs slowed restitution, while mexiletine, a known inhibitor of INa, shortened basic APD but also slowed restitution. These results indicate that although basic APD has an important role in restitution, other transmembrane currents, such as INa or Ito, can also affect restitution kinetics. This raises the possibility that ion channel modifier drugs slowing restitution kinetics may have antiarrhythmic properties by altering restitution. LA - English DB - MTMT ER - TY - JOUR AU - Bitay, Miklós AU - Varga, Sándor AU - Babik, Barna AU - Havasi, Kálmán AU - Szűcsborus, Tamás TI - Infective endocarditis complicated with coronary artery septic embolization: is it worth to be mentioned?. Case presentation and review of the literature TS - Case presentation and review of the literature JF - REVIEWS IN CARDIOVASCULAR MEDICINE J2 - REV CARDIOVASC MED VL - 20 PY - 2019 IS - 1 SP - 35 EP - 39 PG - 5 SN - 1530-6550 DO - 10.31083/j.rcm.2019.01.4241 UR - https://m2.mtmt.hu/api/publication/30750856 ID - 30750856 N1 - Szövegében 3 oldalnál rövidebb esetismertetés, ezért besorolása rövid közlemény az MTA V. Osztályának ajánlása alapján. (BCS, SZTE admin4) AB - Coronary artery septic embolization is a rare, but severe complication of infective endocarditis involving the leftside of the valves. The first case mentioned in the literature was a postmortem finding of a left anterior descending coronary artery occlusion by a vegetation fragment. Since this case, there have been several therapeutic strategies published with this clinical setting including medical treatment, percutaneous coronary angioplasty addressing coronary occlusion, surgical intervention for both the infected valve and coronary embolization, and hybrid procedures with transcatheter septic embolus aspiration followed by surgical valvular interventions. Out of the three interventions mentioned, the latter provided the best results and was in concordance with results observed in a case of mitral valve infected endocarditis complicated with acute occlusion of the left anterior descending coronary artery in patient whose comorbidities included hypertrophic obstructive cardiomyopathy. A transcatheter left anterior descending coronary artery embolus aspiration was performed , followed by a surgical mitral valve replacement and septal myectomy with an uneventful postoperative course. Although rare, this severe complication of infective endocarditis has a specific clinical course and therapeutic strategy, and in our opinion, it could be mentioned as a separate entity among embolic complications of infective endocarditis in future guidelines. Previously published cases suggest that the hybrid intervention might be the therapy of choice for this clinical setting; however, larger studies are necessary for confirmation. LA - English DB - MTMT ER -