@article{MTMT:34567822,
	title = {Transzkatéteres aortabillentyű implantációjának fejlődése a dél-magyarországi régióban},
	url = {https://m2.mtmt.hu/api/publication/34567822},
	author = {Szűcsborus, Tamás and Sasi, Viktor and Katona, András and Szántó, Gyula Tamás and Andréka, Judit and Szabó-Biczók, Antal Norbert and Bitay, Miklós and Palásty, Z and Babik, Barna and Ungi, Imre and Szili-Török, Tamás and Ruzsa, Zoltán},
	journal-iso = {MBA},
	journal = {MAGYAR BELORVOSI ARCHIVUM},
	volume = {76},
	unique-id = {34567822},
	issn = {0133-5464},
	year = {2023},
	pages = {335-336},
	orcid-numbers = {Sasi, Viktor/0000-0001-7844-9447; Babik, Barna/0000-0003-3739-8879; Ungi, Imre/0000-0002-2011-0069; Szili-Török, Tamás/0000-0002-7165-8243; Ruzsa, Zoltán/0000-0002-2474-5723}
}

@article{MTMT:33124707,
	title = {Species-dependent differences in the inhibition of various potassium currents and in their effects on repolarization in cardiac ventricular muscle},
	url = {https://m2.mtmt.hu/api/publication/33124707},
	author = {Árpádffy-Lovas, Tamás and Mohammed, Aiman and Naveed, Muhammad and Koncz, Istvan and Baláti, Beáta and Bitay, Miklós and Jost, Norbert László and Nagy, Norbert and Baczkó, István and Virág, László and Varró, András},
	doi = {10.1139/cjpp-2022-0028},
	journal-iso = {CAN J PHYSIOL PHARM},
	journal = {CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY},
	volume = {100},
	unique-id = {33124707},
	issn = {0008-4212},
	abstract = {Even though rodents are accessible model animals, their electrophysiological properties are deeply different from those of humans, making the translation of rat studies to humans rather difficult. We compared the mechanisms of ventricular repolarization in various animal models to those of humans by measuring cardiac ventricular action potentials from ventricular papillary muscle preparations using conventional microelectrodes and applying selective inhibitors of various potassium transmembrane ion currents. Inhibition of the IK1 current (10 μmol/L barium chloride) significantly prolonged rat ventricular repolarization, but only slightly prolonged it in dogs, and did not affect it in humans. On the contrary, IKr inhibition (50 nmol/L dofetilide) significantly prolonged repolarization in humans, rabbits, and dogs, but not in rats. Inhibition of the IKur current (1 μmol/L XEN-D0101) only prolonged rat ventricular repolarization and had no effect in humans or dogs. Inhibition of the IKs (500 nmol/L HMR-1556) and Ito currents (100 μmol/L chromanol-293B) elicited similar effects in all investigated species. We conclude that dog ventricular preparations have the strongest translational value and rat ventricular preparations have the weakest translational value in cardiac electrophysiological experiments. © 2022 The Author(s).},
	keywords = {RABBITS; metabolism; MYOCARDIUM; RATS; POTASSIUM; human; human; animal; physiology; dog; HEART; action potential; potassium channel; action potential duration; comparison; cardiac muscle; ion currents; heart ventricle; Leporidae; rat},
	year = {2022},
	eissn = {1205-7541},
	pages = {880-889},
	orcid-numbers = {Baczkó, István/0000-0002-9588-0797; Varró, András/0000-0003-0745-3603}
}

@article{MTMT:32601757,
	title = {„Off -pump”, teljes artériás revaszkularizáció kétoldali belső mellkasi érrel: 15 éves után követés = Off -Pump Total Arterial Revascularization With Bilateral Internal Thoracic Arteries (Aortic No-Touch Technique): 15 Follow-Up},
	url = {https://m2.mtmt.hu/api/publication/32601757},
	author = {Bitay, Miklós and Shadmanian, A and Kovacev, M and Szűcs, Sz and Varga, Sándor and Szabó-Biczók, Antal Norbert and Bari, Gábor},
	journal-iso = {CARDIOL HUNG},
	journal = {CARDIOLOGIA HUNGARICA},
	volume = {51},
	unique-id = {32601757},
	issn = {0133-5596},
	year = {2021},
	eissn = {1588-0230},
	pages = {B357-B358}
}

@article{MTMT:32601740,
	title = {Az aortaív rekonstrukciós műtétei „branch-graft” érprotézissel: a szegedi stratégia = Aortic arch reconstruction using branched vascular grafts: the operative strategy in Szeged},
	url = {https://m2.mtmt.hu/api/publication/32601740},
	author = {Bari, Gábor and Szabó-Biczók, Antal Norbert and Varga, Sándor and Iglói, Gábor and Kovacev, M and Shadmanian, A and Szűcs, Sz and Bitay, Miklós and Hegedűs, Zoltán},
	journal-iso = {CARDIOL HUNG},
	journal = {CARDIOLOGIA HUNGARICA},
	volume = {51},
	unique-id = {32601740},
	issn = {0133-5596},
	year = {2021},
	eissn = {1588-0230},
	pages = {B357}
}

@article{MTMT:32510023,
	title = {Arrow Shaped Ministernotomy Approach for the Ross Procedure},
	url = {https://m2.mtmt.hu/api/publication/32510023},
	author = {Bitay, Miklós and Shadmanian, Ali and Kovacev, Marko and Szabó-Biczók, Antal Norbert and Iglói, Gábor},
	doi = {10.1080/24748706.2021.1898904},
	journal-iso = {STRUCT HEART},
	journal = {STRUCTURAL HEART},
	volume = {5},
	unique-id = {32510023},
	issn = {2474-8706},
	year = {2021},
	eissn = {2474-8714},
	pages = {19-19}
}

@article{MTMT:32462718,
	title = {Ioncsatorna-gátló vegyületek humán, kutya, nyúl, tengerimalac és patkány kamrai akciós potenciálra gyakorolt hatásainak összehasonlítása = Comparison of effects of ion channel blocking substances on human, dog, rabbit, and guinea-pig cardiac ventricular preparations},
	url = {https://m2.mtmt.hu/api/publication/32462718},
	author = {Árpádffy-Lovas, Tamás and Naveed, Muhammad and Mohammed, Aiman and Baláti, B and Bitay, Miklós and Jost, Norbert László and Nagy, Norbert and Baczkó, István and Virág, László and Varró, András},
	journal-iso = {CARDIOL HUNG},
	journal = {CARDIOLOGIA HUNGARICA},
	volume = {51},
	unique-id = {32462718},
	issn = {0133-5596},
	year = {2021},
	eissn = {1588-0230},
	pages = {B248-B248},
	orcid-numbers = {Baczkó, István/0000-0002-9588-0797; Varró, András/0000-0003-0745-3603}
}

@article{MTMT:31807185,
	title = {Kv1.1 potassium channel subunit deficiency alters ventricular arrhythmia susceptibility, contractility, and repolarization},
	url = {https://m2.mtmt.hu/api/publication/31807185},
	author = {Trosclair, Krystle and Si, Man and Watts, Megan and Gautier, Nicole M and Voigt, Niels and Traylor, James and Bitay, Miklós and Baczkó, István and Dobrev, Dobromir and Hamilton, Kathryn A and Bhuiyan, Md Shenuarin and Dominic, Paari and Glasscock, Edward},
	doi = {10.14814/phy2.14702},
	journal-iso = {PHYSIOL REPORTS},
	journal = {PHYSIOLOGICAL REPORTS},
	volume = {9},
	unique-id = {31807185},
	abstract = {Epilepsy-associated Kv1.1 voltage-gated potassium channel subunits encoded by the Kcna1 gene have traditionally been considered absent in heart, but recent studies reveal they are expressed in cardiomyocytes where they could regulate intrinsic cardiac electrophysiology. Although Kv1.1 now has a demonstrated functional role in atria, its role in the ventricles has never been investigated. In this work, electrophysiological, histological, and gene expression approaches were used to explore the consequences of Kv1.1 deficiency in the ventricles of Kcna1 knockout (KO) mice at the organ, cellular, and molecular levels to determine whether the absence of Kv1.1 leads to ventricular dysfunction that increases the risk of premature or sudden death. When subjected to intracardiac pacing, KO mice showed normal baseline susceptibility to inducible ventricular arrhythmias (VA) but resistance to VA under conditions of sympathetic challenge with isoproterenol. Echocardiography revealed cardiac contractile dysfunction manifesting as decreased ejection fraction and fractional shortening. In whole-cell patch-clamp recordings, KO ventricular cardiomyocytes exhibited action potential prolongation indicative of impaired repolarization. Imaging, histological, and transcript analyses showed no evidence of structural or channel gene expression remodeling, suggesting that the observed deficits are likely electrogenic due to Kv1.1 deficiency. Immunoblots of patient heart samples detected the presence of Kv1.1 at relatively high levels, implying that Kv1.1 contributes to human cardiac electrophysiology. Taken together, this work describes an important functional role for Kv1.1 in ventricles where its absence causes repolarization and contractility deficits but reduced susceptibility to arrhythmia under conditions of sympathetic drive.},
	keywords = {CONTRACTILITY; action potential; Arrhythmia; Repolarization; K-channel},
	year = {2021},
	eissn = {2051-817X},
	orcid-numbers = {Baczkó, István/0000-0002-9588-0797}
}

@article{MTMT:31974293,
	title = {Ioncsatorna-gátló­ vegyületek­ humán­ és­ rágcsáló­ kamrai­ akciós­ potenciálra­ gyakorolt­ hatásainak­ összehasonlítása = Comparison­ of­ ion­ channel­ inhibitor­ effects ­in­ human­ and­ rat­ cardiac­ ventricular­ action­ potentials},
	url = {https://m2.mtmt.hu/api/publication/31974293},
	author = {Árpádffy-Lovas, Tamás and Baláti, B and Bitay, Miklós and Jost, Norbert László and Nagy, Norbert and Baczkó, István and Virág, László and Varró, András},
	journal-iso = {CARDIOL HUNG},
	journal = {CARDIOLOGIA HUNGARICA},
	volume = {50},
	unique-id = {31974293},
	issn = {0133-5596},
	year = {2020},
	eissn = {1588-0230},
	pages = {166-166},
	orcid-numbers = {Baczkó, István/0000-0002-9588-0797; Varró, András/0000-0003-0745-3603}
}

@article{MTMT:31295810,
	title = {Electrical Restitution and Its Modifications by Antiarrhythmic Drugs in Undiseased Human Ventricular Muscle},
	url = {https://m2.mtmt.hu/api/publication/31295810},
	author = {Árpádffy-Lovas, Tamás and Baczkó, István and Baláti, Beáta and Bitay, Miklós and Jost, Norbert László and Lengyel, Csaba Attila and Nagy, Norbert and Takács, János and Varró, András and Virág, László},
	doi = {10.3389/fphar.2020.00479},
	journal-iso = {FRONT PHARMACOL},
	journal = {FRONTIERS IN PHARMACOLOGY},
	volume = {11},
	unique-id = {31295810},
	abstract = {Introduction: Re-entry is a basic mechanism of ventricular fibrillation, which can be elicited by extrasystolic activity, but the timing of an extrasystole can be critical. The action potential duration (APD) of an extrasystole depends on the proximity of the preceding beat, and the relation between its timing and its APD is called electrical restitution. The aim of the present work was to study and compare the effect of several antiarrhythmic drugs on restitution in preparations from undiseased human ventricular muscle, and other mammalian species. 
		Methods: Action potentials were recorded in preparations obtained from rat, guinea pig, rabbit, and dog hearts; and from undiseased human donor hearts using the conventional microelectrode technique. Preparations were stimulated with different basic cycle lengths (BCLs) ranging from 300 to 5,000 ms. To study restitution, single test pulses were applied at every 20th beat while the preparation was driven at 1,000 ms BCL. 
		Results: Marked differences were found between the animal and human preparations regarding restitution and steady-state frequency dependent curves. In human ventricular muscle, restitution kinetics were slower in preparations with large phase 1 repolarization with shorter APDs at 1000 ms BCL compared to preparations with small phase 1. Preparations having APD longer than 300 ms at 1000 ms BCL had slower restitution kinetics than those having APD shorter than 250 ms. The selective IKr inhibitors E-4031 and sotalol increased overall APD and slowed the restitution kinetics, while IKs inhibition did not influence APD and electrical restitution. Mexiletine and nisoldipine shortened APD, but only mexiletine slowed restitution kinetics. 
		Discussion: Frequency dependent APD changes, including electrical restitution, were partly determined by the APD at the BCL. Small phase 1 associated with slower restitution suggests a role of Ito in restitution. APD prolonging drugs slowed restitution, while mexiletine, a known inhibitor of INa, shortened basic APD but also slowed restitution. These results indicate that although basic APD has an important role in restitution, other transmembrane currents, such as INa or Ito, can also affect restitution kinetics. This raises the possibility that ion channel modifier drugs slowing restitution kinetics may have antiarrhythmic properties by altering restitution.},
	keywords = {Arrhythmia; human ventricle; ELECTRICAL RESTITUTION; Action potential (AP); cardiac electrophysiogy},
	year = {2020},
	eissn = {1663-9812},
	orcid-numbers = {Baczkó, István/0000-0002-9588-0797; Lengyel, Csaba Attila/0000-0002-0434-0067; Varró, András/0000-0003-0745-3603}
}

@article{MTMT:30750856,
	title = {Infective endocarditis complicated with coronary artery septic embolization: is it worth to be mentioned?. Case presentation and review of the literature},
	url = {https://m2.mtmt.hu/api/publication/30750856},
	author = {Bitay, Miklós and Varga, Sándor and Babik, Barna and Havasi, Kálmán and Szűcsborus, Tamás},
	doi = {10.31083/j.rcm.2019.01.4241},
	journal-iso = {REV CARDIOVASC MED},
	journal = {REVIEWS IN CARDIOVASCULAR MEDICINE},
	volume = {20},
	unique-id = {30750856},
	issn = {1530-6550},
	abstract = {Coronary artery septic embolization is a rare, but severe complication of infective endocarditis involving the leftside of the valves. The first case mentioned in the literature was a postmortem finding of a left anterior descending coronary artery occlusion by a vegetation fragment. Since this case, there have been several therapeutic strategies published with this clinical setting including medical treatment, percutaneous coronary angioplasty addressing coronary occlusion, surgical intervention for both the infected valve and coronary embolization, and hybrid procedures with transcatheter septic embolus aspiration followed by surgical valvular interventions. Out of the three interventions mentioned, the latter provided the best results and was in concordance with results observed in a case of mitral valve infected endocarditis complicated with acute occlusion of the left anterior descending coronary artery in patient whose comorbidities included hypertrophic obstructive cardiomyopathy. A transcatheter left anterior descending coronary artery embolus aspiration was performed , followed by a surgical mitral valve replacement and septal myectomy with an uneventful postoperative course. Although rare, this severe complication of infective endocarditis has a specific clinical course and therapeutic strategy, and in our opinion, it could be mentioned as a separate entity among embolic complications of infective endocarditis in future guidelines. Previously published cases suggest that the hybrid intervention might be the therapy of choice for this clinical setting; however, larger studies are necessary for confirmation.},
	keywords = {Infective endocarditis; Hybrid approach; Coronary artery septic embolization; infective endocarditis guidelines},
	year = {2019},
	eissn = {2153-8174},
	pages = {35-39},
	orcid-numbers = {Babik, Barna/0000-0003-3739-8879}
}