TY - JOUR AU - Benkő, Ria AU - Bíró, Tivadar AU - Matuz, Mária TI - Gyógyszerosztó automata: alkalmazás a napi klinikai gyakorlatban [Automatic medication dispenser: application in daily clinical practice] JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 93 PY - 2023 IS - S1 SP - S34 EP - S34 PG - 1 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/34392931 ID - 34392931 LA - Hungarian DB - MTMT ER - TY - THES AU - Bíró, Tivadar TI - Application of cyclodextrins and mucoadhesive preservative system in ophthalmic formulations [Ciklodextrinek és mukoadhezív tartósító rendszer alkalmazása szemészeti készítmények fejlesztésében] PB - Szegedi Tudományegyetem (SZTE) PY - 2022 SP - 50 DO - 10.14232/phd.10873 UR - https://m2.mtmt.hu/api/publication/32852532 ID - 32852532 LA - English DB - MTMT ER - TY - JOUR AU - Bíró, Tivadar AU - Bocsik, Alexandra AU - Jurišić Dukovski, Bisera AU - Gróf, Ilona AU - Lovrić, Jasmina AU - Pannonhalminé Csóka, Ildikó AU - Deli, Mária Anna AU - Aigner, Zoltán TI - New Approach in Ocular Drug Delivery. In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations TS - In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations JF - DRUG DESIGN DEVELOPMENT AND THERAPY J2 - DRUG DES DEV THER VL - 15 PY - 2021 SP - 351 EP - 360 PG - 10 SN - 1177-8881 DO - 10.2147/DDDT.S264745 UR - https://m2.mtmt.hu/api/publication/31890902 ID - 31890902 AB - Background: Optimal transcorneal penetration is necessary for ocular therapy; meanwhile, it is limited by the complex structure and defensive mechanisms of the eye. Antimicrobial stability of topical ophthalmic formulations is especially important. According to previous studies, the mostly used preservative, benzalkonium-chloride is irritative and toxic on corneal epithelial cells; therefore, novel non-toxic, antimicrobial agents are required. In this study, prednisolone-containing ophthalmic formulations were developed with expected optimal permeation without toxic or irritative effects. Methods: The toxicity and permeability of prednisolone-containing eye drops were studied on a human corneal epithelial cell line (HCE-T) and ex vivo cornea model. The lipophilic drug is dissolved by the formation of cyclodextrin inclusion complex. Zinc-containing mucoadhesive biopolymer was applied as an alternative preservative agent, whose toxicity was compared with benzalkonium-chloride. Results: As the results show, benzalkonium-chloride-containing samples were toxic on HCE-T cells. The biopolymer caused no cell damage after the treatment. This was confirmed by immunohistochemistry assay. The in vitro permeability was significantly higher in formulations with prednisolone-cyclodextrin complex compared with suspension formulation. According to the ex vivo permeability study, the biopolymer-containing samples had significantly lower permeability. Conclusion: Considering the mucoadhesive attribute of target formulations, prolonged absorption is expected after application with less frequent administration. It can be stated that the compositions are innovative approaches as novel non-toxic ophthalmic formulations with optimal drug permeability. LA - English DB - MTMT ER - TY - JOUR AU - Bíró, Tivadar AU - Bocsik, Alexandra AU - Gróf, Ilona AU - Bisera, Jurisic Dukowski AU - Jasmina, Lovric AU - Deli, Mária Anna AU - Aigner, Zoltán TI - Investigation of the permeability and cytotoxicity in novel topical ophthalmic formulations using in vitro and ex vivo models JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 90 PY - 2020 IS - 2-3 SP - 86 EP - 86 PG - 1 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/31978759 ID - 31978759 LA - English DB - MTMT ER - TY - BOOK ED - Bíró, Tivadar TI - II. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science. 23-24 January, 2020 : book of abstracts TS - 23-24 January, 2020 : book of abstracts PB - University of Szeged C1 - Szeged PY - 2020 SP - 46 DO - 10.14232/syrptbrs.2020.af UR - https://m2.mtmt.hu/api/publication/31342228 ID - 31342228 N1 - Az ISBN ellenére típusa Egyéb konferenciakötet, mert terjedelme nem éri el a könyveknél elvárt 48 oldalt. (BSzÁ, SZTE admin5, 2023-07-19) LA - English DB - MTMT ER - TY - CONF AU - Bíró, Tivadar AU - Aigner, Zoltán ED - Bíró, Tivadar TI - In vitro and ex vivo investigation of steroid containing ocular drug delivery systems T2 - II. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science PB - University of Szeged C1 - Szeged PY - 2020 SP - 6 EP - 6 PG - 1 DO - 10.14232/syrptbrs.2020.op1 UR - https://m2.mtmt.hu/api/publication/31311283 ID - 31311283 LA - English DB - MTMT ER - TY - JOUR AU - Bíró, Tivadar AU - Aigner, Zoltán TI - Current Approaches to Use Cyclodextrins and Mucoadhesive Polymers in Ocular Drug Delivery—A Mini-Review JF - SCIENTIA PHARMACEUTICA J2 - SCI PHARM VL - 87 PY - 2019 IS - 3 PG - 10 SN - 0036-8709 DO - 10.3390/scipharm87030015 UR - https://m2.mtmt.hu/api/publication/30727229 ID - 30727229 N1 - Export Date: 11 January 2020 CODEN: SCPHA Correspondence Address: Aigner, Z.; University of Szeged, Institute of Pharmaceutical Technology and Regulatory Affairs, Eötvös u. 6, Hungary; email: aigner@pharm.u-szeged.hu Chemicals/CAS: 2 hydroxypropyl beta cyclodextrin, 94035-02-6, 128446-35-5; amlodipine, 88150-42-9, 103129-82-4, 736178-83-9; carbomer, 9007-20-9, 9062-04-8; chitosan, 9012-76-4; cyclodextrin, 12619-70-4; cyclosporine, 59865-13-3, 63798-73-2, 79217-60-0; dexamethasone acetate, 1177-87-3; flurbiprofen, 5104-49-4; hydroxyethylcellulose, 9004-62-0; hydroxypropylmethylcellulose, 9004-65-3; methylcellulose, 79484-92-7, 9004-67-5; nepafenac, 78281-72-8 Tradenames: nevanac Export Date: 13 January 2020 CODEN: SCPHA Correspondence Address: Aigner, Z.; University of Szeged, Institute of Pharmaceutical Technology and Regulatory Affairs, Eötvös u. 6, Hungary; email: aigner@pharm.u-szeged.hu Chemicals/CAS: 2 hydroxypropyl beta cyclodextrin, 94035-02-6, 128446-35-5; amlodipine, 88150-42-9, 103129-82-4, 736178-83-9; carbomer, 9007-20-9, 9062-04-8; chitosan, 9012-76-4; cyclodextrin, 12619-70-4; cyclosporine, 59865-13-3, 63798-73-2, 79217-60-0; dexamethasone acetate, 1177-87-3; flurbiprofen, 5104-49-4; hydroxyethylcellulose, 9004-62-0; hydroxypropylmethylcellulose, 9004-65-3; methylcellulose, 79484-92-7, 9004-67-5; nepafenac, 78281-72-8 Tradenames: nevanac LA - English DB - MTMT ER - TY - BOOK ED - Bíró, Tivadar ED - Pannonhalminé Csóka, Ildikó TI - I. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science PB - University of Szeged C1 - Szeged PY - 2019 SP - 25 DO - 10.14232/syrptbrs.2019.af UR - https://m2.mtmt.hu/api/publication/30461742 ID - 30461742 N1 - book of abstracts LA - English DB - MTMT ER - TY - CHAP AU - Bíró, Tivadar AU - Aigner, Zoltán ED - Bíró, Tivadar ED - Pannonhalminé Csóka, Ildikó TI - Novel ophthalmic formulations to increase the efficacy and stability T2 - I. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science PB - University of Szeged C1 - Szeged PY - 2019 SP - 18 EP - 18 PG - 1 DO - 10.14232/syrptbrs.2019.op15 UR - https://m2.mtmt.hu/api/publication/30461741 ID - 30461741 LA - English DB - MTMT ER - TY - JOUR AU - Fekete, Helga AU - Bíró, Tivadar AU - Soós, Judit AU - Pallagi, Edina AU - Aigner, Zoltán AU - Pannonhalminé Csóka, Ildikó TI - Implementation of Patient Reported Outcome Measures (PROMs) in QbD based formulation development in opthalmology JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 88 PY - 2018 IS - 3 SP - 206 EP - 206 PG - 1 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/30656370 ID - 30656370 LA - English DB - MTMT ER -