@article{MTMT:34392931, title = {Gyógyszerosztó automata: alkalmazás a napi klinikai gyakorlatban [Automatic medication dispenser: application in daily clinical practice]}, url = {https://m2.mtmt.hu/api/publication/34392931}, author = {Benkő, Ria and Bíró, Tivadar and Matuz, Mária}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {93}, unique-id = {34392931}, issn = {0001-6659}, year = {2023}, eissn = {1587-1495}, pages = {S34-S34}, orcid-numbers = {Benkő, Ria/0000-0002-8009-8962; Matuz, Mária/0000-0002-7877-2399} } @mastersthesis{MTMT:32852532, title = {Application of cyclodextrins and mucoadhesive preservative system in ophthalmic formulations [Ciklodextrinek és mukoadhezív tartósító rendszer alkalmazása szemészeti készítmények fejlesztésében]}, url = {https://m2.mtmt.hu/api/publication/32852532}, author = {Bíró, Tivadar}, doi = {10.14232/phd.10873}, publisher = {SZTE}, unique-id = {32852532}, year = {2022} } @article{MTMT:31890902, title = {New Approach in Ocular Drug Delivery. In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations}, url = {https://m2.mtmt.hu/api/publication/31890902}, author = {Bíró, Tivadar and Bocsik, Alexandra and Jurišić Dukovski, Bisera and Gróf, Ilona and Lovrić, Jasmina and Pannonhalminé Csóka, Ildikó and Deli, Mária Anna and Aigner, Zoltán}, doi = {10.2147/DDDT.S264745}, journal-iso = {DRUG DES DEV THER}, journal = {DRUG DESIGN DEVELOPMENT AND THERAPY}, volume = {15}, unique-id = {31890902}, issn = {1177-8881}, abstract = {Background: Optimal transcorneal penetration is necessary for ocular therapy; meanwhile, it is limited by the complex structure and defensive mechanisms of the eye. Antimicrobial stability of topical ophthalmic formulations is especially important. According to previous studies, the mostly used preservative, benzalkonium-chloride is irritative and toxic on corneal epithelial cells; therefore, novel non-toxic, antimicrobial agents are required. In this study, prednisolone-containing ophthalmic formulations were developed with expected optimal permeation without toxic or irritative effects. Methods: The toxicity and permeability of prednisolone-containing eye drops were studied on a human corneal epithelial cell line (HCE-T) and ex vivo cornea model. The lipophilic drug is dissolved by the formation of cyclodextrin inclusion complex. Zinc-containing mucoadhesive biopolymer was applied as an alternative preservative agent, whose toxicity was compared with benzalkonium-chloride. Results: As the results show, benzalkonium-chloride-containing samples were toxic on HCE-T cells. The biopolymer caused no cell damage after the treatment. This was confirmed by immunohistochemistry assay. The in vitro permeability was significantly higher in formulations with prednisolone-cyclodextrin complex compared with suspension formulation. According to the ex vivo permeability study, the biopolymer-containing samples had significantly lower permeability. Conclusion: Considering the mucoadhesive attribute of target formulations, prolonged absorption is expected after application with less frequent administration. It can be stated that the compositions are innovative approaches as novel non-toxic ophthalmic formulations with optimal drug permeability.}, year = {2021}, pages = {351-360}, orcid-numbers = {Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Deli, Mária Anna/0000-0001-6084-6524} } @article{MTMT:31978759, title = {Investigation of the permeability and cytotoxicity in novel topical ophthalmic formulations using in vitro and ex vivo models}, url = {https://m2.mtmt.hu/api/publication/31978759}, author = {Bíró, Tivadar and Bocsik, Alexandra and Gróf, Ilona and Bisera, Jurisic Dukowski and Jasmina, Lovric and Deli, Mária Anna and Aigner, Zoltán}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {90}, unique-id = {31978759}, issn = {0001-6659}, year = {2020}, eissn = {1587-1495}, pages = {86-86}, orcid-numbers = {Deli, Mária Anna/0000-0001-6084-6524} } @misc{MTMT:31342228, title = {II. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science. 23-24 January, 2020 : book of abstracts}, url = {https://m2.mtmt.hu/api/publication/31342228}, doi = {10.14232/syrptbrs.2020.af}, editor = {Bíró, Tivadar}, publisher = {Szegedi Tudományegyetem; Szegedi Tudományegyetem}, unique-id = {31342228}, year = {2020} } @CONFERENCE{MTMT:31311283, title = {In vitro and ex vivo investigation of steroid containing ocular drug delivery systems}, url = {https://m2.mtmt.hu/api/publication/31311283}, author = {Bíró, Tivadar and Aigner, Zoltán}, booktitle = {II. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science}, doi = {10.14232/syrptbrs.2020.op1}, unique-id = {31311283}, year = {2020}, pages = {6-6} } @article{MTMT:30727229, title = {Current Approaches to Use Cyclodextrins and Mucoadhesive Polymers in Ocular Drug Delivery—A Mini-Review}, url = {https://m2.mtmt.hu/api/publication/30727229}, author = {Bíró, Tivadar and Aigner, Zoltán}, doi = {10.3390/scipharm87030015}, journal-iso = {SCI PHARM}, journal = {SCIENTIA PHARMACEUTICA}, volume = {87}, unique-id = {30727229}, issn = {0036-8709}, year = {2019}, eissn = {2218-0532} } @misc{MTMT:30461742, title = {I. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science}, url = {https://m2.mtmt.hu/api/publication/30461742}, doi = {10.14232/syrptbrs.2019.af}, editor = {Bíró, Tivadar and Pannonhalminé Csóka, Ildikó}, publisher = {Szegedi Tudományegyetem}, unique-id = {30461742}, year = {2019}, orcid-numbers = {Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781} } @{MTMT:30461741, title = {Novel ophthalmic formulations to increase the efficacy and stability}, url = {https://m2.mtmt.hu/api/publication/30461741}, author = {Bíró, Tivadar and Aigner, Zoltán}, booktitle = {I. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science}, doi = {10.14232/syrptbrs.2019.op15}, unique-id = {30461741}, year = {2019}, pages = {18-18} } @article{MTMT:30656370, title = {Implementation of Patient Reported Outcome Measures (PROMs) in QbD based formulation development in opthalmology}, url = {https://m2.mtmt.hu/api/publication/30656370}, author = {Fekete, Helga and Bíró, Tivadar and Soós, Judit and Pallagi, Edina and Aigner, Zoltán and Pannonhalminé Csóka, Ildikó}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {88}, unique-id = {30656370}, issn = {0001-6659}, year = {2018}, eissn = {1587-1495}, pages = {206-206}, orcid-numbers = {Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781} }