@article{MTMT:34741193, title = {Comparison of microbial communities and the profile of sulfate-reducing bacteria in patients with ulcerative colitis and their association with bowel diseases: a pilot study}, url = {https://m2.mtmt.hu/api/publication/34741193}, author = {Kushkevych, Ivan and Martínková, Kristýna and Mráková, Lenka and Giudici, Francesco and Baldi, Simone and Novak, David and Gajdács, Márió and Vítězová, Monika and Dordevic, Dani and Amedei, Amedeo and Rittmann, Simon K.-M. R.}, doi = {10.15698/mic2024.03.817}, journal-iso = {MICROBIAL CELL}, journal = {MICROBIAL CELL}, volume = {11}, unique-id = {34741193}, issn = {2311-2638}, abstract = {Considerable evidence has accumulated regarding the molecular relationship between gut microbiota (GM) composition and the onset (clinical presentation and prognosis of ulcerative colitis (UC)). In addition, it is well documented that short-chain fatty acid (SCFA)-producing bacteria may play a fundamental role in maintaining an anti-inflammatory intestinal homeostasis, but sulfate- and sulfite reducing bacteria may be responsible for the production of toxic metabolites, such as hydrogen sulfide and acetate. Hence, the present study aimed to assess the GM composition – focusing on sulfate-reducing bacteria (SRB) – in patients with severe, severe-active and moderate UC. Each one of the six enrolled patients provided two stool samples in the following way: one sample was cultivated in a modified SRB-medium before 16S rRNA sequencing and the other was not cultivated. Comparative phylogenetic analysis was conducted on each sample. Percentage of detected gut microbial genera showed considerable variation based on the patients’ disease severity and cultivation in the SRB medium. In detail, samples without cultivation from patients with moderate UC showed a high abundance of the genera Bacteroides, Bifidobacterium and Ruminococcus, but after SRB cultivation, the dominant genera were Bacteroides, Klebsiella and Bilophila. On the other hand, before SRB cultivation, the main represented genera in patients with severe UC were Escherichia-Shigella, Proteus, Methanothermobacter and Methanobacterium. However, after incubation in the SRB medium Bacteroides, Proteus, Alistipes and Lachnoclostridium were predominant. Information regarding GM compositional changes in UC patients may aid the development of novel therapeutic strategies (e.g., probiotic preparations containing specific bacterial strains) to counteract the mechanisms of virulence of harmful bacteria and the subsequent inflammatory response that is closely related to the pathogenesis of inflammatory bowel diseases.}, year = {2024}, eissn = {2311-2638}, pages = {79-89}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365} } @article{MTMT:34721811, title = {Characterization of antibiotic and disinfectant susceptibility in biofilm-forming Acinetobacter baumannii: A focus on environmental isolates}, url = {https://m2.mtmt.hu/api/publication/34721811}, author = {Pallós, Péter and Gajdács, Márió and Zsoldiné Urbán, Edit and Szabados, Yvett and Szalai, Klaudia and Hevesi, Lívia and Horváth, Anna and Kuklis, Anna and Morjaria, Devina and Iffat, Wajiha and Hetta, Helal F. and Piredda, Nicola and Donadu, Matthew Gavino}, doi = {10.1556/1886.2024.00014}, journal-iso = {EUR J MICROBIOL IMMU}, journal = {EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY}, unique-id = {34721811}, issn = {2062-509X}, abstract = {The clinical role of Acinetobacter baumannii has been highlighted in numerous infectious syndromes with a high mortality rate, due to the high prevalence of multidrug-resistant (MDR) isolates. The treatment and eradication of this pathogen is hindered by biofilm-formation, providing protection from noxious environmental factors and antimicrobials. The aim of this study was to assess the antibiotic susceptibility, antiseptic susceptibility and biofilm-forming capacity using phenotypic methods in environmental A. baumannii isolates. One hundred and fourteen ( n = 114) isolates were collected, originating from various environmental sources and geographical regions. Antimicrobial susceptibility testing was carried out using the disk diffusion method, while antiseptic susceptibility was performed using the agar dilution method. Determination of biofilm-forming capacity was carried out using a microtiter-plate based method. Resistance in environmental A. baumannii isolates were highest for ciprofloxacin (64.03%, n = 73), levofloxacin (62.18%, n = 71) and trimethoprim-sulfamethoxazole (61.40%, n = 70), while lowest for colistin (1.75%, n = 2). Efflux pump overexpression was seen in 48.25% of isolates ( n = 55), 49.12% ( n = 56) were classified as MDR. 6.14% ( n = 7), 9.65% ( n = 11), 24.65% ( n = 28) and 59.65% ( n = 68) of isolates were non-biofilm producers, weak, medium, and strong biofilm producers, respectively. No significant differences were observed between non-MDR vs. MDR isolates regarding their distribution of biofilm-producers ( P = 0.655). The MIC ranges for the tested antiseptics were as follows: benzalkonium chloride 16–128 μg mL −1 , chlorhexidine digluconate 4–128 μg mL −1 , formaldehyde 64–256 μg mL −1 and triclosan 2–16 μg mL −1 , respectively. The conscientious use of antiseptics, together with periodic surveillance, is essential to curb the spread of these bacteria, and to maintain current infection prevention capabilities.}, year = {2024}, eissn = {2062-8633}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Zsoldiné Urbán, Edit/0000-0002-9602-7552} } @article{MTMT:34721808, title = {Correlation between Stenotrophomonas maltophilia incidence and systemic antibiotic use: A 10-year retrospective, observational study in Hungary}, url = {https://m2.mtmt.hu/api/publication/34721808}, author = {Gajdács, Márió and Matuz, Mária and Benkő, Ria and Pető, Zoltán and Hajdú, Edit}, doi = {10.1556/1886.2024.00022}, journal-iso = {EUR J MICROBIOL IMMU}, journal = {EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY}, unique-id = {34721808}, issn = {2062-509X}, abstract = {Extensive use of carbapenems may lead to selection pressure for Stenotrophomonas maltophilia (SM) in hospital environments. The aim of our study was to assess the possible association between systemic antibiotic use and the incidence of SM. A retrospective, observational study was carried out in a tertiary-care hospital in Hungary, between January 1st 2010 and December 31st 2019. Incidence-density for SM and SM resistant to trimethoprim-sulfamethoxazole (SXT) was standardized for 1000 patient-days, while systemic antibiotic use was expressed as defined daily doses (DDDs) per 100 patient-days. Mean incidence density for SM infections was 0.42/1000 patient-days; 11.08% were were resistant to SXT, the mean incidence density for SXT-resistant SM was 0.047/1000 patient-days. Consumption rate for colistin, glycopeptides and carbapenems increased by 258.82, 278.94 and 372.72% from 2010 to 2019, respectively. Strong and significant positive correlations were observed with the consumption of carbapenems (r: 0.8759; P < 0.001 and r: 0.8968; P < 0.001), SXT (r: 0.7552; P = 0.011 and r: 0.7004; P = 0.024), and glycopeptides (r: 0.7542; P = 0.012 and r: 0.8138; P < 0.001) with SM and SXT-resistant SM incidence-density/1000 patient-days, respectively. Implementation of institutional carbapenem-sparing strategies are critical in preserving these life-saving drugs, and may affect the microbial spectrum of infections in clinical settings.}, year = {2024}, eissn = {2062-8633}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Matuz, Mária/0000-0002-7877-2399; Benkő, Ria/0000-0002-8009-8962} } @article{MTMT:34654218, title = {Editorial: Knowledge, attitude and practices of the public and healthcare-professionals towards sustainable use of antimicrobials: the intersection of pharmacology and social medicine}, url = {https://m2.mtmt.hu/api/publication/34654218}, author = {Gajdács, Márió and Jamshed, Shazia}, doi = {10.3389/frabi.2024.1374463}, journal-iso = {Front. Antibiot.}, journal = {Frontiers in Antibiotics}, volume = {3}, unique-id = {34654218}, year = {2024}, eissn = {2813-2467}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365} } @CONFERENCE{MTMT:34501884, title = {A probiotikumokra és bél-mikrobiótára vonatkozó internetes keresések Google TrendsTM-alapú infodemiológiai vizsgálata: hazai viszonyok és nemzetkozi kitekintés}, url = {https://m2.mtmt.hu/api/publication/34501884}, author = {Pallós, Péter Márk and Szikora, Fruzsina and Balogh, Georgina and Gajdács, Márió}, booktitle = {MHT XLVIII. Vándorgyűlés - Program és összefoglalók}, unique-id = {34501884}, abstract = {Magyar Higiénikusok Társasága XLVIII. Vándorgyűlés 2023. szeptember 5-6., Szentendre}, year = {2023}, pages = {45-45}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365} } @CONFERENCE{MTMT:34501879, title = {Hogyan befolyásolta a COVID-19 világjárvány a gyógyszerészhallgatók ismereteit és attitűdjét a fertőző betegségekkel és antimikrobiális rezisztenciával kapcsolatban? Egy összehasonlító, keresztmetszeti vizsgálat eredményei}, url = {https://m2.mtmt.hu/api/publication/34501879}, author = {Gajdács, Márió and Márta, Adrienn and Burián, Katalin and Benkő, Ria and Paulik, Edit and Szabó, Andrea}, booktitle = {MHT XLVIII. Vándorgyűlés - Program és összefoglalók}, unique-id = {34501879}, abstract = {Magyar Higiénikusok Társasága XLVIII. Vándorgyűlés 2023. szeptember 5-6., Szentendre}, year = {2023}, pages = {29-29}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Burián, Katalin/0000-0003-1300-2374; Benkő, Ria/0000-0002-8009-8962; Paulik, Edit/0000-0002-3446-4327} } @CONFERENCE{MTMT:34501876, title = {A hazai gyógyszerészek fertőző betegségekkel és antimikrobiális rezisztenciával kapcsolatos attitűdje és ismeretei: kvantitatív, keresztmetszeti vizsgálat}, url = {https://m2.mtmt.hu/api/publication/34501876}, author = {Gajdács, Márió and Balog, Péter and Kívés, Zsuzsanna and Háznagyné Radnai, Erzsébet and Burián, Katalin and Benkő, Ria and Paulik, Edit and Szabó, Andrea}, booktitle = {MHT XLVIII. Vándorgyűlés - Program és összefoglalók}, unique-id = {34501876}, abstract = {Magyar Higiénikusok Társasága XLVIII. Vándorgyűlés 2023. szeptember 5-6., Szentendre}, year = {2023}, pages = {28-28}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Kívés, Zsuzsanna/0000-0002-3698-8466; Háznagyné Radnai, Erzsébet/0000-0003-4034-5989; Burián, Katalin/0000-0003-1300-2374; Benkő, Ria/0000-0002-8009-8962; Paulik, Edit/0000-0002-3446-4327} } @CONFERENCE{MTMT:34500725, title = {A hazai antibiotikumokra és antibiotikum-rezisztenciára vonatkozó, 2010-2020 közötti internetes keresések kvalitatív és kvantitatív elemzése: mit javasol „Dr. Google”?}, url = {https://m2.mtmt.hu/api/publication/34500725}, author = {Pallós, Péter Márk and Kívés, Zsuzsanna and Gajdács, Márió}, booktitle = {XV. Fiatal Higiénikusok Fóruma: Program és összefoglalók}, unique-id = {34500725}, year = {2023}, pages = {25-25}, orcid-numbers = {Kívés, Zsuzsanna/0000-0002-3698-8466; Gajdács, Márió/0000-0003-1270-0365} } @CONFERENCE{MTMT:34500723, title = {Stenotrophomonas maltophilia epidemiológiája és az antibiotikum-fogyasztás közötti összefüggések: 10-éves korrelációs vizsgálat}, url = {https://m2.mtmt.hu/api/publication/34500723}, author = {Gajdács, Márió and Benkő, Ria and Matuz, Mária and Bodó, Gabriella and Pető, Zoltán and Hajdú, Edit}, booktitle = {XV. Fiatal Higiénikusok Fóruma: Program és összefoglalók}, unique-id = {34500723}, year = {2023}, pages = {12-12}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Benkő, Ria/0000-0002-8009-8962; Matuz, Mária/0000-0002-7877-2399} } @CONFERENCE{MTMT:34500722, title = {Gyógyszerészek kiégési szintje és azt befolyásoló tényezők a SARS-CoV-2 pandémia első hulláma alatt}, url = {https://m2.mtmt.hu/api/publication/34500722}, author = {Gajdács, Márió and Kuklis, Anna and Balogh, Georgina and Kárász, Sára and Háznagyné Radnai, Erzsébet}, booktitle = {XV. Fiatal Higiénikusok Fóruma: Program és összefoglalók}, unique-id = {34500722}, year = {2023}, pages = {11-11}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Háznagyné Radnai, Erzsébet/0000-0003-4034-5989} }