@article{MTMT:33547706,
	title = {Soluplus® promotes efficient transport of meloxicam to the central nervous system via nasal administration},
	url = {https://m2.mtmt.hu/api/publication/33547706},
	author = {Sipos, Bence and Bella, Zsolt and Gróf, Ilona and Veszelka, Szilvia and Deli, Mária Anna and Szűcs, Kálmán Ferenc and Sztojkov-Ivanov, Anita and Ducza, Eszter and Gáspár, Róbert and Kecskeméti, Gábor and Janáky, Tamás and Volk, Balázs and Budai-Szűcs, Mária and Ambrus, Rita and Révész, Piroska and Pannonhalminé Csóka, Ildikó and Katona, Gábor},
	doi = {10.1016/j.ijpharm.2023.122594},
	journal-iso = {INT J PHARM},
	journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS},
	volume = {632},
	unique-id = {33547706},
	issn = {0378-5173},
	year = {2023},
	eissn = {1873-3476},
	orcid-numbers = {Sipos, Bence/0000-0002-0131-4728; Deli, Mária Anna/0000-0001-6084-6524; Gáspár, Róbert/0000-0002-1571-7579; Kecskeméti, Gábor/0000-0002-5584-6869; Janáky, Tamás/0000-0002-6466-8283; Volk, Balázs/0000-0002-2019-1874; Budai-Szűcs, Mária/0000-0001-5187-5702; Révész, Piroska/0000-0002-5336-6052; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Katona, Gábor/0000-0003-1564-4813}
}

@article{MTMT:33079552,
	title = {Immunofluorescent Evidence for Nuclear Localization of Aromatase in Astrocytes in the Rat Central Nervous System},
	url = {https://m2.mtmt.hu/api/publication/33079552},
	author = {Kata, Diána and Gróf, Ilona and Hoyk, Zsófia and Ducza, Eszter and Deli, Mária Anna and Zupkó, István and Földesi, Imre},
	doi = {10.3390/ijms23168946},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {33079552},
	issn = {1661-6596},
	abstract = {Estrogens regulate a variety of neuroendocrine, reproductive and also non-reproductive brain functions. Estradiol biosynthesis in the central nervous system (CNS) is catalyzed by the enzyme aromatase, which is expressed in several brain regions by neurons, astrocytes and microglia. In this study, we performed a complex fluorescent immunocytochemical analysis which revealed that aromatase is colocalized with the nuclear stain in glial fibrillary acidic protein (GFAP) positive astrocytes in cell cultures. Confocal immunofluorescent Z-stack scanning analysis confirmed the colocalization of aromatase with the nuclear DAPI signal. Nuclear aromatase was also detectable in the S100 beta positive astrocyte subpopulation. When the nuclear aromatase signal was present, estrogen receptor alpha was also abundant in the nucleus. Immunostaining of frozen brain tissue sections showed that the nuclear colocalization of the enzyme in GFAP-positive astrocytes is also detectable in the adult rat brain. CD11b/c labelled microglial cells express aromatase, but the immunopositive signal was distributed only in the cytoplasm both in the ramified and amoeboid microglial forms. Immunostaining of rat ovarian tissue sections and human granulosa cells revealed that aromatase was present only in the cytoplasm. This novel observation suggests a new unique mechanism in astrocytes that may regulate certain CNS functions via estradiol production.},
	keywords = {CELLS; GENE-EXPRESSION; IMMUNOREACTIVITY; reproduction; ESTROGEN; ESTRADIOL; Estrogen Receptor alpha; neuroinflammation; microglia; AROMATASE; ASTROCYTE; Biochemistry & Molecular Biology; ESTROGEN-RECEPTOR BETA; Brain aromatase},
	year = {2022},
	eissn = {1422-0067},
	orcid-numbers = {Kata, Diána/0000-0002-4432-9380; Deli, Mária Anna/0000-0001-6084-6524; Zupkó, István/0000-0003-3243-5300; Földesi, Imre/0000-0002-3329-8136}
}

@mastersthesis{MTMT:32846886,
	title = {Tenyészetes epitélsejt modellek alkalmazása biológiailag aktív peptidek és adjuváns terápiás szerek hatásának vizsgálatára [Application of epithelial cell culture models to study the effects of biologically active peptides and adjuvant therapeutic agents]},
	url = {https://m2.mtmt.hu/api/publication/32846886},
	author = {Gróf, Ilona},
	doi = {10.14232/phd.10864},
	publisher = {SZTE},
	unique-id = {32846886},
	year = {2021}
}

@article{MTMT:32570862,
	title = {Fehérje méretű molekulák humán sejtekbe juttatása lipid-raft mediált endocitózissal},
	url = {https://m2.mtmt.hu/api/publication/32570862},
	author = {Hetényi, Anasztázia and Imre, Norbert and Szabó, Enikő and Bodnár, Brigitta and Szkalisity, Ábel and Gróf, Ilona and Bocsik, Alexandra and Deli, Mária Anna and Horváth, Péter and Czibula, Ágnes and Monostori, Éva and Martinek, Tamás},
	journal-iso = {BIOKÉMIA},
	journal = {BIOKÉMIA: A MAGYAR BIOKÉMIAI EGYESÜLET FOLYÓIRATA},
	volume = {45},
	unique-id = {32570862},
	issn = {0133-8455},
	year = {2021},
	eissn = {2060-8152},
	pages = {67-83},
	orcid-numbers = {Hetényi, Anasztázia/0000-0001-8080-6992; Deli, Mária Anna/0000-0001-6084-6524; Czibula, Ágnes/0000-0003-4461-2773; Monostori, Éva/0000-0002-7442-3562; Martinek, Tamás/0000-0003-3168-8066}
}

@article{MTMT:32531953,
	title = {In Vitro Comparative Study of Solid Lipid and PLGA Nanoparticles Designed to Facilitate Nose-to-Brain Delivery of Insulin},
	url = {https://m2.mtmt.hu/api/publication/32531953},
	author = {Akel, Hussein and Pannonhalminé Csóka, Ildikó and Ambrus, Rita and Bocsik, Alexandra and Gróf, Ilona and Mészáros, Mária and Szecskó, Anikó and Kozma, Gábor and Veszelka, Szilvia and Deli, Mária Anna and Kónya, Zoltán and Katona, Gábor},
	doi = {10.3390/ijms222413258},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {22},
	unique-id = {32531953},
	issn = {1661-6596},
	year = {2021},
	eissn = {1422-0067},
	orcid-numbers = {Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Kozma, Gábor/0000-0003-2033-0720; Deli, Mária Anna/0000-0001-6084-6524; Kónya, Zoltán/0000-0002-9406-8596; Katona, Gábor/0000-0003-1564-4813}
}

@article{MTMT:32067156,
	title = {Bicarbonate Evokes Reciprocal Changes in Intracellular Cyclic di-GMP and Cyclic AMP Levels in Pseudomonas aeruginosa},
	url = {https://m2.mtmt.hu/api/publication/32067156},
	author = {Ruksakiet, Kasidid and Stercz, Balázs and Tóth, Gergő and Pongsiri, Jaikumpun and Gróf, Ilona and Tengölics, Roland and Lohinai, Zsolt and Horváth, Péter and Deli, Mária Anna and Steward, Martin Charles and Dobay, Orsolya and Zsembery, Ákos},
	doi = {10.3390/biology10060519},
	journal-iso = {BIOLOGY-BASEL},
	journal = {BIOLOGY-BASEL},
	volume = {10},
	unique-id = {32067156},
	year = {2021},
	eissn = {2079-7737},
	orcid-numbers = {Ruksakiet, Kasidid/0000-0003-3152-2138; Stercz, Balázs/0000-0002-9585-8397; Tóth, Gergő/0000-0001-5341-319X; Pongsiri, Jaikumpun/0000-0001-9160-2645; Lohinai, Zsolt/0000-0003-2695-5166; Horváth, Péter/0000-0001-7149-4173; Deli, Mária Anna/0000-0001-6084-6524; Dobay, Orsolya/0000-0001-7094-2288; Zsembery, Ákos/0000-0003-0253-9379}
}

@article{MTMT:31995751,
	title = {Development of In Situ Gelling Meloxicam-Human Serum Albumin Nanoparticle Formulation for Nose-to-Brain Application},
	url = {https://m2.mtmt.hu/api/publication/31995751},
	author = {Katona, Gábor and Sipos, Bence and Budai-Szűcs, Mária and Balogh, György Tibor and Veszelka, Szilvia and Gróf, Ilona and Deli, Mária Anna and Volk, Balázs and Révész, Piroska and Pannonhalminé Csóka, Ildikó},
	doi = {10.3390/pharmaceutics13050646},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {13},
	unique-id = {31995751},
	issn = {1999-4923},
	abstract = {The aim of this study was to develop an intranasal in situ thermo-gelling meloxicam-human serum albumin (MEL-HSA) nanoparticulate formulation applying poloxamer 407 (P407), which can be administered in liquid state into the nostril, and to increase the resistance of the formulation against mucociliary clearance by sol-gel transition on the nasal mucosa, as well as to improve drug absorption. Nanoparticle characterization showed that formulations containing 12-15% w/w P407 met the requirements of intranasal administration. The Z-average (in the range of 180-304 nm), the narrow polydispersity index (PdI, from 0.193 to 0.328), the zeta potential (between -9.4 and -7.0 mV) and the hypotonic osmolality (200-278 mOsmol/L) of MEL-HSA nanoparticles predict enhanced drug absorption through the nasal mucosa. Based on the rheological, muco-adhesion, drug release and permeability studies, the 14% w/w P407 containing formulation (MEL-HSA-P14%) was considered as the optimized formulation, which allows enhanced permeability of MEL through blood-brain barrier-specific lipid fraction. Cell line studies showed no cell damage after 1-h treatment with MEL-HSA-P14% on RPMI 2650 human endothelial cells' moreover, enhanced permeation (four-fold) of MEL from MEL-HSA-P14% was observed in comparison to pure MEL. Overall, MEL-HSA-P14% can be promising for overcoming the challenges of nasal drug delivery.},
	keywords = {Quality by Design; rapid equilibrium dialysis; muco-adhesion; brain PAMPA; RPMI 2650 nasal epithelial cell},
	year = {2021},
	eissn = {1999-4923},
	orcid-numbers = {Katona, Gábor/0000-0003-1564-4813; Sipos, Bence/0000-0002-0131-4728; Budai-Szűcs, Mária/0000-0001-5187-5702; Balogh, György Tibor/0000-0003-3347-1880; Deli, Mária Anna/0000-0001-6084-6524; Volk, Balázs/0000-0002-2019-1874; Révész, Piroska/0000-0002-5336-6052; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@article{MTMT:31890902,
	title = {New Approach in Ocular Drug Delivery. In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations},
	url = {https://m2.mtmt.hu/api/publication/31890902},
	author = {Bíró, Tivadar and Bocsik, Alexandra and Jurišić Dukovski, Bisera and Gróf, Ilona and Lovrić, Jasmina and Pannonhalminé Csóka, Ildikó and Deli, Mária Anna and Aigner, Zoltán},
	doi = {10.2147/DDDT.S264745},
	journal-iso = {DRUG DES DEV THER},
	journal = {DRUG DESIGN DEVELOPMENT AND THERAPY},
	volume = {15},
	unique-id = {31890902},
	issn = {1177-8881},
	abstract = {Background: Optimal transcorneal penetration is necessary for ocular therapy; meanwhile, it is limited by the complex structure and defensive mechanisms of the eye. Antimicrobial stability of topical ophthalmic formulations is especially important. According to previous studies, the mostly used preservative, benzalkonium-chloride is irritative and toxic on corneal epithelial cells; therefore, novel non-toxic, antimicrobial agents are required. In this study, prednisolone-containing ophthalmic formulations were developed with expected optimal permeation without toxic or irritative effects. Methods: The toxicity and permeability of prednisolone-containing eye drops were studied on a human corneal epithelial cell line (HCE-T) and ex vivo cornea model. The lipophilic drug is dissolved by the formation of cyclodextrin inclusion complex. Zinc-containing mucoadhesive biopolymer was applied as an alternative preservative agent, whose toxicity was compared with benzalkonium-chloride. Results: As the results show, benzalkonium-chloride-containing samples were toxic on HCE-T cells. The biopolymer caused no cell damage after the treatment. This was confirmed by immunohistochemistry assay. The in vitro permeability was significantly higher in formulations with prednisolone-cyclodextrin complex compared with suspension formulation. According to the ex vivo permeability study, the biopolymer-containing samples had significantly lower permeability. Conclusion: Considering the mucoadhesive attribute of target formulations, prolonged absorption is expected after application with less frequent administration. It can be stated that the compositions are innovative approaches as novel non-toxic ophthalmic formulations with optimal drug permeability.},
	year = {2021},
	pages = {351-360},
	orcid-numbers = {Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:31978759,
	title = {Investigation of the permeability and cytotoxicity in novel topical ophthalmic formulations using in vitro and ex vivo models},
	url = {https://m2.mtmt.hu/api/publication/31978759},
	author = {Bíró, Tivadar and Bocsik, Alexandra and Gróf, Ilona and Bisera, Jurisic Dukowski and Jasmina, Lovric and Deli, Mária Anna and Aigner, Zoltán},
	journal-iso = {ACTA PHARM HUNG},
	journal = {ACTA PHARMACEUTICA HUNGARICA},
	volume = {90},
	unique-id = {31978759},
	issn = {0001-6659},
	year = {2020},
	eissn = {1587-1495},
	pages = {86-86},
	orcid-numbers = {Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:31385933,
	title = {Development and Characterization of Potential Ocular Mucoadhesive Nano Lipid Carriers Using Full Factorial Design},
	url = {https://m2.mtmt.hu/api/publication/31385933},
	author = {L. Kiss, Eszter and Berkó, Szilvia and Gácsi, Attila and Kovács, Anita and Katona, Gábor and Soós, Judit and Csányi, Erzsébet and Gróf, Ilona and Harazin, András and Deli, Mária Anna and Balogh, György Tibor and Budai-Szűcs, Mária},
	doi = {10.3390/pharmaceutics12070682},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {12},
	unique-id = {31385933},
	issn = {1999-4923},
	year = {2020},
	eissn = {1999-4923},
	orcid-numbers = {Berkó, Szilvia/0000-0002-3842-8876; Kovács, Anita/0000-0001-5593-1329; Katona, Gábor/0000-0003-1564-4813; Csányi, Erzsébet/0000-0002-3010-1959; Harazin, András/0000-0002-0904-5606; Deli, Mária Anna/0000-0001-6084-6524; Balogh, György Tibor/0000-0003-3347-1880; Budai-Szűcs, Mária/0000-0001-5187-5702}
}