TY - JOUR AU - Horváth, Marianna AU - Kovács, Tamás AU - Kun, József AU - Gyenesei, Attila AU - Damjanova, Ivelina AU - Tigyi, Zoltán AU - Schneider, György TI - Virulence Characteristics and Molecular Typing of Carbapenem-Resistant ST15 Klebsiella pneumoniae Clinical Isolates, Possessing the K24 Capsular Type JF - ANTIBIOTICS J2 - ANTIBIOTICS-BASEL VL - 12 PY - 2023 IS - 3 PG - 22 SN - 2079-6382 DO - 10.3390/antibiotics12030479 UR - https://m2.mtmt.hu/api/publication/33728546 ID - 33728546 AB - Klebsiella pneumoniae is an opportunistic pathogen that frequently causes nosocomial and community-acquired (CA) infections. Until now, a limited number of studies has been focused on the analyses of changes affecting the virulence attributes. Genotypic and phenotypic methods were used to characterise the 39 clinical K. pneumoniae isolates; all belonged to the pan-drug resistant, widespread clone ST 15 and expressed the K24 capsule. PFGE has revealed that the isolates could be divided into three distinct genomic clusters. All isolates possessed allS and uge genes, known to contribute to the virulence of K. pneumoniae and 10.25% of the isolates showed hypermucoviscosity, 94.87% produced type 1 fimbriae, 92.3% produced type 3 fimbriae, and 92.3% were able to produce biofilm. In vivo persistence could be supported by serum resistance 46.15%, enterobactin (94.87%) and aerobactin (5.12%) production and invasion of the INT407 and T24 cell lines. Sequence analysis of the whole genomes of the four representative strains 11/3, 50/1, 53/2 and 53/3 has revealed high sequence homology to the reference K. pneumoniae strain HS11286. Our results represent the divergence of virulence attributes among the isolates derived from a common ancestor clone ST 15, in an evolutionary process that occurred both in the hospital and in the community. LA - English DB - MTMT ER - TY - THES AU - Horváth, Marianna TI - Karbapenem rezisztens Klebsiella pneumoniae izolátumok virulencia faktorainka vizsgálata és vB_KpnS_Kp13 bakteriofág identifikálása PY - 2020 UR - https://m2.mtmt.hu/api/publication/31808187 ID - 31808187 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Horváth, Marianna AU - Kovács, Tamás AU - Koderi Valappil, Sarshad AU - Ábrahám, Hajnalka AU - Rákhely, Gábor AU - Schneider, György TI - Identification of a newly isolated lytic bacteriophage against K24 capsular type, carbapenem resistant Klebsiella pneumoniae isolates JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 10 PY - 2020 IS - 1 PG - 11 SN - 2045-2322 DO - 10.1038/s41598-020-62691-8 UR - https://m2.mtmt.hu/api/publication/31272367 ID - 31272367 LA - English DB - MTMT ER - TY - JOUR AU - Schneider, György AU - Szentes, Nikolett AU - Horváth, Marianna AU - Dorn, Ágnes AU - Cox, A AU - Nagy, G AU - Doffkay, Zsolt AU - Maróti, Gergely AU - Rákhely, Gábor AU - Kovács, Tamás TI - Kinetics of Targeted Phage Rescue in a Mouse Model of Systemic Escherichia coli K1 JF - BIOMED RESEARCH INTERNATIONAL J2 - BIOMED RES INT VL - 2018 ET - 0 PY - 2018 PG - 8 SN - 2314-6133 DO - 10.1155/2018/7569645 UR - https://m2.mtmt.hu/api/publication/3400835 ID - 3400835 AB - Escherichia (E.) coli K1 strains remain common causative agents of neonatal sepsis and meningitis. We have isolated a lytic bacteriophage (Phi IK1) against E. coli strain IHE3034 and tested its specificity in vitro, as well as distribution and protective efficacy in vivo. The phage was shown to be specific to the K1 capsular polysaccharide. In the lethal murine model, a high level of protection was afforded by the phage with strict kinetics. A single dose of 1 x 10(8) phage particles administered 10 and 60 minutes following the bacterial challenge elicited 100 % and 95 % survival, respectively. No mice could be rescued if phage administration occurred 3 hours postinfection. Tissue distribution surveys in the surviving mice revealed that the spleen was the primary organ in which accumulation of active Phi IK1 phages could be detected two weeks after phage administration. These results suggest that bacteriophages have potential as therapeutic agents in the control of systemic infections. LA - English DB - MTMT ER - TY - JOUR AU - Kőrösi, László Tamás AU - Bognár, Balázs AU - Horváth, Marianna AU - Schneider, György AU - Kovács, János AU - Scarpellini, Alice AU - Castelli, Andrea AU - Colombo, Massimo AU - Prato, Mirko TI - Hydrothermal evolution of PF-co-doped TiO2 nanoparticles and their antibacterial activity against carbapenem-resistant Klebsiella pneumoniae JF - APPLIED CATALYSIS B-ENVIRONMENTAL J2 - APPL CATAL B-ENVIRON VL - 231 PY - 2018 SP - 115 EP - 122 PG - 8 SN - 0926-3373 DO - 10.1016/j.apcatb.2018.03.012 UR - https://m2.mtmt.hu/api/publication/3343546 ID - 3343546 N1 - Research Institute for Viticultureand Oenology, University of Pécs, Pázmány Péter u. 4, Pécs, H-7634, Hungary Institute of Organic and MedicinalChemistry, University of Pécs, Szigeti st. 12, Pécs, H-7624, Hungary Department of Medical Microbiology and Immunology, Medical School, University of Pécs, Szigeti st. 12, Pécs, H-7624, Hungary Environmental Analytical and Geoanalytical Research Group, Szentágothai Research Centre, University of Pécs, Ifjúság u. 20, Pécs, H-7624, Hungary Electron Microscopy Facility, Istituto Italiano di Tecnologia, via Morego 30, Genova, 16163, Italy Department of Nanochemistry, Istituto Italiano di Tecnologia, via Morego 30, Genova, 16163, Italy Materials Characterization Facility, Istituto Italiano di Tecnologia, via Morego 30, Genova, 16163, Italy Cited By :27 Export Date: 18 September 2023 CODEN: ACBEE Correspondence Address: Kőrösi, L.; Research Institute for Viticultureand Oenology, Pázmány Péter u. 4, Hungary; email: korosi.laszlo@pte.hu LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Tamás AU - Lootz, Kinga AU - Dorn, Ágnes AU - Andrieu, Josu AU - Horváth, Marianna AU - Mátyás, Adrienne AU - Schneider, György TI - Potential of small-scale jar systems to extend the shelf life of raw meats, and hinder the proliferation of Campylobacter jejuni and Enterohemorrhagic Escherichia coli JF - LWT-FOOD SCIENCE AND TECHNOLOGY J2 - LWT-FOOD SCI TECHNOL VL - 79 PY - 2017 SP - 525 EP - 533 PG - 9 SN - 0023-6438 DO - 10.1016/j.lwt.2016.10.058 UR - https://m2.mtmt.hu/api/publication/3139666 ID - 3139666 LA - English DB - MTMT ER - TY - JOUR AU - Melegh, Szilvia Zsóka AU - Schneider, György AU - Horváth, Marianna AU - Jakab, Ferenc AU - Emődy, Levente AU - Tigyi, Zoltán TI - Identification and characterization of CTX-M-15 producing Klebsiella pneumoniae clone ST101 in a Hungarian university teaching hospital JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 62 PY - 2015 IS - 3 SP - 233 EP - 245 PG - 13 SN - 1217-8950 DO - 10.1556/030.62.2015.3.2 UR - https://m2.mtmt.hu/api/publication/2916733 ID - 2916733 LA - English DB - MTMT ER -