@article{MTMT:33644822,
	title = {HCN channels at the cell soma ensure the rapid electrical reactivity of fast-spiking interneurons in human neocortex},
	url = {https://m2.mtmt.hu/api/publication/33644822},
	author = {Szegedi, Viktor and Bakos , Emőke and Furdan, Szabina and H. Kovács, Bálint Barna and Varga, Dániel and Erdélyi, Miklós and Barzó, Pál and Szűcs, Attila and Tamás, Gábor and Lamsa, Karri},
	doi = {10.1371/journal.pbio.3002001},
	journal-iso = {PLOS BIOL},
	journal = {PLOS BIOLOGY},
	volume = {21},
	unique-id = {33644822},
	issn = {1544-9173},
	abstract = {Accumulating evidence indicates that there are substantial species differences in the properties of mammalian neurons, yet theories on circuit activity and information processing in the human brain are based heavily on results obtained from rodents and other experimental animals. This knowledge gap may be particularly important for understanding the neocortex, the brain area responsible for the most complex neuronal operations and showing the greatest evolutionary divergence. Here, we examined differences in the electrophysiological properties of human and mouse fast-spiking GABAergic basket cells, among the most abundant inhibitory interneurons in cortex. Analyses of membrane potential responses to current input, pharmacologically isolated somatic leak currents, isolated soma outside-out patch recordings, and immunohistochemical staining revealed that human neocortical basket cells abundantly express hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channel isoforms HCN1 and HCN2 at the cell soma membrane, whereas these channels are sparse at the rodent basket cell soma membrane. Antagonist experiments showed that HCN channels in human neurons contribute to the resting membrane potential and cell excitability at the cell soma, accelerate somatic membrane potential kinetics, and shorten the lag between excitatory postsynaptic potentials and action potential generation. These effects are important because the soma of human fast-spiking neurons without HCN channels exhibit low persistent ion leak and slow membrane potential kinetics, compared with mouse fast-spiking neurons. HCN channels speed up human cell membrane potential kinetics and help attain an input–output rate close to that of rodent cells. Computational modeling demonstrated that HCN channel activity at the human fast-spiking cell soma membrane is sufficient to accelerate the input–output function as observed in cell recordings. Thus, human and mouse fast-spiking neurons exhibit functionally significant differences in ion channel composition at the cell soma membrane to set the speed and fidelity of their input–output function. These HCN channels ensure fast electrical reactivity of fast-spiking cells in human neocortex.},
	year = {2023},
	eissn = {1545-7885},
	orcid-numbers = {Szegedi, Viktor/0000-0003-4191-379X; Varga, Dániel/0000-0003-0391-5057; Erdélyi, Miklós/0000-0002-9501-5752; Barzó, Pál/0000-0001-8717-748X; Szűcs, Attila/0000-0001-9733-4135; Tamás, Gábor/0000-0002-7905-6001; Lamsa, Karri/0000-0002-4609-1337}
}

@mastersthesis{MTMT:32846921,
	title = {Fiziológiás és patológiás agyi állapotok celluláris és hálózati mechanizmusai [Cellular and network mechanisms of physiological and pathological brain states]},
	url = {https://m2.mtmt.hu/api/publication/32846921},
	author = {Furdan, Szabina},
	doi = {10.14232/phd.10910},
	publisher = {SZTE},
	unique-id = {32846921},
	year = {2021}
}

@article{MTMT:32467760,
	title = {Human neocortical expansion involves glutamatergic neuron diversification},
	url = {https://m2.mtmt.hu/api/publication/32467760},
	author = {Berg, J. and Sorensen, S.A. and Ting, J.T. and Miller, J.A. and Chartrand, T. and Buchin, A. and Bakken, T.E. and Budzillo, A. and Dee, N. and Ding, S.-L. and Gouwens, N.W. and Hodge, R.D. and Kalmbach, B. and Lee, C. and Lee, B.R. and Alfiler, L. and Baker, K. and Barkan, E. and Beller, A. and Berry, K. and Bertagnolli, D. and Bickley, K. and Bomben, J. and Braun, T. and Brouner, K. and Casper, T. and Chong, P. and Crichton, K. and Dalley, R. and de, Frates R. and Desta, T. and Lee, S.D. and D’Orazi, F. and Dotson, N. and Egdorf, T. and Enstrom, R. and Farrell, C. and Feng, D. and Fong, O. and Furdan, Szabina and Galakhova, A.A. and Gamlin, C. and Gary, A. and Glandon, A. and Goldy, J. and Gorham, M. and Goriounova, N.A. and Gratiy, S. and Graybuck, L. and Gu, H. and Hadley, K. and Hansen, N. and Heistek, T.S. and Henry, A.M. and Heyer, D.B. and Hill, D.J. and Hill, C. and Hupp, M. and Jarsky, T. and Kebede, S. and Keene, L. and Kim, L. and Kim, M.-H. and Kroll, M. and Latimer, C. and Levi, B.P. and Link, K.E. and Mallory, M. and Mann, R. and Marshall, D. and Maxwell, M. and McGraw, M. and McMillen, D. and Melief, E. and Mertens, E.J. and Mezei, L. and Mihut, Norbert and Mok, S. and Molnár, Gábor and Mukora, A. and Ng, L. and Ngo, K. and Nicovich, P.R. and Nyhus, J. and Oláh, Gáspár and Oldre, A. and Omstead, V. and Ozsvár, Attila and Park, D. and Peng, H. and Pham, T. and Pom, C.A. and Potekhina, L. and Rajanbabu, R. and Ransford, S. and Reid, D. and Rimorin, C. and Ruiz, A. and Sandman, D. and Sulc, J. and Sunkin, S.M. and Szafer, A. and Szemenyei, Viktor and Thomsen, E.R. and Tieu, M. and Torkelson, A. and Trinh, J. and Tung, H. and Wakeman, W. and Waleboer, F. and Ward, K. and Wilbers, R. and Williams, G. and Yao, Z. and Yoon, J.-G. and Anastassiou, C. and Arkhipov, A. and Barzó, Pál and Bernard, A. and Cobbs, C. and de, Witt Hamer P.C. and Ellenbogen, R.G. and Esposito, L. and Ferreira, M. and Gwinn, R.P. and Hawrylycz, M.J. and Hof, P.R. and Idema, S. and Jones, A.R. and Keene, C.D. and Ko, A.L. and Murphy, G.J. and Ng, L. and Ojemann, J.G. and Patel, A.P. and Phillips, J.W. and Silbergeld, D.L. and Smith, K. and Tasic, B. and Yuste, R. and Segev, I. and de, Kock C.P.J. and Mansvelder, H.D. and Tamás, Gábor and Zeng, H. and Koch, C. and Lein, E.S.},
	doi = {10.1038/s41586-021-03813-8},
	journal-iso = {NATURE},
	journal = {NATURE},
	volume = {598},
	unique-id = {32467760},
	issn = {0028-0836},
	year = {2021},
	eissn = {1476-4687},
	pages = {151-158},
	orcid-numbers = {Oláh, Gáspár/0000-0003-4708-2368; Ozsvár, Attila/0000-0001-5803-1174; Barzó, Pál/0000-0001-8717-748X; Tamás, Gábor/0000-0002-7905-6001}
}

@article{MTMT:32167983,
	title = {Activity of the Lateral Hypothalamus during Genetically Determined Absence Seizures},
	url = {https://m2.mtmt.hu/api/publication/32167983},
	author = {Sere, Péter and Nikolett, Zsigri and Raffai, Tímea and Furdan, Szabina and Győri, Fanni and Vincenzo, Crunelli and Lőrincz, László Magor},
	doi = {10.3390/ijms22179466},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {22},
	unique-id = {32167983},
	issn = {1661-6596},
	year = {2021},
	eissn = {1422-0067}
}

@article{MTMT:31987689,
	title = {Reciprocal lateral hypothalamic and raphé GABAergic projections promote wakefulness},
	url = {https://m2.mtmt.hu/api/publication/31987689},
	author = {Gazea, Mary and Furdan, Szabina and Sere, Péter and Oesch, Lukas and Molnár, Benedek and Giovanni, Giuseppe Di and Fenno, Lief E. and Ramakrishnan, Charu and Mattis, Joanna and Deisseroth, Karl and Dymecki, Susan M. and Adamantidis, Antoine R. and Lőrincz, László Magor},
	doi = {10.1523/JNEUROSCI.2850-20.2021},
	journal-iso = {J NEUROSCI},
	journal = {JOURNAL OF NEUROSCIENCE},
	volume = {41},
	unique-id = {31987689},
	issn = {0270-6474},
	year = {2021},
	eissn = {1529-2401},
	pages = {4840-4849},
	orcid-numbers = {Giovanni, Giuseppe Di/0000-0003-2006-563X; Ramakrishnan, Charu/0000-0002-3474-6332; Dymecki, Susan M./0000-0003-0910-9881; Adamantidis, Antoine R./0000-0003-2531-5175}
}

@article{MTMT:30399139,
	title = {Expression of GLP-1 receptors in insulin-containing interneurons of rat cerebral cortex},
	url = {https://m2.mtmt.hu/api/publication/30399139},
	author = {Csajbók, Éva and Kocsis, Ágnes Katalin and Faragó, Nóra and Furdan, Szabina and Kovács, Balázs and Lovas, Sándor and Molnár, Gábor and Likó, István and Zvara, Ágnes and Puskás, László and Patócs, Attila Balázs and Tamás, Gábor},
	doi = {10.1007/s00125-018-4803-z},
	journal-iso = {DIABETOLOGIA},
	journal = {DIABETOLOGIA},
	volume = {62},
	unique-id = {30399139},
	issn = {0012-186X},
	abstract = {Aims/hypothesisGlucagon-like peptide 1 (GLP-1) receptors are expressed by pancreatic beta cells and GLP-1 receptor signalling promotes insulin secretion. GLP-1 receptor agonists have neural effects and are therapeutically promising for mild cognitive impairment and Alzheimer's disease. Our previous results showed that insulin is released by neurogliaform neurons in the cerebral cortex, but the expression of GLP-1 receptors on insulin-producing neocortical neurons has not been tested. In this study, we aimed to determine whether GLP-1 receptors are present in insulin-containing neurons.MethodsWe harvested the cytoplasm of electrophysiologically and anatomically identified neurogliaform interneurons during patch-clamp recordings performed in slices of rat neocortex. Using single-cell digital PCR, we determined copy numbers of Glp1r mRNA and other key genes in neurogliaform cells harvested in conditions corresponding to hypoglycaemia (0.5mmol/l glucose) and hyperglycaemia (10mmol/l glucose). In addition, we performed whole-cell patch-clamp recordings on neurogliaform cells to test the effects of GLP-1 receptor agonists for functional validation of single-cell digital PCR results.ResultsSingle-cell digital PCR revealed GLP-1 receptor expression in neurogliaform cells and showed that copy numbers of mRNA of the Glp1r gene in hyperglycaemia exceeded those in hypoglycaemia by 9.6 times (p<0.008). Moreover, single-cell digital PCR confirmed co-expression of Glp1r and Ins2 mRNA in neurogliaform cells. Functional expression of GLP-1 receptors was confirmed with whole-cell patch-clamp electrophysiology, showing a reversible effect of GLP-1 on neurogliaform cells. This effect was prevented by pre-treatment with the GLP-1 receptor-specific antagonist exendin-3(9-39) and was absent in hypoglycaemia. In addition, single-cell digital PCR of neurogliaform cells revealed that the expression of transcription factors (Pdx1, Isl1, Mafb) are important in beta cell development.Conclusions/interpretationOur results provide evidence for the functional expression of GLP-1 receptors in neurons known to release insulin in the cerebral cortex. Hyperglycaemia increases the expression of GLP-1 receptors in neurogliaform cells, suggesting that endogenous incretins and therapeutic GLP-1 receptor agonists might have effects on these neurons, similar to those in pancreatic beta cells.},
	year = {2019},
	eissn = {1432-0428},
	pages = {717-725},
	orcid-numbers = {Likó, István/0000-0001-7668-4726; Patócs, Attila Balázs/0000-0001-7506-674X; Tamás, Gábor/0000-0002-7905-6001}
}

@article{MTMT:27581009,
	title = {Suppression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Function in Thalamocortical Neurons Prevents Genetically Determined and Pharmacologically Induced Absence Seizures},
	url = {https://m2.mtmt.hu/api/publication/27581009},
	author = {David, Francois and Carcak, Nihan and Furdan, Szabina and Onat, Filiz and Gould, Timothy and Mészáros, Ádám and Di Giovanni, Giuseppe and Hernandez, Vivian M and Chan, C Savio and Lőrincz, László Magor and Crunelli, Vincenzo},
	doi = {10.1523/JNEUROSCI.0896-17.2018},
	journal-iso = {J NEUROSCI},
	journal = {JOURNAL OF NEUROSCIENCE},
	volume = {38},
	unique-id = {27581009},
	issn = {0270-6474},
	year = {2018},
	eissn = {1529-2401},
	pages = {6615-6627},
	orcid-numbers = {David, Francois/0000-0003-1993-8931; Di Giovanni, Giuseppe/0000-0003-2006-563X}
}

@CONFERENCE{MTMT:3086329,
	title = {Origin of olfactory inputs to brainstem dorsal raphé nucleus neurons},
	url = {https://m2.mtmt.hu/api/publication/3086329},
	author = {Furdan, Szabina and Lőrincz, László Magor},
	booktitle = {1st Hungarian Neuroscience Doctoral Conference},
	unique-id = {3086329},
	year = {2016},
	pages = {16-16}
}

@article{MTMT:3085614,
	title = {Routing of olfactory inputs to the brainstem raphé nucleus},
	url = {https://m2.mtmt.hu/api/publication/3085614},
	author = {Furdan, Szabina and Lőrincz, László Magor},
	doi = {10.1016/j.clinph.2015.11.417},
	journal-iso = {CLIN NEUROPHYSIOL},
	journal = {CLINICAL NEUROPHYSIOLOGY},
	volume = {127},
	unique-id = {3085614},
	issn = {1388-2457},
	year = {2016},
	eissn = {1872-8952}
}

@CONFERENCE{MTMT:3085606,
	title = {Origin of olfactory inputs to brainstem dorsal raphé nucleus neurons},
	url = {https://m2.mtmt.hu/api/publication/3085606},
	author = {Furdan, Szabina and Lőrincz, László Magor},
	booktitle = {IBRO Workshop 2016},
	unique-id = {3085606},
	year = {2016},
	pages = {43-44}
}