@article{MTMT:34754751,
	title = {PARP14 contributes to the development of the tumor-associated macrophage phenotype},
	url = {https://m2.mtmt.hu/api/publication/34754751},
	author = {Sturniolo, I and Váróczy, Cs and Regdon, Zsolt and Mázló, A and Muzsai, Sz and Bácsi, A and Intili, G and Hegedűs, Csaba and Boothby, MR and Holechek, J and Ferraris, D and Schüler, H and Virág, László},
	doi = {10.3390/ijms25073601},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34754751},
	issn = {1661-6596},
	year = {2024},
	eissn = {1422-0067},
	pages = {1-21}
}

@article{MTMT:32886684,
	title = {Tricetin Reduces Inflammation and Acinar Cell Injury in Cerulein-Induced Acute Pancreatitis: The Role of Oxidative Stress-Induced DNA Damage Signaling},
	url = {https://m2.mtmt.hu/api/publication/32886684},
	author = {Nagy-Pénzes, Máté and Hajnády, Zoltán and Regdon, Zsolt and Demény, Máté Ágoston and Kovács, Katalin and El-Hamoly, Tarek and Maléth, József and Hegyi, Péter and Hegedűs, Csaba and Virág, László},
	doi = {10.3390/biomedicines10061371},
	journal-iso = {BIOMEDICINES},
	journal = {BIOMEDICINES},
	volume = {10},
	unique-id = {32886684},
	year = {2022},
	eissn = {2227-9059},
	orcid-numbers = {Maléth, József/0000-0001-5768-3090; Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:32628668,
	title = {The multitargeted receptor tyrosine kinase inhibitor sunitinib induces resistance of HER2 positive breast cancer cells to trastuzumab-mediated ADCC},
	url = {https://m2.mtmt.hu/api/publication/32628668},
	author = {Guti, Eliza and Regdon, Zsolt and Sturniolo, Isotta and Kiss, Alexandra and Kovács, Katalin and Demény, Máté Ágoston and Szöőr, Árpád and Vereb, György and Szöllősi, János and Hegedűs, Csaba and Polgár, Zsuzsanna and Virág, László},
	doi = {10.1007/s00262-022-03146-z},
	journal-iso = {CANCER IMMUNOL IMMUN},
	journal = {CANCER IMMUNOLOGY IMMUNOTHERAPY},
	volume = {71},
	unique-id = {32628668},
	issn = {1432-0851},
	abstract = {Despite recent advances in the development of novel personalized therapies, breast cancer continues to challenge physicians with resistance to various advanced therapies. The anticancer action of the anti-HER2 antibody, trastuzumab, involves antibody-dependent cell-mediated cytotoxicity (ADCC) by natural killer (NK) cells. Here, we report a repurposing screen of 774 clinically used compounds on NK-cell + trastuzumab-induced killing of JIMT-1 breast cancer cells. Using a calcein-based high-content screening (HCS) assay for the image-based quantitation of ADCC that we have developed and optimized for this purpose, we have found that the multitargeted tyrosine kinase inhibitor sunitinib inhibits ADCC in this model. The cytoprotective effect of sunitinib was also confirmed with two other assays (lactate dehydrogenase release, and electric cell substrate impedance sensing, ECIS). The drug suppressed NK cell activation as indicated by reduced granzyme B deposition on to the target cells and inhibition of interferon-γ production by the NK cells. Moreover, sunitinib induced downregulation of HER2 on the target cells' surface, changed the morphology and increased adherence of the target cells. Moreover, sunitinib also triggered the autophagy pathway (speckled LC3b) as an additional potential underlying mechanism of the cytoprotective effect of the drug. Sunitinib-induced ADCC resistance has been confirmed in a 3D tumor model revealing the prevention of apoptotic cell death (Annexin V staining) in JIMT-1 spheroids co-incubated with NK cells and trastuzumab. In summary, our HCS assay may be suitable for the facile identification of ADCC boosting compounds. Our data urge caution concerning potential combinations of ADCC-based immunotherapies and sunitinib.},
	keywords = {breast cancer; natural killer cell; trastuzumab; sunitinib; antibody-dependent cell mediated cytotoxicity (ADCC); Herceptin},
	year = {2022},
	eissn = {0340-7004},
	pages = {2151-2168}
}

@article{MTMT:32499339,
	title = {Beneficial effects of tricetin in cerulein induced acute pancreatitis},
	url = {https://m2.mtmt.hu/api/publication/32499339},
	author = {Nagy-Pénzes, Máté and Hajnády, Zoltán and Regdon, Zsolt and Virág, László},
	journal-iso = {FEBS OPEN BIO},
	journal = {FEBS OPEN BIO},
	volume = {11},
	unique-id = {32499339},
	issn = {2211-5463},
	year = {2021},
	eissn = {2211-5463},
	pages = {493-494}
}

@article{MTMT:32499259,
	title = {Role of OGG1 in cerulein induced acute pancreatitis},
	url = {https://m2.mtmt.hu/api/publication/32499259},
	author = {Hajnády, Zoltán and Nagy-Pénzes, Máté and Regdon, Zsolt and Virág, László},
	journal-iso = {FEBS OPEN BIO},
	journal = {FEBS OPEN BIO},
	volume = {11},
	unique-id = {32499259},
	issn = {2211-5463},
	year = {2021},
	eissn = {2211-5463},
	pages = {492-493}
}

@article{MTMT:32499240,
	title = {The multi-targeted receptor tyrosine kinase inhibitor sunitinib inhibits natural killer cell-mediated antibody-dependent cellular cytotoxicity against JIMT-1 breast carcinoma cells},
	url = {https://m2.mtmt.hu/api/publication/32499240},
	author = {Guti, Eliza and Hegedűs, Csaba and Regdon, Zsolt and Polgár, Zsuzsanna and Virág, László},
	journal-iso = {FEBS OPEN BIO},
	journal = {FEBS OPEN BIO},
	volume = {11},
	unique-id = {32499240},
	issn = {2211-5463},
	year = {2021},
	eissn = {2211-5463},
	pages = {405-406}
}

@article{MTMT:32498912,
	title = {Oxidative stress-induced DNA damage signaling: the role of poly(ADP-ribose) polymerase 1},
	url = {https://m2.mtmt.hu/api/publication/32498912},
	author = {Regdon, Zsolt and Demény, Máté Ágoston and Hegedűs, Csaba and Kiss, Alexandra and Szabo, E. and Virág, László},
	journal-iso = {FEBS OPEN BIO},
	journal = {FEBS OPEN BIO},
	volume = {11},
	unique-id = {32498912},
	issn = {2211-5463},
	year = {2021},
	eissn = {2211-5463},
	pages = {61-61}
}

@article{MTMT:32154894,
	title = {NMNAT1 is a survival factor in actinomycin D-induced osteosarcoma cell death},
	url = {https://m2.mtmt.hu/api/publication/32154894},
	author = {Kiss, Alexandra and Csikos, Cs and Regdon, Zsolt and Polgár, Zsuzsanna and Virág, László and Hegedűs, Csaba},
	doi = {10.3390/ijms22168869},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {22},
	unique-id = {32154894},
	issn = {1661-6596},
	year = {2021},
	eissn = {1422-0067}
}

@article{MTMT:31938546,
	title = {Poly(ADP-ribose) polymerase 1 promotes inflammation and fibrosis in a mouse model of chronic pancreatitis},
	url = {https://m2.mtmt.hu/api/publication/31938546},
	author = {El-Hamoly, T and Hajnády, Zoltán and Nagy-Pénzes, Máté and Bakondi, Edina and Regdon, Zsolt and Demény, Máté Ágoston and Kovács, Katalin and Hegedűs, Csaba and Abd, El-Rahman SS and Szabó, Éva and Maléth, József and Hegyi, Péter and Virág, László},
	doi = {10.3390/ijms22073593},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {22},
	unique-id = {31938546},
	issn = {1661-6596},
	year = {2021},
	eissn = {1422-0067},
	orcid-numbers = {Maléth, József/0000-0001-5768-3090; Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:31902961,
	title = {Blood flow restriction during the resting periods of high-intensity resistance training does not alter performance but decreases MIR-1 and MIR-133A levels in human skeletal muscle},
	url = {https://m2.mtmt.hu/api/publication/31902961},
	author = {Torma, Ferenc Gergely and Bakonyi, Péter and Regdon, Zsolt and Gombos, Zoltán and Jókai, Mátyás and Bábszky, Gergely and Fridvalszki, Marcell Norbert and Virág, László and Naito, Hisashi and Iftikhar Bukhari, Syed.Rehan and Radák, Zsolt},
	doi = {10.1016/j.smhs.2021.02.002},
	journal-iso = {SPORTS MED HEALTH SCI},
	journal = {SPORTS MEDICINE AND HEALTH SCIENCE},
	volume = {3},
	unique-id = {31902961},
	issn = {2666-3376},
	year = {2021},
	pages = {40-45},
	orcid-numbers = {Bakonyi, Péter/0000-0002-6120-3384; Bábszky, Gergely/0000-0002-5939-8434; Fridvalszki, Marcell Norbert/0000-0001-9445-9397; Virág, László/0000-0002-7099-6718; Naito, Hisashi/0000-0002-0522-9512; Iftikhar Bukhari, Syed.Rehan/0000-0003-0457-336X; Radák, Zsolt/0000-0003-1297-6804}
}