@article{MTMT:34536265,
	title = {Sources of Variance in Human Tear Proteomic Samples: Statistical Evaluation, Quality Control, Normalization, and Biological Insight},
	url = {https://m2.mtmt.hu/api/publication/34536265},
	author = {Bruszel, Bella and Tóth-Molnár, Edit and Janáky, Tamás and Szabó, Zoltán},
	doi = {10.3390/ijms25031559},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34536265},
	issn = {1661-6596},
	abstract = {Human tear fluid contains numerous compounds, which are present in highly variable amounts owing to the dynamic and multipurpose functions of tears. A better understanding of the level and sources of variance is essential for determining the functions of the different tear components and the limitations of tear samples as a potential biomarker source. In this study, a quantitative proteomic method was used to analyze variations in the tear protein profiles of healthy volunteers. High day-to-day and inter-eye personal variances were observed in the tear volumes, protein content, and composition of the tear samples. Several normalization and outlier exclusion approaches were evaluated to decrease variances. Despite the intrapersonal variances, statistically significant differences and cluster analysis revealed that proteome profile and immunoglobulin composition of tear fluid present personal characteristics. Using correlation analysis, we could identify several correlating protein clusters, mainly related to the source of the proteins. Our study is the first attempt to achieve more insight into the biochemical background of human tears by statistical evaluation of the experimentally observed dynamic behavior of the tear proteome. As a pilot study for determination of personal protein profiles of the tear fluids of individual patients, it contributes to the application of this noninvasively collectible body fluid in personal medicine.},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Tóth-Molnár, Edit/0000-0001-7989-1616; Janáky, Tamás/0000-0002-6466-8283; Szabó, Zoltán/0000-0001-8278-8038}
}

@article{MTMT:33594496,
	title = {Synthesis and Antiproliferative Activity of Steroidal Diaryl Ethers},
	url = {https://m2.mtmt.hu/api/publication/33594496},
	author = {Kovács, Édua and Ali, Hazhmat and Minorics, Renáta and Traj, Péter and Resch, Vivien Erzsébet and Paragi, Gábor and Bruszel, Bella and Zupkó, István and Mernyák, Erzsébet},
	doi = {10.3390/molecules28031196},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {28},
	unique-id = {33594496},
	issn = {1420-3049},
	abstract = {Novel 13α-estrone derivatives have been synthesized via direct arylation of the phenolic hydroxy function. Chan–Lam couplings of arylboronic acids with 13α-estrone as a nucleophilic partner were carried out under copper catalysis. The antiproliferative activities of the newly synthesized diaryl ethers against a panel of human cancer cell lines (A2780, MCF-7, MDA-MB 231, HeLa, SiHa) were investigated by means of MTT assays. The quinoline derivative displayed substantial antiproliferative activity against MCF-7 and HeLa cell lines with low micromolar IC50 values. Disturbance of tubulin polymerization has been confirmed by microplate-based photometric assay. Computational calculations reveal significant interactions of the quinoline derivative with the taxoid binding site of tubulin.},
	year = {2023},
	eissn = {1420-3049},
	orcid-numbers = {Minorics, Renáta/0000-0001-9685-813X; Resch, Vivien Erzsébet/0000-0003-0044-5731; Paragi, Gábor/0000-0001-5408-1748; Zupkó, István/0000-0003-3243-5300; Mernyák, Erzsébet/0000-0003-4494-1817}
}

@article{MTMT:32924828,
	title = {Diet-Induced Hypercholesterolemia Leads to Cardiac Dysfunction and Alterations in the Myocardial Proteome},
	url = {https://m2.mtmt.hu/api/publication/32924828},
	author = {Szabó, Márton Richárd and Pipicz, Márton and Sárközy, Márta and Bruszel, Bella and Szabó, Zoltán and Csont, Tamás Bálint},
	doi = {10.3390/ijms23137387},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {32924828},
	issn = {1661-6596},
	abstract = {Elevated blood cholesterol is a major risk factor for coronary heart disease. Moreover, direct effects on the myocardium also contribute to the adverse effects of hypercholesterolemia. Here, we investigated the effect of hypercholesterolemia on the cardiac proteome. Male Wistar rats were fed with a laboratory rodent chow supplemented with 2% cholesterol for 8 weeks to induce hypercholesterolemia. The protein expression data obtained from the proteomic characterization of left ventricular samples from normo- and hypercholesterolemic animals were subjected to gene ontology (GO) and protein interaction analyses. Elevated circulating cholesterol levels were accompanied by diastolic dysfunction in cholesterol-fed rats. The proteomic characterization of left ventricular samples revealed altered expression of 45 proteins due to hypercholesterolemia. Based on the Gene Ontology analysis, hypercholesterolemia was associated with disturbed expression of cytoskeletal and contractile proteins. Beta-actin was downregulated in the hypercholesterolemic myocardium, and established a prominent hub of the protein interaction network. Analysis of the unfiltered dataset revealed concordant downregulated expression patterns in proteins associated with the arrangement of the contractile system (e.g., cardiac-specific troponins and myosin complex), and in subunits of the mitochondrial respiratory chain. We conclude that the observed changes in the cardiac proteome may contribute to the development of diastolic dysfunction in hypercholesterolemia.},
	year = {2022},
	eissn = {1422-0067},
	orcid-numbers = {Szabó, Márton Richárd/0000-0003-0415-5192; Pipicz, Márton/0000-0002-0944-1684; Sárközy, Márta/0000-0002-5929-2146; Szabó, Zoltán/0000-0001-8278-8038; Csont, Tamás Bálint/0000-0001-5792-2768}
}

@article{MTMT:32489937,
	title = {Indoleamine 2,3-Dioxygenase Cannot Inhibit Chlamydia trachomatis Growth in HL-60 Human Neutrophil Granulocytes},
	url = {https://m2.mtmt.hu/api/publication/32489937},
	author = {Virók, Dezső and Tömösi, Ferenc and Keller-Pintér, Anikó and Szabó, Kitti and Bogdanov, Anita and Póliska, Szilárd and Rázga, Zsolt and Bruszel, Bella and Cseh, Zsuzsanna and Kókai, Dávid and Paróczai, Dóra and Endrész, Valéria and Janáky, Tamás and Burián, Katalin},
	doi = {10.3389/fimmu.2021.717311},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {12},
	unique-id = {32489937},
	issn = {1664-3224},
	year = {2021},
	eissn = {1664-3224},
	orcid-numbers = {Tömösi, Ferenc/0000-0002-6657-5777; Keller-Pintér, Anikó/0000-0002-4105-8458; Szabó, Kitti/0000-0002-1177-2036; Bogdanov, Anita/0000-0003-3067-8835; Rázga, Zsolt/0000-0003-4717-8482; Endrész, Valéria/0000-0002-9402-3857; Janáky, Tamás/0000-0002-6466-8283; Burián, Katalin/0000-0003-1300-2374}
}

@article{MTMT:32161034,
	title = {Microwave-assisted Phospha-Michael addition reactions in the 13alpha-oestrone series and in vitro antiproliferative properties},
	url = {https://m2.mtmt.hu/api/publication/32161034},
	author = {Mernyák, Erzsébet and Bartha, Sándor and Kóczán , Lili and Jójárt, Rebeka and Resch, Vivien Erzsébet and Paragi, Gábor and Vágvölgyi, Máté and Hunyadi, Attila and Bruszel, Bella and Zupkó, István and Minorics, Renáta},
	doi = {10.1080/14756366.2021.1963241},
	journal-iso = {J ENZYM INHIB MED CH},
	journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY},
	volume = {36},
	unique-id = {32161034},
	issn = {1475-6366},
	year = {2021},
	eissn = {1475-6374},
	pages = {1931-1937},
	orcid-numbers = {Mernyák, Erzsébet/0000-0003-4494-1817; Resch, Vivien Erzsébet/0000-0003-0044-5731; Paragi, Gábor/0000-0001-5408-1748; Vágvölgyi, Máté/0000-0002-2233-9422; Hunyadi, Attila/0000-0003-0074-3472; Zupkó, István/0000-0003-3243-5300; Minorics, Renáta/0000-0001-9685-813X}
}

@{MTMT:31647876,
	title = {Prediabetes induced by fructose-enriched diet influences cardiac lipidome and proteome and leads to deterioration of cardiac function prior to the development of excessive oxidative stress and cell damage},
	url = {https://m2.mtmt.hu/api/publication/31647876},
	author = {Szűcs, Gergő and Apjok-Sója, Andrea and Péter, Mária and Sárközy, Márta and Bruszel, Bella and Siska, Andrea and Földesi, Imre and Szabó, Zoltán and Janáky, Tamás and László, Vígh and Gábor, Balogh and Csont, Tamás Bálint},
	booktitle = {Proceedings of the EFOP-3.6.2-16-2017-00006 (LIVE LONGER) project},
	unique-id = {31647876},
	year = {2020},
	pages = {73-73},
	orcid-numbers = {Szűcs, Gergő/0000-0003-1874-2718; Apjok-Sója, Andrea/0000-0003-3691-5889; Sárközy, Márta/0000-0002-5929-2146; Földesi, Imre/0000-0002-3329-8136; Szabó, Zoltán/0000-0001-8278-8038; Janáky, Tamás/0000-0002-6466-8283; Csont, Tamás Bálint/0000-0001-5792-2768}
}

@article{MTMT:31390897,
	title = {Small Extracellular Vesicles Isolated from Serum May Serve as Signal-Enhancers for the Monitoring of CNS Tumors},
	url = {https://m2.mtmt.hu/api/publication/31390897},
	author = {Dobra, Gabriella and Bukva, Mátyás and Szabó, Zoltán and Bruszel, Bella and Harmati, Mária and Gyukity-Sebestyén, Edina and Jenei, Adrienn and Szűcs, Mónika and Horváth, Péter and Bíró, Tamás and Klekner, Álmos and Buzás, Krisztina},
	doi = {10.3390/ijms21155359},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {21},
	unique-id = {31390897},
	issn = {1661-6596},
	year = {2020},
	eissn = {1422-0067},
	orcid-numbers = {Dobra, Gabriella/0000-0002-2814-7720; Bukva, Mátyás/0000-0002-5225-0285; Szabó, Zoltán/0000-0001-8278-8038; Harmati, Mária/0000-0002-4875-5723; Gyukity-Sebestyén, Edina/0000-0003-1383-6301; Szűcs, Mónika/0000-0002-8791-9452; Buzás, Krisztina/0000-0001-8933-2033}
}

@article{MTMT:31522265,
	title = {Extracellular vesicles: promising source of glioblastoma biomarkers},
	url = {https://m2.mtmt.hu/api/publication/31522265},
	author = {Bukva, Mátyás and Dobra, Gabriella and Szabó, Zoltán and Bruszel, Bella and Zsolt, Szegletes and András, Kincses and Edina, Gyukity-Sebestyén and Mária, Harmati and Álmos, Klekner and Buzás, Krisztina},
	journal-iso = {IMMUNOLÓGIAI SZEMLE},
	journal = {IMMUNOLÓGIAI SZEMLE},
	volume = {11},
	unique-id = {31522265},
	issn = {2061-0203},
	year = {2019},
	pages = {24-24},
	orcid-numbers = {Bukva, Mátyás/0000-0002-5225-0285; Dobra, Gabriella/0000-0002-2814-7720; Szabó, Zoltán/0000-0001-8278-8038; Buzás, Krisztina/0000-0001-8933-2033}
}

@article{MTMT:31009490,
	title = {Prediabetes Induced by Fructose-Enriched Diet Influences Cardiac Lipidome and Proteome and Leads to Deterioration of Cardiac Function prior to the Development of Excessive Oxidative Stress and Cell Damage},
	url = {https://m2.mtmt.hu/api/publication/31009490},
	author = {Szűcs, Gergő and Apjok-Sója, Andrea and Péter, Mária and Sárközy, Márta and Bruszel, Bella and Siska, Andrea and Földesi, Imre and Szabó, Zoltán and Janáky, Tamás and Vigh, László and Balogh, Gábor and Csont, Tamás Bálint},
	doi = {10.1155/2019/3218275},
	journal-iso = {OXID MED CELL LONGEV},
	journal = {OXIDATIVE MEDICINE AND CELLULAR LONGEVITY},
	volume = {2019},
	unique-id = {31009490},
	issn = {1942-0900},
	year = {2019},
	eissn = {1942-0994},
	orcid-numbers = {Szűcs, Gergő/0000-0003-1874-2718; Apjok-Sója, Andrea/0000-0003-3691-5889; Sárközy, Márta/0000-0002-5929-2146; Siska, Andrea/0000-0002-3329-8136; Földesi, Imre/0000-0002-3329-8136; Szabó, Zoltán/0000-0001-8278-8038; Janáky, Tamás/0000-0002-6466-8283; Csont, Tamás Bálint/0000-0001-5792-2768}
}

@misc{MTMT:3336877,
	title = {Lacrimal proteome: possible source of biomarkers?},
	url = {https://m2.mtmt.hu/api/publication/3336877},
	author = {Bruszel, Bella and Zoltan, Szabo and Janáky, Tamás},
	editor = {Stephen, R Pennington},
	unique-id = {3336877},
	year = {2017},
	pages = {428-429},
	orcid-numbers = {Janáky, Tamás/0000-0002-6466-8283}
}