TY - JOUR AU - Wirth, Roland AU - Maróti, Gergely AU - Mihók, Róbert AU - Simon-Fiala, Donát AU - Antal, Márk Ádám AU - Pap, Bernadett AU - Nagy-Demcsák, Anett AU - Minárovits, János AU - Kovács, Kornél Lajos TI - A case study of salivary microbiome in smokers and non-smokers in Hungary: analysis by shotgun metagenome sequencing JF - JOURNAL OF ORAL MICROBIOLOGY J2 - J ORAL MICROBIOL VL - 12 PY - 2020 IS - 1 PG - 12 SN - 2000-2297 DO - 10.1080/20002297.2020.1773067 UR - https://m2.mtmt.hu/api/publication/31336753 ID - 31336753 N1 - Chemicals/CAS: carbon monoxide, 630-08-0; DNA, 9007-49-2 Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Regional Development Fund, FEDER Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFI, PD121085, FK123899 Funding text 1: The support of the grant GINOP-2.3.2-15-2016-00011 by the European Regional Development Fund to a project led by JM is kindly acknowledged. Additional projects GINOP-2.2.1-15-2017-00081, GINOP-2.2.1-15-2017-00033, and EFOP-3.6.2-16-2017-00010 also contributed to this work. The grants were managed by European Union Economic Development and Innovation Operational Programme, National Research, Development and Innovation Office (NKFIH), Hungary. RW and GM received support from the Hungarian NKFIH fund projects PD121085 and FK123899 financed under the PD16 and FK16 funding schemes. This work was also supported by the János Bolyai Research Scholarship (for GM) of the Hungarian Academy of Sciences. Department of Biotechnology, University of Szeged, Szeged, Hungary Institute of Plant Biology, Biological Research Center, Szeged, Hungary Department of Operative and Esthetic Dentistry, Faculty of Dentistry, University of Szeged, Szeged, Hungary Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry,, University of Szeged, Szeged, Hungary Export Date: 10 March 2021 Correspondence Address: Kovács, K.L.; Department of Biotechnology, Hungary; email: kovacs.kornel@bio.u-szeged.hu Chemicals/CAS: carbon monoxide, 630-08-0; DNA, 9007-49-2 Funding details: 2.2.1-15-2017-00033, EFOP-3.6.2-16-2017-00010, GINOP-2.3.2-15-2017-00811 Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Regional Development Fund, FEDER, GINOP-2.2.1-15-2017-00033 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFI, FK123899, GINOP-2.3.2-15-2016-00011, PD121085 Funding text 1: The support of the grant GINOP-2.3.2-15-2016-00011 by the European Regional Development Fund to a project led by JM is kindly acknowledged. Additional projects GINOP-2.2.1-15-2017-00081, GINOP-2.2.1-15-2017-00033, and EFOP-3.6.2-16-2017-00010 also contributed to this work. The grants were managed by European Union Economic Development and Innovation Operational Programme, National Research, Development and Innovation Office (NKFIH), Hungary. RW and GM received support from the Hungarian NKFIH fund projects PD121085 and FK123899 financed under the PD16 and FK16 funding schemes. This work was also supported by the János Bolyai Research Scholarship (for GM) of the Hungarian Academy of Sciences. Funding text 2: This work was supported by the European Union Economic Development and Innovation Operational Programme, National Research, Development and Innovation Office (NKFIH), Hungary [GINOP-2.3.2-15-2016-00011]; European Union Economic Development and Innovation Operational Programme, National Research, Development and Innovation Office (NKFIH), Hungary [GINOP-2.3.2-15-2016-00011]; Hungarian NKFIH fund [FK123899]; European Union Economic Development and Innovation Operational Programme, National Research, Development and Innovation Office (NKFIH) [EFOP-3.6.2-16-2017-00010]; European Union Economic Development and Innovation Operational Programme, National Research, Development and Innovation Office (NKFIH), Hungary [2.2.1-15-2017-00033]; European Union Economic Development and Innovation Operational Programme, National Research, Development and Innovation Office (NKFIH), Hungary [GINOP-2.3.2-15-2017-00811]; Hungarian NKFIH fund [PD121085]. The support of the grant GINOP-2.3.2-15-2016-00011 by the European Regional Development Fund to a project led by JM is kindly acknowledged. Additional projects GINOP-2.2.1-15-2017-00081, GINOP-2.2.1-15-2017-00033, and EFOP-3.6.2-16-2017-00010 also contributed to this work. The grants were managed by European Union Economic Development and Innovation Operational Programme, National Research, Development and Innovation Office (NKFIH), Hungary. RW and GM received support from the Hungarian NKFIH fund projects PD121085 and FK123899 financed under the PD16 and FK16 funding schemes. This work was also supported by the J?nos Bolyai Research Scholarship (for GM) of the Hungarian Academy of Sciences. Department of Biotechnology, University of Szeged, Szeged, Hungary Institute of Plant Biology, Biological Research Center, Szeged, Hungary Department of Operative and Esthetic Dentistry, Faculty of Dentistry, University of Szeged, Szeged, Hungary Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry,, University of Szeged, Szeged, Hungary Export Date: 14 March 2021 Correspondence Address: Kovács, K.L.; Department of Biotechnology, Hungary; email: kovacs.kornel@bio.u-szeged.hu Chemicals/CAS: carbon monoxide, 630-08-0; DNA, 9007-49-2 Funding details: 2.2.1-15-2017-00033, EFOP-3.6.2-16-2017-00010, GINOP-2.3.2-15-2017-00811 Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Regional Development Fund, FEDER, GINOP-2.2.1-15-2017-00033 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFI, FK123899, GINOP-2.3.2-15-2016-00011, PD121085 Funding text 1: The support of the grant GINOP-2.3.2-15-2016-00011 by the European Regional Development Fund to a project led by JM is kindly acknowledged. Additional projects GINOP-2.2.1-15-2017-00081, GINOP-2.2.1-15-2017-00033, and EFOP-3.6.2-16-2017-00010 also contributed to this work. The grants were managed by European Union Economic Development and Innovation Operational Programme, National Research, Development and Innovation Office (NKFIH), Hungary. RW and GM received support from the Hungarian NKFIH fund projects PD121085 and FK123899 financed under the PD16 and FK16 funding schemes. This work was also supported by the János Bolyai Research Scholarship (for GM) of the Hungarian Academy of Sciences. Funding text 2: This work was supported by the European Union Economic Development and Innovation Operational Programme, National Research, Development and Innovation Office (NKFIH), Hungary [GINOP-2.3.2-15-2016-00011]; European Union Economic Development and Innovation Operational Programme, National Research, Development and Innovation Office (NKFIH), Hungary [GINOP-2.3.2-15-2016-00011]; Hungarian NKFIH fund [FK123899]; European Union Economic Development and Innovation Operational Programme, National Research, Development and Innovation Office (NKFIH) [EFOP-3.6.2-16-2017-00010]; European Union Economic Development and Innovation Operational Programme, National Research, Development and Innovation Office (NKFIH), Hungary [2.2.1-15-2017-00033]; European Union Economic Development and Innovation Operational Programme, National Research, Development and Innovation Office (NKFIH), Hungary [GINOP-2.3.2-15-2017-00811]; Hungarian NKFIH fund [PD121085]. The support of the grant GINOP-2.3.2-15-2016-00011 by the European Regional Development Fund to a project led by JM is kindly acknowledged. Additional projects GINOP-2.2.1-15-2017-00081, GINOP-2.2.1-15-2017-00033, and EFOP-3.6.2-16-2017-00010 also contributed to this work. The grants were managed by European Union Economic Development and Innovation Operational Programme, National Research, Development and Innovation Office (NKFIH), Hungary. RW and GM received support from the Hungarian NKFIH fund projects PD121085 and FK123899 financed under the PD16 and FK16 funding schemes. This work was also supported by the J?nos Bolyai Research Scholarship (for GM) of the Hungarian Academy of Sciences. AB - Objective To investigate the role of cigarette smoking in disease-development through altering the composition of the oral microbial community. Periodontitis and oral cancer are highly prevalent in Hungary; therefore, the salivary microbiome of smoker and non-smoker Hungarian adults was characterized. Methods Shotgun metagenome sequencing of salivary DNA samples from 22 individuals (11 non-smokers and 11 current smokers) was performed using the Ion Torrent PGMTM platform. Quality-filtered reads were analysed by both alignment-based sequence similarity searches and genome-centric binning. Results Prevotella, Veillonella and Streptococcus were the predominant genera in the saliva of both groups. Although the overall composition and diversity of the microbiota were similar, Prevotella was significantly more abundant in salivary samples of current smokers compared to non-smokers. Members of the genus Prevotella were implicated in the development of inflammatory diseases and oral cancer. The abundance of the genus Megasphaera also increased in current smokers, whereas the genera Neisseria, Oribacterium, Capnocytophaga and Porphyromonas were significantly reduced. The data generated by read-based taxonomic classification and genome-centric binning mutually validated the two distinct metagenomic approaches. Conclusion Smoking-associated dysbiosis of the salivary microbiome in current cigarette smokers, especially increased abundance of Prevotella and Megasphaera genera, may facilitate disease development. LA - English DB - MTMT ER - TY - CHAP AU - Niller, Hans Helmut AU - Nagy-Demcsák, Anett AU - Minárovits, János ED - Krell, Tino TI - DNA Methylation in Eukaryotes: Regulation and Function T2 - Cellular Ecophysiology of Microbe PB - Springer Netherlands CY - Cham (Németország) SN - 9783319207964 T3 - Handbook of Hydrocarbon and Lipid Microbiology PY - 2018 SP - 509 EP - 570 PG - 62 DO - 10.1007/978-3-319-50542-8_24 UR - https://m2.mtmt.hu/api/publication/3362718 ID - 3362718 LA - English DB - MTMT ER - TY - JOUR AU - Hettmann, Andrea AU - Nagy-Demcsák, Anett AU - Bach, Ádám AU - Decsi, Gábor Sándor AU - Dencs, Ágnes AU - Pálinkó, Dóra AU - Rovó, László AU - Terhes, Gabriella AU - Zsoldiné Urbán, Edit AU - Buzás, Krisztina AU - Nagy, Katalin AU - Takács, Mária AU - Minárovits, János TI - Prevalence and genotypes of human papillomavirus in saliva and tumor samples of head and neck cancer patients in Hungary JF - INFECTION GENETICS AND EVOLUTION J2 - INFECT GENET EVOL VL - 59 PY - 2018 SP - 99 EP - 106 PG - 8 SN - 1567-1348 DO - 10.1016/j.meegid.2018.01.030 UR - https://m2.mtmt.hu/api/publication/3329787 ID - 3329787 N1 - Megjegyzés-27366097 N1 Funding details: i4i, Invention for Innovation Programme N1 Funding details: Ministry of Economy N1 Funding details: SIBS, CAS, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences N1 Funding details: STRIDE Center, Southeastern Transportation Research, Innovation, Development and Education Center N1 Funding details: ERDF, European Regional Development Fund N1 Funding text: This work was supported by the grant GINOP-2.3.2-15-2016-00011 to a consortium led by the University of Szeged, Szeged, Hungary (participants: the University of Debrecen, Debrecen, and the Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary), project leader Janos Minarovits. The grant was funded by the European Regional Development Fund of the European Union and managed in the framework of Economic Development and Innovation Operational Programme by the Ministry of National Economy, National Research, Development and Innovation Office, Budapest, Hungary. Division of Virology, National Public Health Institute, Budapest, Hungary Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Szeged, Hungary Department of Otorhinolaryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Oral Surgery, Faculty of Dentistry, University of Szeged, Szeged, Hungary Institute of Clinical Microbiology, University of Szeged, Faculty of Medicine, Szeged, Hungary Hungarian Academy of Sciences, Biological Research Centre, Szeged, Hungary Export Date: 9 January 2019 CODEN: IGENC Correspondence Address: Minarovits, J.; Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64, Hungary; email: minarovits.janos@stoma.szote.u-szeged.hu Funding details: Ministry of Economy Funding details: European Regional Development Fund, FEDER Funding text 1: This work was supported by the grant GINOP-2.3.2-15-2016-00011 to a consortium led by the University of Szeged, Szeged, Hungary (participants: the University of Debrecen, Debrecen, and the Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary), project leader Janos Minarovits. The grant was funded by the European Regional Development Fund of the European Union and managed in the framework of Economic Development and Innovation Operational Programme by the Ministry of National Economy, National Research, Development and Innovation Office, Budapest, Hungary. Division of Virology, National Public Health Institute, Budapest, Hungary Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Szeged, Hungary Department of Otorhinolaryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Oral Surgery, Faculty of Dentistry, University of Szeged, Szeged, Hungary Institute of Clinical Microbiology, University of Szeged, Faculty of Medicine, Szeged, Hungary Hungarian Academy of Sciences, Biological Research Centre, Szeged, Hungary Cited By :1 Export Date: 26 August 2019 CODEN: IGENC Correspondence Address: Minarovits, J.; Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64, Hungary; email: minarovits.janos@stoma.szote.u-szeged.hu Funding details: Hungary Funding details: Ministry of Economy Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Regional Development Fund Funding details: Office of Research, Innovation and Economic Development, California State Polytechnic University, Pomona Funding text 1: This work was supported by the grant GINOP-2.3.2-15-2016-00011 to a consortium led by the University of Szeged, Szeged, Hungary (participants: the University of Debrecen, Debrecen, and the Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary), project leader Janos Minarovits. The grant was funded by the European Regional Development Fund of the European Union and managed in the framework of Economic Development and Innovation Operational Programme by the Ministry of National Economy, National Research, Development and Innovation Office, Budapest, Hungary. Division of Virology, National Public Health Institute, Budapest, Hungary Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Szeged, Hungary Department of Otorhinolaryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Oral Surgery, Faculty of Dentistry, University of Szeged, Szeged, Hungary Institute of Clinical Microbiology, University of Szeged, Faculty of Medicine, Szeged, Hungary Hungarian Academy of Sciences, Biological Research Centre, Szeged, Hungary Cited By :1 Export Date: 14 January 2020 CODEN: IGENC Correspondence Address: Minarovits, J.; Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 64, Hungary; email: minarovits.janos@stoma.szote.u-szeged.hu Funding details: Hungary Funding details: Ministry of Economy Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Regional Development Fund Funding details: Office of Research, Innovation and Economic Development, California State Polytechnic University, Pomona Funding text 1: This work was supported by the grant GINOP-2.3.2-15-2016-00011 to a consortium led by the University of Szeged, Szeged, Hungary (participants: the University of Debrecen, Debrecen, and the Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary), project leader Janos Minarovits. The grant was funded by the European Regional Development Fund of the European Union and managed in the framework of Economic Development and Innovation Operational Programme by the Ministry of National Economy, National Research, Development and Innovation Office, Budapest, Hungary. Funding Agency and Grant Number: European Regional Development Fund of the European UnionEuropean Union (EU); [GINOP-2.3.2-15-2016-00011] Funding text: This work was supported by the grant GINOP-2.3.2-15-2016-00011 to a consortium led by the University of Szeged, Szeged, Hungary (participants: the University of Debrecen, Debrecen, and the Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary), project leader Janos Minarovits. The grant was funded by the European Regional Development Fund of the European Union and managed in the framework of Economic Development and Innovation Operational Programme by the Ministry of National Economy, National Research, Development and Innovation Office, Budapest, Hungary. AB - Abstract In addition to traditional risk factors such as smoking, alcohol consumption and betel nut use, human papillomavirus (HPV) infection also plays a role in the development of head and neck squamous cell carcinomas (HNSCCs). Although among European countries the highest incidence and mortality rates of head and neck cancer types were recorded in Hungary, data regarding HPV prevalence in HNSCCs is scarce. We collected biopsy and saliva samples from patients diagnosed with HNSCC or oral potentially malignant disorders (OPMDs) and tested them for the presence of HPV using the PCR consensus primer set MY09/11 and the GP5+/6+ primer pair. HPV genotypes were assessed by sequencing of the amplified PCR fragments. Oral mucosa and saliva samples from tumor- and OPMD-free individuals were also analysed. HPV was detected in 11 out of 60 HNSCC samples (18%). All of the HPV positive tumors carried HPV type 16. 5 out of the 57 saliva samples collected from HNSCC patients was HPV positive (8.8%); among them, in addition to HPV16, HPV13 was also detected. Tumors located to the oropharynx had the highest HPV positivity rate with 50% (7 out of 14), which was significantly higher than the HPV prevalence in oral mucosa samples collected from controls (0 out of 20; p > 0.001) or in OPMD biopsies (0 out of 21, p > 0.001). 2 out of 57 control saliva samples (3.5%, subtype HPV13 and 11) and 3 out of 39 saliva samples from OPMD patients (7.7%, subtype HPV18, 81 and 10) were HPV positive. Our data suggested that HPV16 infection may contribute, in concert with cigarette smoking, to the development of a subset of head and neck cancers in Hungary. HPV16 infection per se does not account, however, for the high HNSCC incidence rate recorded in this country. LA - English DB - MTMT ER - TY - JOUR AU - Hettmann, Andrea AU - Nagy-Demcsák, Anett AU - Bach, Ádám AU - Decsi, Gábor Sándor AU - Dencs, Ágnes AU - Pálinkó, Dóra AU - Rovó, László AU - Terhes, Gabriella AU - Zsoldiné Urbán, Edit AU - Nagy, Katalin AU - Takács, Mária AU - Minárovits, János TI - Prevalence of human papillomavirus (HPV) and torque teno virus (TTV) in saliva and tumor biopsy samples of head and neck cancer patients in Hungary JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 64 PY - 2017 IS - Suppl. 1 SP - 127 EP - 127 PG - 1 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/3288416 ID - 3288416 LA - English DB - MTMT ER - TY - JOUR AU - Hettmann, Andrea AU - Nagy-Demcsák, Anett AU - Bach, Ádám AU - Decsi, Gábor Sándor AU - Dencs, Ágnes AU - Pálinkó, Dóra AU - Rovó, László AU - Nagy, Katalin AU - Minárovits, János AU - Takács, Mária TI - Detection and Phylogenetic Analysis of Torque Teno Virus in Salivary and Tumor Biopsy Samples from Head and Neck Carcinoma Patients JF - INTERVIROLOGY J2 - INTERVIROLOGY VL - 59 PY - 2016 IS - 2 SP - 123 EP - 129 PG - 7 SN - 0300-5526 DO - 10.1159/000452974 UR - https://m2.mtmt.hu/api/publication/3164445 ID - 3164445 AB - Objectives: Because torque teno virus (TTV) has been implicated in tumorigenesis as a cocarcinogen, we studied TTV prevalence in saliva and biopsy samples from head and neck cancer (HNCC) patients, patients with premalignant lesions of oral cancer, and controls. We also wished to determine the TTV genotypes in HNCC patients. Methods: A seminested polymerase chain reaction (PCR) amplifying the N22 region of the TTV genome, as well as direct sequencing of PCR fragments, was used. Results: TTV prevalence was higher in HNCC patients (saliva: 27/71, 38%; tumor biopsy: 22/74, 30%) than in controls (saliva: 8/56, 14%; oral mucosa: 1/19, 5%). TTV prevalence was also high in patients with premalignant lesions of oral carcinoma (saliva: 9/18, 50%; biopsy: 5/21, 24%). By phylogenetic analysis, TTV belonging mostly to genotypes 1 and 2 was found in HNCC patients. In most of the cases, identical TTV strains were present in the biopsy and salivary sample of the same HNCC patient. In addition, the same TTV strain was detected in 2 laryngeal carcinoma biopsies obtained from 2 independent patients. Conclusions: Our data are compatible with the idea that TTV might act as a cocarcinogen in certain cases of HNCC. Alternatively, HNCC may facilitate either TTV replication or TTV entry into the saliva. © 2016 S. Karger AG, Basel LA - English DB - MTMT ER - TY - JOUR AU - Minárovits, János AU - Nagy-Demcsák, Anett AU - Bánáti, Ferenc AU - Niller, HH TI - Epigenetic dysregulation in virus-associated neoplasms JF - ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY J2 - ADV EXP MED BIOL VL - 879 PY - 2016 SP - 71 EP - 90 PG - 20 SN - 0065-2598 DO - 10.1007/978-3-319-24738-0_4 UR - https://m2.mtmt.hu/api/publication/2995120 ID - 2995120 AB - The oncoproteins of human tumor viruses regularly interact with the cellular epigenetic machinery. Such interactions alter the epigenome of the host cell and reprogram its gene expression pattern. Altered levels or redistribution of (cytosine-5)-DNA methyltransferases and changes in the cellular methylome were observed in Kaposi sarcoma-associated herpesvirus (KSHV), hepatitis B virus (HBV), hepatitis D virus (HDV), hepatitis C virus (HCV), and human papillomavirus (HPV) associated neoplasms and cell lines. Methylation-mediated silencing of cellular promoters was also noted in Merkel cell polyomavirus (MCPyV) positive Merkel cell carcinomas, and, as discussed elsewhere, in EBV-associated malignancies and adenovirus-induced rodent tumors as well. Promoter activation also occurred, either associated with DNA hypomethylation or with the induction of euchromatic histone modifi cations by viral oncoproteins. It is worthy to notice that HCV infection induced large, hypomethylated blocks of cellular chromatin, although the exact molecular mechanism remains to be elucidated. In hepatoma cells expressing HBx, the oncoprotein encoded by the HBV genome, demethylation of the repetitive satellite 2 sequences was observed, due to downregulation of the de novo DNA methyltransferase DNMT3B. Tax and HBZ, the oncoproteins of human T-cell lymphotropic virus type I (HTLV-I), can both activate and silence distinct cellular promoters by interacting with cellular enzymes involved in histone modification. © Springer International Publishing Switzerland 2016. LA - English DB - MTMT ER - TY - JOUR AU - Hettmann, Andrea AU - Nagy-Demcsák, Anett AU - Decsi, Gábor Sándor AU - Bach, Ádám AU - Pálinkó, Dóra AU - Rovó, László AU - Nagy, Katalin AU - Takács, Mária AU - Minárovits, János TI - Infectious Agents Associated with Head and Neck Carcinomas JF - ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY J2 - ADV EXP MED BIOL VL - 897 PY - 2016 SP - 63 EP - 80 PG - 18 SN - 9783319263199 SN - 0065-2598 DO - 10.1007/5584_2015_5005 UR - https://m2.mtmt.hu/api/publication/2982844 ID - 2982844 N1 - Advances in Microbiology, Infectious Diseases and Public Health Volume 1. Editors: Gianfranco Donelli. ISBN: 978-3-319-26319-9 (Print) 978-3-319-26320-5 (Online) AB - In addition to traditional risk factors such as smoking habits and alcohol consumption, certain microbes also play an important role in the generation of head and neck carcinomas. Infection with high-risk human papillomavirus types is strongly associated with the development of oropharyngeal carcinoma, and Epstein-Barr virus appears to be indispensable for the development of non-keratinizing squamous cell carcinoma of the nasopharynx. Other viruses including torque teno virus and hepatitis C virus may act as co-carcinogens, increasing the risk of malignant transformation. A shift in the composition of the oral microbiome was associated with the development of oral squamous cell carcinoma, although the causal or casual role of oral bacteria remains to be clarified. Conversion of ethanol to acetaldehyde, a mutagenic compound, by members of the oral microflora as well as by fungi including Candida albicans and others is a potential mechanism that may increase oral cancer risk. In addition, distinct Candida spp. also produce NBMA (N-nitrosobenzylmethylamine), a potent carcinogen. Inflammatory processes elicited by microbes may also facilitate tumorigenesis in the head and neck region. LA - English DB - MTMT ER - TY - JOUR AU - Niller, HH AU - Áy, Éva AU - Bánáti, Ferenc AU - Nagy-Demcsák, Anett AU - Takács, Mária AU - Minárovits, János TI - Wild type HBx and truncated HBx: Pleiotropic regulators driving sequential genetic and epigenetic steps of hepatocarcinogenesis and progression of HBV-associated neoplasms JF - REVIEWS IN MEDICAL VIROLOGY J2 - REV MED VIROL VL - 26 PY - 2016 IS - 1 SP - 57 EP - 73 PG - 17 SN - 1052-9276 DO - 10.1002/rmv.1864 UR - https://m2.mtmt.hu/api/publication/2982843 ID - 2982843 N1 - Funding Agency and Grant Number: Doktories TDK project [TAMOP-4.2.2.B-15-005] Funding text: The support of TAMOP-4.2.2.B-15-005 "Doktories TDK project" for AD and JM is kindly acknowledged. Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany Department of Retrovirology, National Center for Epidemiology, Budapest, Hungary RT-Europe Nonprofit Research Center, Mosonmagyarovar, Hungary University of Szeged, Faculty of Dentistry, Department of Oral Biology and Experimental Dental Research, Szeged, Hungary Division of Virology, National Center for Epidemiology, Budapest, Hungary Cited By :2 Export Date: 24 February 2020 CODEN: RMVIE Correspondence Address: Niller, H.H.; Institute for Medical Microbiology and Hygiene, University of Regensburg, Franz-Josef-Strauss Allee 11, Germany; email: Hans-Helmut.Niller@klinik.uni-regensburg.de Chemicals/CAS: DNA methyltransferase, 9037-42-7; gelatinase B, 146480-36-6; histone acetyltransferase, 9054-51-7; histone deacetylase, 9076-57-7; interstitial collagenase, 9001-12-1; prostaglandin E2, 363-24-6; stromelysin 2, 140610-48-6; uracil DNA glycosidase, 59088-21-0; uvomorulin, 112956-45-3; vasculotropin, 127464-60-2 Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany Department of Retrovirology, National Center for Epidemiology, Budapest, Hungary RT-Europe Nonprofit Research Center, Mosonmagyarovar, Hungary University of Szeged, Faculty of Dentistry, Department of Oral Biology and Experimental Dental Research, Szeged, Hungary Division of Virology, National Center for Epidemiology, Budapest, Hungary Cited By :2 Export Date: 28 February 2020 CODEN: RMVIE Correspondence Address: Niller, H.H.; Institute for Medical Microbiology and Hygiene, University of Regensburg, Franz-Josef-Strauss Allee 11, Germany; email: Hans-Helmut.Niller@klinik.uni-regensburg.de Chemicals/CAS: DNA methyltransferase, 9037-42-7; gelatinase B, 146480-36-6; histone acetyltransferase, 9054-51-7; histone deacetylase, 9076-57-7; interstitial collagenase, 9001-12-1; prostaglandin E2, 363-24-6; stromelysin 2, 140610-48-6; uracil DNA glycosidase, 59088-21-0; uvomorulin, 112956-45-3; vasculotropin, 127464-60-2 Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany Department of Retrovirology, National Center for Epidemiology, Budapest, Hungary RT-Europe Nonprofit Research Center, Mosonmagyarovar, Hungary University of Szeged, Faculty of Dentistry, Department of Oral Biology and Experimental Dental Research, Szeged, Hungary Division of Virology, National Center for Epidemiology, Budapest, Hungary Cited By :2 Export Date: 3 September 2020 CODEN: RMVIE Correspondence Address: Niller, H.H.; Institute for Medical Microbiology and Hygiene, University of Regensburg, Franz-Josef-Strauss Allee 11, Germany; email: Hans-Helmut.Niller@klinik.uni-regensburg.de Chemicals/CAS: DNA methyltransferase, 9037-42-7; gelatinase B, 146480-36-6; histone acetyltransferase, 9054-51-7; histone deacetylase, 9076-57-7; interstitial collagenase, 9001-12-1; prostaglandin E2, 363-24-6; stromelysin 2, 140610-48-6; uracil DNA glycosidase, 59088-21-0; uvomorulin, 112956-45-3; vasculotropin, 127464-60-2 Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany Department of Retrovirology, National Center for Epidemiology, Budapest, Hungary RT-Europe Nonprofit Research Center, Mosonmagyarovar, Hungary University of Szeged, Faculty of Dentistry, Department of Oral Biology and Experimental Dental Research, Szeged, Hungary Division of Virology, National Center for Epidemiology, Budapest, Hungary Cited By :2 Export Date: 7 September 2020 CODEN: RMVIE Correspondence Address: Niller, H.H.; Institute for Medical Microbiology and Hygiene, University of Regensburg, Franz-Josef-Strauss Allee 11, Germany; email: Hans-Helmut.Niller@klinik.uni-regensburg.de Chemicals/CAS: DNA methyltransferase, 9037-42-7; gelatinase B, 146480-36-6; histone acetyltransferase, 9054-51-7; histone deacetylase, 9076-57-7; interstitial collagenase, 9001-12-1; prostaglandin E2, 363-24-6; stromelysin 2, 140610-48-6; uracil DNA glycosidase, 59088-21-0; uvomorulin, 112956-45-3; vasculotropin, 127464-60-2 AB - Hepatitis B virus (HBV) is one of the causative agents of hepatocellular carcinoma. The molecular mechanisms of tumorigenesis are complex. One of the host factors involved is apparently the long-lasting inflammatory reaction which accompanies chronic HBV infection. Although HBV lacks a typical viral oncogene, the HBx gene encoding a pleiotropic regulatory protein emerged as a major player in liver carcinogenesis. Here we review the tumorigenic functions of HBx with an emphasis on wild type and truncated HBx variants, and their role in the transcriptional dysregulation and epigenetic reprogramming of the host cell genome. We suggest that HBx acquired by the HBV genome during evolution acts like a cellular proto-onc gene that is activated by deletion during hepatocarcinogenesis. The resulting viral oncogene (v-onc gene) codes for a truncated HBx protein that facilitates tumor progression. Copyright (c) 2015 John Wiley & Sons, Ltd. LA - English DB - MTMT ER - TY - JOUR AU - Nagy-Demcsák, Anett AU - Decsi, Gábor Sándor AU - Bach, Ádám AU - Pálinkó, Dóra AU - Rovó, László AU - Nagy, Katalin AU - Zsoldiné Urbán, Edit AU - Sóki, József AU - Minárovits, János TI - Detection of Fusobacterium nucleatum in salivary samples of head and neck cancer patients by real time PCR JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 62 PY - 2015 IS - Suppl. 1 SP - 144 EP - 145 PG - 2 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/2955574 ID - 2955574 LA - English DB - MTMT ER - TY - JOUR AU - Andrea, Hettman AU - Nagy-Demcsák, Anett AU - Decsi, Gábor Sándor AU - Bach, Ádám AU - Pálinkó, Dóra AU - Rovó, László AU - Nagy, Katalin AU - Takács, Mária AU - Minárovits, János TI - The prevalence of human papilloma virus and torque teno virus in head and neck cancer patients in south-east Hungary JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 62 PY - 2015 IS - Suppl. 1 SP - 157 EP - 157 PG - 1 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/2922174 ID - 2922174 LA - English DB - MTMT ER -