@article{MTMT:35173267, title = {Kinetic monitoring of molecular interactions during surfactant-driven self-propelled droplet motion by high spatial resolution waveguide sensing}, url = {https://m2.mtmt.hu/api/publication/35173267}, author = {Farkas, Enikő and Kovács, Kinga Dóra and Székács, Inna and Péter, Beatrix and Lagzi, István László and Kitahata, Hiroyuki and Suematsu, Nobuhiko J. and Horváth, Róbert}, doi = {10.1016/j.jcis.2024.07.236}, journal-iso = {J COLLOID INTERF SCI}, journal = {JOURNAL OF COLLOID AND INTERFACE SCIENCE}, volume = {677}, unique-id = {35173267}, issn = {0021-9797}, abstract = {Hypothesis: Self-driven actions, like motion, are fundamental characteristics of life. Today, intense research focuses on the kinetics of droplet motion. Quantifying macroscopic motion and exploring the underlying mechanisms are crucial in self-structuring and self-healing materials, advancements in soft robotics, innovations in self-cleaning environmental processes, and progress within the pharmaceutical industry. Usually, the driving forces inducing macroscopic motion act at the molecular scale, making their real-time and high-resolution investigation challenging. Label-free surface sensitive measurements with high lateral resolution could in situ measure both molecular-scale interactions and microscopic motion. Experiments: We employ surface-sensitive label-free sensors to investigate the kinetic changes in a self-assembled monolayer of the trimethyl(octadecyl)azanium chloride surfactant on a substrate surface during the self-propelled motion of nitrobenzene droplets. The adsorption–desorption of the surfactant at various concentrations, its removal due to the moving organic droplet, and rebuilding mechanisms at droplet-visited areas are all investigated with excellent time, spatial, and surface mass density resolution. Findings: We discovered concentration dependent velocity fluctuations, estimated the adsorbed amount of surfactant molecules, and revealed multilayer coverage at high concentrations. The desorption rate of surfactant (18.4 s−1) during the microscopic motion of oil droplets was determined by in situ differentiating between droplet visited and non-visited areas.}, keywords = {ADSORPTION; self-assembly; Droplet motion; Marangoni effect; Self-propelled motion; Oil/water interfaces; Resonant waveguide grating imager; OWLS optical biosensor; Characterization of surface properties; Droplet-surfactant interaction}, year = {2025}, eissn = {1095-7103}, pages = {352-364}, orcid-numbers = {Horváth, Róbert/0000-0001-8617-2302} } @misc{MTMT:36333981, title = {From protein-peptide interactions to cell adhesion: label-free biophysical insights into peptide activity}, url = {https://m2.mtmt.hu/api/publication/36333981}, author = {Borbély, Krisztina and Balogh, Dóra Anett and Kurunczi, Sándor and Farkas, Enikő and Péter, Beatrix and Székács, Inna and Endre, Gabriella and Kondorosi, Eva and Horváth, Róbert}, unique-id = {36333981}, year = {2025}, orcid-numbers = {Kurunczi, Sándor/0000-0002-6567-5231; Horváth, Róbert/0000-0001-8617-2302} } @misc{MTMT:36334145, title = {Self-Propelled Droplet Motion with Characterization of Real-Time Kinetic Analysis of Surfactant Interactions by Label-Free Surface-Sensitive Biosensors}, url = {https://m2.mtmt.hu/api/publication/36334145}, author = {Farkas, Enikő and Kovács, Kinga Dóra and Székács, Inna and Péter, Beatrix and Lagzi, Istvan and Kitahata, Hiroyuki and J. Suematsu, Nobuhiko and Horváth, Róbert}, unique-id = {36334145}, year = {2025}, orcid-numbers = {Horváth, Róbert/0000-0001-8617-2302} } @misc{MTMT:36334149, title = {Real time, Nanometer Scale Resolution Kinetic Detection of Self Propelled Droplet Motion by Waveguide Biosensor}, url = {https://m2.mtmt.hu/api/publication/36334149}, author = {Farkas, Enikő and Kovács, Kinga Dóra and Székács, Inna and Péter, Beatrix and Lagzi, Istvan and Kitahata, Hiroyuki and J. Suematsu, Nobuhiko and Horváth, Róbert}, unique-id = {36334149}, year = {2025}, orcid-numbers = {Horváth, Róbert/0000-0001-8617-2302} } @misc{MTMT:36334158, title = {Technical advancements in circulating tumor cell sorting using a piezoelectric micropipette}, url = {https://m2.mtmt.hu/api/publication/36334158}, author = {Balogh, Dóra Anett and Novák, Szabolcs and Farkas, Enikő and Péter, Beatrix and Domokos, Heléna Brigitta and Szabó, Bálint and Horváth, Róbert}, unique-id = {36334158}, year = {2025}, orcid-numbers = {Szabó, Bálint/0000-0002-9865-6336; Horváth, Róbert/0000-0001-8617-2302} } @misc{MTMT:36435130, title = {GCI-based profiling of protein-peptide interactions}, url = {https://m2.mtmt.hu/api/publication/36435130}, author = {Borbély, Krisztina and Balogh, Dóra Anett and Kurunczi, Sándor and Farkas, Enikő and Péter, Beatrix and Székács, Inna and Endre, Gabriella and Kondorosi, Eva and Horváth, Róbert}, unique-id = {36435130}, year = {2025}, orcid-numbers = {Kurunczi, Sándor/0000-0002-6567-5231; Horváth, Róbert/0000-0001-8617-2302} } @misc{MTMT:35672592, title = {Cells and Model Particles in Lateral Focusing Microfluidics}, url = {https://m2.mtmt.hu/api/publication/35672592}, author = {Bányai, Anita and Farkas, Enikő and Jankovics, Hajnalka and Székács, Inna and Leelőssyné Tóth, Eszter and Vonderviszt, Ferenc and Horváth, Róbert and Varga, Máté and Fürjes, Péter}, unique-id = {35672592}, year = {2024}, orcid-numbers = {Jankovics, Hajnalka/0000-0002-9746-9424; Leelőssyné Tóth, Eszter/0000-0002-4013-499X; Vonderviszt, Ferenc/0000-0002-6498-8172; Horváth, Róbert/0000-0001-8617-2302; Fürjes, Péter/0000-0002-8022-4367} } @misc{MTMT:35672976, title = {Applications of label-free biophysical methods in studying living cells}, url = {https://m2.mtmt.hu/api/publication/35672976}, author = {Magyaródi, Beatrix and Kovács, Kinga Dóra and Kovács, Boglárka and Farkas, Enikő and Székács, Inna and Vonderviszt, Ferenc and Horváth, Róbert}, unique-id = {35672976}, year = {2024}, orcid-numbers = {Vonderviszt, Ferenc/0000-0002-6498-8172; Horváth, Róbert/0000-0001-8617-2302} } @misc{MTMT:35674490, title = {Discovery of cell adhesion-modifying effects of glyphosate on living cells by label-free optical biosensing}, url = {https://m2.mtmt.hu/api/publication/35674490}, author = {Székács, Inna and Farkas, Enikő and Kovács, Boglárka and Takács, Eszter and Oláh (Ottucsák), Marianna and Székács, András and Horváth, Róbert}, unique-id = {35674490}, year = {2024}, orcid-numbers = {Székács, András/0000-0001-5816-3775; Horváth, Róbert/0000-0001-8617-2302} } @article{MTMT:33552859, title = {Dean-Flow Affected Lateral Focusing and Separation of Particles and Cells in Periodically Inhomogeneous Microfluidic Channels}, url = {https://m2.mtmt.hu/api/publication/33552859}, author = {Bányai, Anita and Farkas, Enikő and Jankovics, Hajnalka and Székács, Inna and Leelőssyné Tóth, Eszter and Vonderviszt, Ferenc and Horváth, Róbert and Varga, Máté and Fürjes, Péter}, doi = {10.3390/s23020800}, journal-iso = {SENSORS-BASEL}, journal = {SENSORS}, volume = {23}, unique-id = {33552859}, abstract = {The purpose of the recent work is to give a better explanation of how Dean vortices affect lateral focusing, and to understand how cell morphology can alter the focusing position compared to spherical particles. The position and extent of the focused region were investigated using polystyrene fluorescent beads with different bead diameters (Ø = 0.5, 1.1, 1.97, 2.9, 4.8, 5.4, 6.08, 10.2, 15.8, 16.5 µm) at different flow rates (0.5, 1, 2 µL/s). Size-dependent focusing generated a precise map of the equilibrium positions of the spherical beads at the end of the periodically altering channels, which gave a good benchmark for focusing multi-dimensional particles and cells. The biological samples used for experiments were rod-shaped Escherichia coli (E. coli), discoid biconcave-shaped red blood cells (RBC), round or ovoid-shaped yeast, Saccharomyces cerevisiae, and soft-irregular-shaped HeLa cancer-cell-line cells to understand how the shape of the cells affects the focusing position at the end of the channel.}, keywords = {Microfluidics; Computational fluid dynamics; Cell manipulation; Dean flow; hydrodynamic lift; lateral focusing}, year = {2023}, eissn = {1424-8220}, orcid-numbers = {Jankovics, Hajnalka/0000-0002-9746-9424; Leelőssyné Tóth, Eszter/0000-0002-4013-499X; Vonderviszt, Ferenc/0000-0002-6498-8172; Horváth, Róbert/0000-0001-8617-2302; Fürjes, Péter/0000-0002-8022-4367} }