TY - JOUR AU - Kanaan, Reem AU - Borbásné Farkas, Kornélia AU - Hegyi, Péter AU - Soós, Alexandra AU - Hegyi, Dávid AU - Németh, Katalin AU - Horváth, Orsolya AU - Tenk, Judit AU - Mikó, Alexandra AU - Szentesi, Andrea Ildikó AU - Balaskó, Márta AU - Szakács, Zsolt AU - Vasas, Andrea AU - Csupor, Dezső AU - Gyöngyi, Zoltán TI - Rats sniff out pulmonary tuberculosis from sputum : a diagnostic accuracy meta-analysis JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 11 PY - 2021 IS - 1 PG - 12 SN - 2045-2322 DO - 10.1038/s41598-021-81086-x UR - https://m2.mtmt.hu/api/publication/31827589 ID - 31827589 AB - In Sub-Saharan Africa, African giant pouched rats (Cricetomys gambianus) are trained to identify TB patients by smelling sputum. We conducted a systematic review and meta-analysis of the data to see if this novel method is comparable to traditional laboratory screening and detection methods like Ziehl-Neelsen stain-based assays (ZN) and bacterial culture. The search and data processing strategy is registered at PROSPERO (CRD42019123629). Medline via PubMed, EMBASE, Web of Science, and Cochrane Library databases were systematically searched for the keywords "pouched rat" and "tuberculosis". Data from 53,181 samples obtained from 24,600 patients were extracted from seven studies. Using sample-wise detection, the sensitivity of the studies was 86.7% [95% CI 80.4-91.2%], while the specificity was 88.4% [95% CI 79.7-93.7%]. For patient-wise detection, the sensitivity was 81.3% [95% CI 64.0-91.4%], while the specificity was 73.4% [95% CI 62.8-81.9%]. Good and excellent classification was assessed by hierarchical summary receiver-operating characteristic analysis for patient-wise and sample-wise detections, respectively. Our study is the first systematic review and meta-analysis of the above relatively inexpensive and rapid screening method. The results indicate that African giant pouched rats can discriminate healthy controls from TB individuals by sniffing sputum with even a higher accuracy than a single ZN screening. LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Barbara AU - Lantos, Tamás AU - Hegyi, Péter AU - Viola, Réka AU - Vasas, Andrea AU - Benkő, Ria AU - Gyöngyi, Zoltán AU - Vincze, Áron AU - Csécsei, Péter AU - Mikó, Alexandra AU - Hegyi, Dávid AU - Szentesi, Andrea Ildikó AU - Matuz, Mária AU - Csupor, Dezső TI - Ginger (Zingiber officinale): An alternative for the prevention of postoperative nausea and vomiting. A meta-analysis JF - PHYTOMEDICINE: INTERNATIONAL JOURNAL OF PHYTOTHERAPY AND PHYTOPHARMACOLOGY J2 - PHYTOMEDICINE VL - 50 PY - 2018 SP - 8 EP - 18 PG - 11 SN - 0944-7113 DO - 10.1016/j.phymed.2018.09.007 UR - https://m2.mtmt.hu/api/publication/3425593 ID - 3425593 AB - Postoperative nausea and vomiting (PONV) is a distressing outcome related to surgeries. Traditionally, ginger has been used in the treatment of nausea and vomiting for thousands of years. Recently, several randomized, placebo-controlled clinical trials (RCTs) have been conducted to evaluate the efficacy of ginger in PONV.To systematically evaluate the efficacy of ginger on postoperative nausea and vomiting (PONV) compared to placebo, based on RCTs.The meta-analysis was reported following the PRISMA guidelines using the PICO format, and it was registered with the PROSPERO register.PubMed, Embase, the Cochrane Central Register of Controlled Trials and Web of Science were searched for relevant studies. Human, placebo-controlled clinical studies of patients undergoing any types of surgery, receiving pharmacological doses of ginger per os were included. Only clinical trials with explicit description of the ginger preparation used were analysed. No language or publication year restrictions was applied.Ten randomized trials including a total of 918 patients were pooled for the statistical analysis. The present meta-analysis supports that ginger has a significant effect on the severity of PONV based on visual analogue scale (VAS) results: in a fixed effects model the pooled standardized mean difference (SMD) was -0.247 (favouring ginger; [LL]: -0.455, [UL]: -0.040, p-value: 0.019). Moreover, our results suggest that ginger reduces the incidence of postoperative nausea and vomiting, as well antiemetic drug demand; however, these effects are not statistically significant compared to placebo, which may be explained by underdosing.According to our thorough meta-analysis ginger is safe and well tolerated, and decreases the severity of PONV, and may lower the incidence of postoperative nausea and vomiting, which in turn may reduce antiemetic drug demand, suggesting that ginger may be a useful alternative to antiemetic medications to alleviate PONV. LA - English DB - MTMT ER - TY - CHAP AU - Hegyi, Dávid AU - Németh, Katalin AU - Orsolya, Horváth AU - Raposa, Bence AU - Gyöngyi, Zoltán ED - Ács, Kamilla ED - Bódog, Ferenc ED - Mechler, Mátyás Illés ED - Mészáros, Orsolya TI - Detection of VOCs in tuberculosis patients: a short rewiev of clinical studies T2 - Book of Abstracts: Interdisciplinary Doctoral Conference 2017 = Absztraktkötet. Interdiszciplináris Doktorandusz Konferencia 2017 PB - Pécsi Tudományegyetem Doktorandusz Önkormányzat CY - Pécs SN - 9789634291121 PY - 2017 SP - 99 PG - 1 UR - https://m2.mtmt.hu/api/publication/3317095 ID - 3317095 LA - English DB - MTMT ER - TY - BOOK ED - Bódog, Ferenc ED - Csiszár, Beáta ED - Hegyi, Dávid ED - Pónusz, Róbert TI - DKK17-Doktoranduszok a Klinikai Kutatásokban absztraktkötet ET - 0 PB - Pécsi Tudományegyetem Doktorandusz Önkormányzat CY - Pécs PY - 2017 SP - 89 SN - 9789634291602 UR - https://m2.mtmt.hu/api/publication/3285967 ID - 3285967 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Horváth, Orsolya AU - Hegyi, Dávid AU - Gerencsér, Gellért AU - Gyöngyi, Zoltán ED - Haffner, Tamás ED - Kovács, Áron TI - Daganatos megbetegedések diagnosztizálása kutyával T2 - Absztrakt kötet PB - Sopianae Kulturális Egyesület CY - Pécs SN - 9786158044431 PY - 2016 SP - 30 PG - 1 UR - https://m2.mtmt.hu/api/publication/3262801 ID - 3262801 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Raposa, Bence AU - Pónusz, Róbert AU - Gerencsér, Gellért AU - Budán, Ferenc Csaba AU - Gyöngyi, Zoltán AU - Tibold, Antal AU - Hegyi, Dávid AU - Kiss, István AU - Koller, Ákos AU - Varjas, Tímea TI - Food additives: sodium benzoate, potassium sorbate, azorubine and tartrazine modify the expression of NFkB, GADD45A and MAPK8 genes JF - PHYSIOLOGY INTERNATIONAL J2 - PHYSIOL INT VL - 103 PY - 2016 IS - 3 SP - 334 EP - 343 PG - 10 SN - 2498-602X DO - 10.1556/2060.103.2016.3.6 UR - https://m2.mtmt.hu/api/publication/3110762 ID - 3110762 N1 - Export Date: 27 January 2024; CODEN: APHDU LA - English DB - MTMT ER - TY - BOOK ED - Ács, Kamilla ED - Bencze, Noémi ED - Bódog, Ferenc ED - Haffner, Tamás ED - Hegyi, Dávid ED - Horváth, Orsolya Melinda ED - Hüber, Gabriella Margit ED - Kovács, Áron ED - Kis Kelemen, Bence ED - Lajkó, Adrienn ED - Schilli, Gabriella Krisztina ED - Stankovicsné Szendi, Anna ED - Szilágyi, Tamás Gábor ED - Varga, Zoltán TI - 5th Interdisciplinary Doctoral Conference : Book of abstracts =V. Interdiszciplináris Doktorandusz Konferencia : Absztraktkötet ET - 0 PB - Pécsi Tudományegyetem Doktorandusz Önkormányzat CY - Pécs PY - 2016 SP - 206 SN - 9789634290377 UR - https://m2.mtmt.hu/api/publication/3072069 ID - 3072069 LA - English DB - MTMT ER -