TY - JOUR AU - Gölöncsér, Flóra AU - Baranyi, Mária AU - Tod, Pál AU - Maácz, Fruzsina AU - Sperlágh, Beáta TI - P2X7 receptor inhibition alleviates mania-like behavior independently of interleukin-1β JF - ISCIENCE J2 - ISCIENCE VL - 27 PY - 2024 IS - 3 PG - 23 SN - 2589-0042 DO - 10.1016/j.isci.2024.109284 UR - https://m2.mtmt.hu/api/publication/34735575 ID - 34735575 LA - English DB - MTMT ER - TY - JOUR AU - Varga, Bernadett AU - Baranyi, Mária AU - Gölöncsér, Flóra AU - Tod, Pál AU - Sperlágh, Beáta TI - The antidepressant effect of short- and long-term zinc exposition is partly mediated by P2X7 receptors in male mice JF - FRONTIERS IN PHARMACOLOGY J2 - FRONT PHARMACOL VL - 14 PY - 2023 PG - 12 SN - 1663-9812 DO - 10.3389/fphar.2023.1241406 UR - https://m2.mtmt.hu/api/publication/34206800 ID - 34206800 AB - Background: As a member of the purinergic receptor family, divalent cation-regulated ionotropic P2X7 (P2rx7) plays a role in the pathophysiology of psychiatric disorders. This study aimed to investigate whether the effects of acute zinc administration and long-term zinc deprivation on depression-like behaviors in mice are mediated by P2X7 receptors. LA - English DB - MTMT ER - TY - JOUR AU - Mut-Arbona, Paula AU - Huang, Lumei AU - Baranyi, Mária AU - Tod, Pál AU - Iring, András AU - Calzaferri, Francesco AU - de los Ríos, Cristobal AU - Sperlágh, Beáta TI - Dual Role of the P2X7 Receptor in Dendritic Outgrowth during Physiological and Pathological Brain Development. JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 43 PY - 2023 IS - 7 SP - 1125 EP - 1142 PG - 18 SN - 0270-6474 DO - 10.1523/JNEUROSCI.0805-22.2022 UR - https://m2.mtmt.hu/api/publication/33642580 ID - 33642580 AB - At high levels, extracellular ATP operates as a “danger” molecule under pathologic conditions through purinergic receptors, including the ionotropic P2X7 receptor (P2X7R). Its endogenous activation is associated with neurodevelopmental disorders; however, its function during early embryonic stages remains largely unclear. Our objective was to determine the role of P2X7R in the regulation of neuronal outgrowth. For this purpose, we performed Sholl analysis of dendritic branches on primary hippocampal neurons and in acute hippocampal slices from WT mice and mice with genetic deficiency or pharmacological blockade of P2X7R. Because abnormal dendritic branching is a hallmark of certain neurodevelopmental disorders, such as schizophrenia, a model of maternal immune activation (MIA)-induced schizophrenia, was used for further morphologic investigations. Subsequently, we studied MIA-induced behavioral deficits in young adult mice females and males. Genetic deficiency or pharmacological blockade of P2X7R led to branching deficits under physiological conditions. Moreover, pathologic activation of the receptor led to deficits in dendritic outgrowth on primary neurons from WT mice but not those from P2X7R KO mice exposed to MIA. Likewise, only MIA-exposed WT mice displayed schizophrenia-like behavioral and cognitive deficits. Therefore, we conclude that P2X7R has different roles in the development of hippocampal dendritic arborization under physiological and pathologic conditions. LA - English DB - MTMT ER - TY - THES AU - Tod, Pál TI - Functional recovery of the post-ischemic kidney after delayed contralateral nephrectomy: Pivotal role of inflammation and miRNAs PY - 2022 SP - 107 DO - 10.14753/SE.2022.2613 UR - https://m2.mtmt.hu/api/publication/32851632 ID - 32851632 LA - English DB - MTMT ER - TY - JOUR AU - Kristóf, Zsüliet AU - Baranyi, Mária AU - Tod, Pál AU - Mut-Arbona, Paula AU - Demeter, Kornél AU - Bitter, István AU - Sperlágh, Beáta TI - Elevated serum purine levels in schizophrenia: a reverse translational study to identify novel inflammatory biomarkers JF - INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY J2 - INT J NEUROPSYCHOPH VL - 25 PY - 2022 IS - 8 SP - 645 EP - 659 PG - 15 SN - 1461-1457 DO - 10.1093/ijnp/pyac026 UR - https://m2.mtmt.hu/api/publication/32791102 ID - 32791102 N1 - Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Budapest, Hungary Doctoral School of Mental Health Sciences, United States János Szentágothai Neuroscience Doctoral School, Hungary Semmelweis University, Budapest, Hungary Behavior Unit, Institute of Experimental Medicine, Budapest, Hungary Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary Cited By :4 Export Date: 5 November 2023 CODEN: IJNUF Correspondence Address: Sperlágh, B.Szigony 43, Hungary; email: sperlagh@koki.hu Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; adenosine, 58-61-7; adenosine diphosphate, 20398-34-9, 58-64-0; adenosine triphosphate, 15237-44-2, 56-65-5, 987-65-5; aripiprazole, 129722-12-9; C reactive protein, 9007-41-4; cariprazine, 839712-12-8, 1083076-69-0, 955400-75-6; clozapine, 5786-21-0; haloperidol, 52-86-8, 1511-16-6; heparin, 37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5, 9041-08-1; interleukin 12, 138415-13-1; interleukin 8, 114308-91-7; isoflurane, 26675-46-7; lithium, 7439-93-2; olanzapine, 132539-06-1, 221373-09-7, 221373-18-8; phencyclidine, 77-10-1, 956-90-1; purine, 120-73-0; quetiapine, 111974-72-2, 111974-69-7; risperidone, 106266-06-2; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Biomarkers; Interleukin-12; Interleukin-1beta; Interleukin-6; Purines Manufacturers: Flarebio, United States; MyBioSource, United States Funding details: 131629 Funding details: Horizon 2020 Framework Programme, H2020, 766124 Funding text 1: The authors are grateful for the colleagues at the 3 participating psychiatric wards (Department of Psychiatry and Psychotherapy, Semmelweis University; Department of Psychiatry and Psychiatric Rehabilitation, Jahn Ferenc Hospital; Saint John Hospital); for the colleagues of the Department of Otorhinolaryngology and Laboratory Medicine, Semmelweis University for helping with the blood collection; and for Springer Nature Author Services for the language editing. This work was supported by the Hungarian Research and Development Fund (grant no. 131629), the Hungarian Brain Research Program (2017-1.2.1-NKP-2017-00002 awarded to B.S. [laboratory studies] and to I.B. [clinical study]), and the European Union’s Horizon 2020 Research and Innovation Program Marie Skłodowska Curie grant (no. 766124). LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Dorottya AU - Tod, Pál AU - Gölöncsér, Flóra AU - Román, Viktor AU - Lendvai, Balázs AU - Bereczkiné Otrokocsi, Lilla AU - Sperlágh, Beáta TI - Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1β pathway. JF - BRAIN BEHAVIOR AND IMMUNITY J2 - BRAIN BEHAV IMMUN VL - 101 PY - 2022 SP - 318 EP - 332 PG - 15 SN - 0889-1591 DO - 10.1016/j.bbi.2022.01.015 UR - https://m2.mtmt.hu/api/publication/32624327 ID - 32624327 N1 - L AB - Autism spectrum disorder (ASD) is a complex neurodevelopmental condition caused by interactions of environmental and genetic factors. Recently we showed that activation of the purinergic P2X7 receptors is necessary and sufficient to convert maternal immune activation (MIA) to ASD-like features in male offspring mice. Our aim was to further substantiate these findings and identify downstream signaling pathways coupled to P2X7 upon MIA. Maternal treatment with the NLRP3 antagonist MCC950 and a neutralising IL-1β antibody during pregnancy counteracted the development of autistic characteristics in offspring mice. We also explored time-dependent changes of a widespread cytokine and chemokine profile in maternal blood and fetal brain samples of poly(I:C)/saline-treated dams. MIA-induced increases in plasma IL-1β, RANTES, MCP-1, and fetal brain IL-1β, IL-2, IL-6, MCP-1 concentrations are regulated by the P2X7/NLRP3 pathway. Offspring treatment with the selective P2X7 receptor antagonist JNJ47965567 was effective in the prevention of autism-like behavior in mice using a repeated dosing protocol. Our results highlight that in addition to P2X7, NLRP3, as well as inflammatory cytokines, may also be potential biomarkers and therapeutic targets of social deficits and repetitive behaviors observed in autism spectrum disorder. LA - English DB - MTMT ER - TY - JOUR AU - Kaucsár, Tamás AU - Róka, Beáta AU - Tod, Pál AU - Do, Thanh Phuong AU - Hegedűs, Zoltán AU - Szénási, Gábor AU - Hamar, Péter TI - Divergent regulation of lncRNA expression by ischemia in adult and aging mice. JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 44 PY - 2022 IS - 1 SP - 429 EP - 445 PG - 17 SN - 2509-2715 DO - 10.1007/s11357-021-00460-9 UR - https://m2.mtmt.hu/api/publication/32470555 ID - 32470555 N1 - * Megosztott szerzőség AB - Elderly patients have increased susceptibility to acute kidney injury (AKI). Long noncoding RNAs (lncRNA) are key regulators of cellular processes, and have been implicated in both aging and AKI. Our aim was to study the effects of aging and ischemia-reperfusion injury (IRI) on the renal expression of lncRNAs. Adult and old (10- and 26-30-month-old) C57BL/6 N mice were subjected to unilateral IRI followed by 7 days of reperfusion. Renal expression of 90 lncRNAs and mRNA expression of injury, regeneration, and fibrosis markers was measured by qPCR in the injured and contralateral control kidneys. Tubular injury, regeneration, and fibrosis were assessed by histology. Urinary lipocalin-2 excretion was increased in old mice prior to IRI, but plasma urea was similar. In the control kidneys of old mice tubular cell necrosis and apoptosis, mRNA expression of kidney injury molecule-1, fibronectin-1, p16, and p21 was elevated. IRI increased plasma urea concentration only in old mice, but injury, regeneration, and fibrosis scores and their mRNA markers were similar in both age groups. AK082072 and Y lncRNAs were upregulated, while H19 and RepA transcript were downregulated in the control kidneys of old mice. IRI upregulated Miat, Igf2as, SNHG5, SNHG6, RNCR3, Malat1, Air, Linc1633, and Neat1 v1, while downregulated Linc1242. LncRNAs H19, AK082072, RepA transcript, and Six3os were influenced by both aging and IRI. Our results indicate that both aging and IRI alter renal lncRNA expression suggesting that lncRNAs have a versatile and complex role in aging and kidney injury. An Ingenuity Pathway Analysis highlighted that the most downregulated H19 may be linked to aging/senescence through p53. LA - English DB - MTMT ER - TY - JOUR AU - Tod, Pál AU - Borbásné Farkas, Kornélia AU - Németh, Dávid AU - Szénási, Gábor AU - Vincze, Áron AU - Hágendorn, Roland AU - Czakó, László AU - Illés, Dóra AU - Izbéki, Ferenc AU - Dunás-Varga, Veronika AU - Papp, Mária AU - Hamvas, József AU - Varga, Márta AU - Gombos, Katalin AU - Nagy, Tamás AU - Márton, Zsolt AU - Faluhelyi, Nándor AU - Török, Imola AU - Ince, Ali Tüzün AU - Galeev, Shamil AU - Hegyi, Péter Jenő AU - Szentesi, Andrea Ildikó AU - Párniczky, Andrea AU - Szakács, Zsolt AU - Hegyi, Péter AU - Hamar, Péter TI - Initial Renal Function (eGFR) Is a Prognostic Marker of Severe Acute Pancreatitis: A Cohort-Analysis of 1,224 Prospectively Collected Cases JF - FRONTIERS IN MEDICINE J2 - FRONT MED VL - 8 PY - 2021 PG - 10 SN - 2296-858X DO - 10.3389/fmed.2021.671917 UR - https://m2.mtmt.hu/api/publication/32153531 ID - 32153531 N1 - Szentágothai Research Centre, Medical School, Institute for Translational Medicine, University of Pécs, Pécs, Hungary School of Medicine, Institute of Translational Medicine, Semmelweis University, Budapest, Hungary Division of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary Department of Medicine, University of Szeged, Szeged, Hungary Szent György University Teaching Hospital of Fejér County, Székesfehérvár, Hungary Division of Gastroenterology, Department of Internal Medicine, University of Debrecen, Debrecen, Hungary Peterfy Hospital, Budapest, Hungary Dr. Réthy Pál Hospital, Békéscsaba, Hungary Department of Laboratory Medicine, Medical School, University of Pécs, Pécs, Hungary Department of Radiology, Medical School, University of Pécs, Pécs, Hungary County Emergency Clinical Hospital - Gastroenterology, University of Medicine, Pharmacy, Sciences and Technology, Târgu Mureṣ, Romania School of Medicine, Hospital of Bezmialem Vakif University, Istanbul, Turkey Saint Luke Clinical Hospital, St. Petersburg, Russian Federation Department of Medicine, Centre for Translational Medicine, University of Szeged, Szeged, Hungary Heim Pál National Pediatric Institute, Budapest, Hungary Centre for Translational Medicine, Medical School, Semmelweis University, Budapest, Hungary Division of Pancreatic Diseases, Heart and Vascular Center, Medical School, Semmelweis University, Budapest, Hungary Cited By :4 Export Date: 26 January 2024 Correspondence Address: Hamar, P.; Szentágothai Research Centre, Hungary; email: hampet@net.sote.hu LA - English DB - MTMT ER - TY - JOUR AU - Róka, Beáta AU - Tod, Pál AU - Kaucsár, Tamás AU - Bukosza, Éva Nóra AU - Vörös, Imre AU - Varga, Zoltán AU - Petrovich, Balázs AU - Ágg, Bence AU - Ferdinandy, Péter AU - Szénási, Gábor AU - Hamar, Péter TI - Delayed Contralateral Nephrectomy Halted Post-Ischemic Renal Fibrosis Progression and Inhibited the Ischemia-Induced Fibromir Upregulation in Mice JF - BIOMEDICINES J2 - BIOMEDICINES VL - 9 PY - 2021 IS - 7 PG - 19 SN - 2227-9059 DO - 10.3390/biomedicines9070815 UR - https://m2.mtmt.hu/api/publication/32122064 ID - 32122064 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Révész, Csaba AU - Wasik, Anita A. AU - Godó, Mária AU - Tod, Pál AU - Lehtonen, Sanna AU - Szénási, Gábor AU - Hamar, Péter TI - Cold Saline Perfusion before Ischemia-Reperfusion Is Harmful to the Kidney and Is Associated with the Loss of Ezrin, a Cytoskeletal Protein, in Rats JF - BIOMEDICINES J2 - BIOMEDICINES VL - 9 PY - 2021 IS - 1 PG - 12 SN - 2227-9059 DO - 10.3390/biomedicines9010030 UR - https://m2.mtmt.hu/api/publication/31797383 ID - 31797383 N1 - * Megosztott szerzőség LA - English DB - MTMT ER -