@article{MTMT:34687262,
	title = {Preparation, characterization and in vitro evaluation of the antimicrobial and antitumor activity of MnOx nanoparticles},
	url = {https://m2.mtmt.hu/api/publication/34687262},
	author = {Rónavári, Andrea and Ochirkhuyag, Altantuya and Igaz, Nóra and Szerencsés, Bettina and Ballai, Gergő and Huliák, Ildikó and Bocz, Csenge and Kovács, Ákos and Pfeiffer, Ilona and Csontné Kiricsi, Mónika and Kónya, Zoltán},
	doi = {10.1016/j.colsurfa.2024.133528},
	journal-iso = {COLLOID SURFACE A},
	journal = {COLLOIDS AND SURFACES A : PHYSICOCHEMICAL AND ENGINEERING ASPECTS},
	volume = {688},
	unique-id = {34687262},
	issn = {0927-7757},
	year = {2024},
	eissn = {1873-4359},
	orcid-numbers = {Rónavári, Andrea/0000-0001-7054-0975; Ochirkhuyag, Altantuya/0000-0001-6495-7360; Igaz, Nóra/0000-0003-1580-4397; Pfeiffer, Ilona/0000-0003-0680-7596; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Kónya, Zoltán/0000-0002-9406-8596}
}

@CONFERENCE{MTMT:34154600,
	title = {The possible modulatory effects of metal nanoparticles on macrophage polarization in co-culture},
	url = {https://m2.mtmt.hu/api/publication/34154600},
	author = {Adamecz, Dóra Izabella and Petra, Bicskei and Árva, Hédi and Igaz, Nóra and Veres, Éva and Rónavári, Andrea and Gácser, Attila and Kónya, Zoltán and Csontné Kiricsi, Mónika},
	booktitle = {Abstracts for the 47th FEBS Congress},
	unique-id = {34154600},
	year = {2023},
	orcid-numbers = {Adamecz, Dóra Izabella/0000-0002-1883-9600; Igaz, Nóra/0000-0003-1580-4397; Rónavári, Andrea/0000-0001-7054-0975; Kónya, Zoltán/0000-0002-9406-8596; Csontné Kiricsi, Mónika/0000-0002-8416-2052}
}

@CONFERENCE{MTMT:34154565,
	title = {Radiosensitizing effect of metal nanoparticles in combination with histone deacetylase inhibitors},
	url = {https://m2.mtmt.hu/api/publication/34154565},
	author = {Igaz, Nóra and Szőke, Krisztina and Bocz, Csenge and Kovács, Dávid and Rónavári, Andrea and Szabó, Emilia Rita and Polanek, Róbert and Buhala, Andrea and Vizler, Csaba and Tiszlavicz, László and Rázga, Zsolt and Hideghéty, Katalin and Kónya, Zoltán and Csontné Kiricsi, Mónika},
	booktitle = {FAMÉ 2023},
	unique-id = {34154565},
	year = {2023},
	pages = {75-76},
	orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Rónavári, Andrea/0000-0001-7054-0975; Szabó, Emilia Rita/0000-0003-3611-2066; Polanek, Róbert/0000-0003-3645-8331; Tiszlavicz, László/0000-0003-1134-6587; Rázga, Zsolt/0000-0003-4717-8482; Hideghéty, Katalin/0000-0001-7080-2365; Kónya, Zoltán/0000-0002-9406-8596; Csontné Kiricsi, Mónika/0000-0002-8416-2052}
}

@article{MTMT:34067381,
	title = {Phase-separated ribosome-nascent chain complexes in genotoxic stress response},
	url = {https://m2.mtmt.hu/api/publication/34067381},
	author = {Szatmári, Orsolya and Nagy-Mikó, Bence and Györkei, Ádám and Varga, Dániel and H. Kovács, Bálint Barna and Igaz, Nóra and Bognár, Bence and Rázga, Zsolt and Nagy, Gábor and Zsindely, Nóra and Bodai, László and Papp, Balázs and Erdélyi, Miklós and Csontné Kiricsi, Mónika and Blastyák, András and Collart, Martine A and Boros, Imre Miklós and Villanyi, Zoltan},
	doi = {10.1261/rna.079755.123},
	journal-iso = {RNA},
	journal = {RNA-A PUBLICATION OF THE RNA SOCIETY},
	volume = {29},
	unique-id = {34067381},
	issn = {1355-8382},
	abstract = {Assemblysomes are EDTA- and RNase-resistant ribonucleoprotein (RNP) complexes of paused ribosomes with protruding nascent polypeptide chains. They have been described in yeast and human cells for the proteasome subunit Rpt1, and the disordered N-terminal part of the nascent chain was found to be indispensable for the accumulation of the Rpt1-RNP into assemblysomes. Motivated by this, to find other assemblysome-associated RNPs we used bioinformatics to rank subunits of Saccharomyces cerevisiae protein complexes according to their N-terminal disorder propensity. The results revealed that gene products involved in DNA repair are enriched among the top candidates. The Sgs1 DNA helicase was chosen for experimental validation. We found that indeed nascent chains of Sgs1 form EDTA-resistant RNP condensates, assemblysomes by definition. Moreover, upon exposure to UV, SGS1 mRNA shifted from assemblysomes to polysomes, suggesting that external stimuli are regulators of assemblysome dynamics. We extended our studies to human cell lines. The BLM helicase, ortholog of yeast Sgs1, was identified upon sequencing assemblysome-associated RNAs from the MCF7 human breast cancer cell line, and mRNAs encoding DNA repair proteins were overall enriched. Using the radiation-resistant A549 cell line, we observed by transmission electron microscopy that 1,6-hexanediol, an agent known to disrupt phase-separated condensates, depletes ring ribosome structures compatible with assemblysomes from the cytoplasm of cells and makes the cells more sensitive to X-ray treatment. Taken together these findings suggest that assemblysomes may be a component of the DNA damage response from yeast to human.},
	year = {2023},
	eissn = {1469-9001},
	pages = {1557-1574},
	orcid-numbers = {Varga, Dániel/0000-0003-0391-5057; Igaz, Nóra/0000-0003-1580-4397; Rázga, Zsolt/0000-0003-4717-8482; Nagy, Gábor/0000-0001-5464-1135; Zsindely, Nóra/0000-0002-6189-3100; Bodai, László/0000-0001-8411-626X; Erdélyi, Miklós/0000-0002-9501-5752; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Boros, Imre Miklós/0000-0001-8504-9687}
}

@article{MTMT:33416616,
	title = {Estradiol-Based Salicylaldehyde (Thio)semicarbazones and Their Copper Complexes with Anticancer, Antibacterial and Antioxidant Activities},
	url = {https://m2.mtmt.hu/api/publication/33416616},
	author = {Petrasheuskaya, Tatsiana and Kovács, Ferenc and Igaz, Nóra and Rónavári, Andrea and Hajdu, Bálint and Nagyné Bereczki, Laura and May, Nóra Veronika and Spengler, Gabriella and Gyurcsik, Béla and Csontné Kiricsi, Mónika and Nagyné Frank, Éva and Enyedy, Éva Anna},
	doi = {10.3390/molecules28010054},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {28},
	unique-id = {33416616},
	issn = {1420-3049},
	abstract = {A series of novel estradiol-based salicylaldehyde (thio)semicarbazones ((T)SCs) bearing (O,N,S) and (O,N,O) donor sets and their Cu(II) complexes were developed and characterized in detail by 1H and ¹³C nuclear magnetic resonance spectroscopy, UV–visible and electron paramagnetic resonance spectroscopy, electrospray ionization mass spectrometry and elemental analysis. The structure of the Cu(II)-estradiol-semicarbazone complex was revealed by X-ray crystallography. Proton dissociation constants of the ligands and stability constants of the metal complexes were determined in 30% (v/v) DMSO/H2O. Estradiol-(T)SCs form mono-ligand complexes with Cu(II) ions and exhibit high stability with the exception of estradiol-SC. The Cu(II) complexes of estradiol-TSC and its N,N-dimethyl derivative displayed the highest cytotoxicity among the tested compounds in MCF-7, MCF-7 KCR, DU-145, and A549 cancer cells. The complexes do not damage DNA according to both in vitro cell-free and cellular assays. All the Cu(II)-TSC complexes revealed significant activity against the Gram-positive Staphylococcus aureus bacteria strain. Estradiol-TSCs showed efficient antioxidant activity, which was decreased by complexation with Cu(II) ions. The exchange of estrone moiety to estradiol did not result in significant changes to physico-chemical and biological properties.},
	year = {2023},
	eissn = {1420-3049},
	orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Rónavári, Andrea/0000-0001-7054-0975; May, Nóra Veronika/0000-0003-4770-4681; Spengler, Gabriella/0000-0001-8085-0950; Gyurcsik, Béla/0000-0003-1894-7414; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Nagyné Frank, Éva/0000-0002-1332-0551; Enyedy, Éva Anna/0000-0002-8058-8128}
}

@article{MTMT:33003489,
	title = {Functionalized Mesoporous Silica Nanoparticles for Drug-Delivery to Multidrug-Resistant Cancer Cells},
	url = {https://m2.mtmt.hu/api/publication/33003489},
	author = {Igaz, Nóra and Bélteky, Péter and Kovács, Dávid and Papp, Csaba Gergő and Rónavári, Andrea and Szabó, Diána and Gácser, Attila and Kónya, Zoltán and Csontné Kiricsi, Mónika},
	doi = {10.2147/IJN.S363952},
	journal-iso = {INT J NANOMED},
	journal = {INTERNATIONAL JOURNAL OF NANOMEDICINE},
	volume = {17},
	unique-id = {33003489},
	issn = {1176-9114},
	abstract = {Background: Multidrug resistance is a common reason behind the failure of chemotherapy. Even if the therapy is effective, serious adverse effects might develop due to the low specificity and selectivity of antineoplastic agents. Mesoporous silica nanoparticles (MSNs) are promising materials for tumor-targeting and drug-delivery due to their small size, relatively inert nature, and extremely large specific surfaces that can be functionalized by therapeutic and targeting entities. We aimed to create a fluorescently labeled MSN-based drug-delivery system and investigate their internalization and drug-releasing capability in drug-sensitive MCF-7 and P-glycoprotein-overexpressing multidrug-resistant MCF-7 KCR cancer cells.Methods and Results: To track the uptake and subcellular distribution of MSNs, particles with covalently coupled red fluorescent Rhodamine B (RhoB) were produced (RhoB@MSNs). Both MCF-7 and MCF-7 KCR cells accumulated a significant amount of RhoB@MSNs. The intracellular RhoB@MSN concentrations did not differ between sensitive and multidrug-resistant cells and were kept at the same level even after cessation of RhoB@MSN exposure. Although most RhoB@MSNs resided in the cytoplasm, significantly more RhoB@MSNs co-localized with lysosomes in multidrug-resistant cells compared to sensitive counterparts. To examine the drug-delivery capability of these particles, RhoB@Rho123@MSNs were established, where RhoB-functionalized nanoparticles carried green fluorescent Rhodamine 123 (Rho123) -a P-glycoprotein substrate - as cargo within mesopores. Significantly higher Rho123 fluorescence intensity was detected in RhoB@Rho123@MSN-treated multidrug-resistant cells than in free Rho123-exposed counterparts. The exceptional drug-delivery potential of MSNs was further verified using Mitomycin C (MMC)-loaded RhoB@MSNs (RhoB@MMC@MSNs). Exposures to RhoB@MMC@MSNs significantly decreased the viability not only of drug-sensitive but of multidrug-resistant cells and the elimination of MDR cells was significantly more robust than upon free MMC treatments.Conclusion: The efficient delivery of Rho123 and MMC to multidrug-resistant cells via MSNs, the amplified and presumably prolonged intracellular drug concentration, and the consequently enhanced cytotoxic effects envision the enormous potential of MSNs to defeat multidrug-resistant cancer.},
	year = {2022},
	eissn = {1178-2013},
	pages = {3079-3096},
	orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Papp, Csaba Gergő/0000-0003-4450-0667; Rónavári, Andrea/0000-0001-7054-0975; Kónya, Zoltán/0000-0002-9406-8596; Csontné Kiricsi, Mónika/0000-0002-8416-2052}
}

@misc{MTMT:32783378,
	title = {Phase separated ribosome nascent chain complexes paused in translation are capable to continue expression of proteins playing role in genotoxic stress response upon DNA damage},
	url = {https://m2.mtmt.hu/api/publication/32783378},
	author = {Szatmári, Orsolya and Györkei, Á and Varga, Dániel and H. Kovács, Bálint Barna and Igaz, Nóra and Német, K and Bagi, N and Nagy-Mikó, B and Balogh, D and Rázga, Zsolt and Erdélyi, Miklós and Papp, B and Csontné Kiricsi, Mónika and Blastyák, A and Collart, MA and Boros, Imre Miklós and Villanyi, Zoltan},
	doi = {10.1101/2022.03.16.484567},
	unique-id = {32783378},
	year = {2022},
	orcid-numbers = {Varga, Dániel/0000-0003-0391-5057; Igaz, Nóra/0000-0003-1580-4397; Rázga, Zsolt/0000-0003-4717-8482; Erdélyi, Miklós/0000-0002-9501-5752; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Boros, Imre Miklós/0000-0001-8504-9687}
}

@article{MTMT:32607262,
	title = {Candida albicans Enhances the Progression of Oral Squamous Cell Carcinoma In Vitro and In Vivo},
	url = {https://m2.mtmt.hu/api/publication/32607262},
	author = {Vadovics, Máté and Ho, Jemima and Igaz, Nóra and Alföldi, Róbert and Rakk, Dávid and Veres, Éva and Szücs, Balázs and Horváth, Márton and Tóth, Renáta and Szűcs, Attila and Csibi, Andrea and Horváth, Péter and Tiszlavicz, László and Vágvölgyi, Csaba and Nosanchuk, Joshua D. and Szekeres, András and Csontné Kiricsi, Mónika and Henley-Smith, Rhonda and Moyes, David L. and Thavaraj, Selvam and Brown, Rhys and Puskás, László and Naglik, Julian R. and Gácser, Attila},
	doi = {10.1128/mBio.03144-21},
	journal-iso = {MBIO},
	journal = {MBIO},
	volume = {13},
	unique-id = {32607262},
	issn = {2161-2129},
	abstract = {Oral squamous cell carcinoma (OSCC) is associated with oral Candida albicans infection, although it is unclear whether the fungus promotes the genesis and progression of OSCC or whether cancer facilitates fungal growth. In this study, we investigated whether C. albicans can potentiate OSCC tumor development and progression. In vitro, the presence of live C. albicans, but not Candida parapsilosis, enhanced the progression of OSCC by stimulating the production of matrix metalloproteinases, oncometabolites, protumor signaling pathways, and overexpression of prognostic marker genes associated with metastatic events. C. albicans also upregulated oncogenes in nonmalignant cells. Using a newly established xenograft in vivo mouse model to investigate OSCC-C. albicans interactions, oral candidiasis enhanced the progression of OSCC through inflammation and induced the overexpression of metastatic genes and significant changes in markers of the epithelial-mesenchymal transition. Finally, using the 4-nitroquinoline 1-oxide (4NQO) murine model, we directly correlate these in vitro and short-term in vivo findings with the progression of oncogenesis over the long term. Taken together, these data indicate that C. albicans upregulates oncogenes, potentiates a premalignant phenotype, and is involved in early and late stages of malignant promotion and progression of oral cancer. IMPORTANCE Oral squamous cell carcinoma (OSCC) is a serious health issue worldwide that accounts for 2% to 4% of all cancer cases. Previous studies have revealed a higher yeast carriage and diversity in oral cancer patients than in healthy individuals. Furthermore, fungal colonization in the oral cavity bearing OSCC is higher on the neoplastic epithelial surface than on adjacent healthy surfaces, indicating a positive association between oral yeast carriage and epithelial carcinoma. In addition to this, there is strong evidence supporting the idea that Candida contributes to carcinogenesis events in the oral cavity. Here, we show that an increase in Candida albicans burden promotes an oncogenic phenotype in the oral cavity. Copyright © 2022 Vadovics et al.},
	keywords = {CANCER; Candida albicans; Progression; Oral squamous cell carcinoma},
	year = {2022},
	eissn = {2150-7511},
	orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Tóth, Renáta/0000-0001-7395-0689; Szűcs, Attila/0000-0003-2803-7123; Tiszlavicz, László/0000-0003-1134-6587; Vágvölgyi, Csaba/0000-0003-0009-7773; Szekeres, András/0000-0003-1651-4623; Csontné Kiricsi, Mónika/0000-0002-8416-2052}
}

@article{MTMT:32592254,
	title = {Cancer Therapy by Silver Nanoparticles: Fiction or Reality?},
	url = {https://m2.mtmt.hu/api/publication/32592254},
	author = {Kovács, Dávid and Igaz, Nóra and Gopisetty, Mohana Krishna and Csontné Kiricsi, Mónika},
	doi = {10.3390/ijms23020839},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {32592254},
	issn = {1661-6596},
	abstract = {As an emerging new class, metal nanoparticles and especially silver nanoparticles hold great potential in the field of cancer biology. Due to cancer-specific targeting, the consequently attenuated side-effects and the massive anti-cancer features render nanoparticle therapeutics desirable platforms for clinically relevant drug development. In this review, we highlight those characteristics of silver nanoparticle-based therapeutic concepts that are unique, exploitable, and achievable, as well as those that represent the critical hurdle in their advancement to clinical utilization. The collection of findings presented here will describe the features that distinguish silver nanoparticles from other anti-cancer agents and display the realistic opportunities and implications in oncotherapeutic innovations to find out whether cancer therapy by silver nanoparticles is fiction or reality.},
	year = {2022},
	eissn = {1422-0067},
	orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Gopisetty, Mohana Krishna/0000-0002-4310-3478; Csontné Kiricsi, Mónika/0000-0002-8416-2052}
}

@{MTMT:33104916,
	title = {The role of mitoprotection in the cytoprotective effect of kynurenic acid against simulated ischemia/reoxygenation-induced cardiac cell damage},
	url = {https://m2.mtmt.hu/api/publication/33104916},
	author = {Nógrádi-Halmi, Dóra and Molnár-Gáspár, Renáta and Diószegi, Petra and Csontné Kiricsi, Mónika and Igaz, Nóra and Roland, Patai and Tamás, Polgár and László, Juhász and Csont, Tamás Bálint},
	booktitle = {Hungarian Molecular Life Sciences 2021},
	unique-id = {33104916},
	year = {2021},
	pages = {140},
	orcid-numbers = {Nógrádi-Halmi, Dóra/0000-0001-9496-9354; Molnár-Gáspár, Renáta/0000-0001-9673-4532; Diószegi, Petra/0000-0001-8109-2266; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Igaz, Nóra/0000-0003-1580-4397; Csont, Tamás Bálint/0000-0001-5792-2768}
}