@CONFERENCE{MTMT:34826051, title = {A Retinoprotective Compound in Type 2 Diabetes Mellitus}, url = {https://m2.mtmt.hu/api/publication/34826051}, author = {Molitor, Dorottya and Dénes , Diána and Váczy, Alexandra and Lina, Li and Mérész, Balázs and Réka, Radics and Patkó, Evelin Viktória and Szabó, Edina and Reglődi, Dóra and Atlasz, Tamás}, booktitle = {Absztraktkötet: XII. Interdiszciplináris Doktorandusz Konferencia = Book of Abstract: XII. Interdisciplinary Doctoral Conference}, unique-id = {34826051}, year = {2024}, pages = {144-144}, orcid-numbers = {Atlasz, Tamás/0000-0002-8112-8633} } @CONFERENCE{MTMT:34825988, title = {The Protective Effect of PACAP38 in Type 2 Diabetic Retinal Disease}, url = {https://m2.mtmt.hu/api/publication/34825988}, author = {Lina, Li and Patkó, Evelin Viktória and Varga, András and Dénes , Diána and Molitor, Dorottya and Szabó, Edina and Mérész, Balázs and Reglődi, Dóra and Váczy, Alexandra and Atlasz, Tamás}, booktitle = {Absztraktkötet: XII. Interdiszciplináris Doktorandusz Konferencia = Book of Abstract: XII. Interdisciplinary Doctoral Conference}, unique-id = {34825988}, year = {2024}, pages = {81-81}, orcid-numbers = {Atlasz, Tamás/0000-0002-8112-8633} } @CONFERENCE{MTMT:34566473, title = {Examination of retinoprotective compound in type 2 diabetes mellitus}, url = {https://m2.mtmt.hu/api/publication/34566473}, author = {Dénes , Diána and Váczy, Alexandra and Li, Lina and Molitor, Dorottya and Varga, András and Reka, Radics and Patkó, Evelin Viktória and Szabó, Edina and Reglődi, Dóra and Atlasz, Tamás}, booktitle = {7th Hungarian Neuroscience Doctoral Conference for Undergraduate Students, Graduate Students and Junior Post-Docs (HUNDOC) Booklet}, unique-id = {34566473}, year = {2024}, pages = {29-29}, orcid-numbers = {Atlasz, Tamás/0000-0002-8112-8633} } @CONFERENCE{MTMT:34566439, title = {Negative Effects of Maternal Smoking on Retinopathy of Prematurity}, url = {https://m2.mtmt.hu/api/publication/34566439}, author = {Molitor, Dorottya and Váczy, Alexandra and Szabó, Edina and Patkó, Evelin Viktória and Mérész, Balázs and Reglődi, Dóra and Atlasz, Tamás}, booktitle = {7th Hungarian Neuroscience Doctoral Conference for Undergraduate Students, Graduate Students and Junior Post-Docs (HUNDOC) Booklet}, unique-id = {34566439}, year = {2024}, pages = {73-73}, orcid-numbers = {Atlasz, Tamás/0000-0002-8112-8633} } @CONFERENCE{MTMT:34566361, title = {The Protective Effect of PACAP38 in Type 2 Diabetic Retinal Disease}, url = {https://m2.mtmt.hu/api/publication/34566361}, author = {Li, Lina and Patkó, Evelin Viktória and Varga, András and Dénes , Diána and Molitor, Dorottya and Szabó, Edina and Mérész, Balázs and Reglődi, Dóra and Váczy, Alexandra and Atlasz, Tamás}, booktitle = {7th Hungarian Neuroscience Doctoral Conference for Undergraduate Students, Graduate Students and Junior Post-Docs (HUNDOC) Booklet}, unique-id = {34566361}, year = {2024}, pages = {66-66}, orcid-numbers = {Atlasz, Tamás/0000-0002-8112-8633} } @article{MTMT:34542678, title = {Investigation of PACAP38 and PAC1 Receptor Expression in Human Retinoblastoma and the Effect of PACAP38 Administration on Human Y-79 Retinoblastoma Cells}, url = {https://m2.mtmt.hu/api/publication/34542678}, author = {Tóth, Dénes and Fábián, Eszter and Szabó, Edina and Patkó, Evelin Viktória and Vicena, Viktória and Váczy, Alexandra and Atlasz, Tamás and Tornóczky, Tamás and Reglődi, Dóra}, doi = {10.3390/life14020185}, journal-iso = {LIFE-BASEL}, journal = {LIFE-BASEL}, volume = {14}, unique-id = {34542678}, abstract = {Retinoblastoma represents the most prevalent malignant neoplasm affecting the eyes in childhood. The clear-cut origin of retinoblastoma has not yet been determined; however, based on experiments, it has been suggested that RB1 loss in cone photoreceptors causes retinoblastoma. Pituitary adenylate-cyclase activating polypeptide (PACAP) is a pleiotropic neuropeptide which has been shown to be affected in certain tumorous transformations, such as breast, lung, kidney, pancreatic, colon, and endocrine cancers. This study aimed to investigate potential changes in both PACAP38 and PAC1 receptor (PAC1R) expression in human retinoblastoma and the effect of PACAP38 administration on the survival of a human retinoblastoma cell line (Y-79). We analyzed human enucleation specimens removed because of retinoblastoma for PACAP38 and PAC1R immunostaining and the effect of PACAP38 on the survival of the Y-79 cell line. We described for the first time that human retinoblastoma cells from patients showed only perinuclear, dot-like immunopositivity for both PACAP38 and PAC1R, irrespective of laterality, genetic background, or histopathological features. Nanomolar (100 nM and 500 nM) PACAP38 concentrations had no effect on the viability of Y-79 cells, while micromolar (2 µM and 6 µM) PACAP38 significantly decreased tumor cell viability. These findings, along with general observations from animal studies showing that PACAP38 has strong anti-apoptotic, anti-inflammatory, and antioxidant effects on ocular tissues, together suggest that PACAP38 and its analogs are promising candidates in retinoblastoma therapy.}, keywords = {immunohistochemistry; PACAP; Cell Survival; Cell viability; retinoblastoma; enucleation}, year = {2024}, eissn = {2075-1729}, orcid-numbers = {Tóth, Dénes/0000-0002-9074-3478; Atlasz, Tamás/0000-0002-8112-8633} } @CONFERENCE{MTMT:34566722, title = {Retinoprotektív vegyületek vizsgálata 2-es típusú diabétesz mellitusban}, url = {https://m2.mtmt.hu/api/publication/34566722}, author = {Radics, Réka and Dénes , Diána and Váczy, Alexandra and Li, Lina and Molitor, Dorottya and Varga, András and Patkó, Evelin Viktória and Szabó, Edina and Reglődi, Dóra and Atlasz, Tamás}, booktitle = {A Magyar Anatómus Társaság 2023. évi konferenciája}, unique-id = {34566722}, year = {2023}, pages = {97-98}, orcid-numbers = {Atlasz, Tamás/0000-0002-8112-8633} } @CONFERENCE{MTMT:34566700, title = {Növényi hormonok hatásának vizsgálata iszkémiás retinopátiában}, url = {https://m2.mtmt.hu/api/publication/34566700}, author = {Mérész, Balázs and Bosnyák, Inez and Molitor, Dorottya and Li, Lina and Patkó, Evelin Viktória and Szabó, Edina and Nagy, Ágnes and Reglődi, Dóra and Atlasz, Tamás and Váczy, Alexandra}, booktitle = {A Magyar Anatómus Társaság 2023. évi konferenciája}, unique-id = {34566700}, year = {2023}, pages = {95-96}, orcid-numbers = {Atlasz, Tamás/0000-0002-8112-8633} } @CONFERENCE{MTMT:34566689, title = {PACAP fragmens hatása glaukóma patkánymodellben}, url = {https://m2.mtmt.hu/api/publication/34566689}, author = {Patkó, Evelin Viktória and Szabó, Edina and Váczy, Alexandra and Molitor, Dorottya and Tóth, Gábor and Reglődi, Dóra and Atlasz, Tamás}, booktitle = {A Magyar Anatómus Társaság 2023. évi konferenciája}, unique-id = {34566689}, year = {2023}, pages = {91-92}, orcid-numbers = {Atlasz, Tamás/0000-0002-8112-8633} } @CONFERENCE{MTMT:34566660, title = {A terhesség alatti dohányzás hatása a koraszülött retinopátiára}, url = {https://m2.mtmt.hu/api/publication/34566660}, author = {Molitor, Dorottya and Váczy, Alexandra and Szabó, Edina and Patkó, Evelin Viktória and Mérész, Balázs and Reglődi, Dóra and Atlasz, Tamás}, booktitle = {A Magyar Anatómus Társaság 2023. évi konferenciája}, unique-id = {34566660}, year = {2023}, pages = {84-85}, orcid-numbers = {Atlasz, Tamás/0000-0002-8112-8633} }