@article{MTMT:34538619, title = {P674 Real-world experiences of switching to subcutaneous formulation in IBD patients on maintenance vedolizumab treatment}, url = {https://m2.mtmt.hu/api/publication/34538619}, author = {Bacsur, Péter and Resál, Tamás and Farkas, Bernadett and Sarlós, P and Iliás, Á and Kata, Diána and Bálint, Anita and Fábián, Anna and Bor, Renáta and Szepes, Zoltán and Molnár, Tamás and Farkas, Klaudia}, doi = {10.1093/ecco-jcc/jjad212.0804}, journal-iso = {J CROHNS COLITIS}, journal = {JOURNAL OF CROHNS & COLITIS}, volume = {18}, unique-id = {34538619}, issn = {1873-9946}, year = {2024}, eissn = {1876-4479}, pages = {i1279-i1280}, orcid-numbers = {Bacsur, Péter/0000-0002-8534-0068; Resál, Tamás/0000-0002-3842-9094; Kata, Diána/0000-0002-4432-9380; Bálint, Anita/0000-0002-3624-896X; Fábián, Anna/0000-0002-0824-7476; Bor, Renáta/0000-0001-9393-5240; Szepes, Zoltán/0000-0002-9466-8719; Molnár, Tamás/0000-0002-4913-7599; Farkas, Klaudia/0000-0003-0599-182X} } @article{MTMT:34538603, title = {P421 The faecal biomarker LDN-051 is a novel tool for monitoring disease activity and therapeutic response in Inflammatory Bowel Diseases}, url = {https://m2.mtmt.hu/api/publication/34538603}, author = {Jójárt, Boldizsár and Resál, Tamás and Kata, Diána and Molnár, Tünde and Bacsur, Péter and Szabó, Viktória and Varga, Árpád and Szántó, Kata Judit and Pallagi, Petra and Földesi, Imre and Molnár, Tamás and Maléth, József and Farkas, Klaudia}, doi = {10.1093/ecco-jcc/jjad212.0551}, journal-iso = {J CROHNS COLITIS}, journal = {JOURNAL OF CROHNS & COLITIS}, volume = {18}, unique-id = {34538603}, issn = {1873-9946}, year = {2024}, eissn = {1876-4479}, pages = {i869-i869}, orcid-numbers = {Jójárt, Boldizsár/0000-0002-2764-3925; Resál, Tamás/0000-0002-3842-9094; Kata, Diána/0000-0002-4432-9380; Molnár, Tünde/0000-0002-6842-6521; Bacsur, Péter/0000-0002-8534-0068; Szabó, Viktória/0000-0001-6547-9102; Varga, Árpád/0000-0002-2379-139X; Szántó, Kata Judit/0000-0003-0749-5061; Pallagi, Petra/0000-0001-8906-0840; Földesi, Imre/0000-0002-3329-8136; Molnár, Tamás/0000-0002-4913-7599; Maléth, József/0000-0001-5768-3090; Farkas, Klaudia/0000-0003-0599-182X} } @article{MTMT:34167015, title = {Plasminogen activator inhibitor 1 is a novel faecal biomarker for monitoring disease activity and therapeutic response in inflammatory bowel diseases}, url = {https://m2.mtmt.hu/api/publication/34167015}, author = {Jójárt, Boldizsár and Resál, Tamás and Kata, Diána and Molnár, Tünde and Bacsur, Péter and Szabó, Viktória and Varga, Árpád and Szántó, Kata Judit and Pallagi, Petra and Földesi, Imre and Molnár, Tamás and Maléth, József and Farkas, Klaudia}, doi = {10.1093/ecco-jcc/jjad160}, journal-iso = {J CROHNS COLITIS}, journal = {JOURNAL OF CROHNS & COLITIS}, volume = {18}, unique-id = {34167015}, issn = {1873-9946}, abstract = {Crohn's disease and ulcerative colitis require lifelong treatment and patient monitoring. Current biomarkers have several limitations, therefore, there is an unmet need to identify novel biomarkers in inflammatory bowel disease (IBD). Previously, the role of plasminogen activator inhibitor 1 (PAI-1) was established in the pathogenesis of IBD and suggested as a potential biomarker. Therefore, we aimed to comprehensively analyze the selectivity of PAI-1 in IBD, its correlation with the disease activity, and its potential to predict therapeutic response.Blood, colon biopsy, organoid cultures (OC), and faecal samples were used from active and inactive IBD patients and control subjects. Serpin E1 gene expressions and PAI-1 protein levels and localization in serum, biopsy, and fecal samples were evaluated by qRT-PCR, ELISA, and immunostaining, respectively.The study population comprised 132 IBD patients (56 CD and 76 UC) and 40 non-IBD patients. We demonstrated that the serum, mucosal, and faecal PAI-1 concentration is elevated in IBD patients, showing clinical and endoscopic activity. In responders (decrease of eMayo≥3 in UC; or SES-CD>50% in CD), the initial PAI-1 level decreased significantly upon successful therapy. OCs derived from active IBD patients produced higher concentrations of PAI-1 than the controls, suggesting that epithelial cells could be a source of PAI-1. Moreover, faecal PAI-1 selectively increases in active IBD but not other organic gastrointestinal diseases.The serum, mucosal, and faecal PAI-1 concentration correlates with the disease activity and therapeutic response in IBD, suggesting that PAI-1 could be utilized as a novel non-invasive, disease-specific faecal biomarker in the patient follow-up.}, keywords = {Inflammatory bowel disease; PAI-1; faecal marker}, year = {2024}, eissn = {1876-4479}, pages = {392-405}, orcid-numbers = {Jójárt, Boldizsár/0000-0002-2764-3925; Resál, Tamás/0000-0002-3842-9094; Kata, Diána/0000-0002-4432-9380; Molnár, Tünde/0000-0002-6842-6521; Bacsur, Péter/0000-0002-8534-0068; Szabó, Viktória/0000-0001-6547-9102; Varga, Árpád/0000-0002-2379-139X; Szántó, Kata Judit/0000-0003-0749-5061; Pallagi, Petra/0000-0001-8906-0840; Földesi, Imre/0000-0002-3329-8136; Molnár, Tamás/0000-0002-4913-7599; Maléth, József/0000-0001-5768-3090; Farkas, Klaudia/0000-0003-0599-182X} } @article{MTMT:34593890, title = {LDN-051 a novel fecal biomarker for monitoring disease activity and therapeutic response in inflammatory bowel diseases – results of a phase 2 clinical trial}, url = {https://m2.mtmt.hu/api/publication/34593890}, author = {Jójárt, Boldizsár and Resál, Tamás and Kata, Diána and Molnár, Tünde and Bacsur, Péter and Szabó, Viktória and Varga, Árpád and Szántó, Kata Judit and Földesi, Imre and Molnár, Tamás and Maléth, József and Farkas, Klaudia}, journal-iso = {UEG JOURNAL}, journal = {UNITED EUROPEAN GASTROENTEROLOGY JOURNAL}, volume = {11}, unique-id = {34593890}, issn = {2050-6406}, year = {2023}, eissn = {2050-6414}, pages = {291-292}, orcid-numbers = {Jójárt, Boldizsár/0000-0002-2764-3925; Resál, Tamás/0000-0002-3842-9094; Kata, Diána/0000-0002-4432-9380; Molnár, Tünde/0000-0002-6842-6521; Bacsur, Péter/0000-0002-8534-0068; Szabó, Viktória/0000-0001-6547-9102; Varga, Árpád/0000-0002-2379-139X; Szántó, Kata Judit/0000-0003-0749-5061; Földesi, Imre/0000-0002-3329-8136; Molnár, Tamás/0000-0002-4913-7599; Maléth, József/0000-0001-5768-3090; Farkas, Klaudia/0000-0003-0599-182X} } @article{MTMT:34034445, title = {Letter: Experience of switching vedolizumab treatment from intravenous to subcutaneous formulation in Hungary}, url = {https://m2.mtmt.hu/api/publication/34034445}, author = {Bacsur, Péter and Iliás, Ákos and Resál, Tamás and Kata, Diána and Molnár, Tamás and Farkas, Klaudia}, doi = {10.1111/apt.17610}, journal-iso = {ALIMENT PHARM THER}, journal = {ALIMENTARY PHARMACOLOGY & THERAPEUTICS}, volume = {58}, unique-id = {34034445}, issn = {0269-2813}, year = {2023}, eissn = {1365-2036}, pages = {262-263}, orcid-numbers = {Bacsur, Péter/0000-0002-8534-0068; Iliás, Ákos/0000-0002-9865-2642; Resál, Tamás/0000-0002-3842-9094; Kata, Diána/0000-0002-4432-9380; Molnár, Tamás/0000-0002-4913-7599; Farkas, Klaudia/0000-0003-0599-182X} } @article{MTMT:34012213, title = {Plasminogen activator inhibitor 1 - a novel potential biomarker in inflammatory bowel diseases}, url = {https://m2.mtmt.hu/api/publication/34012213}, author = {Jójárt, Boldizsár and Resál, Tamás and Kata, Diána and Molnár, Tünde and Bacsur, Péter and Szabó, Viktória and Varga, Árpád and Szántó, Kata Judit and Földesi, Imre and Molnár, Tamás and Maléth, József and Farkas, Klaudia}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {9}, unique-id = {34012213}, year = {2023}, eissn = {2415-9107}, pages = {85-85}, orcid-numbers = {Jójárt, Boldizsár/0000-0002-2764-3925; Resál, Tamás/0000-0002-3842-9094; Kata, Diána/0000-0002-4432-9380; Molnár, Tünde/0000-0002-6842-6521; Bacsur, Péter/0000-0002-8534-0068; Szabó, Viktória/0000-0001-6547-9102; Varga, Árpád/0000-0002-2379-139X; Szántó, Kata Judit/0000-0003-0749-5061; Földesi, Imre/0000-0002-3329-8136; Molnár, Tamás/0000-0002-4913-7599; Maléth, József/0000-0001-5768-3090; Farkas, Klaudia/0000-0003-0599-182X} } @article{MTMT:33611606, title = {Identification of the PAI-1, as a potential non-invasive, fecal biomarker in the Inflammatory Bowel Diseases}, url = {https://m2.mtmt.hu/api/publication/33611606}, author = {Jójárt, Boldizsár and Molnár, Tünde and Kata, Diána and Szabó, Viktória and Varga, Árpád and Resál, Tamás and Bacsur, Péter and Szántó, Kata Judit and Földesi, Imre and Molnár, Tamás and Maléth, József and Farkas, Klaudia}, doi = {10.1093/ecco-jcc/jjac190.0314}, journal-iso = {J CROHNS COLITIS}, journal = {JOURNAL OF CROHNS & COLITIS}, volume = {17}, unique-id = {33611606}, issn = {1873-9946}, year = {2023}, eissn = {1876-4479}, pages = {i336-i337}, orcid-numbers = {Jójárt, Boldizsár/0000-0002-2764-3925; Molnár, Tünde/0000-0002-6842-6521; Kata, Diána/0000-0002-4432-9380; Szabó, Viktória/0000-0001-6547-9102; Varga, Árpád/0000-0002-2379-139X; Resál, Tamás/0000-0002-3842-9094; Bacsur, Péter/0000-0002-8534-0068; Szántó, Kata Judit/0000-0003-0749-5061; Földesi, Imre/0000-0002-3329-8136; Molnár, Tamás/0000-0002-4913-7599; Maléth, József/0000-0001-5768-3090; Farkas, Klaudia/0000-0003-0599-182X} } @CONFERENCE{MTMT:34014805, title = {Human colon organoids as disease model of inflammatory bowel disease}, url = {https://m2.mtmt.hu/api/publication/34014805}, author = {Molnár, Tünde and Jójárt, Boldizsár and Resál, Tamás and Szántó, Kata Judit and Kata, Diána and Földesi, Imre and Molnár, Tamás and Maléth, József and Farkas, Klaudia}, booktitle = {Abstracts of papers presented at the EMBL Partnership Conference}, unique-id = {34014805}, year = {2022}, pages = {142-142}, orcid-numbers = {Molnár, Tünde/0000-0002-6842-6521; Jójárt, Boldizsár/0000-0002-2764-3925; Resál, Tamás/0000-0002-3842-9094; Szántó, Kata Judit/0000-0003-0749-5061; Kata, Diána/0000-0002-4432-9380; Földesi, Imre/0000-0002-3329-8136; Molnár, Tamás/0000-0002-4913-7599; Maléth, József/0000-0001-5768-3090; Farkas, Klaudia/0000-0003-0599-182X} } @CONFERENCE{MTMT:34014799, title = {PAI-1 level reflects to the disease activity and therapy response in inflammatory bowel disease - potential new biomarker}, url = {https://m2.mtmt.hu/api/publication/34014799}, author = {Jójárt, Boldizsár and Molnár, Tünde and Kata, Diána and Szabó, Viktória and Varga, Árpád and Resál, Tamás and Bacsur, Péter and Szántó, Kata Judit and Földesi, Imre and Molnár, Tamás and Maléth, József and Farkas, Klaudia}, booktitle = {Abstracts of papers presented at the EMBL Partnership Conference}, unique-id = {34014799}, year = {2022}, pages = {119-119}, orcid-numbers = {Jójárt, Boldizsár/0000-0002-2764-3925; Molnár, Tünde/0000-0002-6842-6521; Kata, Diána/0000-0002-4432-9380; Szabó, Viktória/0000-0001-6547-9102; Varga, Árpád/0000-0002-2379-139X; Resál, Tamás/0000-0002-3842-9094; Bacsur, Péter/0000-0002-8534-0068; Szántó, Kata Judit/0000-0003-0749-5061; Földesi, Imre/0000-0002-3329-8136; Molnár, Tamás/0000-0002-4913-7599; Maléth, József/0000-0001-5768-3090; Farkas, Klaudia/0000-0003-0599-182X} } @article{MTMT:34013131, title = {Defining the human colon organoid’s cytokine pattern in inflammatory bowel disease}, url = {https://m2.mtmt.hu/api/publication/34013131}, author = {Molnár, Tünde and Jójárt, Boldizsár and Resál, Tamás and Szántó, Kata Judit and Kata, Diána and Földesi, Imre and Molnár, Tamás and Maléth, József and Farkas, Klaudia}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {8}, unique-id = {34013131}, year = {2022}, eissn = {2415-9107}, pages = {91-91}, orcid-numbers = {Molnár, Tünde/0000-0002-6842-6521; Jójárt, Boldizsár/0000-0002-2764-3925; Resál, Tamás/0000-0002-3842-9094; Szántó, Kata Judit/0000-0003-0749-5061; Kata, Diána/0000-0002-4432-9380; Földesi, Imre/0000-0002-3329-8136; Molnár, Tamás/0000-0002-4913-7599; Maléth, József/0000-0001-5768-3090; Farkas, Klaudia/0000-0003-0599-182X} }