TY - JOUR AU - Gyarmati, Benjámin Sándor AU - Dargó, Gergő AU - Szilágyi, Barnabás Áron AU - Vincze, Anna AU - Facskó, Réka AU - Budai-Szűcs, Mária AU - L. Kiss, Eszter AU - Szente, Lajos AU - Szilágyi, András Ferenc AU - Balogh, György Tibor TI - Synthesis, complex formation and corneal permeation of cyclodextrin-modified, thiolated poly(aspartic acid) as self-gelling formulation of dexamethasone JF - EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS J2 - EUR J PHARM BIOPHARM VL - 174 PY - 2022 SP - 1 EP - 9 PG - 9 SN - 0939-6411 DO - 10.1016/j.ejpb.2022.03.008 UR - https://m2.mtmt.hu/api/publication/32759014 ID - 32759014 N1 - Department of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., Budapest, H-1111, Hungary Department of Chemical and Process Engineering, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rakpart 3., Budapest, H-1111, Hungary Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös utca 6., Szeged, H-6720, Hungary CycloLab Cyclodextrin R. and D. Laboratory, Ltd, H-1070 Budapest, Illatos út 7, Hungary Institute of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös utca 6., Szeged, H-6720, Hungary Export Date: 5 May 2022 CODEN: EJPBE Correspondence Address: Balogh, G.T.; Department of Chemical and Process Engineering, Műegyetem rakpart 3., Hungary; email: balogh.gyorgy@vbk.bme.hu Correspondence Address: Szilagyi, A.; Department of Physical Chemistry and Materials Science, Műegyetem rkp. 3., Hungary; email: szilagyi.andras@vkb.bme.hu LA - English DB - MTMT ER - TY - CONF AU - Katona, Gábor AU - Balogh, György Tibor AU - Dargó, Gergő AU - Gáspár, Róbert AU - Márki, Árpád AU - Ducza, Eszter AU - Sztojkov-Ivanov, Anita AU - Tömösi, Ferenc AU - Kecskeméti, Gábor AU - Janáky, Tamás AU - Kiss, Tamás AU - Ambrus, Rita AU - Pallagi, Edina AU - Révész, Piroska AU - Pannonhalminé Csóka, Ildikó ED - Malgorzata, Sznitowska TI - Quality by Design based formulation of intranasal meloxicam containing human serum albumin nanoparticles T2 - 13th Central European Symposium on Pharmaceutical Technology PB - Medical University of Gdansk C1 - Gdansk PY - 2021 SP - 71 EP - 71 PG - 1 UR - https://m2.mtmt.hu/api/publication/32475125 ID - 32475125 LA - English DB - MTMT ER - TY - JOUR AU - Dargó, Gergő AU - Balogh, György Tibor TI - Új vizsgálati módszerek gyógyszer-makromolekula kölcsönhatások fizikai-kémiai jellemzésére JF - MAGYAR KÉMIAI FOLYÓIRAT - KÉMIAI KÖZLEMÉNYEK (1997-) J2 - MAGY KÉM FOLY KÉM KÖZL VL - 127 PY - 2021 IS - 1 SP - 21 EP - 30 PG - 10 SN - 1418-9933 DO - 10.24100/MKF.2021.01.21 UR - https://m2.mtmt.hu/api/publication/32109773 ID - 32109773 N1 - "Dargó Gergő azonos című PhD értekezéséhez kapcsolódó Tézisfüzet alapján készült." Dargó Gergő kutatómunkáját támogatta a Richter Gedeon Tálentum Alapítvány. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Vincze, Anna AU - Dargó, Gergő AU - Rácz, Anita AU - Balogh, György Tibor TI - A corneal-PAMPA-based in silico model for predicting corneal permeability JF - JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS J2 - J PHARMACEUT BIOMED ANAL VL - 203 PY - 2021 PG - 10 SN - 0731-7085 DO - 10.1016/j.jpba.2021.114218 UR - https://m2.mtmt.hu/api/publication/32074659 ID - 32074659 N1 - Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, Műegyetem Rakpart 3., Budapest, 1111, Hungary Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6., Szeged, 6720, Hungary Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Magyar Tudósok Krt. 2., Budapest, 1117, Hungary Cited By :6 Export Date: 1 March 2024 CODEN: JPBAD Correspondence Address: Balogh, G.T.; Department of Chemical and Environmental Process Engineering, Műegyetem rakpart 3., Hungary; email: balogh.gyorgy@vbk.bme.hu Correspondence Address: Rácz, A.; Institute of Materials and Environmental Chemistry, Magyar Tudósok Krt. 2., Hungary; email: racz.anita@ttk.hu Chemicals/CAS: betaxolol, 63659-18-7, 72424-72-7, 93221-48-8; bevantolol, 59170-23-9; bromfenac, 91714-94-2, 120638-55-3, 91714-93-1; bufuralol, 54340-62-4; deoxycorticosterone, 64-85-7; emetine, 316-42-7, 483-18-1; ethoxzolamide, 452-35-7; etoposide, 33419-42-0, 433304-61-1; flurbiprofen, 5104-49-4; hydrocortisone, 50-23-7; loperamide, 34552-83-5, 53179-11-6; nepafenac, 78281-72-8; penbutolol, 38363-32-5, 38363-40-5; quinine, 130-89-2, 130-95-0, 14358-44-2, 549-48-4, 549-49-5, 60-93-5, 7549-43-1; risperidone, 106266-06-2; sparfloxacin, 111542-93-9; trimethoprim, 738-70-5; verapamil, 152-11-4, 52-53-9; Membranes, Artificial Manufacturers: Toronto Research Chemicals, Canada LA - English DB - MTMT ER - TY - CONF AU - Dargó, Gergő AU - Laczkó, Dávid AU - László, Óvári AU - Kristóf, Gazda AU - Márió, Nacsa AU - Erika, Jantyikné Tamás AU - Eszter, Blanár AU - Dóra, Rutterschmid AU - László, Lorántfy AU - Árpád, Könczöl ED - Giorgo, Carta ED - Janet, Cunningham TI - Centrifugal Partition Chromatography at Industrial Scale: Concept, Instrumentation and Applications T2 - ePrep 2021 - 34th International Symposium on Preparative & Process Chromatography PY - 2021 UR - https://m2.mtmt.hu/api/publication/32066904 ID - 32066904 LA - English DB - MTMT ER - TY - JOUR AU - Golcs, Ádám AU - Dargó, Gergő AU - Balogh, György Tibor AU - Huszthy, Péter AU - Tóth, Tünde TI - Development of a microplate-format direct optode sensor for ultra-high-throughput environmental and wastewater monitoring of Pb2+ JF - ANALYTICA CHIMICA ACTA J2 - ANAL CHIM ACTA VL - 1167 PY - 2021 SN - 0003-2670 DO - 10.1016/j.aca.2021.338586 UR - https://m2.mtmt.hu/api/publication/32020249 ID - 32020249 LA - English DB - MTMT ER - TY - JOUR AU - Lorántfy, László AU - Rutterschmid, Dóra AU - Örkényi, Róbert Zoltán AU - Bakonyi, Dávid AU - Faragó, József AU - Dargó, Gergő AU - Könczöl, Árpád TI - Continuous Industrial-Scale Centrifugal Partition Chromatography with Automatic Solvent System Handling: Concept and Instrumentation JF - ORGANIC PROCESS RESEARCH & DEVELOPMENT J2 - ORG PROCESS RES DEV VL - 24 PY - 2020 IS - 11 SP - 2676 EP - 2688 PG - 13 SN - 1083-6160 DO - 10.1021/acs.oprd.0c00338 UR - https://m2.mtmt.hu/api/publication/31748109 ID - 31748109 LA - English DB - MTMT ER - TY - JOUR AU - Balogh Weiser, Diána AU - Decsi, Balázs AU - Réka, Krammer AU - Dargó, Gergő AU - Ender, Ferenc AU - Mizsei, János AU - Berkecz, Róbert AU - Gyarmati, Benjámin Sándor AU - Szilágyi, András Ferenc AU - Tötös, Róbert AU - Paizs, Csaba AU - Poppe, László AU - Balogh, György Tibor TI - Magnetic Nanoparticles with Dual Surface Functions—Efficient Carriers for Metalloporphyrin-Catalyzed Drug Metabolite Synthesis in Batch and Continuous-Flow Reactors JF - NANOMATERIALS J2 - NANOMATERIALS-BASEL VL - 10 PY - 2020 IS - 12 PG - 16 SN - 2079-4991 DO - 10.3390/nano10122329 UR - https://m2.mtmt.hu/api/publication/31672178 ID - 31672178 N1 - Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Department of Electron Devices, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-111, Hungary SpinSplit Llc., Vend u. 17, Budapest, H-1025, Hungary Institute of Pharmaceutical Analysis, Faculty of Pharmacy, University of Szeged, Somogyi utca 4., Szeged, H-6720, Hungary Biocatalysis and Biotransformation Research Center, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University of Cluj-Napoca, Arany János str. 11, Cluj-Napoca, 400028, Romania Institute of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Cited By :2 Export Date: 5 April 2022 Correspondence Address: Balogh-Weiser, D.; Department of Organic Chemistry and Technology, Műegyetem rkp. 3, Hungary; email: dweiser@mail.bme.hu Correspondence Address: Balogh-Weiser, D.; Department of Physical Chemistry and Materials Science, Műegyetem rkp. 3, Hungary; email: dweiser@mail.bme.hu Correspondence Address: Balogh, G.T.; Department of Chemical and Environmental Process Engineering, Műegyetem rkp. 3, Hungary; email: gytbalogh@mail.bme.hu Correspondence Address: Balogh, G.T.; Institute of Pharmacodynamics and Biopharmacy, Eötvös u. 6, Hungary; email: gytbalogh@mail.bme.hu Funding details: NKP-20-2 Funding details: 103413, P37_273 Funding details: National Authority for Scientific Research and Innovation, ANCSI Funding details: European Commission, EC, EFOP-3.6.1-16-2016-00008 Funding details: European Regional Development Fund, ERDF Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding details: Ministry for Innovation and Technology Funding text 1: Funding: The research reported in this paper and carried out at BME has been supported by the NRDI Fund (TKP2020 NC, Grant No. BME-NC) based on the charter of bolster issued by the NRDI Office under the auspices of the Ministry for Innovation and Technology. Furthermore, we want to thank the financial support from NEMSyB, ID P37_273, Cod MySMIS 103413 funded by the Romanian Ministry for European Funds, through the National Authority for Scientific Research and Innovation (ANCSI) and cofounded by the European Regional Development Fund, Competitiveness Operational Program 2014-2020 (POC). The authors also acknowledge New National Excellence Programme of the Ministry of Innovation and Technology for the financial support, including ÚNKP-20-2 fellowship of R. Krammer and EU-funded Hungarian grant EFOP-3.6.1-16-2016-00008. Funding text 2: The research reported in this paper and carried out at BME has been supported by the NRDI Fund (TKP2020 NC, Grant No. BME-NC) based on the charter of bolster issued by the NRDI Office under the auspices of the Ministry for Innovation and Technology. Furthermore, we want to thank the financial support from NEMSyB, ID P37_273, Cod MySMIS 103413 funded by the Romanian Ministry for European Funds, through the National Authority for Scientific Research and Innovation (ANCSI) and cofounded by the European Regional Development Fund, Competitiveness Operational Program 2014-2020 (POC). The authors also acknowledge New National Excellence Programme of the Ministry of Innovation and Technology for the financial support, including ?NKP-20-2 fellowship of R. Krammer and EU-funded Hungarian grant EFOP-3.6.1-16-2016-00008. AB - The dual functionalization of magnetic nanoparticles with inert (methyl) and reactive (aminopropyl) groups enables efficient immobilization of synthetic metalloporphyrins (such as 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin and 5,10,15,20-tetrakis-(4-sulfonatophenyl)iron(II) porphyrin) via covalent or ionic interactions. The proportion of reactive function on the surface has significant effect on the biomimetic activity of metalloporphyrins. The optimized magnetic nanocatalyst containing porphyrin was successfully applied for biomimetic oxidation of antihypertensive drug Amlodipine in batch and continuous-flow reactors as well. LA - English DB - MTMT ER - TY - JOUR AU - Vincze, Anna AU - Dargó, Gergő AU - Balogh, György Tibor TI - Cornea-PAMPA as an Orthogonal in Vitro Physicochemical Model of Corneal Permeability JF - PERIODICA POLYTECHNICA-CHEMICAL ENGINEERING J2 - PERIOD POLYTECH CHEM ENG VL - 64 PY - 2020 IS - 3 SP - 384 EP - 390 PG - 7 SN - 0324-5853 DO - 10.3311/PPch.15601 UR - https://m2.mtmt.hu/api/publication/31323897 ID - 31323897 N1 - Funding Agency and Grant Number: New National Excellence Program of the Ministry of Human Capacities [UNKP-19-2-I-BME-370] Funding text: This research was funded by the New National Excellence Program of the Ministry of Human Capacities (grant number UNKP-19-2-I-BME-370). AB - The present study was aimed to investigate the relationships between permeability and membrane retention values (logPe and MR) of the in vitro non-cellular permeability assay, corneal-PAMPA in comparison with experimental Caco-2 permeability data and calculated physicochemical properties (MW, clogP, clogD7.4 , TPSA). For the investigation, 50 structurally and physicochemically diverse drugs were selected and measured in PAMPA model optimized for corneal permeability. The results showed corneal-PAMPA model's orthogonality in terms of passive diffusion to the FDA approved Caco-2 as a gastrointestinal absorption model, while the comparison with physicochemical properties revealed trends between logPe , MR and the lipophilicity descriptors and TPSA. LA - English DB - MTMT ER - TY - JOUR AU - Dargó, Gergő AU - Bajusz, Dávid AU - Simon, Kristof AU - Müller, Judit AU - Balogh, György Tibor TI - Human serum albumin binding in a vial: a novel UV-pH titration method to assist drug design JF - JOURNAL OF MEDICINAL CHEMISTRY J2 - J MED CHEM VL - 63 PY - 2020 IS - 4 SP - 1763 EP - 1774 PG - 12 SN - 0022-2623 DO - 10.1021/acs.jmedchem.0c00046 UR - https://m2.mtmt.hu/api/publication/31154990 ID - 31154990 LA - English DB - MTMT ER -