@article{MTMT:34398897, title = {In gratitude for the collaborative partnership with David E. Minnikin}, url = {https://m2.mtmt.hu/api/publication/34398897}, author = {Váradi, Orsolya Anna and Marcsik, Antónia and Masson, Muriel and Molnár, Erika and Pap, Ildikó and Spekker, Olga and Szekeres, András and Pálfi, György}, doi = {10.1016/j.tube.2023.102364}, journal-iso = {TUBERCULOSIS}, journal = {TUBERCULOSIS}, volume = {143}, unique-id = {34398897}, issn = {1472-9792}, year = {2023}, eissn = {1873-281X}, orcid-numbers = {Váradi, Orsolya Anna/0000-0002-7825-265X; Marcsik, Antónia/0000-0002-3121-4365; Molnár, Erika/0000-0001-6660-9239; Spekker, Olga/0000-0002-0350-1906; Szekeres, András/0000-0003-1651-4623} } @{MTMT:34107341, title = {Középkori magyar uralkodók archeogenetikai vizsgálata}, url = {https://m2.mtmt.hu/api/publication/34107341}, author = {Varga, Gergely István and Kristóf, Lilla Alida and Maár, Kitti and Kis, Luca and Schütz, Oszkár and Váradi, Orsolya Anna and Kovács, Bence and Gînguță, Alexandra and Tihanyi, Balázs and Nagy, Péter and Maróti, Zoltán and Nyerki, Emil and Török, Tibor and Neparáczki, Endre}, booktitle = {László királytól Szent Lászlóig}, doi = {10.53644/MKI.LKSZL.2023.137}, unique-id = {34107341}, abstract = {Középkori uralkodóink sírjai a történelem viharaiban elvesztek, maradványaik ismeretlen helyen, azonosítatlanul nyugszanak. Máig egyedül III. Béla maradványai kerültek elő, valamint szent királyaink ereklyéi maradtak meg az utókornak, melyek eredetiségét azonban sokan kétségbe vonják. Munkánk során a legtöbb királyunk temetkezési helyéül szolgált székesfehérvári királyi bazilika területén feltárt maradványok archeogenetikai vizsgálatát végezzük el, és azonosítjuk uralkodóink csontvázait. Emellett a Szent László-herma koponyaereklyéjét is megvizsgáltuk, hogy valódiságát igazoljuk. Míg a székesfehérvári vizsgálatokból csak részeredményeket közlünk, lévén a munka még nem fejeződött be, addig a Herma vizsgálata lezajlott, bemutatjuk, hogy eredetisége igazolást nyert, valóban Szent László koponyáját rejti. Mi több, azt is ismertetjük, hogyan járult hozzá Szent László genomvizsgálata az Árpád-házi maradványok személyazonosításához, és kimutatjuk a honfoglalók genetikai örökségét a Szent Király örökítőanyagában.}, keywords = {archeogenomika; ásatag DNS; teljes genomszekvenálás; rokonságifok-becslés; főkomponens-elemzés; qpAdm-elemzés; filogenetikai elemzés}, year = {2023}, pages = {137-159}, orcid-numbers = {Varga, Gergely István/0000-0001-9073-5788; Maár, Kitti/0000-0002-1207-6569; Kis, Luca/0000-0002-1021-2854; Schütz, Oszkár/0000-0001-5521-3044; Váradi, Orsolya Anna/0000-0002-7825-265X; Kovács, Bence/0000-0002-4915-1462; Tihanyi, Balázs/0000-0001-5124-4468; Maróti, Zoltán/0000-0002-0515-117X; Nyerki, Emil/0000-0003-1168-763X; Török, Tibor/0000-0002-2128-1126; Neparáczki, Endre/0000-0003-3466-0368} } @misc{MTMT:33926563, title = {Új irányok a honfoglalás kori koponyasebészet kutatásában}, url = {https://m2.mtmt.hu/api/publication/33926563}, author = {Király, Kitty and Kis, Luca and Váradi, Orsolya Anna and Tihanyi, Balázs and Bereczki, Zsolt}, unique-id = {33926563}, year = {2023}, orcid-numbers = {Kis, Luca/0000-0002-1021-2854; Váradi, Orsolya Anna/0000-0002-7825-265X; Tihanyi, Balázs/0000-0001-5124-4468} } @misc{MTMT:33926499, title = {Új irányok a tuberkulózis paleopatológiai és paleoepidemiológiai kutatásában - A Sárrétudvari-Hízóföld honfoglalás kori lelőhely példájából levonható tanulságok}, url = {https://m2.mtmt.hu/api/publication/33926499}, author = {Spekker, Olga and Molnár, Erika and Kis, Luca and Váradi, Orsolya Anna and Tihanyi, Balázs}, unique-id = {33926499}, year = {2023}, orcid-numbers = {Spekker, Olga/0000-0002-0350-1906; Molnár, Erika/0000-0001-6660-9239; Kis, Luca/0000-0002-1021-2854; Váradi, Orsolya Anna/0000-0002-7825-265X; Tihanyi, Balázs/0000-0001-5124-4468} } @article{MTMT:33088518, title = {The archaeogenomic validation of Saint Ladislaus' relic provides insights into the Árpád dynasty's genealogy}, url = {https://m2.mtmt.hu/api/publication/33088518}, author = {Varga, Gergely István and Kristóf, Lilla Alida and Maár, Kitti and Kis, Luca and Schütz, Oszkár and Váradi, Orsolya Anna and Kovács, Bence and Gînguță, Alexandra and Tihanyi, Balázs and Nagy, Péter L and Maróti, Zoltán and Nyerki, Emil and Török, Tibor and Neparáczki, Endre}, doi = {10.1016/j.jgg.2022.06.008}, journal-iso = {J GENET GENOMICS}, journal = {JOURNAL OF GENETICS AND GENOMICS}, volume = {50}, unique-id = {33088518}, issn = {1673-8527}, year = {2023}, eissn = {1873-5533}, pages = {58-61}, orcid-numbers = {Varga, Gergely István/0000-0001-9073-5788; Maár, Kitti/0000-0002-1207-6569; Kis, Luca/0000-0002-1021-2854; Schütz, Oszkár/0000-0001-5521-3044; Váradi, Orsolya Anna/0000-0002-7825-265X; Kovács, Bence/0000-0002-4915-1462; Tihanyi, Balázs/0000-0001-5124-4468; Maróti, Zoltán/0000-0002-0515-117X; Nyerki, Emil/0000-0003-1168-763X; Török, Tibor/0000-0002-2128-1126; Neparáczki, Endre/0000-0003-3466-0368} } @article{MTMT:33535962, title = {Lipid biomarkerek HPLC-HRMS vizsgálata történeti embertani minták tbc diagnosztikája során}, url = {https://m2.mtmt.hu/api/publication/33535962}, author = {Váradi, Orsolya Anna}, doi = {10.20330/AnthropKozl.2022.63.97}, journal-iso = {ANTHROPOLOGIAI KÖZLEMÉNYEK}, journal = {ANTHROPOLOGIAI KÖZLEMÉNYEK}, volume = {63}, unique-id = {33535962}, issn = {0003-5440}, abstract = {Tuberculosis (TB) is not only an infectious disease but one of the top 10 causes of death, spreading mainly with aerosol transmission and accompanying the history of humankind for several millennia. TB is caused in humans and animals by members of the Mycobacterium tuberculosis complex. For better understanding of the disease and the evolutional background of its causative agent, involvement of palaeopathological investigations is surpassingly important. Traditionally, palaeopathology is using a broad variety of markers, which are observable by macroscopic investigations. These markers are mainly related to different extra-pulmonary forms of TB. However, these manifestations develop only in a few cases. Moreover, many markers are not pathognomonic of TB. Therefore, to avoid underestimation of TB prevalence in paleopathological studies, the diagnosis on archaeological material requires a multidisciplinary approach. For better estimation of TB incidence in past populations, an array of specific biomarkers can be brought into play to confirm initial, macromorphology-based skeletal diagnoses, namely aDNA and lipid biomarkers. The three lipid biomarker groups, which are mainly involved in such investigations are the mycolic acids (MAs), the mycocerosic acids (MCs) and the C27 mycolipenic acid (ML). These unique lipids can be located in the lipid-rich mycobacterial cell wall. The application of lipid-based TB diagnostic approach has been proved to be robust and reliable through many examples. A variety of analytical methods have been employed for mycobacterial lipid biomarker profiling. Fluorescence HPLC is well-developed for the analysis of mycolic acids and phthiocerols. Furthermore, one isolated case of direct mass spectrometric detection of M. tuberculosis free mycolic acids has been also introduced. Our aim was to establish a lipid-biomarker-based HPLC-MS method for TB diagnosis in historical human samples, as this instrumentation is available in many laboratories, has the potential of a quick and sensitive and at the same time an affordable measurement protocol. We successfully developed and optimised a method, which is capable to separate and detect MAs and MCs. Moreover, we optimised the sample pre-treatment process. We started to build an MA and MC lipid profile library, which can serve as a comparison to diagnose TB. For the verification of new methods and the estimation of reliability of new markers in macroscopic analysis, palaeopathologists usually use well-documented collections of skeletons and mummies from the pre-antibiotic era. For this purpose, we chose to test our method on the Vác Mummy Collection. In the case of four out of six mummified individuals, MC profiles of characteristic M. tuberculosis MCs were recorded. The HPLC-ESI-MS method, developed for the detection of MCs, opens a new avenue for the detection of ancient mycobacterial disease, encompassing both tuberculosis, leprosy and joint cases.}, year = {2022}, pages = {97-108}, orcid-numbers = {Váradi, Orsolya Anna/0000-0002-7825-265X} } @article{MTMT:33364825, title = {Multi-disciplinary analysis of an elite Xiongnu tomb from Belkhin Am cemetery, Ulaanbaatar}, url = {https://m2.mtmt.hu/api/publication/33364825}, author = {Varga, Gergely István and Maár, Kitti and Ginguta, Alexandra and Váradi, Orsolya Anna and Kovács, Bence and Tihanyi, Balázs and Maróti, Zoltán and Makoldi, Miklós Zsombor and Eregzen, Gelegdorj and Batbold, Natsag and Amgalantugs, Tsend and Erdene-Ochir, Nasan-Ochir and Horváth-Lugossy, Gábor and Obrusánszky, Borbála Anna and Török, Tibor and Neparáczki, Endre}, doi = {10.53644/EH.2022.2.101}, journal-iso = {EPHEMER HUNGAROL}, journal = {EPHEMERIS HUNGAROLOGICA}, volume = {2}, unique-id = {33364825}, issn = {2786-3522}, abstract = {The Xiongnu Empire was the first integrated political formation of Eastern Steppe nomads, whose history is known from the contemporaneous Chinese written sources and the archaeological findings of their burials. Here we present a complex multidisciplinary study of a tomb from the Xiongnu cemetery of Belkhin Am. The archaeological features characterized the grave as an elite Xiongnu burial. By radiocarbon analysis the tomb could be dated to the middle of the Xiongnu era, between the 1st century BCE and 1st century CE. The phylogenetic connections of the human remains found in the grave were in concordance with its Inner East Asian location.}, keywords = {ancient DNA; mitochondrial DNA; PHYLOGENETIC ANALYSIS; radiocarbon dating; archaeogenetics}, year = {2022}, eissn = {2786-3514}, pages = {101-113}, orcid-numbers = {Varga, Gergely István/0000-0001-9073-5788; Maár, Kitti/0000-0002-1207-6569; Váradi, Orsolya Anna/0000-0002-7825-265X; Kovács, Bence/0000-0002-4915-1462; Tihanyi, Balázs/0000-0001-5124-4468; Maróti, Zoltán/0000-0002-0515-117X; Török, Tibor/0000-0002-2128-1126; Neparáczki, Endre/0000-0003-3466-0368} } @CONFERENCE{MTMT:33095425, title = {The development, verification and objectives of a mycocerosic acid based HPLC-HRMS method for TB diagnostics in paleopathology}, url = {https://m2.mtmt.hu/api/publication/33095425}, author = {Váradi, Orsolya Anna and Spekker, Olga and Maixner, Frank and Zink, Albert and Rakk, Dávid and Vágvölgyi, Csaba and Terhes, Gabriella and Szvák, Enikő and Pap, Ildikó and Szikossy, Ildikó and Pálfi, György and Szekeres, András and Minnikin, David}, booktitle = {ICEPT-3 Meeting. Tuberculosis in Evolution. Program}, unique-id = {33095425}, year = {2022}, pages = {9-9}, orcid-numbers = {Váradi, Orsolya Anna/0000-0002-7825-265X; Spekker, Olga/0000-0002-0350-1906; Vágvölgyi, Csaba/0000-0003-0009-7773; Terhes, Gabriella/0000-0002-7301-9672; Szekeres, András/0000-0003-1651-4623} } @CONFERENCE{MTMT:33095422, title = {The first reported archaeological case with calvarial tuberculosis from the present-day territory of Hungary}, url = {https://m2.mtmt.hu/api/publication/33095422}, author = {Spekker, Olga and Váradi, Orsolya Anna and Szekeres, András and Jäger, Heidi Yoko and Zink, Albert and Berner, Margit and Pany-Kucera, Doris and Strondl, Liesa and Klostermann, Paul and Samu, Levente and Király, Kitty and Bereczki, Zsolt and Molnár, Erika and Pálfi, György and Tihanyi, Balázs}, booktitle = {ICEPT-3 Meeting. Tuberculosis in Evolution. Program}, unique-id = {33095422}, year = {2022}, pages = {7-7}, orcid-numbers = {Spekker, Olga/0000-0002-0350-1906; Váradi, Orsolya Anna/0000-0002-7825-265X; Szekeres, András/0000-0003-1651-4623; Molnár, Erika/0000-0001-6660-9239; Tihanyi, Balázs/0000-0001-5124-4468} } @CONFERENCE{MTMT:33091244, title = {In search of TB among the members of the Hausmann family: Mycocerosic acid-based TB diagnostics via HPLC-HRMS.}, url = {https://m2.mtmt.hu/api/publication/33091244}, author = {Váradi, Orsolya Anna and Spekker, Olga and Szikossy, Ildikó and Szvák, Enikő and Rakk, Dávid and Terhes, Gabriella and Pap, Ildikó and Frank, Maixner and Albert, Zink and Vágvölgyi, Csaba and Helen, D. Donoghue and David, E. Minnikin and Szekeres, András and Pálfi, György}, booktitle = {Abstract Book:10th World Congress on Mummy Studies Bolzano, Italy 05-09 September 2022.}, unique-id = {33091244}, year = {2022}, pages = {153-153}, orcid-numbers = {Váradi, Orsolya Anna/0000-0002-7825-265X; Spekker, Olga/0000-0002-0350-1906; Terhes, Gabriella/0000-0002-7301-9672; Vágvölgyi, Csaba/0000-0003-0009-7773; Szekeres, András/0000-0003-1651-4623} }