TY - JOUR AU - Gazsó-Gerhát, Gabriella AU - Gombos, Rita I AU - Tóth, Krisztina AU - Kaltenecker, Péter AU - Szikora, Szilárd AU - Bíró, Judit AU - Csapó, Enikő AU - Asztalos, Zoltán Imre AU - Mihály, József TI - FRL and DAAM are required for lateral adhesion of interommatidial cells and patterning of the retinal floor JF - DEVELOPMENT J2 - DEVELOPMENT VL - 150 PY - 2023 IS - 22 PG - 13 SN - 0950-1991 DO - 10.1242/dev.201713 UR - https://m2.mtmt.hu/api/publication/34409947 ID - 34409947 N1 - Institute of Genetics, HUN-REN Biological Research Centre, Temesvári krt. 62, Szeged, H-6726, Hungary Doctoral School in Biology, Faculty of Science and Informatics, University of Szeged, Szeged, H-6726, Hungary Aktogen Hungary Ltd., Szeged, H-6726, Hungary Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, H-6726, Hungary Department of Genetics, University of Szeged, Szeged, H-6726, Hungary Export Date: 6 March 2024 CODEN: DEVPE Correspondence Address: Mihály, J.; Institute of Genetics, Temesvári krt. 62, Hungary; email: mihaly.jozsef@brc.hu AB - Optical insulation of the unit eyes (ommatidia) is an important prerequisite of precise sight with compound eyes. Separation of the ommatidia is ensured by pigment cells that organize into a hexagonal lattice in the Drosophila eye, forming thin walls between the facets. Cell adhesion, mediated by apically and latero-basally located junctional complexes, is crucial for stable attachment of these cells to each other and the basal lamina. Whereas former studies have focused on the formation and remodelling of the cellular connections at the apical region, here, we report a specific alteration of the lateral adhesion of the lattice cells, leaving the apical junctions largely unaffected. We found that DAAM and FRL, two formin-type cytoskeleton regulatory proteins, play redundant roles in lateral adhesion of the interommatidial cells and patterning of the retinal floor. We show that formin-dependent cortical actin assembly is crucial for latero-basal sealing of the ommatidial lattice. We expect that the investigation of these previously unreported eye phenotypes will pave the way toward a better understanding of the three-dimensional aspects of compound eye development. LA - English DB - MTMT ER - TY - JOUR AU - Pintér, Réka AU - Huber, Tamás AU - Bukovics, Péter AU - Gaszler, Péter AU - Leipold Vig, Andrea AU - Szütsné Tóth, Mónika Ágnes AU - Gazsó-Gerhát, Gabriella AU - Farkas, Dávid AU - Migh, Ede AU - Mihály, József AU - Bugyi, Beáta TI - The Activities of the Gelsolin Homology Domains of Flightless-I in Actin Dynamics JF - FRONTIERS IN MOLECULAR BIOSCIENCES J2 - FRONT MOL BIOSCI VL - 7 PY - 2020 PG - 18 SN - 2296-889X DO - 10.3389/fmolb.2020.575077 UR - https://m2.mtmt.hu/api/publication/31595814 ID - 31595814 N1 - Department of Biophysics, Medical School, University of Pécs, Pécs, Hungary Biological Research Centre Szeged, Institute of Genetics, Szeged, Hungary Faculty of Science and Informatics, Doctoral School in Biology, University of Szeged, Szeged, Hungary Szentágothai Research Center, Pécs, Hungary Cited By :3 Export Date: 26 January 2024 Correspondence Address: Bugyi, B.; Department of Biophysics, Hungary; email: beata.bugyi@aok.pte.hu Correspondence Address: Bugyi, B.; Szentágothai Research CenterHungary; email: beata.bugyi@aok.pte.hu LA - English DB - MTMT ER - TY - JOUR AU - Dehapiot, Benoit AU - Clément, Raphaël AU - Alégot, Hervé AU - Gazsó-Gerhát, Gabriella AU - Philippe, Jean-Marc AU - Lecuit, Thomas TI - Assembly of a persistent apical actin network by the formin Frl/Fmnl tunes epithelial cell deformability JF - NATURE CELL BIOLOGY J2 - NAT CELL BIOL VL - 22 PY - 2020 SP - 791 EP - 802 PG - 12 SN - 1465-7392 DO - 10.1038/s41556-020-0524-x UR - https://m2.mtmt.hu/api/publication/31334081 ID - 31334081 N1 - Aix Marseille Université, CNRS, IBDM-UMR7288, Turing Center for Living Systems, Marseille, France Institute of Genetics, Biological Research Centre, HAS, Szeged, Hungary Doctoral School of Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary Collège de France, Paris, France Cited By :2 Export Date: 21 January 2021 CODEN: NCBIF Correspondence Address: Lecuit, T.; Aix Marseille Université, France; email: thomas.lecuit@univ-amu.fr LA - English DB - MTMT ER - TY - GEN AU - Gazsó-Gerhát, Gabriella AU - Gombos, R AU - Szikora, S AU - Toth, K AU - Foldi, I AU - Mihaly, J TI - Redundant role of DAAM and FRL formins in pigment cell development in the Drosophila eye CY - www.edrc2019.com PY - 2019 UR - https://m2.mtmt.hu/api/publication/30855502 ID - 30855502 LA - English DB - MTMT ER - TY - GEN AU - Gazsó-Gerhát, Gabriella AU - Gombos, R AU - Szikora, S AU - Mihaly, J TI - Examination of the redundancy between DAAM and FRL formins during pigment cell development in the Drosophila eye PY - 2019 UR - https://m2.mtmt.hu/api/publication/30744938 ID - 30744938 LA - English DB - MTMT ER - TY - CONF AU - Gazsó-Gerhát, Gabriella AU - Gombos, R AU - Szikora, S AU - Mihaly, J TI - Examination of the redundancy between DAAM and FRL during eye development in Drosohila melanogaster T2 - NEUROFLY 2018 C1 - Krakkó PY - 2018 PG - 1 UR - https://m2.mtmt.hu/api/publication/3414696 ID - 3414696 LA - English DB - MTMT ER - TY - GEN AU - Gazsó-Gerhát, Gabriella AU - Gombos, R AU - Mihaly, J TI - Investigation of the redundancy between two formin proteins dDAAM and FRL during eye development in Drosophila melanogaster PY - 2017 UR - https://m2.mtmt.hu/api/publication/3241341 ID - 3241341 LA - English DB - MTMT ER - TY - GEN AU - Gombos, R AU - Migh, E AU - Gazsó-Gerhát, Gabriella AU - Mihaly, J TI - The Formin DAAM functions as Molecular Effector of the Planar Cell Polaritry Pathway during Axonal Development in Drososphila PY - 2016 PG - 1 UR - https://m2.mtmt.hu/api/publication/3178637 ID - 3178637 LA - English DB - MTMT ER - TY - JOUR AU - Gazsó-Gerhát, Gabriella AU - Muzsnai, Ágota AU - Zsákai, Annamária AU - Bodzsár, Éva TI - A Down-szindrómás gyermekek testi fejlettsége JF - GYERMEKGYÓGYÁSZATI TOVÁBBKÉPZŐ SZEMLE J2 - GYERMEKGYÓGYÁSZATI TOVÁBBKÉPZŐ SZEMLE VL - 21 PY - 2016 IS - 3 SP - 120 EP - 124 PG - 5 SN - 1585-4396 UR - https://m2.mtmt.hu/api/publication/3178611 ID - 3178611 LA - Hungarian DB - MTMT ER - TY - GEN AU - Gazsó-Gerhát, Gabriella AU - Nagy, V AU - Gombos, R AU - Földi, I AU - Mihaly, J TI - Identification of the Genetic Interaction Partners of the Formin dDAAM Required for Axonal Growth in Drosophila PY - 2015 SP - 15 EP - 15 UR - https://m2.mtmt.hu/api/publication/3085774 ID - 3085774 LA - English DB - MTMT ER -