@article{MTMT:32989211,
	title = {The effect of Cyclophilin D depletion on liver regeneration following associating liver partition and portal vein ligation for staged hepatectomy},
	url = {https://m2.mtmt.hu/api/publication/32989211},
	author = {Daradics, Noémi and Horváth, Gergő and Tretter, László and Paál, Ágnes and Fülöp, András and Budai, András and Szijártó, Attila},
	doi = {10.1371/journal.pone.0271606},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {17},
	unique-id = {32989211},
	issn = {1932-6203},
	abstract = {Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) is a modification of two-stage hepatectomy profitable for patients with inoperable hepatic tumors by standard techniques. Unfortunately, initially poor postoperative outcome was associated with ALPPS, in which mitochondrial dysfunction played an essential role. Inhibition of cyclophilins has been already proposed to be efficient as a mitochondrial therapy in liver diseases. To investigate the effect of Cyclophilin D (CypD) depletion on mitochondrial function, biogenesis and liver regeneration following ALPPS a CypD knockout (KO) mice model was created.Male wild type (WT) (n = 30) and CypD KO (n = 30) mice underwent ALPPS procedure. Animals were terminated pre-operatively and 24, 48, 72 or 168 h after the operation. Mitochondrial functional studies and proteomic analysis were performed. Regeneration rate and mitotic activity were assessed.The CypD KO group displayed improved mitochondrial function, as both ATP production (P < 0.001) and oxygen consumption (P < 0.05) were increased compared to the WT group. The level of mitochondrial biogenesis coordinator peroxisome proliferator-activated receptor γ co-activator 1-α (PGC1-α) was also elevated in the CypD KO group (P < 0.001), which resulted in the induction of the mitochondrial oxidative phosphorylation system. Liver growth increased in the CypD KO group compared to the WT group (P < 0.001).Our study demonstrates the beneficial effect of CypD depletion on the mitochondrial vulnerability following ALPPS. Based on our results we propose that CypD inhibition should be further investigated as a possible mitochondrial therapy following ALPPS.},
	year = {2022},
	eissn = {1932-6203},
	orcid-numbers = {Daradics, Noémi/0000-0001-6918-7406; Horváth, Gergő/0000-0001-5386-9509; Tretter, László/0000-0001-5638-2886; Paál, Ágnes/0000-0003-2292-3714; Budai, András/0000-0002-4634-2140}
}

@article{MTMT:32552854,
	title = {The role of farnesoid X receptor in accelerated liver regeneration in rats subjected to ALPPS},
	url = {https://m2.mtmt.hu/api/publication/32552854},
	author = {Daradics, Noémi and Olthof, P.B. and Budai, András and Heger, M. and van, Gulik T.M. and Fülöp, András and Szijártó, Attila},
	doi = {10.3390/curroncol28060438},
	journal-iso = {CURR ONCOL},
	journal = {CURRENT ONCOLOGY (TORONTO)},
	volume = {28},
	unique-id = {32552854},
	issn = {1198-0052},
	year = {2021},
	eissn = {1718-7729},
	pages = {5240-5254},
	orcid-numbers = {Daradics, Noémi/0000-0001-6918-7406; Budai, András/0000-0002-4634-2140}
}

@article{MTMT:32461928,
	title = {Az intraduktális papilláris mucinózus neoplázia (Ipmn) jellegzetességei},
	url = {https://m2.mtmt.hu/api/publication/32461928},
	author = {Németh , Kristóf and Budai, András},
	journal-iso = {MAGYAR ONKOLÓGIA},
	journal = {MAGYAR ONKOLÓGIA},
	volume = {65},
	unique-id = {32461928},
	issn = {0025-0244},
	year = {2021},
	eissn = {2060-0399},
	pages = {223-230},
	orcid-numbers = {Budai, András/0000-0002-4634-2140}
}

@article{MTMT:32175343,
	title = {The effects of physical prehabilitation: Improved liver regeneration and mitochondrial function after ALPPS operation in a rodent model},
	url = {https://m2.mtmt.hu/api/publication/32175343},
	author = {Fard-Aghaie, Mohammed-Hossein and Budai, András and Daradics, Noémi and Horváth, Gergő and Oldhafer, Karl and Szijártó, Attila and Fülöp, András},
	doi = {10.1002/jhbp.945},
	journal-iso = {J HEPATO-BIL-PAN SCI},
	journal = {JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES},
	volume = {28},
	unique-id = {32175343},
	issn = {1868-6974},
	abstract = {Background: To identify the role of physical prehabilitation (PP) in liver regeneration, mitochondrial function, biogenesis, and inflammatory response was investigated after associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in a rodent model. Methods: Male Wistar rats (n = 60) underwent ALPPS. Animals were divided (n = 30) to the physical prehabilitation group (PP) and sedentary group (S). The animals were exsanguinated before (0 hour) and 24, 48, 72, or 168 hours after the operation. Regeneration rate and proliferation index were assessed. Mitochondrial function, biogenesis, and inflammatory response were evaluated. Results: Regeneration rate and Ki67 index were significantly increased in the PP group compared to the S group (P <.001). Due to the changes in oxidative capacity and ATP production rate, the P/O ratio of PP group compared to the S group was significantly increased (P <.05). PP group was characterized by accelerated mitochondrial biogenesis and less intense inflammatory response compared to the S group. Conclusions: To our knowledge, this is the first demonstration of the beneficial effects of PP on liver regeneration, mitochondrial function, biogenesis, and the inflammatory response after ALPPS. © 2021 The Authors. Journal of Hepato-Biliary-Pancreatic Sciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Hepato-Biliary-Pancreatic Surgery},
	keywords = {Animals; Mitochondria; Hepatectomy; Exercise; Liver Regeneration},
	year = {2021},
	eissn = {1868-6982},
	pages = {692-702},
	orcid-numbers = {Budai, András/0000-0002-4634-2140; Daradics, Noémi/0000-0001-6918-7406; Horváth, Gergő/0000-0001-5386-9509}
}

@mastersthesis{MTMT:31866300,
	title = {Morfológiai és funkcionális változások akcelerált májregeneráció során},
	url = {https://m2.mtmt.hu/api/publication/31866300},
	author = {Budai, András},
	doi = {10.14753/SE.2020.2368},
	unique-id = {31866300},
	year = {2020},
	orcid-numbers = {Budai, András/0000-0002-4634-2140}
}

@article{MTMT:3426954,
	title = {Mitochondrial function after associating liver partition and portal vein ligation for staged hepatectomy in an experimental model},
	url = {https://m2.mtmt.hu/api/publication/3426954},
	author = {Budai, András and Horváth, Gergő and Tretter, László and Radák, Zsolt and Koltai, Erika and Bori, Zoltán and Torma, Ferenc Gergely and Lukáts, Ákos and Röhlich, Pál and Szijártó, Attila and Fülöp, András},
	doi = {10.1002/bjs.10978},
	journal-iso = {BRIT J SURG},
	journal = {BRITISH JOURNAL OF SURGERY},
	volume = {106},
	unique-id = {3426954},
	issn = {0007-1323},
	year = {2019},
	eissn = {1365-2168},
	pages = {120-131},
	orcid-numbers = {Budai, András/0000-0002-4634-2140; Horváth, Gergő/0000-0001-5386-9509; Tretter, László/0000-0001-5638-2886; Radák, Zsolt/0000-0003-1297-6804; Koltai, Erika/0000-0002-1370-2955; Bori, Zoltán/0000-0003-1253-060X}
}

@article{MTMT:3200784,
	title = {Animal Models for Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS): Achievements and Future Perspectives},
	url = {https://m2.mtmt.hu/api/publication/3200784},
	author = {Budai, András and Fülöp, András and Hahn, Oszkár and Ónody, Péter Zoltán and Kovács, Tibor and Németh, Tibor and Dunay, Miklós Pál and Szijártó, Attila},
	doi = {10.1159/000453108},
	journal-iso = {EUR SURG RES},
	journal = {EUROPEAN SURGICAL RESEARCH},
	volume = {58},
	unique-id = {3200784},
	issn = {0014-312X},
	year = {2017},
	eissn = {1421-9921},
	pages = {140-157},
	orcid-numbers = {Budai, András/0000-0002-4634-2140; Kovács, Tibor/0000-0003-2440-1223}
}

@article{MTMT:3096210,
	title = {Liver regeneration after different degrees of portal vein ligation},
	url = {https://m2.mtmt.hu/api/publication/3096210},
	author = {Lauber, Dávid Tibor and Tihanyi, Dóra Krisztina and Czigány, Zoltán and Kovács, Tibor and Budai, András and Drozgyik, D and Fülöp, András and Szijártó, Attila},
	doi = {10.1016/j.jss.2016.03.032},
	journal-iso = {J SURG RES},
	journal = {JOURNAL OF SURGICAL RESEARCH},
	volume = {203},
	unique-id = {3096210},
	issn = {0022-4804},
	abstract = {BACKGROUND: Selective portal vein ligation (PVL) is followed by ipsilateral atrophy and contralateral hypertrophy of the liver lobes. Although the atrophy-hypertrophy complex induced by PVL is a well-documented phenomenon, the effect of different degrees of extended portal vein occlusion on liver regeneration is not known. The aim of this study was to assess the effects of different degrees of portal occlusion on portal pressure and liver regeneration. MATERIALS AND METHODS: Male Wistar rats (n = 96; 220-250 g) were randomized into three groups and underwent 70%, 80%, or 90% portal vein ligation, respectively. The portal pressure was measured immediately and 24, 48, 72, 120, and 168 h after PVL (n = 6/group/time point). The hepatic lobes and the spleen were weighed, and liver regeneration ratio was calculated. Changes in liver histology and the mitotic activity were assessed on hematoxylin-eosin stained slides. RESULTS: Higher degree of portal occlusion triggered a stronger regenerative response (regeneration ratio of PVL 70%168h = 2.23 +/- 0.13, PVL 80%168h = 3.11 +/- 0.37, PVL 90%168h = 4.68 +/- 0.48) PVL led to an immediate increase in portal pressure, the value of which changed proportionally to the mass of liver tissue deprived of portal perfusion (PVL 70%acute = 17 +/- 2 mm Hg, PVL 80%acute = 19 +/- 1 mm Hg, PVL 90%acute = 26 +/- 4 mm Hg). Findings in histology showed necro-apoptotic lesions in the atrophic liver lobes and increased mitotic cell count in the hypertrophic lobes. The mitotic cell count of PVL 90% peaked earlier and at a significantly higher value than of PVL 70% and PVL 80% (PVL 9024h%: 96.0 +/- 3.5 PVL 70%48h: 64.0 +/- 2.1, PVL 80%48h: 56.3 +/- 4.0). The mitotic index after 24 h showed a strong correlation with the acute portal hypertension. CONCLUSIONS: A higher degree of portal vein occlusion leads to a greater regenerative response, presumably triggered by the proportional increase in portal pressure, which supports the role of the so-called "blood-flow" theory of PVL-triggered liver regeneration.},
	year = {2016},
	eissn = {1095-8673},
	pages = {451-458},
	orcid-numbers = {Tihanyi, Dóra Krisztina/0000-0001-9498-8707; Kovács, Tibor/0000-0003-2440-1223; Budai, András/0000-0002-4634-2140}
}

@article{MTMT:2883410,
	title = {Alterations in Hepatic Lobar Function in Regenerating Rat Liver},
	url = {https://m2.mtmt.hu/api/publication/2883410},
	author = {Fülöp, András and Budai, András and Czigány, Zoltán and Lotz, Gábor and Dezső, Katalin and Paku, Sándor and Harsányi, László and Szijártó, Attila},
	doi = {10.1016/j.jss.2015.04.033},
	journal-iso = {J SURG RES},
	journal = {JOURNAL OF SURGICAL RESEARCH},
	volume = {197},
	unique-id = {2883410},
	issn = {0022-4804},
	year = {2015},
	eissn = {1095-8673},
	pages = {307-317},
	orcid-numbers = {Budai, András/0000-0002-4634-2140; Lotz, Gábor/0000-0002-6921-8978; Dezső, Katalin/0000-0002-4856-0483; Paku, Sándor/0000-0003-2664-7729; Harsányi, László/0000-0003-2657-0039}
}

@article{MTMT:2547916,
	title = {Demonstration of Metabolic and Cellular Effects of Portal Vein Ligation Using Multi-Modal PET/MRI Measurements in Healthy Rat Liver},
	url = {https://m2.mtmt.hu/api/publication/2547916},
	author = {Fülöp, András and Szijártó, Attila and Harsányi, László and Budai, András and Pekli, Damján and Korsós, D and Horváth, I and Stelczerné Kovács, Noémi and Karlinger, Kinga and Máthé, Domokos and Szigeti, Krisztián},
	doi = {10.1371/journal.pone.0090760},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {9},
	unique-id = {2547916},
	issn = {1932-6203},
	abstract = {OBJECTIVES: In the early recognition of portal vein ligation (PVL) induced tumor progression, positron emission tomography and magnetic resonance imaging (PET/MRI) could improve diagnostic accuracy of conventionally used methods. It is unknown how PVL affects metabolic patterns of tumor free hepatic tissues. The aim of this preliminary study is to evaluate the effect of PVL on glucose metabolism, using PET/MRI imaging in healthy rat liver. MATERIALS AND METHODS: Male Wistar rats (n = 30) underwent PVL. 2-deoxy-2-(18F)fluoro-D-glucose (FDG) PET/MRI imaging (nanoScan PET/MRI) and morphological/histological examination were performed before (Day 0) and 1, 2, 3, and 7 days after PVL. Dynamic PET data were collected and the standardized uptake values (SUV) for ligated and non-ligated liver lobes were calculated in relation to cardiac left ventricle (SUVVOI/SUVCLV) and mean liver SUV (SUVVOI/SUVLiver). RESULTS: PVL induced atrophy of ligated lobes, while non-ligated liver tissue showed compensatory hypertrophy. Dynamic PET scan revealed altered FDG kinetics in both ligated and non-ligated liver lobes. SUVVOI/SUVCLV significantly increased in both groups of lobes, with a maximal value at the 2nd postoperative day and returned near to the baseline 7 days after the ligation. After PVL, ligated liver lobes showed significantly higher tracer uptake compared to the non-ligated lobes (significantly higher SUVVOI/SUVLiver values were observed at postoperative day 1, 2 and 3). The homogenous tracer biodistribution observed before PVL reappeared by 7th postoperative day. CONCLUSION: The observed alterations in FDG uptake dynamics should be taken into account during the assessment of PET data until the PVL induced atrophic and regenerative processes are completed.},
	year = {2014},
	eissn = {1932-6203},
	orcid-numbers = {Harsányi, László/0000-0003-2657-0039; Budai, András/0000-0002-4634-2140; Karlinger, Kinga/0000-0002-0846-6687}
}